| 628771 | Abi2 | abl-interactor 2 | ENCODES a protein that exhibits identical protein binding (ortholog); signaling adaptor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN camera-type eye development (ortholog); cell migration (ortholog); dendrite development (ortholog); FOUND IN actin filament (ortholog); adherens j unction (ortholog); cytosol (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 9 | 69321072 | 69490630 | Rat | 119 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 735242 | Abi2 | abl interactor 2 | Predicted to enable several functions, including SH3 domain binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Predicted to contribute to small GTPase binding activity. Involved in lens fiber cell morphogenesis; postsynaptic actin cytoskeleton orga nization; and regulation of dendritic spine morphogenesis. Acts upstream of or within camera-type eye development; generation of neurons; and learning or memory. Located in adherens junction and dendrite. Is active in dendritic spine; glutamatergic synapse; and postsynaptic actin cytoskeleton. Is expressed in several structures, including future brain; intestine smooth muscle circular layer; lens; nervous system; and trunk. Orthologous to human ABI2 (abl interactor 2). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 60444927 | 60521104 | Mouse | 172 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1353143 | ABI2 | abl interactor 2 | Enables several functions, including SH3 domain binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Contributes to small GTPase binding activity. Involved in several processes, including Rac protein signal transduction; positive regulation of cellul ar component organization; and zonula adherens assembly. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in several cellular components, including actin filament; filopodium tip; and lamellipodium. Part of SCAR complex. Is active in adherens junction. [provided by Alliance of Genome Resources, Jul 2025] | 2 | 203328394 | 203432169 | Human | 149 | symbol , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 9027875 | Abi2 | abl interactor 2 | ENCODES a protein that exhibits identical protein binding (ortholog); signaling adaptor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN camera-type eye development (ortholog); cell migration (ortholog); dendrite development (ortholog); FOUND IN actin filament (ortholog); adherens j unction (ortholog); cytosol (ortholog) | NW_004955457 | 11451851 | 11562692 | Chinchilla | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11977565 | ABI2 | abl interactor 2 | ENCODES a protein that exhibits identical protein binding (ortholog); small GTPase binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN camera-type eye development (ortholog); cell migration (ortholog); dendrite development (ortholog); FOUND IN actin filament (ortholog); adhe rens junction (ortholog); dendrite (ortholog) | 2B | 90561708 | 90663072 | Bonobo | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12173203 | ABI2 | abl interactor 2 | ENCODES a protein that exhibits identical protein binding (ortholog); small GTPase binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN camera-type eye development (ortholog); cell migration (ortholog); dendrite development (ortholog); FOUND IN actin filament (ortholog); adhe rens junction (ortholog); dendrite (ortholog) | 37 | 12162815 | 12278505 | Dog | 56 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12568125 | Abi2 | abl interactor 2 | ENCODES a protein that exhibits identical protein binding (ortholog); small GTPase binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN camera-type eye development (ortholog); cell migration (ortholog); dendrite development (ortholog); FOUND IN actin filament (ortholog); adhe rens junction (ortholog); dendrite (ortholog) | NW_004936631 | 30109 | 101748 | Squirrel | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14138843 | ABI2 | abl interactor 2 | ENCODES a protein that exhibits identical protein binding (ortholog); small GTPase binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN camera-type eye development (ortholog); cell migration (ortholog); dendrite development (ortholog); FOUND IN actin filament (ortholog); adhe rens junction (ortholog); dendrite (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 58 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18398874 | ABI2 | abl interactor 2 | ENCODES a protein that exhibits identical protein binding (ortholog); small GTPase binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN camera-type eye development (ortholog); cell migration (ortholog); dendrite development (ortholog); FOUND IN actin filament (ortholog); adhe rens junction (ortholog); dendrite (ortholog) | | | | Green Monkey | 59 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18917752 | Abi2 | abl interactor 2 | ENCODES a protein that exhibits identical protein binding (ortholog); small GTPase binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN camera-type eye development (ortholog); cell migration (ortholog); dendrite development (ortholog); FOUND IN actin filament (ortholog); adhe rens junction (ortholog); cytosol (ortholog) | | | | Naked Mole-Rat | 57 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235996 | abi2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626066103 | Abi2 | abl interactor 2 | ENCODES a protein that exhibits identical protein binding (ortholog); signaling adaptor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN camera-type eye development (ortholog); cell migration (ortholog); dendrite development (ortholog); FOUND IN actin filament (ortholog); adherens j unction (ortholog); cytosol (ortholog) | | | | Black Rat | 50 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249836 | abi2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155235997 | abi2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 16561048 | AC080075.1 | novel transcript, antisense to abl interactor 2 (ABI2) | | | | | Human | | name | gene, lncrna |
| 1349444 | HLA-A | major histocompatibility complex, class I, A | HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen so that they can be recognized by cytotoxic T cells. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. More than 6000 HLA-A alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020] | 6 | 29942532 | 29945870 | Human | 300 | UniProt , GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 8979037 | Actb | actin beta | ENCODES a protein that exhibits ATP hydrolysis activity (ortholog); identical protein binding (ortholog); kinesin binding (ortholog); INVOLVED IN adherens junction assembly (ortholog); apical protein localization (ortholog); axonogenesis (ortholog); PARTICIPATES IN auditory mechanotransduction pathw ay; INO80 family mediated chromatin remodeling pathway; mitochondria transport pathway; ASSOCIATED WITH Aminoacylase 1 Deficiency (ortholog); Animal Mammary Neoplasms (ortholog); Baraitser-Winter syndrome (ortholog); FOUND IN actin cytoskeleton (ortholog); adherens junction (ortholog); apical junction complex (ortholog) | NW_004955460 | 10358100 | 10361585 | Chinchilla | 173 | GenBank Protein | gene, protein-coding, MODEL [RefSeq] |
| 14023381 | ACTB | actin beta | ENCODES a protein that exhibits protein kinase binding (ortholog); INVOLVED IN microtubule-based process; axonogenesis (ortholog); cellular response to electrical stimulus (ortholog); PARTICIPATES IN auditory mechanotransduction pathway; INO80 family mediated chromatin remodeling pathway; mitochondr ia transport pathway; ASSOCIATED WITH Aminoacylase 1 Deficiency (ortholog); Animal Mammary Neoplasms (ortholog); Baraitser-Winter syndrome (ortholog); FOUND IN actin cytoskeleton (ortholog); axon (ortholog); cytoskeleton (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 134 | GenBank Protein | gene, protein-coding, MODEL [RefSeq] |
| 1320118 | Arrdc2 | arrestin domain containing 2 | Predicted to be involved in protein transport. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytoplasm and plasma membrane. Is expressed in bone; metanephros; and testis. Orthologous to human ARRDC2 (arrestin domain containing 2). [provided by Alliance of Genome Resources , Jul 2025] | 8 | 71287773 | 71293173 | Mouse | 121 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1550271 | Arrdc3 | arrestin domain containing 3 | Predicted to enable beta-3 adrenergic receptor binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including fat pad development; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; and negative regulation of locomotion involved in locomotory behavior. Predicted to be located in early endosome and lysosome. Predicted to be active in endosome and plasma membrane. Is expressed in central nervous system; liver; lung; olfactory epithelium; and retina nuclear layer. Orthologous to human ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Apr 2025] | 13 | 81031508 | 81044161 | Mouse | 243 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1323389 | Arrdc4 | arrestin domain containing 4 | Enables ubiquitin-like ligase-substrate adaptor activity. Involved in extracellular vesicle biogenesis; protein transport; and protein ubiquitination. Located in extracellular vesicle and plasma membrane. Orthologous to human ARRDC4 (arrestin domain containing 4). [provided by Alliance of Genome Res ources, Jul 2025] | 7 | 68386742 | 68398986 | Mouse | 179 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1558009 | Asprv1 | aspartic peptidase, retroviral-like 1 | Enables aspartic-type endopeptidase activity. Involved in protein processing and skin development. Predicted to be located in membrane. Is expressed in anterior naris and external naris. Orthologous to human ASPRV1 (aspartic peptidase retroviral like 1). [provided by Alliance of Genome Resources, Ju l 2025] | 6 | 86605216 | 86606692 | Mouse | 82 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 14099307 | B2M | beta-2-microglobulin | ENCODES a protein that exhibits identical protein binding (ortholog); protein homodimerization activity (ortholog); structural molecule activity (ortholog); INVOLVED IN amyloid fibril formation (ortholog); antigen processing and presentation of endogenous peptide antigen via MHC class I (ortholog); antigen processing and presentation of exogenous peptide antigen via MHC class Ib (ortholog); PARTICIPATES IN interleukin-12 signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); Albuminuria (ortholog); arteriosclerosis (ortholog); FOUND IN external side of plasma membrane (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog) | | | | Pig | 134 | GenBank Protein | gene, protein-coding, MODEL [RefSeq] |
| 1343567 | F8 | coagulation factor VIII | This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcript s. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008] | X | 154835792 | 155022723 | Human | 796 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1552455 | Fas | Fas cell surface death receptor | Enables identical protein binding activity. Involved in circadian rhythm; extrinsic apoptotic signaling pathway via death domain receptors; and positive regulation of protein-containing complex assembly. Acts upstream of or within several processes, including activation-induced cell death of T cells ; cellular response to lithium ion; and regulation of hemopoiesis. Located in external side of plasma membrane and extracellular region. Part of CD95 death-inducing signaling complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and limb segment. Used to study Sjogren's syndrome; autoimmune lymphoproliferative syndrome; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 34267926 | 34305175 | Mouse | 2016 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1553064 | Fasl | Fas ligand | Predicted to enable cytokine activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors and retinal cell programmed cell death. Located in external side of plasma membrane . Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system gland; reproductive system; and trophectoderm. Used to study autoimmune lymphoproliferative syndrome and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including cholangiocarcinoma; chronic myeloid leukemia; diabetes mellitus (multiple); pancreatic cancer (multiple); and pre-eclampsia (multiple). Orthologous to human FASLG (Fas ligand). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 161608260 | 161616064 | Mouse | 886 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 736474 | G6PD | glucose-6-phosphate dehydrogenase | This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its ge netic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | X | 154531390 | 154547569 | Human | 1152 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 14027225 | GAPDH | glyceraldehyde-3-phosphate dehydrogenase | ENCODES a protein that exhibits enzyme binding (ortholog); glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity (ortholog); identical protein binding (ortholog); INVOLVED IN cAMP/PKA signal transduction (ortholog); female pregnancy (ortholog); gluconeogenesis (ortholog); PARTIC IPATES IN electron transport chain pathway; Fanconi syndrome pathway; fructose-1,6-bisphosphatase deficiency pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); Alzheimer's disease (ortholog); Animal Disease Models (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); GAIT complex (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide; calcium dichloride; deoxynivalenol | | | | Pig | 162 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1352836 | HLA-B | major histocompatibility complex, class I, B | HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008] | 6 | 31353875 | 31357179 | Human | 573 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 14111924 | HMBS | hydroxymethylbilane synthase | ENCODES a protein that exhibits amine binding (ortholog); carboxylic acid binding (ortholog); hydroxymethylbilane synthase activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); astrocyte differentiation (ortholog); cellular response to amine stimulus (ortholog); PARTICIPATES IN acut e intermittent porphyria pathway; erythropoietic porphyria pathway; heme biosynthetic pathway; ASSOCIATED WITH Abdominal Pain (ortholog); acute intermittent porphyria (ortholog); Acute Intermittent Porphyria, Nonerythroid Variant (ortholog); FOUND IN axon (ortholog); condensed chromosome (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Pig | 97 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14146862 | HPRT1 | hypoxanthine phosphoribosyltransferase 1 | ENCODES a protein that exhibits guanine phosphoribosyltransferase activity (ortholog); hypoxanthine phosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN adenine metabolic process (ortholog); cellular response to insulin stimulus (ortholog); central nervous system neuron development (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); Experimental Diabetes Mellitus (ortholog); familial hypocalciuric hypercalcemia (ortholog); FOUND IN cytoplasm (ortholog) | | | | Pig | 116 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14188766 | IFN-ALPHA-10 | interferon-alpha-10 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN defense response (inferred); defense response to virus (inferred); signal transduction (inferred); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Pig | 8 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14124069 | IFN-ALPHA-4 | interferon-alpha-4 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN defense response (inferred); defense response to virus (inferred); signal transduction (inferred); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Pig | 18 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14028064 | IFN-ALPHA-5 | interferon, alpha 5 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN defense response (inferred); defense response to virus (inferred); signal transduction (inferred); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Pig | 8 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14168958 | IFN-ALPHA-8 | interferon-alpha-8 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN defense response (inferred); defense response to virus (inferred); signal transduction (inferred); FOUND IN extracellular region (inferred); extracellular space (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 19 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 13965875 | IFNA1 | interferon, alpha 1 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN defense response to bacterium (ortholog); defense response to virus (ortholog); natural killer cell activation involved in immune response (ortholog); ASSOCIATED WITH acquired immunodefici ency syndrome (ortholog); adenocarcinoma (ortholog); adult T-cell leukemia/lymphoma (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Pig | 42 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 730858 | IL2 | interleukin 2 | This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T an d B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020] | 4 | 122451470 | 122456725 | Human | 907 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1318069 | Inf2 | inverted formin, FH2 and WH2 domain containing | Predicted to enable actin binding activity and small GTPase binding activity. Acts upstream of or within actin nucleation; gene expression; and regulation of cellular component size. Predicted to be located in perinuclear region of cytoplasm. Is expressed in several structures, including adipose tis sue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate E and focal segmental glomerulosclerosis 5. Orthologous to human INF2 (inverted formin 2). [provided by Alliance of Genome Resources, Jul 2025] | 12 | 112555121 | 112581991 | Mouse | 144 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 14144049 | IRF1 | interferon regulatory factor 1 | ENCODES a protein that exhibits DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); sequence-specific DNA binding (ortholog); transcription cis-regulatory region binding (ortholog); INVOLVED IN apoptotic process (ortholog); canonical NF-kappaB signal transduction (ortho log); CD8-positive, alpha-beta T cell differentiation (ortholog); PARTICIPATES IN interleukin-6 signaling pathway; Jak-Stat signaling pathway; nuclear factor kappa B signaling pathway; ASSOCIATED WITH allergic conjunctivitis (ortholog); asthma (ortholog); bacterial pneumonia (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog) | | | | Pig | 119 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14237466 | IRF2BP1 | interferon regulatory factor 2 binding protein 1 | ENCODES a protein that exhibits transcription corepressor activity (ortholog); ubiquitin protein ligase activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); protein polyubiquitination (ortholog); FOUND IN nucleoplasm (ortholog) | | | | Pig | 8 | GenBank Protein | gene, protein-coding, MODEL [RefSeq] |
| 14184546 | IRF2BP2 | interferon regulatory factor 2 binding protein 2 | ENCODES a protein that exhibits metal ion binding (inferred); transcription corepressor activity (inferred); zinc ion binding (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH acute promyelocytic leukemia (ortholog); common variable immunod eficiency 14 (ortholog); Immune Deficiency, Familial Variable (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Pig | 17 | GenBank Protein | gene, protein-coding, MODEL [RefSeq] |
| 14183272 | IRF3 | interferon regulatory factor 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN antiviral innate immune response (ortholog); cellular response to exogenous dsRNA (ortholo g); cellular response to lipopolysaccharide (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH asthma (ortholog); bacterial pneumonia (ortholog); Herpes Simplex Encephalitis (ortholog); FOUND IN cytoplasm (ortholog); mitochondrion (ortholog); INTERACTS WITH deoxynivalenol; mycotoxin | | | | Pig | 101 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 14036955 | IRF4 | interferon regulatory factor 4 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN chromatin remodeling (ortholog); myeloid dendritic cell differentiation (ortholog); negative regulation of toll-like receptor signaling pathway (ortholog); PARTICIPATES IN interleukin-4 signaling pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); adult T-cell leukemia/lymphoma (ortholog); anaplastic large cell lymphoma (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleosome (inferred) | | | | Pig | 86 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14207493 | IRF5 | interferon regulatory factor 5 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN cellular response to muramyl dipeptide (inferred); cellular response to peptidoglycan (inferr ed); cellular response to virus (inferred); ASSOCIATED WITH arthritis (ortholog); COVID-19 (ortholog); Electric Burns (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Pig | 72 | GenBank Protein | gene, protein-coding, MODEL [RefSeq] |
| 14040383 | IRF7 | interferon regulatory factor 7 | ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (inferred); DNA binding (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN immunoglobulin mediated immune response (ortholog); positive regulation of type I interferon production (ortholog) ; positive regulation of type I interferon-mediated signaling pathway (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Human Influenza (ortholog); immunodeficiency 39 (ortholog); FOUND IN chromatin (inferred); cytoplasm (inferred); cytosol (inferred); INTERACTS WITH chloroquine; deoxynivalenol | | | | Pig | 60 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14235831 | IRF8 | interferon regulatory factor 8 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); INVOLVED IN cellular response to lipopolysaccharide (ortholog); cellular response to type II interferon ( ortholog); defense response to bacterium (ortholog); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; ASSOCIATED WITH B-lymphoblastic leukemia/lymphoma (ortholog); Behcet's disease (ortholog); cardiomyopathy (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred); INTERACTS WITH dibromine | | | | Pig | 82 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 14253173 | IRF9 | interferon regulatory factor 9 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); RNA polymerase II cis-regulatory region sequence-specific DNA binding (inferred); INVOLVED IN DNA-templated transcription (inferred); positive regulation of DNA-templated transcription (infe rred); positive regulation of transcription by RNA polymerase II (inferred); PARTICIPATES IN type II interferon signaling pathway; ASSOCIATED WITH acute pancreatitis (ortholog); Experimental Colitis (ortholog); familial hyperlipidemia (ortholog); FOUND IN cytosol (inferred); nucleus (inferred); INTERACTS WITH graphene oxide | | | | Pig | 42 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1306290 | Ivns1abp | influenza virus NS1A binding protein | INVOLVED IN negative regulation of intrinsic apoptotic signaling pathway (ortholog); negative regulation of protein ubiquitination (ortholog); response to virus (ortholog); PARTICIPATES IN influenza A pathway; ASSOCIATED WITH immunodeficiency 70 (ortholog); Prostatic Neoplasms (ortholog); FOUND IN c ytosol (ortholog); nucleus (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 13 | 65977069 | 65996685 | Rat | 166 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 14138831 | LOC100125545 | TATA-box binding protein | | | | | Pig | | GenBank Protein | gene, protein-coding, MODEL [RefSeq] |
| 13854873 | LOC100153325 | interferon alpha-2 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN defense response (inferred); defense response to virus (inferred); signal transduction (inferred); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Pig | 18 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14149339 | LOC100153661 | interferon alpha-14 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN defense response (inferred); defense response to virus (inferred); signal transduction (inferred); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Pig | 8 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 13843909 | LOC100156936 | interferon alpha-11 | ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN defense response (inferred); defense response to virus (inferred); signal transduction (inferred); FOUND IN extracellular region (inferred); extracellular space (inferred) | | | | Pig | 18 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12281090 | LTBP3 | latent transforming growth factor beta binding protein 3 | ENCODES a protein that exhibits calcium ion binding (inferred); growth factor binding (inferred); transforming growth factor beta binding (inferred); INVOLVED IN bone morphogenesis (ortholog); bone remodeling (ortholog); lung saccule development (ortholog); ASSOCIATED WITH amelogenesis imperfecta (o rtholog); anodontia (ortholog); bone disease (ortholog); FOUND IN extracellular matrix (inferred); extracellular region (inferred) | 18 | 51653783 | 51667793 | Dog | 44 | GenBank Protein | gene, protein-coding, MODEL [RefSeq] |
| 8814309 | Muc2 | mucin 2, oligomeric mucus/gel-forming | ENCODES a protein that exhibits cupric ion binding (ortholog); cuprous ion binding (ortholog); extracellular matrix structural constituent (ortholog); INVOLVED IN cellular response to interleukin-1; cellular response to tumor necrosis factor; apoptotic process (ortholog); ASSOCIATED WITH adenocarcin oma (ortholog); adenoma (ortholog); allergic conjunctivitis (ortholog); FOUND IN extracellular matrix (ortholog); inner mucus layer (ortholog); mucus layer (ortholog) | NW_004955476 | 11108826 | 11135697 | Chinchilla | 74 | GenBank Protein | gene, protein-coding, MODEL [RefSeq] |
| 14254245 | RPL4 | ribosomal protein L4 | ENCODES a protein that exhibits 5S rRNA binding (ortholog); INVOLVED IN brainstem development (ortholog); cell differentiation (ortholog); positive regulation of axon extension (ortholog); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; ASSOCIATED WITH bladder exstrophy-epispadias- cloacal exstrophy complex (ortholog); High Myopia (ortholog); Sepsis (ortholog); FOUND IN A band (ortholog); cytosolic large ribosomal subunit (ortholog); large ribosomal subunit (ortholog) | | | | Pig | 43 | GenBank Protein | gene, protein-coding, MODEL [RefSeq] |
| 1344970 | RTN4RL2 | reticulon 4 receptor like 2 | Enables signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway; corpus callosum development; and negative regulation of neuron projection development. Located in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025] | 11 | 57460528 | 57477534 | Human | 73 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 13897289 | RXRB | retinoid X receptor beta | ENCODES a protein that exhibits identical protein binding (ortholog); nuclear receptor activity (ortholog); nuclear retinoic acid receptor binding (ortholog); INVOLVED IN cardiac muscle cell proliferation (ortholog); in utero embryonic development (ortholog); maternal placenta development (ortholog) ; PARTICIPATES IN retinoic acid signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Disease Progression (ortholog); Stomach Neoplasms (ortholog); FOUND IN cytosol (inferred); nucleolus (inferred); nucleoplasm (inferred); INTERACTS WITH etoxazole | | | | Pig | 66 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 13933510 | RXRG | retinoid X receptor gamma | ENCODES a protein that exhibits identical protein binding (ortholog); RNA polymerase II transcription regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to hormone stimulus (ortholog); heart development (ortholog); neuron differentiation (ortholog); PARTICIPATE S IN retinoic acid signaling pathway; ASSOCIATED WITH lung non-small cell carcinoma (ortholog); Myocardial Ischemia (ortholog); papillary thyroid carcinoma (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred) | | | | Pig | 54 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 13890970 | SDHA | succinate dehydrogenase complex flavoprotein subunit A | ENCODES a protein that exhibits succinate dehydrogenase (quinone) activity (ortholog); INVOLVED IN respiratory electron transport chain (ortholog); succinate metabolic process (ortholog); PARTICIPATES IN citric acid cycle pathway; electron transport chain pathway; fumaric aciduria pathway; ASSOCIATE D WITH B-lymphoblastic leukemia/lymphoma with hypodiploidy (ortholog); Brain Neoplasms (ortholog); Breast Cancer, Familial (ortholog); FOUND IN mitochondrial inner membrane; respiratory chain complex II (succinate dehydrogenase); mitochondrion (ortholog); INTERACTS WITH bisphenol A; glycine betaine; glyphosate | | | | Pig | 109 | GenBank Protein | gene, protein-coding, MODEL [RefSeq] |
| 1344832 | TNFSF10 | TNF superfamily member 10 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] | 3 | 172505508 | 172523430 | Human | 574 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 13870155 | TNFSF13B | TNF superfamily member 13b | ENCODES a protein that exhibits cytokine activity (inferred); tumor necrosis factor receptor binding (inferred); INVOLVED IN positive regulation of B cell proliferation; B cell costimulation (ortholog); B cell differentiation (ortholog); ASSOCIATED WITH Chronic Hepatitis B (ortholog); COVID-19 (orth olog); IgA glomerulonephritis (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); extracellular space (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 34 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1312377 | Vps50 | VPS50 EARP/GARPII complex subunit | Predicted to enable SNARE binding activity. Acts upstream of or within endocytic recycling. Predicted to be located in membrane; perinuclear region of cytoplasm; and recycling endosome. Predicted to be part of EARP complex. Orthologous to human VPS50 (VPS50 subunit of EARP/GARPII complex). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 3498393 | 3603531 | Mouse | 101 | GenBank Protein | gene, protein-coding, VALIDATED [RefSeq] |
| 1313832 | VSX1 | visual system homeobox 1 | The protein encoded by this gene contains a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior pol ymorphous corneal dystrophy and keratoconus. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] | 20 | 25070880 | 25082141 | Human | 238 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 13858001 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN angiogenesis (ortholog); ERK1 and ERK2 cascade (ortholog); histamine secretion by mast cell (ortholog); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; histone modification pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; ASSOCIATED WITH absence epilepsy (ortholog); Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); FOUND IN cell leading edge (ortholog); perinuclear region of cytoplasm (ortholog); postsynaptic specialization (ortholog); INTERACTS WITH aluminium atom; aluminium(0); ammonia | | | | Pig | 187 | GenBank Protein | gene, protein-coding, PROVISIONAL [RefSeq] |
