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Gene: AGO1 (argonaute RISC component 1) Homo sapiens
Symbol: AGO1
Name: argonaute RISC component 1
RGD ID: 1312163
Description: Exhibits RNA polymerase II complex binding activity and nucleic acid binding activity. Involved in several processes, including RNA metabolic process; gene silencing by miRNA; and negative regulation of angiogenesis. Localizes to several cellular components, including RISC complex; RISC-loading complex; and polysome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: argonaute 1; argonaute 1, RISC catalytic component; argonaute RISC catalytic component 1; argonaute1; DKFZp686M13167; eIF-2C 1; EIF2C; eIF2C 1; EIF2C1; eukaryotic translation initiation factor 2C, 1; GERP95; Golgi Endoplasmic Reticulum protein 95 kDa; hAgo1; protein argonaute-1; putative RNA-binding protein Q99; Q99
Mus musculus (house mouse) : Ago1 (argonaute RISC catalytic subunit 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ago1 (argonaute RISC component 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ago1 (argonaute RISC component 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AGO1 (argonaute RISC component 1)
Canis lupus familiaris (dog) : AGO1 (argonaute RISC component 1)
Sus scrofa (pig) : AGO1 (argonaute RISC component 1)
Chlorocebus sabaeus (African green monkey) : AGO1 (argonaute RISC component 1)
Heterocephalus glaber (naked mole-rat) : Ago1 (argonaute RISC component 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl135,869,808 - 35,930,532 (+)EnsemblGRCh38hg38GRCh38
GRCh38135,869,761 - 35,930,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37136,335,412 - 36,395,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,121,397 - 36,162,486 (+)NCBINCBI36hg18NCBI36
Build 34136,017,902 - 36,058,992NCBI
Celera134,623,239 - 34,664,327 (+)NCBI
Cytogenetic Map1p34.3NCBI
HuRef134,466,263 - 34,506,900 (+)NCBIHuRef
CHM1_1136,451,786 - 36,506,281 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AGO1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312163
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.