Irf7 (interferon regulatory factor 7) - Rat Genome Database

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Gene: Irf7 (interferon regulatory factor 7) Rattus norvegicus
Analyze
Symbol: Irf7
Name: interferon regulatory factor 7
RGD ID: 1307828
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including defense response to other organism; positive regulation of macromolecule biosynthetic process; and regulation of innate immune response. Predicted to act upstream of or within immunoglobulin mediated immune response; positive regulation of type I interferon production; and positive regulation of type I interferon-mediated signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 39. Orthologous to human IRF7 (interferon regulatory factor 7); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC293624; MGC125013
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,796,956 - 205,800,543 (-)NCBIGRCr8
mRatBN7.21196,367,380 - 196,370,943 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,367,361 - 196,370,832 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,712,872 - 204,715,929 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,839,500 - 211,842,700 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,513,638 - 204,516,838 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,249,388 - 214,252,909 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,248,837 - 214,252,456 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,166,926 - 221,170,447 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,456,689 - 201,459,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,607,693 - 201,611,125 (-)NCBI
Celera1194,001,244 - 194,004,312 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Irf7RatCOVID-19  ISOIRF7 (Homo sapiens)9068941mRNA:increased expression:bronchoalveolar lavage (human)RGDPMID:32407669 and REF_RGD_ID:30296672
Irf7Ratlymphocytic choriomeningitis disease_progressionISOIrf7 (Mus musculus)124715479 RGD 
Irf7Ratlymphocytic choriomeningitis  ISOIrf7 (Mus musculus)124715479 RGD 
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Irf7RatBeckwith-Wiedemann syndrome  ISOIRF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Beckwith-Wiedemann syndromeClinVarPMID:21910219 more ...
Irf7RatChanarin-Dorfman syndrome  ISOIRF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Neutral lipid storage myopathyClinVarPMID:28492532
Irf7RatCostello syndrome  ISOIRF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Costello syndromeClinVarPMID:28492532
Irf7Ratdelta beta-thalassemia  ISOIRF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Thalassemia and gamma-delta-betaClinVarPMID:2798417
Irf7Ratdevelopmental and epileptic encephalopathy  ISOIRF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:28492532
Irf7Ratearly infantile epileptic encephalopathy  ISOIRF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:28492532
Irf7Ratimmunodeficiency 39  ISOIRF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 39ClinVarPMID:16199547 more ...
Irf7Ratneuronal ceroid lipofuscinosis  ISOIRF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Neuronal ceroid lipofuscinosisClinVarPMID:28492532
Irf7RatSegawa Syndrome, Autosomal Recessive  ISOIRF7 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive DOPA responsive dystoniaClinVarPMID:28492532
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Original Reference(s)
Irf7RatHuman Influenza  ISOIRF7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23326326
Irf7RatInflammation  ISOIRF7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20513754
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Irf7Ratimmunodeficiency 39  ISOIRF7 (Homo sapiens)7240710 OMIM 

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Irf7Rat(-)-alpha-phellandrene increases expressionISOIRF7 (Homo sapiens)6480464alpha phellandrene results in increased expression of IRF7 mRNACTDPMID:25075043
Irf7Rat(1->4)-beta-D-glucan multiple interactionsISOIrf7 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IRF7 mRNACTDPMID:36331819
Irf7Rat(S)-nicotine multiple interactionsISOIRF7 (Homo sapiens)6480464IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]] more ...CTDPMID:31154625
Irf7Rat1,1-dichloroethene increases expressionISOIrf7 (Mus musculus)6480464vinylidene chloride results in increased expression of IRF7 mRNACTDPMID:26682919
Irf7Rat1,2-dimethylhydrazine increases expressionEXP 64804641 and 2-Dimethylhydrazine results in increased expression of IRF7 mRNACTDPMID:27840820
Irf7Rat1,2-dimethylhydrazine increases expressionISOIrf7 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of IRF7 mRNACTDPMID:22206623
Irf7Rat1,2-dimethylhydrazine multiple interactionsISOIrf7 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of IRF7 mRNA]CTDPMID:22206623
Irf7Rat1,2-dimethylhydrazine multiple interactionsEXP 6480464APC protein affects the reaction [1 and 2-Dimethylhydrazine results in increased expression of IRF7 mRNA]CTDPMID:27840820
Irf7Rat17alpha-ethynylestradiol affects expressionISOIrf7 (Mus musculus)6480464Ethinyl Estradiol affects the expression of IRF7 mRNACTDPMID:17555576
Irf7Rat17alpha-ethynylestradiol increases expressionISOIrf7 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of IRF7 mRNACTDPMID:16174780 and PMID:17942748
Irf7Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of IRF7 mRNACTDPMID:16174780 and PMID:17557909
Irf7Rat17alpha-ethynylestradiol multiple interactionsISOIrf7 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IRF7 mRNACTDPMID:17942748
Irf7Rat17beta-estradiol multiple interactionsISOIRF7 (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IRF7 mRNA and [Estradiol co-treated with TGFB1 protein] results in decreased expression of IRF7 mRNACTDPMID:19619570 and PMID:30165855
Irf7Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of IRF7 mRNACTDPMID:35192832
Irf7Rat17beta-estradiol decreases expressionISOIrf7 (Mus musculus)6480464Estradiol results in decreased expression of IRF7 mRNACTDPMID:39298647
Irf7Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of IRF7 mRNACTDPMID:32741896
Irf7Rat17beta-estradiol multiple interactionsISOIrf7 (Mus musculus)6480464[Polyphenols co-treated with Estradiol] results in increased expression of IRF7 mRNACTDPMID:30077407
Irf7Rat17beta-estradiol increases expressionISOIrf7 (Mus musculus)6480464Estradiol results in increased expression of IRF7 mRNACTDPMID:15289156 more ...
Irf7Rat17beta-estradiol increases expressionISOIRF7 (Homo sapiens)6480464Estradiol results in increased expression of IRF7 mRNACTDPMID:19619570
Irf7Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of IRF7 mRNACTDPMID:32741896

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Biological Process
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Irf7Ratcytoplasmic pattern recognition receptor signaling pathway involved_inISOIRF7 (Homo sapiens)1624291 PMID:21931555RGDPMID:21931555
Irf7Ratcytoplasmic pattern recognition receptor signaling pathway involved_inIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratdefense response to virus involved_inIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratdefense response to virus involved_inIEAUniProtKB:P70434 and ensembl:ENSMUSP000000265711600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratdefense response to virus involved_inISOIrf7 (Mus musculus)1624291 PMID:27129230RGDPMID:27129230
Irf7Ratimmune system process involved_inIBAMGI:1096873 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Irf7Ratimmunoglobulin mediated immune response acts_upstream_of_or_withinISOIrf7 (Mus musculus)1624291MGI:3577089 PMID:15800576RGDPMID:15800576
Irf7Ratimmunoglobulin mediated immune response acts_upstream_of_or_withinIEAUniProtKB:P70434 and ensembl:ENSMUSP000000265711600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratpositive regulation of DNA-templated transcription involved_inISOIRF7 (Homo sapiens)1624291 PMID:12374802RGDPMID:12374802
Irf7Ratpositive regulation of DNA-templated transcription involved_inIEAUniProtKB:P70434 and ensembl:ENSMUSP000000265711600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratpositive regulation of DNA-templated transcription involved_inISOIrf7 (Mus musculus)1624291 PMID:27129230RGDPMID:27129230
Irf7Ratpositive regulation of DNA-templated transcription involved_inIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratpositive regulation of DNA-templated transcription involved_inIEAARBA:ARBA000290821600115GO_REF:0000117UniProtGO_REF:0000117
Irf7Ratpositive regulation of interferon-alpha production involved_inISOIRF7 (Homo sapiens)1624291 PMID:16127453RGDPMID:16127453
Irf7Ratpositive regulation of interferon-alpha production involved_inIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratpositive regulation of interferon-beta production involved_inISOIRF7 (Homo sapiens)1624291 PMID:22065573RGDPMID:22065573
Irf7Ratpositive regulation of interferon-beta production involved_inIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratpositive regulation of transcription by RNA polymerase II involved_inISOIRF7 (Homo sapiens)1624291 PMID:16127453 and PMID:17404045RGDPMID:16127453 and PMID:17404045
Irf7Ratpositive regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratpositive regulation of type I interferon production involved_inIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Irf7Ratchromatin is_active_inISOIRF7 (Homo sapiens)1624291 PMID:11473119RGDPMID:11473119
Irf7Ratchromatin is_active_inIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratcytoplasm located_inISOIRF7 (Homo sapiens)1624291UniProtKB:P24001-1 more ...RGDPMID:19176627 and PMID:23729669
Irf7Ratcytoplasm located_inIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratcytosol located_inISOIRF7 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Irf7Ratcytosol located_inIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratnucleoplasm located_inIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratnucleoplasm located_inISOIRF7 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Irf7Ratnucleus part_ofIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Irf7Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Irf7Ratnucleus is_active_inIBAMGI:1350924 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Irf7Ratnucleus part_ofISOIRF7 (Homo sapiens)1624291 PMID:22065573RGDPMID:22065573
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Molecular Function
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Original Reference(s)
Irf7Ratcis-regulatory region sequence-specific DNA binding enablesISOIrf7 (Mus musculus)1624291 PMID:27129230RGDPMID:27129230
Irf7Ratcis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:P70434 and ensembl:ENSMUSP000000265711600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7RatDNA binding enablesISOIRF7 (Homo sapiens)1624291 PMID:12374802RGDPMID:12374802
Irf7RatDNA binding enablesIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7RatDNA-binding transcription factor activity enablesIEAARBA:ARBA000282951600115GO_REF:0000117UniProtGO_REF:0000117
Irf7RatDNA-binding transcription factor activity enablesIEAInterPro:IPR019471 and InterPro:IPR0198171600115GO_REF:0000002InterProGO_REF:0000002
Irf7RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOIRF7 (Homo sapiens)1624291 PMID:17404045RGDPMID:17404045
Irf7RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:P70434 and ensembl:ENSMUSP000000265711600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAMGI:1350924 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Irf7RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOIrf7 (Mus musculus)1624291 PMID:22095711 more ...RGDPMID:22095711 more ...
Irf7Ratprotein binding enablesISOIRF7 (Homo sapiens)1624291UniProtKB:F5HDE4 more ...RGDPMID:11943871 more ...
Irf7Ratprotein binding enablesISOIrf7 (Mus musculus)1624291MGI:97072 more ...RGDPMID:16236719 more ...
Irf7Ratprotein binding enablesISOIRF7 (Sus scrofa)1624291UniProtKB:Q68871 and PMID:21680532RGDPMID:21680532
Irf7Ratprotein binding enablesISOIRF7 (Homo sapiens) and UniProtKB:Q92985-11624291UniProtKB:P03230 and PMID:19017798RGDPMID:19017798
Irf7RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISOIRF7 (Homo sapiens)1624291 PMID:17404045RGDPMID:17404045
Irf7RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIBAPANTHER:PTN000942746 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Irf7RatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
Irf7Ratsequence-specific double-stranded DNA binding enablesISOIRF7 (Homo sapiens)1624291 PMID:28473536RGDPMID:28473536
Irf7Ratsequence-specific double-stranded DNA binding enablesIEAUniProtKB:Q92985 and ensembl:ENSP000004340091600115GO_REF:0000107EnsemblGO_REF:0000107
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Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Irf7Rathepatitis C pathway  IEA 6907045 KEGGrno:05160
Irf7Ratinfluenza A pathway  IEA 6907045 KEGGrno:05164
Irf7Ratmeasles pathway  IEA 6907045 KEGGrno:05162
Irf7RatRetinoic acid-inducible gene (RIG) I-like receptor signaling pathway  IEA 6907045 KEGGrno:04622
Irf7RatToll-like receptor signaling pathway   IEA 6907045 KEGGrno:04620

#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus. Li W, etal., J Virol. 2014 Jul;88(13):7578-88. doi: 10.1128/JVI.03117-13. Epub 2014 Apr 23.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12374802   PMID:12477932   PMID:15800576   PMID:16127453   PMID:17404045   PMID:17618271   PMID:19176627   PMID:21478870   PMID:22065573   PMID:23036922   PMID:23042151   PMID:23160154  
PMID:23729669   PMID:23956435   PMID:27129230   PMID:33152351   PMID:37946128  



Irf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,796,956 - 205,800,543 (-)NCBIGRCr8
mRatBN7.21196,367,380 - 196,370,943 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,367,361 - 196,370,832 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,712,872 - 204,715,929 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,839,500 - 211,842,700 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,513,638 - 204,516,838 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,249,388 - 214,252,909 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,248,837 - 214,252,456 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,166,926 - 221,170,447 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,456,689 - 201,459,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,607,693 - 201,611,125 (-)NCBI
Celera1194,001,244 - 194,004,312 (-)NCBICelera
Cytogenetic Map1q41NCBI
IRF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811612,555 - 615,950 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11612,553 - 615,983 (-)EnsemblGRCh38hg38GRCh38
GRCh3711612,555 - 615,950 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611602,555 - 605,999 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411602,590 - 605,650NCBI
Celera11677,701 - 681,146 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef11427,860 - 431,281 (-)NCBIHuRef
CHM1_111611,595 - 615,009 (-)NCBICHM1_1
T2T-CHM13v2.011661,201 - 664,566 (-)NCBIT2T-CHM13v2.0
Irf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,843,096 - 140,846,412 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,842,619 - 140,846,394 (-)EnsemblGRCm39 Ensembl
GRCm387141,263,183 - 141,266,499 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,262,706 - 141,266,481 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,449,088 - 148,452,300 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,114,509 - 141,117,721 (-)NCBIMGSCv36mm8
Celera7141,056,921 - 141,060,133 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.57NCBI
Irf7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,443,272 - 11,445,657 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,442,781 - 11,445,706 (+)NCBIChiLan1.0ChiLan1.0
IRF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v292,991,578 - 2,994,429 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,207,772 - 2,210,627 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl11647,827 - 651,314 (-)Ensemblpanpan1.1panPan2
IRF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1825,356,590 - 25,359,121 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,292,147 - 26,294,695 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11825,801,663 - 25,804,207 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,446,631 - 25,449,156 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01826,058,831 - 26,061,390 (-)NCBIUU_Cfam_GSD_1.0
Irf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947445,336 - 448,848 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936888445,549 - 448,392 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936888445,340 - 448,801 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2372,238 - 375,378 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12372,235 - 375,572 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22299,457 - 302,151 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IRF7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11430,412 - 433,959 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1429,310 - 432,925 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,490,795 - 97,493,977 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irf7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,850,211 - 21,853,189 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Irf7
17 total Variants

1 to 10 of 107 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11		 pathogenic
NM_203459.2(CAMSAP2):c.2225C>T (p.Thr742Ile) single nucleotide variant Malignant melanoma [RCV000064437] Chr1:200848994 [GRCh38]
Chr1:200818122 [GRCh37]
Chr1:199084745 [NCBI36]
Chr1:1q32.1		 not provided
GRCh38/hg38 1q32.1(chr1:200144603-203112078)x1 copy number loss See cases [RCV000133625] Chr1:200144603..203112078 [GRCh38]
Chr1:200113731..203081206 [GRCh37]
Chr1:198380354..201347829 [NCBI36]
Chr1:1q32.1		 pathogenic
GRCh37/hg19 1q31.3-42.13(chr1:197811907-228997888)x3 copy number gain See cases [RCV000240137] Chr1:197811907..228997888 [GRCh37]
Chr1:1q31.3-42.13		 pathogenic
GRCh37/hg19 1q31.3-44(chr1:195483439-249213000)x3 copy number gain See cases [RCV000449172] Chr1:195483439..249213000 [GRCh37]
Chr1:1q31.3-44		 pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179413479-201764737)x1 copy number loss See cases [RCV000445748] Chr1:179413479..201764737 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_203459.4(CAMSAP2):c.3715A>G (p.Thr1239Ala) single nucleotide variant not specified [RCV004314925] Chr1:200853387 [GRCh38]
Chr1:200822515 [GRCh37]
Chr1:1q32.1		 uncertain significance
NM_203459.4(CAMSAP2):c.4174C>T (p.Arg1392Trp) single nucleotide variant not specified [RCV004304430] Chr1:200857796 [GRCh38]
Chr1:200826924 [GRCh37]
Chr1:1q32.1		 uncertain significance
1 to 10 of 107 rows

Predicted Target Of
Summary Value
Count of predictions:114
Count of miRNA genes:87
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000023504
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 95 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat

1 to 10 of 95 rows
RH129676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,367,408 - 196,367,612 (+)MAPPERmRatBN7.2
Rnor_6.01214,249,417 - 214,249,620NCBIRnor6.0
Rnor_5.01221,166,955 - 221,167,158UniSTSRnor5.0
RGSC_v3.41201,456,718 - 201,456,921UniSTSRGSC3.4
Celera1194,001,273 - 194,001,476UniSTS
RH 3.4 Map11437.31UniSTS
Cytogenetic Map1q41UniSTS
PMC114617P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21196,368,918 - 196,369,940 (+)MAPPERmRatBN7.2
Rnor_6.01214,250,927 - 214,251,948NCBIRnor6.0
Rnor_5.01221,168,465 - 221,169,486UniSTSRnor5.0
RGSC_v3.41201,458,228 - 201,459,249UniSTSRGSC3.4
Celera1194,002,784 - 194,003,805UniSTS
Cytogenetic Map1q41UniSTS
PMC154027P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81205,797,239 - 205,797,707 (+)Marker Load Pipeline
mRatBN7.21196,367,663 - 196,368,131 (+)MAPPERmRatBN7.2
Rnor_6.01214,249,672 - 214,250,139NCBIRnor6.0
Rnor_5.01221,167,210 - 221,167,677UniSTSRnor5.0
RGSC_v3.41201,456,973 - 201,457,440UniSTSRGSC3.4
Celera1194,001,528 - 194,001,996UniSTS
Cytogenetic Map1q41UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 111 91 90 59 25 59 6 218 97 91 45 60 31



Ensembl Acc Id: ENSRNOT00000023504   ⟹   ENSRNOP00000023504
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1196,367,361 - 196,370,832 (-)Ensembl
Rnor_6.0 Ensembl1214,248,837 - 214,252,456 (-)Ensembl
RefSeq Acc Id: NM_001033691   ⟹   NP_001028863
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,796,956 - 205,800,023 (-)NCBI
mRatBN7.21196,367,380 - 196,370,447 (-)NCBI
Rnor_6.01214,249,388 - 214,252,455 (-)NCBI
Rnor_5.01221,166,926 - 221,170,447 (-)NCBI
RGSC_v3.41201,456,689 - 201,459,756 (-)RGD
Celera1194,001,244 - 194,004,312 (-)RGD
Sequence:
RefSeq Acc Id: XM_006230540   ⟹   XP_006230602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,796,956 - 205,800,543 (-)NCBI
mRatBN7.21196,367,380 - 196,370,943 (-)NCBI
Rnor_6.01214,249,388 - 214,252,909 (-)NCBI
Rnor_5.01221,166,926 - 221,170,447 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006230541   ⟹   XP_006230603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,796,956 - 205,800,519 (-)NCBI
mRatBN7.21196,367,380 - 196,370,943 (-)NCBI
Rnor_6.01214,249,388 - 214,252,909 (-)NCBI
Rnor_5.01221,166,926 - 221,170,447 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001028863   ⟸   NM_001033691
- UniProtKB: Q3SWU2 (UniProtKB/TrEMBL),   F7FGY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230603   ⟸   XM_006230541
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006230602   ⟸   XM_006230540
- Peptide Label: isoform X1
- UniProtKB: Q3SWU2 (UniProtKB/TrEMBL),   F7FGY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023504   ⟸   ENSRNOT00000023504
Interferon regulatory factor-3   IRF tryptophan pentad repeat

Name Modeler Protein Id AA Range Protein Structure
AF-F7FGY2-F1-model_v2 AlphaFold F7FGY2 1-456 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 40 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56966 BioCyc
Ensembl Genes ENSRNOG00000017414 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023504 ENTREZGENE
  ENSRNOT00000023504.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  2.60.200.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7442863 IMAGE-MGC_LOAD
InterPro Interferon_regulatory_fac_CS UniProtKB/TrEMBL
  Interferon_regulatory_factor UniProtKB/TrEMBL
  Interferon_regulatory_factor-3 UniProtKB/TrEMBL
  SMAD_dom-like UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report rno:293624 UniProtKB/TrEMBL
MGC_CLONE MGC:125013 IMAGE-MGC_LOAD
NCBI Gene 293624 ENTREZGENE
PANTHER INTERFERON REGULATORY FACTOR UniProtKB/TrEMBL
  INTERFERON REGULATORY FACTOR 7 UniProtKB/TrEMBL
Pfam IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
PhenoGen Irf7 PhenoGen
PRINTS INTFRNREGFCT UniProtKB/TrEMBL
PROSITE IRF UniProtKB/TrEMBL
  IRF_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017414 RatGTEx
SMART IRF UniProtKB/TrEMBL
  IRF-3 UniProtKB/TrEMBL
Superfamily-SCOP SMAD_FHA UniProtKB/TrEMBL
  SSF46785 UniProtKB/TrEMBL
UniProt A6HXS3_RAT UniProtKB/TrEMBL
  A6HXS4_RAT UniProtKB/TrEMBL
  A6HXS5_RAT UniProtKB/TrEMBL
  A6HXS6_RAT UniProtKB/TrEMBL
  A6HXS7_RAT UniProtKB/TrEMBL
  A6HXS9_RAT UniProtKB/TrEMBL
  A6HXT0_RAT UniProtKB/TrEMBL
  F7FGY2 ENTREZGENE
  Q3SWU2 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7FGY2 UniProtKB/TrEMBL
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Irf7  interferon regulatory factor 7  Irf7_predicted  interferon regulatory factor 7 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Irf7_predicted  interferon regulatory factor 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED