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Gene: ARFGEF1 (ADP ribosylation factor guanine nucleotide exchange factor 1) Homo sapiens
Symbol: ARFGEF1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
Description: Exhibits guanyl-nucleotide exchange factor activity; myosin binding activity; and protein kinase A regulatory subunit binding activity. Involved in several processes, including negative regulation of GTPase activity; negative regulation of actin filament polymerization; and positive regulation of protein glycosylation in Golgi. Localizes to several cellular components, including the Golgi membrane; nucleus; and perinuclear region of cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited); ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited); ARFGEP1; BIG1; brefeldin A-inhibited GEP 1; brefeldin A-inhibited guanine nucleotide-exchange protein 1; D730028O18Rik; DKFZP434L057; P200; p200 ARF guanine nucleotide exchange factor; p200 ARF-GEP1
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl867,173,511 - 67,343,781 (-)Ensembl
GRCh38867,174,298 - 67,343,824 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37868,085,746 - 68,255,912 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36868,272,451 - 68,418,466 (-)NCBINCBI36hg18NCBI36
Build 34868,272,450 - 68,418,466NCBI
Celera864,103,297 - 64,249,319 (-)NCBI
Cytogenetic Map8q13.2NCBI
HuRef863,601,813 - 63,748,371 (-)NCBIHuRef
CHM1_1868,165,896 - 68,311,968 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ARFGEF1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348298
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.