Akr1c3 (aldo-keto reductase family 1, member C3) - Rat Genome Database

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Gene: Akr1c3 (aldo-keto reductase family 1, member C3) Rattus norvegicus
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Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
RGD ID: 708428
Description: Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity and aldose reductase (NADPH) activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to ketone; and cellular response to peptide hormone stimulus. Acts upstream of or within progesterone metabolic process. Located in cytosol. Biomarker of polycystic ovary syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; alcohol dependence; and leukemia. Orthologous to human AKR1C3 (aldo-keto reductase family 1 member C3); PARTICIPATES IN isoprenoid metabolic pathway; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (20S)-20-hydroxypregn-4-en-3-one; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20alpha-hydroxysteroid dehydrogenase; Akr1c18; aldo-keto reductase family 1 member C18; aldo-keto reductase family 1, member C18; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); HSD1; LOC171516
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,020,884 - 71,037,779 (+)NCBIGRCr8
mRatBN7.21766,110,970 - 66,127,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,596,139 - 69,613,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,424,984 - 73,441,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,467,962 - 67,484,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,761,126 - 69,778,021 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,761,118 - 69,778,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,465,942 - 71,482,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,269,626 - 77,286,521 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,280,458 - 77,297,354 (+)NCBI
Celera1765,626,116 - 65,643,004 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Akr1c3Ratalcohol dependence  ISOAKR1C3 (Homo sapiens)597621634DNA:SNP:cds:rs12529 (p.H5Q)(human)RGD 
Akr1c3RatB-lymphoblastic leukemia/lymphoma treatmentISOAKR1C3 (Homo sapiens)11541128 RGD 
Akr1c3Ratcastration-resistant prostate carcinoma  ISOAKR1C3 (Homo sapiens)10053626mRNA and protein:increased expression:epithelial cell:RGD 
Akr1c3RatCOVID-19  ISOAKR1C3 (Homo sapiens)9068941mRNA:decreased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Akr1c3Ratductal carcinoma in situ  ISOAKR1C3 (Homo sapiens)10053629protein:increased expression:myoepithelial cells:RGD 
Akr1c3Ratleukemia  ISOAKR1C3 (Homo sapiens)11541126DNA:SNP:intron:rs10508293 (human)RGD 
Akr1c3Ratmyeloid neoplasm  ISOAkr1c18 (Mus musculus)11552589 RGD 
Akr1c3Ratpolycystic ovary syndrome  IEP 11541125 RGD 
Akr1c3Ratpre-eclampsia  ISOAKR1C3 (Homo sapiens)10053633mRNA:decreased expression:blood:RGD 
Akr1c3Ratpre-eclampsia treatmentIEP 11541124 RGD 
Akr1c3Ratprostate cancer disease_progressionISOAKR1C3 (Homo sapiens)10053627protein:increased expression:epithelium:RGD 
Akr1c3RatT-cell acute lymphoblastic leukemia treatmentISOAKR1C3 (Homo sapiens)11541128 RGD 
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Akr1c3Rathypoparathyroidism-deafness-renal disease syndrome  ISOAKR1C3 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypoparathyroidism more ...ClinVarPMID:25741868
Akr1c3Ratprostate cancer  ISOAKR1C3 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383
Akr1c3Ratschizophrenia  ISOAKR1C3 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
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Akr1c3Ratautism spectrum disorder  ISOAKR1C3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Akr1c3Ratcastration-resistant prostate carcinoma  ISOAKR1C3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25555457
Akr1c3Ratdisorder of sexual development  ISOAKR1C3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25304492
Akr1c3RatEndometrial Neoplasms  ISOAKR1C3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16338060
Akr1c3Ratendometriosis  ISOAKR1C3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21232532 and PMID:25446850
Akr1c3RatExperimental Liver Cirrhosis  ISOAKR1C3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136
Akr1c3RatNeoplasms, Hormone-Dependent  ISOAKR1C3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25304492
Akr1c3RatNeoplastic Cell Transformation  ISOAKR1C3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19696165
Akr1c3Ratobesity  ISOAKR1C3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20882379
Akr1c3Ratpolycystic ovary syndrome  ISOAKR1C3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16263811 more ...
Akr1c3RatProstatic Neoplasms  ISOAKR1C3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17507624 and PMID:18306354
Akr1c3RatStomach Neoplasms  ISOAKR1C3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19424620
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Akr1c3Rat(-)-epigallocatechin 3-gallate multiple interactionsISOAKR1C3 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of AKR1C3 mRNACTDPMID:22079256
Akr1c3Rat(20S)-20-hydroxypregn-4-en-3-one multiple interactionsISOAKR1C3 (Homo sapiens)6480464[AKR1C3 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone and [AKR1C3 protein results in increased reduction of Progesterone] which results in increased chemical synthesis of 20-alpha-DihydroprogesteroneCTDPMID:19010312 and PMID:20036328
Akr1c3Rat(20S)-20-hydroxypregn-4-en-3-one increases chemical synthesisEXP 6480464AKR1C18 protein results in increased chemical synthesis of 20-alpha-DihydroprogesteroneCTDPMID:8172618
Akr1c3Rat(20S)-20-hydroxypregn-4-en-3-one increases chemical synthesisISOAKR1C3 (Homo sapiens)6480464AKR1C3 protein results in increased chemical synthesis of 20-alpha-DihydroprogesteroneCTDPMID:25463305
Akr1c3Rat(E)-cinnamyl alcohol increases expressionISOAKR1C3 (Homo sapiens)6480464cinnamyl alcohol results in increased expression of AKR1C3 mRNACTDPMID:20566472
Akr1c3Rat(S)-naringenin decreases activityISOAKR1C3 (Homo sapiens)6480464naringenin results in decreased activity of AKR1C3 proteinCTDPMID:19007764
Akr1c3Rat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsEXP 64804642 more ...CTDPMID:19414516
Akr1c3Rat1,10-phenanthroline decreases activityISOAKR1C3 (Homo sapiens)64804641 and 10-phenanthroline results in decreased activity of AKR1C3 proteinCTDPMID:12604236
Akr1c3Rat1,2-dichloroethane increases expressionISOAkr1c18 (Mus musculus)6480464ethylene dichloride results in increased expression of AKR1C18 mRNACTDPMID:28960355
Akr1c3Rat1,2-dimethylhydrazine decreases expressionISOAkr1c18 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of AKR1C18 mRNACTDPMID:22206623
Akr1c3Rat1,8-Dinitropyrene multiple interactionsISOAKR1C3 (Homo sapiens)6480464[AKR1C3 protein results in increased degradation of 1 and 8-dinitropyrene] which results in increased abundance of 1-amino-8-nitropyreneCTDPMID:36399404
Akr1c3Rat1-Aminopyrene multiple interactionsISOAKR1C3 (Homo sapiens)6480464[AKR1C3 protein results in increased degradation of 1-nitropyrene] which results in increased abundance of 1-aminopyreneCTDPMID:36399404
Akr1c3Rat1-chloro-2,4-dinitrobenzene increases expressionISOAKR1C3 (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of AKR1C3 mRNACTDPMID:20566472
Akr1c3Rat1-chloro-2,4-dinitrobenzene affects expressionISOAkr1c18 (Mus musculus)6480464Dinitrochlorobenzene affects the expression of AKR1C18 mRNACTDPMID:22302311
Akr1c3Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of AKR1C3 mRNACTDPMID:25380136 and PMID:30723492
Akr1c3Rat1-nitropyrene multiple interactionsISOAKR1C3 (Homo sapiens)6480464[AKR1C3 protein results in increased degradation of 1-nitropyrene] which results in increased abundance of 1-aminopyreneCTDPMID:36399404
Akr1c3Rat11-deoxycorticosterone increases metabolic processingISOAkr1c18 (Mus musculus)6480464AKR1C18 protein results in increased metabolism of DesoxycorticosteroneCTDPMID:17122075
Akr1c3Rat13-dihydrodaunorubicin multiple interactionsISOAKR1C3 (Homo sapiens)6480464[AKR1C3 protein results in increased metabolism of Daunorubicin] which results in increased abundance of daunorubicinol more ...CTDPMID:30703376 more ...
Akr1c3Rat13-dihydrodaunorubicin increases chemical synthesisISOAKR1C3 (Homo sapiens)6480464AKR1C3 protein results in increased chemical synthesis of daunorubicinolCTDPMID:33025066
Akr1c3Rat15-deoxy-Delta(12,14)-prostaglandin J2 multiple interactionsISOAKR1C3 (Homo sapiens)6480464[Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12 and 14)-prostaglandin J2CTDPMID:19997560

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Biological Process
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Akr1c3Ratcellular response to calcium ion involved_inISOAKR1C3 (Homo sapiens)1624291 PMID:22170488RGDPMID:22170488
Akr1c3Ratcellular response to corticosteroid stimulus involved_inISOAKR1C3 (Homo sapiens)1624291 PMID:19336506RGDPMID:19336506
Akr1c3Ratcellular response to follicle-stimulating hormone stimulus  IEP 10053618 RGD 
Akr1c3Ratcellular response to forskolin  IEP 10053610 RGD 
Akr1c3Ratcellular response to gonadotropin-releasing hormone  IEP 10053621 RGD 
Akr1c3Ratcellular response to jasmonic acid stimulus involved_inISOAKR1C3 (Homo sapiens)1624291 PMID:19487289RGDPMID:19487289
Akr1c3Ratcellular response to prolactin  IEP 10053613 RGD 
Akr1c3Ratcellular response to prostaglandin D stimulus involved_inISOAKR1C3 (Homo sapiens)1624291 PMID:18508192RGDPMID:18508192
Akr1c3Ratcellular response to prostaglandin stimulus involved_inISOAKR1C3 (Homo sapiens)1624291 PMID:22170488RGDPMID:22170488
Akr1c3Ratcellular response to starvation involved_inISOAKR1C3 (Homo sapiens)1624291 PMID:18641923RGDPMID:18641923
Akr1c3Ratcellular response to testosterone stimulus  IEP 10053618 RGD 
Akr1c3Ratcellular response to transforming growth factor beta stimulus  IMP 10053613 RGD 
Akr1c3Ratdaunorubicin metabolic process involved_inISOAKR1C3 (Homo sapiens)1624291 PMID:20837989RGDPMID:20837989
Akr1c3Ratdaunorubicin metabolic process involved_inIBAPANTHER:PTN000199031 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c3Ratdoxorubicin metabolic process involved_inISOAKR1C3 (Homo sapiens)1624291 PMID:20837989RGDPMID:20837989
Akr1c3Ratdoxorubicin metabolic process involved_inIBAPANTHER:PTN000199031 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c3Ratfarnesol catabolic process involved_inISOAKR1C3 (Homo sapiens)1624291 PMID:21187079RGDPMID:21187079
Akr1c3Ratfemale pregnancy  IEP 10053620 RGD 
Akr1c3RatG protein-coupled receptor signaling pathway involved_inISOAKR1C3 (Homo sapiens)1624291 PMID:18508192RGDPMID:18508192
Akr1c3Ratkeratinocyte differentiation involved_inISOAKR1C3 (Homo sapiens)1624291 PMID:22170488RGDPMID:22170488
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Cellular Component

  
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Akr1c3Ratcytoplasm located_inISOAKR1C3 (Homo sapiens)1624291 PMID:18574251 more ...RGDPMID:18574251 more ...
Akr1c3Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Akr1c3Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Akr1c3Ratcytosol located_inIDA 1299434PMID:8194472MGI 
Akr1c3Ratcytosol is_active_inIBAMGI:1353494 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c3Ratnucleus located_inISOAKR1C3 (Homo sapiens)1624291 PMID:18574251RGDPMID:18574251

Molecular Function
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Akr1c3Rat15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity enablesISOAKR1C3 (Homo sapiens)1624291 PMID:22170488RGDPMID:22170488
Akr1c3Rat17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity  IDA 1299435PMID:8172618RGD 
Akr1c3Rat17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity  IDA 2303525 RGD 
Akr1c3Rat17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity enablesISOAkr1c18 (Mus musculus)1624291MGI:3527218 PMID:15471942RGDPMID:15471942
Akr1c3Rat17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity enablesIEAEC:1.1.1.1491600115GO_REF:0000003UniProtGO_REF:0000003
Akr1c3Rat17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity enablesIEAUniProtKB:Q8K023 and ensembl:ENSMUSP000000216351600115GO_REF:0000107EnsemblGO_REF:0000107
Akr1c3Rat17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity enablesIEARHEA:15853 and RHEA:158571600115GO_REF:0000116RHEAGO_REF:0000116
Akr1c3Rat17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity enablesIDA 1299435PMID:8172618MGI 
Akr1c3Rat17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase [NAD(P)+] activity  IDA 10053609 RGD 
Akr1c3Rataldo-keto reductase (NADPH) activity enablesISOAKR1C3 (Homo sapiens)1624291 PMID:9792917RGDPMID:9792917
Akr1c3Rataldose reductase (NADPH) activity enablesISOAKR1C3 (Homo sapiens)1624291 PMID:21232532RGDPMID:21232532
Akr1c3Rataldose reductase (NADPH) activity enablesIBAFB:FBgn0086254 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c3Ratall-trans-retinol dehydrogenase (NAD+) activity enablesISOAKR1C3 (Homo sapiens)1624291 PMID:21851338RGDPMID:21851338
Akr1c3Ratandrosterone dehydrogenase [NAD(P)+] activity enablesISOAKR1C3 (Homo sapiens)1624291 PMID:16983398RGDPMID:16983398
Akr1c3Ratandrosterone dehydrogenase [NAD(P)+] activity enablesIBAMGI:1924587 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c3Ratbile acid binding enablesIBAMGI:1924587 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Akr1c3RatDelta4-3-oxosteroid 5beta-reductase activity enablesISOAKR1C3 (Homo sapiens)1624291 PMID:16983398RGDPMID:16983398
Akr1c3Ratgeranylgeranyl reductase activity enablesISOAKR1C3 (Homo sapiens)1624291 PMID:21187079RGDPMID:21187079
Akr1c3Ratketoreductase activity enablesISOAKR1C3 (Homo sapiens)1624291 PMID:19487289RGDPMID:19487289
Akr1c3Ratketosteroid monooxygenase activity enablesISOAKR1C3 (Homo sapiens)1624291 PMID:21232532RGDPMID:21232532
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RGD Manual Annotations


  
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Original Reference(s)
Akr1c3Ratdoxorubicin pharmacokinetics pathway   ISOAKR1C3 (Homo sapiens)10395261 RGD 
Akr1c3Ratisoprenoid metabolic pathway  IDA 2303525 RGD 
Akr1c3Ratprostaglandin biosynthetic pathway  TAS 8552774 RGD 

Imported Annotations - SMPDB

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Akr1c3Ratacetylsalicylic acid pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00083
Akr1c3Ratantipyrine drug pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00692
Akr1c3Ratarachidonic acid metabolic pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00075
Akr1c3Ratcelecoxib pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00096
Akr1c3Ratdiclofenac pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00093
Akr1c3Ratdiflunisal pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00289
Akr1c3Ratdoxorubicin pharmacokinetics pathway   ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00650
Akr1c3Ratetodolac pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00084
Akr1c3Ratfenoprofen pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00696
Akr1c3Ratflurbiprofen pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00697
Akr1c3Ratibuprofen pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00086
Akr1c3Ratindometacin pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00104
Akr1c3Ratindometacin pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00104
Akr1c3Ratketoprofen pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00085
Akr1c3Ratketorolac pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00098
Akr1c3Ratleukotriene C4 synthase deficiency pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00353
Akr1c3Ratlornoxicam pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00700
Akr1c3Ratmagnesium salicylate pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00698
Akr1c3Ratmefenamic acid pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00109
Akr1c3Ratmeloxicam pharmacodynamics pathway  ISOAKR1C3 (Homo sapiens)10402751 SMPDBSMP:00106
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Reference Title
Reference Citation
1. Expression of 17beta-hydroxysteroid dehydrogenase type 1 and type 2, P450 aromatase, and 20alpha-hydroxysteroid dehydrogenase enzymes in immature, mature, and pregnant rats. Akinola LA, etal., Endocrinology. 1997 Jul;138(7):2886-92.
2. Identification of a major prolactin-regulated protein as 20 alpha-hydroxysteroid dehydrogenase: coordinate regulation of its activity, protein content, and messenger ribonucleic acid expression. Albarracin CT, etal., Endocrinology 1994 Jun;134(6):2453-60.
3. Paracrine-stimulated gene expression profile favors estradiol production in breast tumors. Amin SA, etal., Mol Cell Endocrinol. 2006 Jul 11;253(1-2):44-55. Epub 2006 Jun 2.
4. Tissue distribution of human AKR1C3 and rat homolog in the adult genitourinary system. Azzarello J, etal., J Histochem Cytochem. 2008 Sep;56(9):853-61. doi: 10.1369/jhc.2008.951384. Epub 2008 Jun 23.
5. Steroidogenic enzyme activities in rat polycystic ovaries. Cooke GM, etal., Can J Physiol Pharmacol. 1993 Mar-Apr;71(3-4):247-53.
6. Inhibition of 20 alpha-hydroxysteroid dehydrogenase activity by follicle-stimulating hormone and androgens in cultured rat granulosa cells: a search for the mechanism of action. Duleba AJ, etal., Biol Reprod. 1985 Sep;33(2):401-10.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Aldo-keto reductase family 1 member C3 (AKR1C3) is a biomarker and therapeutic target for castration-resistant prostate cancer. Hamid AR, etal., Mol Med. 2013 Jan 22;18:1449-55. doi: 10.2119/molmed.2012.00296.
9. [Effects of AKR1C3 on kidney damage of preeclamptic rats]. Jin Y, etal., Zhonghua Yi Xue Za Zhi. 2015 Jan 6;95(1):30-3.
10. Direct stimulation of ovarian progesterone-metabolizing enzyme by gonadotropin-releasing hormone in cultured granulosa cells. Jones PB and Hsueh AJ, J Biol Chem. 1981 Feb 10;256(3):1248-54.
11. The roles of pregn-5-ene-3 beta, 20 alpha-diol and 20 alpha-hydroxy steroid dehydrogenase in the control of progesterone synthesis preceding parturition and lactogenesis in the rat. Kuhn NJ and Briley MS, Biochem J. 1970 Apr;117(2):193-201.
12. Maternal and offspring genetic variants of AKR1C3 and the risk of childhood leukemia. Liu CY, etal., Carcinogenesis. 2008 May;29(5):984-90. doi: 10.1093/carcin/bgn071. Epub 2008 Mar 13.
13. Isolation and characterization of a rat luteal cDNA encoding 20 alpha-hydroxysteroid dehydrogenase. Mao J, etal., Biochem Biophys Res Commun 1994 Jun 30;201(3):1289-95.
14. Expression, purification and characterization of the rat luteal 20 alpha-hydroxysteroid dehydrogenase. Mao J, etal., Endocrinology. 1997 Jan;138(1):182-90.
15. 20 alpha-hydroxysteroid dehydrogenase expression in a murine virus-induced myeloproliferative syndrome. Marcovistz R, etal., Biochimie. 1991 Nov;73(11):1351-3.
16. Possible role of transforming growth factor-beta as a mediator of luteotropic action of prolactin in rat luteal cell cultures. Matsuyama S, etal., Endocrinology. 1990 Oct;127(4):1561-7.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Variation in genes encoding the neuroactive steroid synthetic enzymes 5α-reductase type 1 and 3α-reductase type 2 is associated with alcohol dependence. Milivojevic V, etal., Alcohol Clin Exp Res. 2011 May;35(5):946-52. doi: 10.1111/j.1530-0277.2010.01425.x. Epub 2011 Feb 15.
19. Molecular cloning of cDNA for rat ovarian 20 alpha-hydroxysteroid dehydrogenase (HSD1). Miura R, etal., Biochem J 1994 Apr 15;299 ( Pt 2):561-7.
20. AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia. Moradi Manesh D, etal., Blood. 2015 Sep 3;126(10):1193-202. doi: 10.1182/blood-2014-12-618900. Epub 2015 Jun 26.
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PMID:12477932   PMID:15140254   PMID:15471942   PMID:16983398   PMID:17122075   PMID:18508192   PMID:18641923   PMID:19007764   PMID:19336506   PMID:19429887   PMID:19442656   PMID:19487289  
PMID:19942269   PMID:20036328   PMID:20837989   PMID:21187079   PMID:21232532   PMID:21787718   PMID:21851338   PMID:22170488   PMID:23376485   PMID:23533145   PMID:29627526  



Akr1c3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81771,020,884 - 71,037,779 (+)NCBIGRCr8
mRatBN7.21766,110,970 - 66,127,867 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1769,596,139 - 69,613,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01773,424,984 - 73,441,883 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01767,467,962 - 67,484,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01769,761,126 - 69,778,021 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1769,761,118 - 69,778,021 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01771,465,942 - 71,482,837 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41777,269,626 - 77,286,521 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11777,280,458 - 77,297,354 (+)NCBI
Celera1765,626,116 - 65,643,004 (+)NCBICelera
Cytogenetic Map17q12.2NCBI
AKR1C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38105,048,781 - 5,107,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl105,035,354 - 5,107,686 (+)EnsemblGRCh38hg38GRCh38
GRCh37105,090,973 - 5,149,878 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36105,126,568 - 5,139,878 (+)NCBINCBI36Build 36hg18NCBI36
Build 34105,126,567 - 5,139,878NCBI
Celera105,076,549 - 5,089,836 (+)NCBICelera
Cytogenetic Map10p15.1NCBI
HuRef105,024,814 - 5,083,613 (+)NCBIHuRef
CHM1_1105,091,312 - 5,150,193 (+)NCBICHM1_1
T2T-CHM13v2.0105,049,294 - 5,108,188 (+)NCBIT2T-CHM13v2.0
Akr1c18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,182,614 - 4,200,645 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,182,614 - 4,200,653 (-)EnsemblGRCm39 Ensembl
GRCm38134,132,615 - 4,150,646 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,132,615 - 4,150,654 (-)EnsemblGRCm38mm10GRCm38
MGSCv37134,131,873 - 4,149,877 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,131,873 - 4,149,877 (-)NCBIMGSCv36mm8
Celera134,108,614 - 4,126,601 (-)NCBICelera
Cytogenetic Map13A1NCBI
cM Map132.31NCBI
AKR1C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2817,590,820 - 17,668,960 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11017,660,905 - 17,732,534 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0105,079,580 - 5,157,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1105,061,119 - 5,139,818 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl105,081,214 - 5,139,812 (+)Ensemblpanpan1.1panPan2
AKR1C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1230,661,333 - 30,691,283 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl230,674,558 - 30,690,043 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha227,694,812 - 27,719,595 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0231,042,072 - 31,071,570 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl231,045,998 - 31,070,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1228,135,405 - 28,160,172 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0228,972,376 - 28,997,157 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0229,696,602 - 29,721,383 (+)NCBIUU_Cfam_GSD_1.0
AKR1C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1065,576,464 - 65,678,248 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11065,650,223 - 65,679,878 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21071,902,088 - 71,931,228 (+)NCBISscrofa10.2Sscrofa10.2susScr3

.

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Variants in Akr1c3
119 total Variants

Predicted Target Of
Summary Value
Count of predictions:160
Count of miRNA genes:114
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000023739
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 44 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1358295Aocep1Aortic cell protein QTL 16.17e-07thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
70210Cm15Cardiac mass QTL 156.5heart right ventricle mass (VT:0007033)heart right ventricle wet weight (CMO:0000072)175724672370156904Rat
152023626Bp403Blood pressure QTL 4033.86arterial blood pressure trait (VT:2000000)172393042179524188Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat

1 to 10 of 44 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 11 27 45 64 65 35 15 35 6 132 65 25 17 32 30



Ensembl Acc Id: ENSRNOT00000023739   ⟹   ENSRNOP00000023739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)Ensembl
Rnor_6.0 Ensembl1769,761,118 - 69,778,021 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117083   ⟹   ENSRNOP00000091104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1766,110,963 - 66,127,873 (+)Ensembl
RefSeq Acc Id: NM_138510   ⟹   NP_612519
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81771,020,884 - 71,037,779 (+)NCBI
mRatBN7.21766,110,970 - 66,127,867 (+)NCBI
Rnor_6.01769,761,126 - 69,778,021 (+)NCBI
Rnor_5.01771,465,942 - 71,482,837 (+)NCBI
RGSC_v3.41777,269,626 - 77,286,521 (+)RGD
Celera1765,626,116 - 65,643,004 (+)RGD
Sequence:
1 to 12 of 12 rows
Protein RefSeqs NP_612519 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40601 (Get FASTA)   NCBI Sequence Viewer  
  AAH86579 (Get FASTA)   NCBI Sequence Viewer  
  AAI00249 (Get FASTA)   NCBI Sequence Viewer  
  ABB72484 (Get FASTA)   NCBI Sequence Viewer  
  BAA03317 (Get FASTA)   NCBI Sequence Viewer  
  BAB62013 (Get FASTA)   NCBI Sequence Viewer  
  EDL78573 (Get FASTA)   NCBI Sequence Viewer  
  EDL78574 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023739.4
  ENSRNOP00000104189
GenBank Protein P51652 (Get FASTA)   NCBI Sequence Viewer  
1 to 12 of 12 rows
RefSeq Acc Id: NP_612519   ⟸   NM_138510
- UniProtKB: Q498E4 (UniProtKB/Swiss-Prot),   P51652 (UniProtKB/Swiss-Prot),   A6JLP6 (UniProtKB/TrEMBL),   Q5RJM6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023739   ⟸   ENSRNOT00000023739
Ensembl Acc Id: ENSRNOP00000091104   ⟸   ENSRNOT00000117083
NADP-dependent oxidoreductase

Name Modeler Protein Id AA Range Protein Structure
AF-P51652-F1-model_v2 AlphaFold P51652 1-323 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700547
Promoter ID:EPDNEW_R11070
Type:single initiation site
Name:Akr1c3_1
Description:aldo-keto reductase family 1, member C3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01769,761,115 - 69,761,175EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-8832 BioCyc
Ensembl Genes ENSRNOG00000017531 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023739.6 UniProtKB/Swiss-Prot
  ENSRNOT00000168386 ENTREZGENE
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7307214 IMAGE-MGC_LOAD
  IMAGE:7307445 IMAGE-MGC_LOAD
InterPro AKR1C UniProtKB/Swiss-Prot
  Aldo/ket_reductase_CS UniProtKB/Swiss-Prot
  Aldo/keto_reductase UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:171516 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105325 IMAGE-MGC_LOAD
  MGC:116049 IMAGE-MGC_LOAD
NCBI Gene 171516 ENTREZGENE
PANTHER ALDO/KETO REDUCTASE UniProtKB/Swiss-Prot
Pfam Aldo_ket_red UniProtKB/Swiss-Prot
PharmGKB AKR1C3 RGD
PhenoGen Akr1c3 PhenoGen
PIRSF AKR UniProtKB/Swiss-Prot
PRINTS ALDKETRDTASE UniProtKB/Swiss-Prot
PROSITE ALDOKETO_REDUCTASE_1 UniProtKB/Swiss-Prot
  ALDOKETO_REDUCTASE_2 UniProtKB/Swiss-Prot
  ALDOKETO_REDUCTASE_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017531 RatGTEx
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot
UniProt A0A8I6AD39_RAT UniProtKB/TrEMBL
  A6JLP6 ENTREZGENE, UniProtKB/TrEMBL
  AKC1H_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q498E4 ENTREZGENE
  Q5RJM6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q498E4 UniProtKB/Swiss-Prot
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Akr1c3  aldo-keto reductase family 1, member C3  Akr1c3  aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-09 Akr1c3  aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)  Akr1c18  aldo-keto reductase family 1, member C18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Akr1c18  aldo-keto reductase family 1, member C18      Symbol and Name updated 1299863 APPROVED
2005-09-30 LOC171516        Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in different steroid-producing tissues like ovary, testis, adrenal uterus and placenta 1299435
gene_regulation expression is inhibited by prolactin 1299434