Fst (follistatin) - Rat Genome Database

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Gene: Fst (follistatin) Rattus norvegicus
Analyze
Symbol: Fst
Name: follistatin
RGD ID: 2633
Description: Enables heparan sulfate proteoglycan binding activity. Involved in cellular response to growth factor stimulus and response to organic cyclic compound. Predicted to be located in cytoplasm and nucleus. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activin-binding protein; FOL1; follistatin-A; FS; Fst-288; LOC686745; RATFOL1; similar to follistatin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc   WKY.SHRSP-(Fst-Pklr)/Gcrc   SHRSP.WKY-(D2Rat13-D2Mit5)/Gcrc  
QTLs:   Bp132  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8247,856,345 - 47,863,670 (-)NCBIGRCr8
mRatBN7.2246,123,260 - 46,130,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,123,439 - 46,130,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx253,226,536 - 53,233,459 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0251,284,901 - 51,291,822 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0246,164,805 - 46,171,742 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0246,537,589 - 46,544,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl246,538,700 - 46,544,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0265,576,721 - 65,583,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,542,246 - 46,550,678 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1246,470,478 - 46,478,911 (-)NCBI
Celera241,883,386 - 41,889,989 (-)NCBICelera
Cytogenetic Map2q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-Hydroxybenzo[a]pyrene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
Archazolid B  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
azathioprine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butyric acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corn oil  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
diethyl malate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
GW 4064  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
inulin  (ISO)
isobutanol  (ISO)
isoflavones  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
methamphetamine  (EXP)
Methandrostenolone  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
Monobutylphthalate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxybenzone  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentobarbital  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium iodide  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Dynamics of messenger RNAs encoding inhibin/activin subunits and follistatin in the ovary during the rat estrous cycle. Arai KY, etal., Biol Reprod. 2002 Apr;66(4):1119-26.
2. Rat anterior pituitary folliculostellate cells are targets of interleukin-1beta and a major source of intrapituitary follistatin. Bilezikjian LM, etal., Endocrinology 2003 Feb;144(2):732-40.
3. GnRH pulse frequency modulation of gonadotropin subunit gene transcription in normal gonadotropes-assessment by primary transcript assay provides evidence for roles of GnRH and follistatin. Burger LL, etal., Endocrinology 2002 Sep;143(9):3243-9.
4. Mapping of rat chromosome 2 markers generated from chromosome-sorted DNA. Deng AY, etal., Mamm Genome 1997 Oct;8(10):731-5.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. betaA- and betaC-activin, follistatin, activin receptor mRNA and betaC-activin peptide expression during rat liver regeneration. Gold EJ, etal., J Mol Endocrinol. 2005 Apr;34(2):505-15.
8. Structural basis for the inhibition of activin signalling by follistatin. Harrington AE, etal., EMBO J. 2006 Mar 8;25(5):1035-45. Epub 2006 Feb 16.
9. Crystal structures of the heparan sulfate-binding domain of follistatin. Insights into ligand binding. Innis CA and Hyvonen M, J Biol Chem. 2003 Oct 10;278(41):39969-77. Epub 2003 Jul 16.
10. Multiple defects and perinatal death in mice deficient in follistatin. Matzuk MM, etal., Nature 1995 Mar 23;374(6520):360-3.
11. Granulosa cell tumor mutant FOXL2C134W suppresses GDF-9 and activin A-induced follistatin transcription in primary granulosa cells. McTavish KJ, etal., Mol Cell Endocrinol. 2013 Jun 15;372(1-2):57-64. doi: 10.1016/j.mce.2013.03.021. Epub 2013 Apr 6.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Differential expression of the pituitary gonadotropin subunit genes during male rat sexual maturation: reciprocal relationship between hypothalamic pituitary adenylate cyclase-activating polypeptide and follicle-stimulating hormone beta expression. Moore JP Jr, etal., Biol Reprod. 2003 Jul;69(1):234-41. Epub 2003 Mar 19.
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Pituitary follistatin gene expression in female rats: evidence that inhibin regulates transcription. Prendergast KA, etal., Biol Reprod. 2004 Feb;70(2):364-70. Epub 2003 Oct 15.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Follistatin overexpression in rodent liver tumors: a possible mechanism to overcome activin growth control. Rossmanith W, etal., Mol Carcinog 2002 Sep;35(1):1-5.
22. The UV filter benzophenone 3, alters early follicular assembly in rat whole ovary cultures. Santamaría CG, etal., Toxicol Lett. 2019 Mar 15;303:48-54. doi: 10.1016/j.toxlet.2018.12.016. Epub 2018 Dec 30.
23. Follistatin gene expression in the ovary and extragonadal tissues. Shimasaki S, etal., Mol Endocrinol 1989 Apr;3(4):651-9.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Urbanek M, etal., Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8573-8.
26. Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic-ischemic brain injury in the infant rat. Wu DD, etal., Brain Res. 1999 Jul 24;835(2):369-78. doi: 10.1016/s0006-8993(99)01638-8.
27. Lipopolysaccharide induced activin A-follistatin imbalance affects cardiac fibrosis. Zhang WQ, etal., Chin Med J (Engl). 2012 Jun;125(12):2205-12.
Additional References at PubMed
PMID:8472873   PMID:11948405   PMID:12088867   PMID:12514121   PMID:12697670   PMID:12702211   PMID:15162500   PMID:15305290   PMID:15451575   PMID:15525533   PMID:16123203   PMID:16935389  
PMID:17344471   PMID:18184649   PMID:18781389   PMID:19103603   PMID:20002838   PMID:20032047   PMID:20801187   PMID:21826650   PMID:22033906   PMID:22206666   PMID:22332899   PMID:22464481  
PMID:24006456   PMID:24019467   PMID:27128567   PMID:28277126   PMID:29113826   PMID:32014555   PMID:36899937  


Genomics

Comparative Map Data
Fst
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8247,856,345 - 47,863,670 (-)NCBIGRCr8
mRatBN7.2246,123,260 - 46,130,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,123,439 - 46,130,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx253,226,536 - 53,233,459 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0251,284,901 - 51,291,822 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0246,164,805 - 46,171,742 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0246,537,589 - 46,544,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl246,538,700 - 46,544,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0265,576,721 - 65,583,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,542,246 - 46,550,678 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1246,470,478 - 46,478,911 (-)NCBI
Celera241,883,386 - 41,889,989 (-)NCBICelera
Cytogenetic Map2q14NCBI
FST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38553,480,629 - 53,487,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl553,480,626 - 53,487,134 (+)EnsemblGRCh38hg38GRCh38
GRCh37552,776,459 - 52,782,964 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,812,352 - 52,817,680 (+)NCBINCBI36Build 36hg18NCBI36
Build 34552,812,351 - 52,817,659NCBI
Celera549,730,217 - 49,735,545 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef549,748,385 - 49,754,428 (+)NCBIHuRef
CHM1_1552,779,193 - 52,785,231 (+)NCBICHM1_1
T2T-CHM13v2.0554,308,436 - 54,314,946 (+)NCBIT2T-CHM13v2.0
Fst
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913114,588,798 - 114,595,522 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13114,588,826 - 114,595,487 (-)EnsemblGRCm39 Ensembl
GRCm3813114,452,262 - 114,458,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,452,290 - 114,458,951 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,242,470 - 115,248,938 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613115,574,219 - 115,579,464 (-)NCBIMGSCv36mm8
Celera13118,786,092 - 118,792,681 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.15NCBI
Fst
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544613,925,776 - 13,932,104 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544613,925,833 - 13,932,104 (-)NCBIChiLan1.0ChiLan1.0
FST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2460,454,897 - 60,462,481 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1558,608,522 - 58,616,019 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0560,544,495 - 60,550,516 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1562,163,655 - 62,168,218 (-)NCBIpanpan1.1PanPan1.1panPan2
FST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1461,779,252 - 61,785,666 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl461,779,259 - 61,783,260 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha461,544,683 - 61,551,112 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0462,270,843 - 62,277,297 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl462,271,936 - 62,277,253 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1462,049,664 - 62,056,089 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0462,178,184 - 62,184,600 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0462,695,162 - 62,701,588 (-)NCBIUU_Cfam_GSD_1.0
Fst
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213205,054,434 - 205,060,754 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648013,990,929 - 13,997,248 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648013,990,967 - 13,997,248 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,805,932 - 32,811,421 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,806,341 - 32,811,382 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21634,779,040 - 34,784,066 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,773,646 - 49,780,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,773,980 - 49,780,333 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660821,343,148 - 1,349,927 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fst
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247595,798,067 - 5,805,254 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247595,799,127 - 5,804,802 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fst
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:46
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000015680
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
12879863Bp402Blood pressure QTL 4020.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24112578956532139Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat

Markers in Region
D2Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2246,130,672 - 46,130,826 (+)MAPPERmRatBN7.2
Rnor_6.0246,544,917 - 46,545,070NCBIRnor6.0
Rnor_5.0265,584,009 - 65,584,162UniSTSRnor5.0
RGSC_v3.4246,551,142 - 46,551,296RGDRGSC3.4
RGSC_v3.4246,551,143 - 46,551,296UniSTSRGSC3.4
RGSC_v3.1246,479,375 - 46,479,529RGD
RH 3.4 Map2297.6UniSTS
RH 3.4 Map2297.6RGD
RH 2.0 Map2267.2RGD
Cytogenetic Map2q16UniSTS
D2Arb3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2246,130,674 - 46,130,822 (+)MAPPERmRatBN7.2
Rnor_6.0246,544,919 - 46,545,066NCBIRnor6.0
Rnor_5.0265,584,011 - 65,584,158UniSTSRnor5.0
RGSC_v3.4246,551,144 - 46,551,292RGDRGSC3.4
RGSC_v3.4246,551,145 - 46,551,292UniSTSRGSC3.4
RGSC_v3.1246,479,377 - 46,479,525RGD
Cytogenetic Map2q16UniSTS
AA858520  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map2293.1UniSTS
Cytogenetic Map2q16UniSTS
Fst  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0246,539,696 - 46,541,189NCBIRnor6.0
Rnor_5.0265,578,828 - 65,580,216UniSTSRnor5.0
RGSC_v3.4246,543,186 - 46,544,783UniSTSRGSC3.4
Cytogenetic Map2q16UniSTS




Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 2 1 1 12 17 19 3 1
Low 1 41 38 22 11 22 7 10 58 18 21 8 7
Below cutoff 2 15 15 7 15 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015680   ⟹   ENSRNOP00000015680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl246,123,439 - 46,130,571 (-)Ensembl
Rnor_6.0 Ensembl246,538,700 - 46,544,457 (-)Ensembl
RefSeq Acc Id: NM_012561   ⟹   NP_036693
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8247,856,345 - 47,863,292 (-)NCBI
mRatBN7.2246,123,260 - 46,130,208 (-)NCBI
Rnor_6.0246,537,589 - 46,544,452 (-)NCBI
Rnor_5.0265,576,721 - 65,583,918 (-)NCBI
RGSC_v3.4246,542,246 - 46,550,678 (-)RGD
Celera241,883,386 - 41,889,989 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231953   ⟹   XP_006232015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8247,856,345 - 47,863,670 (-)NCBI
mRatBN7.2246,123,260 - 46,130,583 (-)NCBI
Rnor_6.0246,537,589 - 46,544,813 (-)NCBI
Rnor_5.0265,576,721 - 65,583,918 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006231954   ⟹   XP_006232016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8247,856,345 - 47,863,669 (-)NCBI
mRatBN7.2246,123,260 - 46,130,582 (-)NCBI
Rnor_6.0246,538,745 - 46,544,813 (-)NCBI
Rnor_5.0265,576,721 - 65,583,918 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036693   ⟸   NM_012561
- Peptide Label: precursor
- UniProtKB: Q80XW7 (UniProtKB/Swiss-Prot),   P21674 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006232015   ⟸   XM_006231953
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006232016   ⟸   XM_006231954
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000015680   ⟸   ENSRNOT00000015680
Protein Domains
Follistatin-like   Kazal-like   TB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P21674-F1-model_v2 AlphaFold P21674 1-344 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2633 AgrOrtholog
BioCyc Gene G2FUF-54336 BioCyc
Ensembl Genes ENSRNOG00000011631 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055006368 UniProtKB/Swiss-Prot
  ENSRNOG00060014325 UniProtKB/Swiss-Prot
  ENSRNOG00065020284 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015680 ENTREZGENE
  ENSRNOT00000015680.5 UniProtKB/Swiss-Prot
  ENSRNOT00055010356 UniProtKB/Swiss-Prot
  ENSRNOT00060024506 UniProtKB/Swiss-Prot
  ENSRNOT00065034264 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.290.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Fol_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Follistatin/Osteonectin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24373 UniProtKB/Swiss-Prot
NCBI Gene 24373 ENTREZGENE
PANTHER AGRIN UniProtKB/Swiss-Prot
  FOLLISTATIN UniProtKB/TrEMBL
  FOLLISTATIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FST_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fst PhenoGen
PROSITE KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS51364 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011631 RatGTEx
  ENSRNOG00055006368 RatGTEx
  ENSRNOG00060014325 RatGTEx
  ENSRNOG00065020284 RatGTEx
SMART FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Kazal-type serine protease inhibitors UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SSF57581 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC201576
UniProt A6I5S4_RAT UniProtKB/TrEMBL
  FST_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q80XW7 ENTREZGENE
UniProt Secondary Q80XW7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Fst  follistatin  LOC686745  similar to follistatin  Data merged from RGD:1593716 737654 PROVISIONAL
2006-11-20 LOC686745  similar to follistatin      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Fst  follistatin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mRNA is overexpressed in some hepatocellular carcinomas 728764