FST (follistatin) - Rat Genome Database

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Gene: FST (follistatin) Homo sapiens
Analyze
Symbol: FST
Name: follistatin
RGD ID: 734008
HGNC Page HGNC
Description: Exhibits activin binding activity and activin receptor antagonist activity. Involved in several processes, including hematopoietic progenitor cell differentiation; negative regulation of activin receptor signaling pathway; and positive regulation of hair follicle development. Predicted to localize to extracellular space. Implicated in polycystic ovary syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activin-binding protein; follistatin isoform FST317; FS
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl553,480,626 - 53,487,134 (+)EnsemblGRCh38hg38GRCh38
GRCh38553,480,338 - 53,487,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37552,776,459 - 52,782,964 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,812,352 - 52,817,680 (+)NCBINCBI36hg18NCBI36
Build 34552,812,351 - 52,817,659NCBI
Celera549,730,217 - 49,735,545 (+)NCBI
Cytogenetic Map5q11.2NCBI
HuRef549,748,385 - 49,754,428 (+)NCBIHuRef
CHM1_1552,779,193 - 52,785,231 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-Hydroxypyrene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-Hydroxybenzo[a]pyrene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP)
atrazine  (EXP)
azathioprine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (EXP)
butyric acid  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calciol  (ISO)
calcitriol  (EXP)
carbon nanotube  (EXP,ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
cycloheximide  (EXP)
cyclosporin A  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (EXP)
diethyl malate  (ISO)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
ethanol  (EXP)
fluoranthene  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP)
furan  (ISO)
genistein  (EXP)
geraniol  (EXP)
GW 4064  (ISO)
hydralazine  (EXP)
hydrogen peroxide  (EXP)
indometacin  (EXP)
isobutanol  (EXP)
isoflavones  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
Methandrostenolone  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
Monobutylphthalate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (EXP)
orphenadrine  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
paracetamol  (EXP,ISO)
pentobarbital  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP)
piroxicam  (EXP)
potassium iodide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
rac-lactic acid  (EXP)
raloxifene  (EXP)
ranitidine  (ISO)
resveratrol  (EXP)
SB 431542  (EXP)
serpentine asbestos  (EXP)
sevoflurane  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
triadimefon  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vitamin E  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:2036994   PMID:3380788   PMID:7887917   PMID:8288705   PMID:8536619   PMID:8836491   PMID:9799587   PMID:9828086   PMID:10702675   PMID:11232039   PMID:11580864   PMID:11948405  
PMID:12099690   PMID:12242034   PMID:12477932   PMID:12514121   PMID:12531697   PMID:12651901   PMID:12697670   PMID:12702211   PMID:12720540   PMID:14563935   PMID:14578849   PMID:15064726  
PMID:15296481   PMID:15340161   PMID:15451575   PMID:15472207   PMID:15489334   PMID:15574124   PMID:16150905   PMID:16198295   PMID:16336961   PMID:16627583   PMID:16935389   PMID:17053951  
PMID:17284512   PMID:17296189   PMID:17347381   PMID:17644811   PMID:17893249   PMID:17991437   PMID:18001154   PMID:18184649   PMID:18245525   PMID:18319260   PMID:19011242   PMID:19106105  
PMID:19346981   PMID:19453261   PMID:19460752   PMID:19470636   PMID:19520047   PMID:19597895   PMID:19740438   PMID:20093255   PMID:20623366   PMID:20628624   PMID:20634891   PMID:20734064  
PMID:20801187   PMID:20843798   PMID:20860622   PMID:20926007   PMID:21068158   PMID:21222045   PMID:21350111   PMID:21496809   PMID:21829661   PMID:21846490   PMID:21873635   PMID:21900206  
PMID:21900845   PMID:22395277   PMID:22416010   PMID:22685544   PMID:22693174   PMID:22809401   PMID:23010638   PMID:23023351   PMID:23113792   PMID:23171678   PMID:23249626   PMID:23265961  
PMID:23304117   PMID:23432377   PMID:23523567   PMID:23564759   PMID:24204752   PMID:24232707   PMID:24332943   PMID:24577120   PMID:24667650   PMID:24763182   PMID:24885241   PMID:24927181  
PMID:25361680   PMID:25565002   PMID:25885021   PMID:26086422   PMID:26189841   PMID:26415587   PMID:26652766   PMID:26844494   PMID:26950277   PMID:27159193   PMID:27168011   PMID:27389553  
PMID:27399349   PMID:27621181   PMID:27621190   PMID:27787698   PMID:27807065   PMID:28500669   PMID:28583174   PMID:28647698   PMID:28732565   PMID:29867232   PMID:30021884   PMID:30165829  
PMID:30874767   PMID:31182152   PMID:31402604   PMID:31526145   PMID:31647905   PMID:31757999   PMID:31887804   PMID:32296183  


Genomics

Comparative Map Data
FST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl553,480,626 - 53,487,134 (+)EnsemblGRCh38hg38GRCh38
GRCh38553,480,338 - 53,487,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37552,776,459 - 52,782,964 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36552,812,352 - 52,817,680 (+)NCBINCBI36hg18NCBI36
Build 34552,812,351 - 52,817,659NCBI
Celera549,730,217 - 49,735,545 (+)NCBI
Cytogenetic Map5q11.2NCBI
HuRef549,748,385 - 49,754,428 (+)NCBIHuRef
CHM1_1552,779,193 - 52,785,231 (+)NCBICHM1_1
Fst
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913114,588,798 - 114,595,522 (-)NCBIGRCm39mm39
GRCm39 Ensembl13114,588,826 - 114,595,487 (-)Ensembl
GRCm3813114,452,262 - 114,458,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13114,452,290 - 114,458,951 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713115,242,470 - 115,248,938 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613115,574,219 - 115,579,464 (-)NCBImm8
Celera13118,786,092 - 118,792,681 (-)NCBICelera
Cytogenetic Map13D2.2NCBI
Fst
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2246,123,260 - 46,130,584 (-)NCBI
Rnor_6.0 Ensembl246,538,700 - 46,544,457 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0246,537,589 - 46,544,813 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0265,576,721 - 65,583,918 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4246,542,246 - 46,550,678 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1246,470,478 - 46,478,911 (-)NCBI
Celera241,883,386 - 41,889,989 (-)NCBICelera
Cytogenetic Map2q14NCBI
Fst
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544613,925,776 - 13,932,104 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544613,925,833 - 13,932,104 (-)NCBIChiLan1.0ChiLan1.0
FST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1562,163,655 - 62,168,218 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0560,544,495 - 60,550,516 (-)NCBIMhudiblu_PPA_v0panPan3
FST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1461,779,252 - 61,785,666 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl461,779,259 - 61,783,260 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha461,544,683 - 61,551,112 (-)NCBI
ROS_Cfam_1.0462,270,843 - 62,277,297 (-)NCBI
UMICH_Zoey_3.1462,049,664 - 62,056,089 (-)NCBI
UNSW_CanFamBas_1.0462,178,184 - 62,184,600 (-)NCBI
UU_Cfam_GSD_1.0462,695,162 - 62,701,588 (-)NCBI
Fst
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213205,054,434 - 205,060,754 (-)NCBI
SpeTri2.0NW_00493648013,990,967 - 13,997,248 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1632,805,874 - 32,811,421 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11632,806,341 - 32,811,382 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21634,779,040 - 34,784,066 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FST
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1449,773,646 - 49,780,343 (+)NCBI
ChlSab1.1 Ensembl449,773,980 - 49,780,333 (+)Ensembl
Fst
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247595,799,127 - 5,804,802 (-)NCBI

Position Markers
FST  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37552,780,952 - 52,781,051UniSTSGRCh37
GRCh37552,781,619 - 52,781,797UniSTSGRCh37
GRCh37552,778,769 - 52,779,543UniSTSGRCh37
GRCh37552,779,423 - 52,780,971UniSTSGRCh37
GRCh37552,779,914 - 52,781,053UniSTSGRCh37
Build 36552,817,376 - 52,817,554RGDNCBI36
Celera549,735,241 - 49,735,419RGD
Celera549,733,536 - 49,734,675UniSTS
Celera549,732,391 - 49,733,165UniSTS
Celera549,734,574 - 49,734,673UniSTS
Celera549,733,045 - 49,734,593UniSTS
HuRef549,750,892 - 49,751,666UniSTS
HuRef549,753,075 - 49,753,174UniSTS
HuRef549,751,546 - 49,753,094UniSTS
HuRef549,753,742 - 49,753,920UniSTS
HuRef549,752,037 - 49,753,176UniSTS
SGC33112  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37552,781,022 - 52,781,845UniSTSGRCh37
Celera549,734,644 - 49,735,467UniSTS
Cytogenetic Map5q11.2UniSTS
HuRef549,753,145 - 49,753,968UniSTS
GeneMap99-GB4 RH Map5280.47UniSTS
Whitehead-RH Map5183.7UniSTS
FST  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37552,781,619 - 52,781,797UniSTSGRCh37
GRCh37552,780,952 - 52,781,051UniSTSGRCh37
GRCh37552,778,769 - 52,779,543UniSTSGRCh37
GRCh37552,779,914 - 52,781,053UniSTSGRCh37
GRCh37552,779,423 - 52,780,971UniSTSGRCh37
Build 36552,817,376 - 52,817,554RGDNCBI36
Celera549,735,241 - 49,735,419RGD
Celera549,733,536 - 49,734,675UniSTS
Celera549,732,391 - 49,733,165UniSTS
Celera549,733,045 - 49,734,593UniSTS
Celera549,734,574 - 49,734,673UniSTS
HuRef549,753,075 - 49,753,174UniSTS
HuRef549,750,892 - 49,751,666UniSTS
HuRef549,751,546 - 49,753,094UniSTS
HuRef549,753,742 - 49,753,920UniSTS
HuRef549,752,037 - 49,753,176UniSTS
FST  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37552,781,619 - 52,781,797UniSTSGRCh37
GRCh37552,780,952 - 52,781,051UniSTSGRCh37
GRCh37552,778,769 - 52,779,543UniSTSGRCh37
GRCh37552,779,914 - 52,781,053UniSTSGRCh37
GRCh37552,779,423 - 52,780,971UniSTSGRCh37
Build 36552,817,376 - 52,817,554RGDNCBI36
Celera549,735,241 - 49,735,419RGD
Celera549,733,536 - 49,734,675UniSTS
Celera549,732,391 - 49,733,165UniSTS
Celera549,733,045 - 49,734,593UniSTS
Celera549,734,574 - 49,734,673UniSTS
HuRef549,753,075 - 49,753,174UniSTS
HuRef549,750,892 - 49,751,666UniSTS
HuRef549,751,546 - 49,753,094UniSTS
HuRef549,753,742 - 49,753,920UniSTS
HuRef549,752,037 - 49,753,176UniSTS
FST  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37552,781,619 - 52,781,797UniSTSGRCh37
GRCh37552,780,952 - 52,781,051UniSTSGRCh37
GRCh37552,778,769 - 52,779,543UniSTSGRCh37
GRCh37552,779,914 - 52,781,053UniSTSGRCh37
GRCh37552,779,423 - 52,780,971UniSTSGRCh37
Build 36552,817,376 - 52,817,554RGDNCBI36
Celera549,735,241 - 49,735,419RGD
Celera549,733,536 - 49,734,675UniSTS
Celera549,732,391 - 49,733,165UniSTS
Celera549,733,045 - 49,734,593UniSTS
Celera549,734,574 - 49,734,673UniSTS
HuRef549,753,075 - 49,753,174UniSTS
HuRef549,750,892 - 49,751,666UniSTS
HuRef549,751,546 - 49,753,094UniSTS
HuRef549,753,742 - 49,753,920UniSTS
HuRef549,752,037 - 49,753,176UniSTS
FST  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37552,781,619 - 52,781,797UniSTSGRCh37
GRCh37552,780,952 - 52,781,051UniSTSGRCh37
GRCh37552,778,769 - 52,779,543UniSTSGRCh37
GRCh37552,779,914 - 52,781,053UniSTSGRCh37
GRCh37552,779,423 - 52,780,971UniSTSGRCh37
Build 36552,817,376 - 52,817,554RGDNCBI36
Celera549,735,241 - 49,735,419RGD
Celera549,733,536 - 49,734,675UniSTS
Celera549,732,391 - 49,733,165UniSTS
Celera549,733,045 - 49,734,593UniSTS
Celera549,734,574 - 49,734,673UniSTS
HuRef549,753,075 - 49,753,174UniSTS
HuRef549,750,892 - 49,751,666UniSTS
HuRef549,751,546 - 49,753,094UniSTS
HuRef549,753,742 - 49,753,920UniSTS
HuRef549,752,037 - 49,753,176UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1260
Count of miRNA genes:586
Interacting mature miRNAs:684
Transcripts:ENST00000256759, ENST00000396947, ENST00000491717, ENST00000497789, ENST00000504226
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 1 1 1 1
Medium 743 904 607 486 107 385 3290 312 733 69 564 515 112 939 1899 2
Low 1593 1312 1076 130 330 72 1048 1836 838 222 845 1017 61 1 265 884 3 1
Below cutoff 38 611 36 5 894 6 14 41 1954 96 38 63 1 5 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_028911 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_006350 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_013409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005248400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005248401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005248402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005248403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017008955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024454326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB451330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB451474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ941144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ949678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DR760015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000256759   ⟹   ENSP00000256759
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl553,480,629 - 53,487,134 (+)Ensembl
RefSeq Acc Id: ENST00000396947   ⟹   ENSP00000380151
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl553,480,626 - 53,487,106 (+)Ensembl
RefSeq Acc Id: ENST00000491717
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl553,482,694 - 53,484,111 (+)Ensembl
RefSeq Acc Id: ENST00000497789   ⟹   ENSP00000426971
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl553,484,216 - 53,486,092 (+)Ensembl
RefSeq Acc Id: ENST00000504226   ⟹   ENSP00000426315
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl553,483,611 - 53,486,090 (+)Ensembl
RefSeq Acc Id: NM_006350   ⟹   NP_006341
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38553,480,629 - 53,487,134 (+)NCBI
GRCh37552,776,183 - 52,782,964 (+)NCBI
Build 36552,812,352 - 52,817,680 (+)NCBI Archive
HuRef549,748,385 - 49,754,428 (+)ENTREZGENE
CHM1_1552,779,193 - 52,785,231 (+)NCBI
Sequence:
RefSeq Acc Id: NM_013409   ⟹   NP_037541
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38553,480,629 - 53,487,134 (+)NCBI
GRCh37552,776,183 - 52,782,964 (+)NCBI
Build 36552,812,352 - 52,817,680 (+)NCBI Archive
HuRef549,748,385 - 49,754,428 (+)ENTREZGENE
CHM1_1552,779,193 - 52,785,231 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005248400   ⟹   XP_005248457
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38553,480,339 - 53,487,134 (+)NCBI
GRCh37552,776,183 - 52,782,964 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005248401   ⟹   XP_005248458
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38553,480,341 - 53,487,134 (+)NCBI
GRCh37552,776,183 - 52,782,964 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005248402   ⟹   XP_005248459
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38553,480,338 - 53,485,921 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005248403   ⟹   XP_005248460
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38553,480,340 - 53,487,134 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011543099   ⟹   XP_011541401
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38553,482,333 - 53,487,134 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017008954   ⟹   XP_016864443
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38553,480,338 - 53,485,982 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017008955   ⟹   XP_016864444
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38553,481,517 - 53,487,134 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024454326   ⟹   XP_024310094
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38553,482,335 - 53,487,134 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_006341   ⟸   NM_006350
- Peptide Label: isoform FST317 precursor
- UniProtKB: P19883 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_037541   ⟸   NM_013409
- Peptide Label: isoform FST344 precursor
- UniProtKB: P19883 (UniProtKB/Swiss-Prot),   A0A024QZU6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005248460   ⟸   XM_005248403
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_005248459   ⟸   XM_005248402
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_005248457   ⟸   XM_005248400
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005248458   ⟸   XM_005248401
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011541401   ⟸   XM_011543099
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016864443   ⟸   XM_017008954
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_016864444   ⟸   XM_017008955
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_024310094   ⟸   XM_024454326
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSP00000426315   ⟸   ENST00000504226
RefSeq Acc Id: ENSP00000256759   ⟸   ENST00000256759
RefSeq Acc Id: ENSP00000426971   ⟸   ENST00000497789
RefSeq Acc Id: ENSP00000380151   ⟸   ENST00000396947
Protein Domains
Follistatin-like   Kazal-like   TB

Promoters
RGD ID:6803205
Promoter ID:HG_KWN:50107
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:NM_006350,   OTTHUMT00000253906
Position:
Human AssemblyChrPosition (strand)Source
Build 36552,811,536 - 52,812,337 (+)MPROMDB
RGD ID:6803206
Promoter ID:HG_KWN:50108
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   NB4
Transcripts:OTTHUMT00000319780
Position:
Human AssemblyChrPosition (strand)Source
Build 36552,813,366 - 52,813,866 (+)MPROMDB
RGD ID:6803207
Promoter ID:HG_KWN:50109
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:NB4
Transcripts:OTTHUMT00000319781
Position:
Human AssemblyChrPosition (strand)Source
Build 36552,814,446 - 52,814,946 (+)MPROMDB
RGD ID:6869588
Promoter ID:EPDNEW_H7959
Type:initiation region
Name:FST_2
Description:follistatin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7960  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38553,480,404 - 53,480,464EPDNEW
RGD ID:6869590
Promoter ID:EPDNEW_H7960
Type:initiation region
Name:FST_1
Description:follistatin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H7959  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38553,480,629 - 53,480,689EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q11.1-12.1(chr5:50288355-63149770)x1 copy number loss See cases [RCV000050797] Chr5:50288355..63149770 [GRCh38]
Chr5:49584189..62445597 [GRCh37]
Chr5:49619946..62481353 [NCBI36]
Chr5:5q11.1-12.1
pathogenic
GRCh38/hg38 5q11.1-11.2(chr5:50288355-56717370)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051838]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051838]|See cases [RCV000051838] Chr5:50288355..56717370 [GRCh38]
Chr5:49584189..56013197 [GRCh37]
Chr5:49619946..56048954 [NCBI36]
Chr5:5q11.1-11.2
pathogenic
GRCh38/hg38 5q11.2(chr5:53332485-57152396)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053283]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053283]|See cases [RCV000053283] Chr5:53332485..57152396 [GRCh38]
Chr5:52628315..56448223 [GRCh37]
Chr5:52664072..56483980 [NCBI36]
Chr5:5q11.2
uncertain significance
GRCh38/hg38 5q11.1-11.2(chr5:50462100-55862985)x1 copy number loss See cases [RCV000053451] Chr5:50462100..55862985 [GRCh38]
Chr5:49757934..55158813 [GRCh37]
Chr5:49793691..55194570 [NCBI36]
Chr5:5q11.1-11.2
pathogenic
GRCh38/hg38 5p13.2-q12.1(chr5:35201559-61903141)x3 copy number gain See cases [RCV000137302] Chr5:35201559..61903141 [GRCh38]
Chr5:35201661..61198968 [GRCh37]
Chr5:35237418..61234725 [NCBI36]
Chr5:5p13.2-q12.1
pathogenic
GRCh38/hg38 5p12-q11.2(chr5:45566861-56506493)x3 copy number gain See cases [RCV000138021] Chr5:45566861..56506493 [GRCh38]
Chr5:45566963..55802320 [GRCh37]
Chr5:45602720..55838077 [NCBI36]
Chr5:5p12-q11.2
uncertain significance
GRCh38/hg38 5p15.33-q13.3(chr5:22149-74412725)x3 copy number gain See cases [RCV000138780] Chr5:22149..74412725 [GRCh38]
Chr5:22149..73708550 [GRCh37]
Chr5:75149..73744306 [NCBI36]
Chr5:5p15.33-q13.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5q11.2(chr5:50824656-53452371)x1 copy number loss See cases [RCV000511681] Chr5:50824656..53452371 [GRCh37]
Chr5:5q11.2
uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NM_013409.3(FST):c.85+9G>C single nucleotide variant not provided [RCV000961615] Chr5:53480885 [GRCh38]
Chr5:52776715 [GRCh37]
Chr5:5q11.2
benign
NM_013409.3(FST):c.52C>T (p.Leu18Phe) single nucleotide variant not provided [RCV000888691] Chr5:53480843 [GRCh38]
Chr5:52776673 [GRCh37]
Chr5:5q11.2
benign
NM_013409.3(FST):c.906C>T (p.Cys302=) single nucleotide variant not provided [RCV000921433] Chr5:53485181 [GRCh38]
Chr5:52781011 [GRCh37]
Chr5:5q11.2
likely benign
NM_013409.3(FST):c.454G>C (p.Glu152Gln) single nucleotide variant not provided [RCV000893096] Chr5:53483680 [GRCh38]
Chr5:52779510 [GRCh37]
Chr5:5q11.2
benign
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NM_013409.3(FST):c.581G>A (p.Arg194Gln) single nucleotide variant not provided [RCV000894479] Chr5:53484153 [GRCh38]
Chr5:52779983 [GRCh37]
Chr5:5q11.2
benign
GRCh37/hg19 5q11.1-11.2(chr5:49430268-53182665)x1 copy number loss not provided [RCV001258850] Chr5:49430268..53182665 [GRCh37]
Chr5:5q11.1-11.2
pathogenic
NM_013409.3(FST):c.167G>A (p.Cys56Tyr) single nucleotide variant Orofacial cleft [RCV001261825]|not provided [RCV001270145] Chr5:53482961 [GRCh38]
Chr5:52778791 [GRCh37]
Chr5:5q11.2
likely pathogenic|uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3971 AgrOrtholog
COSMIC FST COSMIC
Ensembl Genes ENSG00000134363 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000256759 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000380151 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000426315 UniProtKB/TrEMBL
  ENSP00000426971 UniProtKB/TrEMBL
Ensembl Transcript ENST00000256759 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000396947 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000497789 UniProtKB/TrEMBL
  ENST00000504226 UniProtKB/TrEMBL
Gene3D-CATH 3.90.290.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000134363 GTEx
HGNC ID HGNC:3971 ENTREZGENE
Human Proteome Map FST Human Proteome Map
InterPro Fol_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Follistatin/Osteonectin_EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TB_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TB_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10468 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 10468 ENTREZGENE
OMIM 136470 OMIM
Pfam FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kazal_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28388 PharmGKB
PROSITE KAZAL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS51364 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FOLN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KAZAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57581 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024QZU6 ENTREZGENE, UniProtKB/TrEMBL
  FST_HUMAN UniProtKB/Swiss-Prot
  H0YA75_HUMAN UniProtKB/TrEMBL
  H0YAF9_HUMAN UniProtKB/TrEMBL
  P19883 ENTREZGENE
  Q6FHE1_HUMAN UniProtKB/TrEMBL
UniProt Secondary B5BU94 UniProtKB/Swiss-Prot
  Q9BTH0 UniProtKB/Swiss-Prot