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Mapping of rat chromosome 2 markers generated from chromosome-sorted DNA.

Authors: Deng, AY  Jackson, CM  Hoebee, B  Rapp, JP 
Citation: Deng AY, etal., Mamm Genome 1997 Oct;8(10):731-5.
Pubmed: (View Article at PubMed) PMID:9321465

A quantitative trait locus (QTL) for blood pressure has recently been mapped to a region of roughly 30 cM on rat Chromosome (Chr) 2 by linkage and by the use of congenic strains. For further fine mapping of the QTL, however, closely linked chromosome markers residing in this 30-cM region are required. In the current work, 36 new markers were generated by screening rat Chr 2-sorted DNA libraries and subsequently mapped using five F2 populations. Combining new and existing markers, the marker density for the 30-cM region approaches, on average, one marker per 1.1 cM.


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RGD Object Information
RGD ID: 68909
Created: 2001-10-15
Species: All species
Last Modified: 2001-10-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.