HPRT1 (hypoxanthine phosphoribosyltransferase 1) - Rat Genome Database

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Gene: HPRT1 (hypoxanthine phosphoribosyltransferase 1) Sus scrofa
Analyze
Symbol: HPRT1
Name: hypoxanthine phosphoribosyltransferase 1
RGD ID: 14146862
Description: ENCODES a protein that exhibits guanine phosphoribosyltransferase activity (ortholog); hypoxanthine phosphoribosyltransferase activity (ortholog); identical protein binding (ortholog); INVOLVED IN adenine metabolic process (ortholog); brain development (ortholog); cellular response to insulin stimulus (ortholog); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; ASSOCIATED WITH autistic disorder (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: HGPRT; HGPRTase; HPRT; hypoxanthine-guanine phosphoribosyltransferase; hypoxanthine-guanine phosphoribosyltransferase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX110,321,208 - 110,357,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X110,321,144 - 110,357,902 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISS)
cytosol  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:6309343   PMID:7190225   PMID:14681463   PMID:15679890   PMID:15847915   PMID:17026777   PMID:17145712   PMID:17697375  


Genomics

Comparative Map Data
HPRT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX110,321,208 - 110,357,899 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X110,321,144 - 110,357,902 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HPRT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX134,460,165 - 134,520,513 (+)EnsemblGRCh38hg38GRCh38
GRCh38X134,460,165 - 134,500,668 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X133,594,195 - 133,634,698 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X133,421,923 - 133,462,362 (+)NCBINCBI36hg18NCBI36
Build 34X133,319,776 - 133,360,216NCBI
CeleraX133,981,004 - 134,021,522 (+)NCBI
Cytogenetic MapXq26.2-q26.3NCBI
HuRefX122,992,617 - 123,032,595 (+)NCBIHuRef
CHM1_1X133,505,941 - 133,546,459 (+)NCBICHM1_1
Hprt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X52,076,955 - 52,110,537 (+)NCBIGRCm39mm39
GRCm39 EnsemblX52,077,014 - 52,110,536 (+)Ensembl
GRCm38X52,988,078 - 53,021,660 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX52,988,137 - 53,021,659 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X50,341,255 - 50,374,837 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X49,232,764 - 49,266,286 (+)NCBImm8
CeleraX40,414,095 - 40,447,630 (+)NCBICelera
Cytogenetic MapXA5NCBI
cM MapX29.31NCBI
Hprt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X132,736,175 - 132,768,149 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX132,736,096 - 132,768,154 (+)Ensembl
Rnor_6.0X158,196,640 - 158,228,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,197,149 - 158,228,749 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 EnsemblX158,623,240 - 158,655,198 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X152,821,947 - 152,854,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0X153,249,874 - 153,281,841 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X139,929,647 - 139,961,616 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X140,003,079 - 140,035,048 (+)NCBI
Cytogenetic MapXq37NCBI
Hprt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955473462,940 - 510,006 (-)NCBIChiLan1.0ChiLan1.0
HPRT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X133,908,233 - 133,948,197 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX133,916,681 - 133,948,197 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X123,609,248 - 123,650,102 (+)NCBIMhudiblu_PPA_v0panPan3
HPRT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X105,115,732 - 105,153,702 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX105,115,732 - 105,153,702 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX91,226,153 - 91,264,410 (+)NCBI
ROS_Cfam_1.0X106,975,655 - 107,013,438 (+)NCBI
UMICH_Zoey_3.1X104,388,675 - 104,426,954 (+)NCBI
UNSW_CanFamBas_1.0X106,254,668 - 106,292,939 (+)NCBI
UU_Cfam_GSD_1.0X106,046,035 - 106,084,329 (+)NCBI
Hprt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X103,263,023 - 103,304,555 (+)NCBI
SpeTri2.0NW_004936691650,753 - 694,362 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HPRT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X109,629,674 - 109,671,409 (+)NCBI
Vero_WHO_p1.0NW_02366606547,224,456 - 47,265,741 (+)NCBI
Hprt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479714,148,580 - 14,184,471 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 7 2 3 5 23 1 2 3
Low 3 2 2 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001032376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021079503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021079504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000122 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF143818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK346023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK392537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK399940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY609416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU468475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ136030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ178126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ845175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU395621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01081037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U32316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U69731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000051852   ⟹   ENSSSCP00000044832
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX110,321,208 - 110,357,899 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000065496   ⟹   ENSSSCP00000041929
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX110,329,765 - 110,357,899 (+)Ensembl
RefSeq Acc Id: NM_001032376   ⟹   NP_001027548
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X110,321,289 - 110,357,898 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021079503   ⟹   XP_020935162
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X110,322,507 - 110,357,902 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021079504   ⟹   XP_020935163
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X110,321,144 - 110,357,892 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020935163   ⟸   XM_021079504
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001027548   ⟸   NM_001032376
- UniProtKB: Q45FY6 (UniProtKB/Swiss-Prot),   B0LXK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020935162   ⟸   XM_021079503
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000041929   ⟸   ENSSSCT00000065496
RefSeq Acc Id: ENSSSCP00000044832   ⟸   ENSSSCT00000051852
Protein Domains
Pribosyltran


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000034896 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00025044949 UniProtKB/Swiss-Prot
  ENSSSCG00030034364 UniProtKB/Swiss-Prot
  ENSSSCG00035005142 UniProtKB/Swiss-Prot
  ENSSSCG00040025932 UniProtKB/Swiss-Prot
  ENSSSCG00045031043 UniProtKB/Swiss-Prot
  ENSSSCG00050027741 UniProtKB/Swiss-Prot
  ENSSSCG00055006870 UniProtKB/Swiss-Prot
  ENSSSCG00060057082 UniProtKB/Swiss-Prot
  ENSSSCG00065048888 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000041929 UniProtKB/TrEMBL
  ENSSSCP00000044832 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCP00025025924 UniProtKB/Swiss-Prot
  ENSSSCP00030021430 UniProtKB/Swiss-Prot
  ENSSSCP00035002255 UniProtKB/Swiss-Prot
  ENSSSCP00040014343 UniProtKB/Swiss-Prot
  ENSSSCP00045036866 UniProtKB/Swiss-Prot
  ENSSSCP00050015522 UniProtKB/Swiss-Prot
  ENSSSCP00055010490 UniProtKB/Swiss-Prot
  ENSSSCP00060033612 UniProtKB/Swiss-Prot
  ENSSSCP00065029032 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000051852 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCT00000065496 UniProtKB/TrEMBL
  ENSSSCT00025061056 UniProtKB/Swiss-Prot
  ENSSSCT00030047570 UniProtKB/Swiss-Prot
  ENSSSCT00035006457 UniProtKB/Swiss-Prot
  ENSSSCT00040034674 UniProtKB/Swiss-Prot
  ENSSSCT00045052993 UniProtKB/Swiss-Prot
  ENSSSCT00050037335 UniProtKB/Swiss-Prot
  ENSSSCT00055013340 UniProtKB/Swiss-Prot
  ENSSSCT00060077778 UniProtKB/Swiss-Prot
  ENSSSCT00065066896 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.2020 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Hxn_phspho_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRibTrfase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRTase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene HPRT1 ENTREZGENE
Pfam Pribosyltran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PUR_PYR_PR_TRANSFER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF53271 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs HGPRTase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287AD45_PIG UniProtKB/TrEMBL
  B0LXK8 ENTREZGENE, UniProtKB/TrEMBL
  HPRT_PIG UniProtKB/Swiss-Prot
  Q00P25_PIG UniProtKB/TrEMBL
  Q45FY6 ENTREZGENE
UniProt Secondary A0SNU9 UniProtKB/Swiss-Prot