FST (follistatin) - Rat Genome Database

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Gene: FST (follistatin) Chlorocebus sabaeus
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Symbol: FST
Name: follistatin
RGD ID: 18460567
Description: ENCODES a protein that exhibits heparan sulfate proteoglycan binding (ortholog); INVOLVED IN ameloblast differentiation (ortholog); BMP signaling pathway (ortholog); cellular response to growth factor stimulus (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); Brain Hypoxia-Ischemia (ortholog); Breast Neoplasms (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,773,646 - 49,780,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,773,980 - 49,780,333 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660821,343,148 - 1,349,927 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,773,646 - 49,780,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl449,773,980 - 49,780,333 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660821,343,148 - 1,349,927 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
FST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38553,480,629 - 53,487,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl553,480,626 - 53,487,134 (+)EnsemblGRCh38hg38GRCh38
GRCh37552,776,459 - 52,782,964 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,812,352 - 52,817,680 (+)NCBINCBI36Build 36hg18NCBI36
Build 34552,812,351 - 52,817,659NCBI
Celera549,730,217 - 49,735,545 (+)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef549,748,385 - 49,754,428 (+)NCBIHuRef
CHM1_1552,779,193 - 52,785,231 (+)NCBICHM1_1
T2T-CHM13v2.0554,308,436 - 54,314,946 (+)NCBIT2T-CHM13v2.0
Fst
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913114,588,798 - 114,595,522 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13114,588,826 - 114,595,487 (-)EnsemblGRCm39 Ensembl
GRCm3813114,452,262 - 114,458,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,452,290 - 114,458,951 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,242,470 - 115,248,938 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613115,574,219 - 115,579,464 (-)NCBIMGSCv36mm8
Celera13118,786,092 - 118,792,681 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1364.15NCBI
Fst
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8247,856,345 - 47,863,670 (-)NCBIGRCr8
mRatBN7.2246,123,260 - 46,130,584 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl246,123,439 - 46,130,571 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx253,226,536 - 53,233,459 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0251,284,901 - 51,291,822 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0246,164,805 - 46,171,742 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0246,537,589 - 46,544,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl246,538,700 - 46,544,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0265,576,721 - 65,583,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,542,246 - 46,550,678 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1246,470,478 - 46,478,911 (-)NCBI
Celera241,883,386 - 41,889,989 (-)NCBICelera
Cytogenetic Map2q14NCBI
Fst
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544613,925,776 - 13,932,104 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544613,925,833 - 13,932,104 (-)NCBIChiLan1.0ChiLan1.0
FST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2460,454,897 - 60,462,481 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1558,608,522 - 58,616,019 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0560,544,495 - 60,550,516 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1562,163,655 - 62,168,218 (-)NCBIpanpan1.1PanPan1.1panPan2
FST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1461,779,252 - 61,785,666 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl461,779,259 - 61,783,260 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha461,544,683 - 61,551,112 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0462,270,843 - 62,277,297 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl462,271,936 - 62,277,253 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1462,049,664 - 62,056,089 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0462,178,184 - 62,184,600 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0462,695,162 - 62,701,588 (-)NCBIUU_Cfam_GSD_1.0
Fst
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213205,054,434 - 205,060,754 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648013,990,929 - 13,997,248 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648013,990,967 - 13,997,248 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,805,932 - 32,811,421 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,806,341 - 32,811,382 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21634,779,040 - 34,784,066 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Fst
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247595,798,067 - 5,805,254 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247595,799,127 - 5,804,802 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 33 11 43
Below cutoff 3 7 17

Sequence


RefSeq Acc Id: ENSCSAT00000014725   ⟹   ENSCSAP00000012689
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl449,773,980 - 49,780,333 (+)Ensembl
RefSeq Acc Id: XM_007972220   ⟹   XP_007970411
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1449,773,647 - 49,779,300 (+)NCBI
Vero_WHO_p1.0NW_0236660821,343,148 - 1,349,924 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007972226   ⟹   XP_007970417
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1449,773,987 - 49,780,343 (+)NCBI
Vero_WHO_p1.0NW_0236660821,343,148 - 1,349,925 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007972236   ⟹   XP_007970427
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1449,773,646 - 49,780,343 (+)NCBI
Vero_WHO_p1.0NW_0236660821,343,148 - 1,349,925 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037994647   ⟹   XP_037850575
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_0236660821,343,148 - 1,349,927 (-)NCBI
Protein Sequences
Protein RefSeqs XP_007970411 (Get FASTA)   NCBI Sequence Viewer  
  XP_007970417 (Get FASTA)   NCBI Sequence Viewer  
  XP_007970427 (Get FASTA)   NCBI Sequence Viewer  
  XP_037850575 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000012689
  ENSCSAP00000012689.1
RefSeq Acc Id: XP_007970427   ⟸   XM_007972236
- Peptide Label: isoform X3
RefSeq Acc Id: XP_007970411   ⟸   XM_007972220
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RVQ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007970417   ⟸   XM_007972226
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCSAP00000012689   ⟸   ENSCSAT00000014725
RefSeq Acc Id: XP_037850575   ⟸   XM_037994647
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000016631 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000014725.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.30 UniProtKB/TrEMBL
  3.90.290.10 UniProtKB/TrEMBL
InterPro Fol_N UniProtKB/TrEMBL
  Follistatin/Osteonectin_EGF UniProtKB/TrEMBL
  Kazal_dom UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
  TB_dom UniProtKB/TrEMBL
  TB_dom_sf UniProtKB/TrEMBL
NCBI Gene FST ENTREZGENE
PANTHER AGRIN UniProtKB/TrEMBL
  FOLLISTATIN-RELATED UniProtKB/TrEMBL
Pfam FOLN UniProtKB/TrEMBL
  FST_N UniProtKB/TrEMBL
  Kazal_2 UniProtKB/TrEMBL
PROSITE KAZAL_2 UniProtKB/TrEMBL
  PS51364 UniProtKB/TrEMBL
SMART FOLN UniProtKB/TrEMBL
  KAZAL UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/TrEMBL
  SSF57581 UniProtKB/TrEMBL
UniProt A0A0D9RVQ0 ENTREZGENE, UniProtKB/TrEMBL