Arfgef1 (ADP ribosylation factor guanine nucleotide exchange factor 1) - Rat Genome Database

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Gene: Arfgef1 (ADP ribosylation factor guanine nucleotide exchange factor 1) Heterocephalus glaber
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Symbol: Arfgef1
Name: ADP ribosylation factor guanine nucleotide exchange factor 1
RGD ID: 18916516
Description: ENCODES a protein that exhibits GTPase activator activity (ortholog); INVOLVED IN neuron projection development (ortholog); positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (ortholog); protein glycosylation (ortholog); ASSOCIATED WITH congenital ptosis (ortholog); DEVELOPMENTAL DELAY, IMPAIRED SPEECH, AND BEHAVIORAL ABNORMALITIES, WITH OR WITHOUT SEIZURES (ortholog); Developmental Disabilities (ortholog); FOUND IN trans-Golgi network (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Brefeldin A-inhibited guanine nucleotide-exchange protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474424,011,136 - 24,143,202 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474424,010,609 - 24,144,474 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074  


Genomics

Comparative Map Data
Arfgef1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474424,011,136 - 24,143,202 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474424,010,609 - 24,144,474 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
ARFGEF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38867,173,511 - 67,343,781 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl867,173,511 - 67,343,781 (-)EnsemblGRCh38hg38GRCh38
GRCh37868,109,893 - 68,256,016 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36868,272,451 - 68,418,466 (-)NCBINCBI36Build 36hg18NCBI36
Build 34868,272,450 - 68,418,466NCBI
Celera864,103,297 - 64,249,319 (-)NCBICelera
Cytogenetic Map8q13.2NCBI
HuRef863,601,813 - 63,748,371 (-)NCBIHuRef
CHM1_1868,165,896 - 68,311,968 (-)NCBICHM1_1
T2T-CHM13v2.0867,599,967 - 67,770,273 (-)NCBIT2T-CHM13v2.0
Arfgef1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39110,207,732 - 10,303,306 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl110,207,796 - 10,302,895 (-)EnsemblGRCm39 Ensembl
GRCm38110,137,507 - 10,232,670 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl110,137,571 - 10,232,670 (-)EnsemblGRCm38mm10GRCm38
MGSCv37110,127,588 - 10,222,751 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36110,122,721 - 10,218,159 (-)NCBIMGSCv36mm8
Celera110,111,100 - 10,206,279 (-)NCBICelera
Cytogenetic Map1A2NCBI
cM Map12.36NCBI
Arfgef1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8513,764,507 - 13,859,237 (+)NCBIGRCr8
mRatBN7.258,982,061 - 9,076,326 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl58,981,540 - 9,076,326 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx511,137,964 - 11,230,261 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0512,761,387 - 12,855,480 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0512,472,621 - 12,564,922 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.058,666,046 - 8,760,458 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl58,666,200 - 8,760,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0513,474,381 - 13,568,680 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.458,498,644 - 8,592,918 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera58,494,495 - 8,587,878 (+)NCBICelera
Cytogenetic Map5q11NCBI
Arfgef1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544411,986,595 - 12,110,172 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544411,986,595 - 12,110,172 (+)NCBIChiLan1.0ChiLan1.0
ARFGEF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2782,934,778 - 83,078,661 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1858,577,096 - 58,720,869 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0863,740,512 - 63,884,189 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1865,402,117 - 65,546,014 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl865,403,386 - 65,545,789 (-)Ensemblpanpan1.1panPan2
ARFGEF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12916,712,872 - 16,852,478 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2916,708,820 - 16,852,844 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2917,028,251 - 17,168,331 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02916,793,854 - 16,933,903 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2916,793,352 - 16,934,175 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12916,825,243 - 16,966,723 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02916,925,119 - 17,065,181 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02917,182,796 - 17,322,945 (-)NCBIUU_Cfam_GSD_1.0
Arfgef1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530367,870,517 - 67,978,189 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364966,807,403 - 6,914,987 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364966,807,388 - 6,914,960 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARFGEF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl467,465,529 - 67,613,611 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1467,465,517 - 67,613,611 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2473,526,804 - 73,674,463 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARFGEF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1863,058,504 - 63,204,238 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl863,057,200 - 63,204,292 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603978,298,523 - 78,446,510 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSHGLT00000016648   ⟹   ENSHGLP00000016479
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474424,011,136 - 24,143,202 (+)Ensembl
RefSeq Acc Id: XM_021256043   ⟹   XP_021111702
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474424,010,609 - 24,144,474 (+)NCBI
Protein Sequences
Protein RefSeqs XP_021111702 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB09579 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000016479
  ENSHGLP00100000571
GenBank Protein JAN99241 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021111702   ⟸   XM_021256043
- UniProtKB: G5BJW8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000016479   ⟸   ENSHGLT00000016648


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011784 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100000482 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000016648 ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLT00100000603 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1000.11 UniProtKB/TrEMBL
  1.10.220.20 UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  DCB_dom UniProtKB/TrEMBL
  Sec7/BIG1-like_C UniProtKB/TrEMBL
  Sec7_C UniProtKB/TrEMBL
  Sec7_C_sf UniProtKB/TrEMBL
  Sec7_dom UniProtKB/TrEMBL
  Sec7_dom_sf UniProtKB/TrEMBL
  Sec7_N UniProtKB/TrEMBL
NCBI Gene Arfgef1 ENTREZGENE
PANTHER BREFELDIN A-INHIBITED GUANINE NUCLEOTIDE-EXCHANGE PROTEIN 1 UniProtKB/TrEMBL
  GUANYL-NUCLEOTIDE EXCHANGE FACTOR UniProtKB/TrEMBL
Pfam BIG2_C UniProtKB/TrEMBL
  DCB UniProtKB/TrEMBL
  DUF1981 UniProtKB/TrEMBL
  Sec7 UniProtKB/TrEMBL
  Sec7_N UniProtKB/TrEMBL
PROSITE SEC7 UniProtKB/TrEMBL
SMART Sec7 UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
  SSF48425 UniProtKB/TrEMBL
UniProt G5BJW8 ENTREZGENE, UniProtKB/TrEMBL