ALOX5 (arachidonate 5-lipoxygenase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: ALOX5 (arachidonate 5-lipoxygenase) Sus scrofa
Analyze
Symbol: ALOX5
Name: arachidonate 5-lipoxygenase
RGD ID: 14296073
Description: ENCODES a protein that exhibits arachidonate 5-lipoxygenase activity (inferred); dioxygenase activity (inferred); iron ion binding (inferred); INVOLVED IN inflammatory response (ortholog); leukotriene biosynthetic process (ortholog); leukotriene metabolic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); adenoma (ortholog); FOUND IN dendrite (ortholog); nuclear envelope (ortholog); sarcolemma (ortholog); INTERACTS WITH cadmium dichloride; deoxynivalenol; ethanol
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,859,019 - 90,907,090 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11490,859,209 - 90,907,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,902,267 - 98,950,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arachidonate metabolic process  (IBA)
dendritic cell migration  (IEA)
glucose homeostasis  (IEA)
humoral immune response  (IEA)
inflammatory response  (IEA,ISO)
leukocyte chemotaxis involved in inflammatory response  (IEA)
leukocyte migration involved in inflammatory response  (IEA)
leukotriene A4 biosynthetic process  (IEA)
leukotriene biosynthetic process  (IEA,ISO)
leukotriene metabolic process  (IEA,ISO)
leukotriene production involved in inflammatory response  (IEA,ISO)
lipid metabolic process  (IEA)
lipid oxidation  (IBA,IEA)
lipoxin biosynthetic process  (IEA)
lipoxygenase pathway  (IBA)
negative regulation of angiogenesis  (IEA)
negative regulation of endothelial cell proliferation  (IEA)
negative regulation of inflammatory response  (IEA)
negative regulation of response to endoplasmic reticulum stress  (IEA)
negative regulation of sprouting angiogenesis  (IEA)
negative regulation of vascular wound healing  (IEA)
negative regulation of wound healing  (IEA)
positive regulation of bone mineralization  (IEA)
positive regulation of cytochrome-c oxidase activity  (ISO)
positive regulation of leukocyte adhesion to arterial endothelial cell  (IEA)
positive regulation of vasoconstriction  (ISO)
regulation of cellular response to oxidative stress  (IEA)
regulation of cytokine production involved in inflammatory response  (IEA)
regulation of fat cell differentiation  (IEA)
regulation of inflammatory response  (IEA)
regulation of inflammatory response to wounding  (IEA)
regulation of insulin secretion  (IEA)
regulation of reactive oxygen species biosynthetic process  (IEA)
response to hyperoxia  (ISO)
response to nutrient  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ALOX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,859,019 - 90,907,090 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11490,859,209 - 90,907,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,902,267 - 98,950,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381045,374,216 - 45,446,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1045,374,176 - 45,446,119 (+)EnsemblGRCh38hg38GRCh38
GRCh371045,869,664 - 45,941,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361045,189,635 - 45,261,571 (+)NCBINCBI36Build 36hg18NCBI36
Build 341045,189,691 - 45,261,567NCBI
Celera1041,889,257 - 41,939,521 (+)NCBICelera
Cytogenetic Map10q11.21NCBI
HuRef1042,394,884 - 42,467,216 (+)NCBIHuRef
CHM1_11045,908,843 - 45,980,778 (+)NCBICHM1_1
T2T-CHM13v2.01046,255,243 - 46,327,106 (+)NCBIT2T-CHM13v2.0
Alox5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396116,387,030 - 116,438,139 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6116,387,038 - 116,438,139 (-)EnsemblGRCm39 Ensembl
GRCm386116,410,071 - 116,461,178 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6116,410,077 - 116,461,178 (-)EnsemblGRCm38mm10GRCm38
MGSCv376116,360,089 - 116,411,196 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366116,375,696 - 116,426,797 (-)NCBIMGSCv36mm8
Celera6118,247,670 - 118,299,116 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.79NCBI
Alox5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84151,203,948 - 151,251,126 (-)NCBIGRCr8
mRatBN7.24149,531,329 - 149,578,696 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4149,531,515 - 149,578,743 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4155,763,428 - 155,810,585 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04151,547,462 - 151,594,624 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04150,170,360 - 150,217,527 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04148,398,004 - 148,446,308 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4148,398,892 - 148,446,303 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04214,345,956 - 214,393,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44152,610,283 - 152,657,891 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14152,855,123 - 152,902,732 (-)NCBI
Celera4138,415,564 - 138,454,485 (-)NCBICelera
Cytogenetic Map4q42NCBI
Alox5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555462,494,819 - 2,550,909 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555462,495,226 - 2,550,909 (+)NCBIChiLan1.0ChiLan1.0
ALOX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2858,201,690 - 58,271,880 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11058,207,019 - 58,277,209 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01042,461,398 - 42,531,576 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11045,639,946 - 45,710,016 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1045,639,946 - 45,710,016 (+)Ensemblpanpan1.1panPan2
ALOX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1282,170,920 - 2,218,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl282,170,920 - 2,219,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha282,405,370 - 2,462,571 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0282,349,844 - 2,407,164 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,349,846 - 2,407,125 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,147,070 - 2,204,281 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,183,953 - 2,241,179 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0282,315,780 - 2,373,040 (-)NCBIUU_Cfam_GSD_1.0
Alox5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721381,798,191 - 81,858,352 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365547,808,355 - 7,867,931 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365547,807,914 - 7,848,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALOX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1941,085,257 - 41,145,760 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl941,085,361 - 41,145,331 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048764,154 - 824,908 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alox5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624966168,250 - 220,522 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624966168,244 - 220,430 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ALOX5
1383 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3

Sequence


Ensembl Acc Id: ENSSSCT00000033520   ⟹   ENSSSCP00000030319
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1490,859,019 - 90,907,090 (-)Ensembl
RefSeq Acc Id: XM_021072736   ⟹   XP_020928395
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11490,859,209 - 90,907,084 (-)NCBI
Sequence:
RefSeq Acc Id: XP_020928395   ⟸   XM_021072736
- UniProtKB: A0A480QV34 (UniProtKB/TrEMBL),   A0A4X1V7S0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000030319   ⟸   ENSSSCT00000033520
Protein Domains
Lipoxygenase   PLAT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010404 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015020894 UniProtKB/TrEMBL
  ENSSSCG00025071153 UniProtKB/TrEMBL
  ENSSSCG00030026226 UniProtKB/TrEMBL
  ENSSSCG00035029241 UniProtKB/TrEMBL
  ENSSSCG00040040125 UniProtKB/TrEMBL
  ENSSSCG00045036716 UniProtKB/TrEMBL
  ENSSSCG00050005143 UniProtKB/TrEMBL
  ENSSSCG00055016842 UniProtKB/TrEMBL
  ENSSSCG00060069990 UniProtKB/TrEMBL
  ENSSSCG00065078497 UniProtKB/TrEMBL
  ENSSSCG00070023152 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000033520 ENTREZGENE
  ENSSSCT00000033520.4 UniProtKB/TrEMBL
  ENSSSCT00015027633.1 UniProtKB/TrEMBL
  ENSSSCT00015027679.1 UniProtKB/TrEMBL
  ENSSSCT00025097734.1 UniProtKB/TrEMBL
  ENSSSCT00025097927.1 UniProtKB/TrEMBL
  ENSSSCT00030036630.1 UniProtKB/TrEMBL
  ENSSSCT00030036633.1 UniProtKB/TrEMBL
  ENSSSCT00035038722.1 UniProtKB/TrEMBL
  ENSSSCT00035038725.1 UniProtKB/TrEMBL
  ENSSSCT00040053753.1 UniProtKB/TrEMBL
  ENSSSCT00040053863.1 UniProtKB/TrEMBL
  ENSSSCT00045063254.1 UniProtKB/TrEMBL
  ENSSSCT00045063286.1 UniProtKB/TrEMBL
  ENSSSCT00045063347.1 UniProtKB/TrEMBL
  ENSSSCT00050007050.1 UniProtKB/TrEMBL
  ENSSSCT00050007057.1 UniProtKB/TrEMBL
  ENSSSCT00055033259.1 UniProtKB/TrEMBL
  ENSSSCT00055033324.1 UniProtKB/TrEMBL
  ENSSSCT00060095550.1 UniProtKB/TrEMBL
  ENSSSCT00060095565.1 UniProtKB/TrEMBL
  ENSSSCT00065108833.1 UniProtKB/TrEMBL
  ENSSSCT00065108838.1 UniProtKB/TrEMBL
  ENSSSCT00070046129.1 UniProtKB/TrEMBL
  ENSSSCT00070046134.1 UniProtKB/TrEMBL
  ENSSSCT00070046141.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.60 UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/TrEMBL
InterPro LipOase UniProtKB/TrEMBL
  LipOase_C UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/TrEMBL
  LipOase_CS UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/TrEMBL
  LipOase_mml UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/TrEMBL
  PLAT_LOX_verte UniProtKB/TrEMBL
NCBI Gene ALOX5 ENTREZGENE
PANTHER POLYUNSATURATED FATTY ACID 5-LIPOXYGENASE UniProtKB/TrEMBL
  PTHR11771 UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
PRINTS LIPOXYGENASE UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
SMART LH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/TrEMBL
  SSF49723 UniProtKB/TrEMBL
UniProt A0A480QV34 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1V7S0 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1V7S3_PIG UniProtKB/TrEMBL
  A0A4X1VB70_PIG UniProtKB/TrEMBL
  A0A8D0W5U6_PIG UniProtKB/TrEMBL
  A0A8D0W856_PIG UniProtKB/TrEMBL
  K7GQZ4_PIG UniProtKB/TrEMBL
VGNC ID VGNC:85266 ENTREZGENE