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Gene: Arfgef2 (ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)) Mus musculus
Symbol: Arfgef2
Name: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Description: Predicted to have several functions, including ARF guanyl-nucleotide exchange factor activity; GABA receptor binding activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in several processes, including Golgi to plasma membrane transport; positive regulation of tumor necrosis factor production; and receptor recycling. Predicted to localize to several cellular components, including the Golgi apparatus; microtubule cytoskeleton; and recycling endosome. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Is expressed in brown fat; central nervous system; duodenum; thymus; and trunk. Orthologous to human ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2); INTERACTS WITH aflatoxin B1; bisphenol A; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI463430; AW493672; BIG2; brefeldin A-inhibited GEP 2; brefeldin A-inhibited guanine nucleotide-exchange protein 2; E230011G24Rik
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382166,805,451 - 166,898,052 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372166,631,081 - 166,723,552 (+)NCBIGRCm37mm9NCBIm37
MGSCv362166,496,769 - 166,589,258 (+)NCBImm8
Celera2172,745,033 - 172,837,457 (+)NCBICelera
Cytogenetic Map2 H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Arfgef2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1332439
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.