Alox5 (arachidonate 5-lipoxygenase) - Rat Genome Database

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Gene: Alox5 (arachidonate 5-lipoxygenase) Heterocephalus glaber
Analyze
Symbol: Alox5
Name: arachidonate 5-lipoxygenase
RGD ID: 18928811
Description: ENCODES a protein that exhibits arachidonate 5-lipoxygenase activity (inferred); dioxygenase activity (inferred); iron ion binding (inferred); INVOLVED IN inflammatory response (ortholog); leukotriene biosynthetic process (ortholog); leukotriene metabolic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); adenoma (ortholog); FOUND IN dendrite (ortholog); nuclear envelope (ortholog); sarcolemma (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624966168,250 - 220,522 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624966168,244 - 220,430 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arachidonate metabolic process  (IEA)
dendritic cell migration  (IEA)
glucose homeostasis  (IEA)
hepoxilin biosynthetic process  (IEA)
humoral immune response  (IEA)
inflammatory response  (IEA,ISO)
leukocyte chemotaxis involved in inflammatory response  (IEA)
leukocyte migration involved in inflammatory response  (IEA)
leukotriene A4 biosynthetic process  (IEA)
leukotriene biosynthetic process  (IEA,ISO)
leukotriene metabolic process  (IEA,ISO)
leukotriene production involved in inflammatory response  (IEA,ISO)
linoleic acid metabolic process  (IEA)
lipid catabolic process  (IEA)
lipid oxidation  (IEA)
lipoxin biosynthetic process  (IEA)
lipoxygenase pathway  (IEA)
negative regulation of angiogenesis  (IEA)
negative regulation of endothelial cell proliferation  (IEA)
negative regulation of inflammatory response  (IEA)
negative regulation of response to endoplasmic reticulum stress  (IEA)
negative regulation of sprouting angiogenesis  (IEA)
negative regulation of vascular wound healing  (IEA)
negative regulation of wound healing  (IEA)
positive regulation of bone mineralization  (IEA)
positive regulation of cytochrome-c oxidase activity  (ISO)
positive regulation of leukocyte adhesion to arterial endothelial cell  (IEA)
positive regulation of vasoconstriction  (ISO)
regulation of cellular response to oxidative stress  (IEA)
regulation of cytokine production involved in inflammatory response  (IEA)
regulation of fat cell differentiation  (IEA)
regulation of inflammatory response  (IEA)
regulation of inflammatory response to wounding  (IEA)
regulation of insulin secretion  (IEA)
regulation of reactive oxygen species biosynthetic process  (IEA)
response to hyperoxia  (ISO)
response to nutrient  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Alox5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624966168,250 - 220,522 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624966168,244 - 220,430 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ALOX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381045,374,216 - 45,446,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1045,374,176 - 45,446,119 (+)EnsemblGRCh38hg38GRCh38
GRCh371045,869,664 - 45,941,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361045,189,635 - 45,261,571 (+)NCBINCBI36Build 36hg18NCBI36
Build 341045,189,691 - 45,261,567NCBI
Celera1041,889,257 - 41,939,521 (+)NCBICelera
Cytogenetic Map10q11.21NCBI
HuRef1042,394,884 - 42,467,216 (+)NCBIHuRef
CHM1_11045,908,843 - 45,980,778 (+)NCBICHM1_1
T2T-CHM13v2.01046,255,243 - 46,327,106 (+)NCBIT2T-CHM13v2.0
Alox5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396116,387,030 - 116,438,139 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6116,387,038 - 116,438,139 (-)EnsemblGRCm39 Ensembl
GRCm386116,410,071 - 116,461,178 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6116,410,077 - 116,461,178 (-)EnsemblGRCm38mm10GRCm38
MGSCv376116,360,089 - 116,411,196 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366116,375,696 - 116,426,797 (-)NCBIMGSCv36mm8
Celera6118,247,670 - 118,299,116 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.79NCBI
Alox5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84151,203,948 - 151,251,126 (-)NCBIGRCr8
mRatBN7.24149,531,329 - 149,578,696 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4149,531,515 - 149,578,743 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4155,763,428 - 155,810,585 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04151,547,462 - 151,594,624 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04150,170,360 - 150,217,527 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04148,398,004 - 148,446,308 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4148,398,892 - 148,446,303 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04214,345,956 - 214,393,337 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44152,610,283 - 152,657,891 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14152,855,123 - 152,902,732 (-)NCBI
Celera4138,415,564 - 138,454,485 (-)NCBICelera
Cytogenetic Map4q42NCBI
Alox5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555462,494,819 - 2,550,909 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555462,495,226 - 2,550,909 (+)NCBIChiLan1.0ChiLan1.0
ALOX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2858,201,690 - 58,271,880 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11058,207,019 - 58,277,209 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01042,461,398 - 42,531,576 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11045,639,946 - 45,710,016 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1045,639,946 - 45,710,016 (+)Ensemblpanpan1.1panPan2
ALOX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1282,170,920 - 2,218,765 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl282,170,920 - 2,219,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha282,405,370 - 2,462,571 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0282,349,844 - 2,407,164 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,349,846 - 2,407,125 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1282,147,070 - 2,204,281 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0282,183,953 - 2,241,179 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0282,315,780 - 2,373,040 (-)NCBIUU_Cfam_GSD_1.0
Alox5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721381,798,191 - 81,858,352 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365547,808,355 - 7,867,931 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365547,807,914 - 7,848,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALOX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1490,859,016 - 90,907,094 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11490,859,209 - 90,907,084 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21498,902,267 - 98,950,236 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1941,085,257 - 41,145,760 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl941,085,361 - 41,145,331 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048764,154 - 824,908 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000000664   ⟹   ENSHGLP00000000624
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624966168,250 - 220,522 (+)Ensembl
Ensembl Acc Id: ENSHGLT00000000665   ⟹   ENSHGLP00000000625
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624966168,304 - 220,039 (+)Ensembl
RefSeq Acc Id: XM_004875205   ⟹   XP_004875262
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624966168,244 - 220,430 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004875262 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB00437 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000000624
GenBank Protein JAN99268 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004875262   ⟸   XM_004875205
- UniProtKB: G5ATS6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000000624   ⟸   ENSHGLT00000000664
Ensembl Acc Id: ENSHGLP00000000625   ⟸   ENSHGLT00000000665


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000545 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000000664 ENTREZGENE
Gene3D-CATH 3.10.450.60 UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/TrEMBL
InterPro LipOase UniProtKB/TrEMBL
  LipOase_C UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/TrEMBL
  LipOase_CS UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/TrEMBL
  LipOase_mml UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/TrEMBL
  PLAT_LOX_verte UniProtKB/TrEMBL
KEGG Report hgl:101700210 UniProtKB/TrEMBL
NCBI Gene Alox5 ENTREZGENE
PANTHER POLYUNSATURATED FATTY ACID 5-LIPOXYGENASE UniProtKB/TrEMBL
  PTHR11771 UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
PRINTS LIPOXYGENASE UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
SMART LH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/TrEMBL
  SSF49723 UniProtKB/TrEMBL
UniProt G5ATS6 ENTREZGENE, UniProtKB/TrEMBL