AGO1 (argonaute RISC component 1) - Rat Genome Database

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Gene: AGO1 (argonaute RISC component 1) Pan paniscus
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Symbol: AGO1
Name: argonaute RISC component 1
RGD ID: 11711288
Description: ENCODES a protein that exhibits RNA endonuclease activity (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); transcription cis-regulatory region binding (ortholog); INVOLVED IN miRNA metabolic process (ortholog); miRNA-mediated gene silencing by mRNA destabilization (ortholog); positive regulation of gene expression (ortholog); PARTICIPATES IN microRNA pathway; ASSOCIATED WITH alcohol dependence (ortholog); Charcot-Marie-Tooth disease dominant intermediate C (ortholog); genetic disease (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: argonaute 1, RISC catalytic component; argonaute RISC catalytic component 1; EIF2C1; eukaryotic translation initiation factor 2C, 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21190,922,849 - 190,963,905 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,038,742 - 190,085,087 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0135,148,984 - 35,196,252 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1136,324,733 - 36,370,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl136,324,733 - 36,360,832 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AGO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21190,922,849 - 190,963,905 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,038,742 - 190,085,087 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0135,148,984 - 35,196,252 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1136,324,733 - 36,370,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl136,324,733 - 36,360,832 (+)Ensemblpanpan1.1panPan2
AGO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38135,869,761 - 35,930,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl135,869,808 - 35,930,532 (+)EnsemblGRCh38hg38GRCh38
GRCh37136,335,362 - 36,396,133 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,121,397 - 36,162,486 (+)NCBINCBI36Build 36hg18NCBI36
Build 34136,017,902 - 36,058,992NCBI
Celera134,623,239 - 34,664,327 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef134,466,263 - 34,506,900 (+)NCBIHuRef
CHM1_1136,465,187 - 36,506,280 (+)NCBICHM1_1
T2T-CHM13v2.0135,732,654 - 35,793,426 (+)NCBIT2T-CHM13v2.0
Ago1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394126,328,805 - 126,362,500 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4126,328,805 - 126,362,376 (-)EnsemblGRCm39 Ensembl
GRCm384126,435,012 - 126,468,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4126,435,012 - 126,468,583 (-)EnsemblGRCm38mm10GRCm38
MGSCv374126,112,256 - 126,145,665 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364125,941,807 - 125,970,725 (-)NCBIMGSCv36mm8
Celera4124,771,815 - 124,805,219 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map460.76NCBI
Ago1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,006,618 - 144,064,740 (-)NCBIGRCr8
mRatBN7.25138,722,111 - 138,757,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5138,722,111 - 138,773,546 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5141,419,895 - 141,454,732 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,189,892 - 143,224,724 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,190,669 - 143,225,508 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05144,444,390 - 144,479,430 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5144,448,792 - 144,479,306 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05148,214,328 - 148,246,407 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45145,797,436 - 145,829,516 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15145,806,727 - 145,840,972 (-)NCBI
Celera5137,218,551 - 137,248,255 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ago1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545213,934,346 - 13,968,624 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545213,935,028 - 13,967,281 (+)NCBIChiLan1.0ChiLan1.0
AGO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,258,359 - 6,294,911 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,263,882 - 6,295,338 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha156,501,590 - 6,538,192 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0156,394,522 - 6,431,156 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl156,395,742 - 6,431,512 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1156,247,517 - 6,284,126 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,321,049 - 6,352,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0156,330,625 - 6,367,229 (-)NCBIUU_Cfam_GSD_1.0
AGO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12096,929,985 - 96,971,074 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2096,934,659 - 96,971,014 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603319,754,613 - 19,801,453 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ago1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476418,904,639 - 18,940,594 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476418,904,607 - 18,940,594 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000046325   ⟹   ENSPPAP00000023500
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl136,324,733 - 36,360,832 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000046335   ⟹   ENSPPAP00000023510
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl136,328,559 - 36,360,832 (+)Ensembl
RefSeq Acc Id: XM_003812579   ⟹   XP_003812627
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21190,922,849 - 190,963,905 (-)NCBI
NHGRI_mPanPan11190,038,742 - 190,085,087 (-)NCBI
Mhudiblu_PPA_v0135,148,984 - 35,195,328 (+)NCBI
PanPan1.1136,324,733 - 36,370,798 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008965043   ⟹   XP_008963291
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21190,922,849 - 190,963,905 (-)NCBI
NHGRI_mPanPan11190,038,742 - 190,085,055 (-)NCBI
Mhudiblu_PPA_v0135,149,018 - 35,195,324 (+)NCBI
PanPan1.1136,324,733 - 36,370,798 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034961257   ⟹   XP_034817148
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21190,922,849 - 190,958,815 (-)NCBI
NHGRI_mPanPan11190,038,742 - 190,080,005 (-)NCBI
Mhudiblu_PPA_v0135,154,059 - 35,195,324 (+)NCBI
RefSeq Acc Id: XM_034961260   ⟹   XP_034817151
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21190,922,849 - 190,953,998 (-)NCBI
NHGRI_mPanPan11190,038,742 - 190,075,189 (-)NCBI
Mhudiblu_PPA_v0135,158,874 - 35,195,324 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003812627 (Get FASTA)   NCBI Sequence Viewer  
  XP_008963291 (Get FASTA)   NCBI Sequence Viewer  
  XP_034817148 (Get FASTA)   NCBI Sequence Viewer  
  XP_034817151 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000023500
  ENSPPAP00000023500.1
  ENSPPAP00000023510.1
RefSeq Acc Id: XP_008963291   ⟸   XM_008965043
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B1P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003812627   ⟸   XM_003812579
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B1M6 (UniProtKB/TrEMBL),   A0A2R9B1P1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034817148   ⟸   XM_034961257
- Peptide Label: isoform X3
- UniProtKB: A0A2R9B1P1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034817151   ⟸   XM_034961260
- Peptide Label: isoform X4
- UniProtKB: A0A2R9B1P1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000023500   ⟸   ENSPPAT00000046325
RefSeq Acc Id: ENSPPAP00000023510   ⟸   ENSPPAT00000046335
Protein Domains
PAZ   Piwi


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034838 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000046325.1 UniProtKB/TrEMBL
  ENSPPAT00000046335.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/TrEMBL
  paz domain UniProtKB/TrEMBL
InterPro ArgoL1 UniProtKB/TrEMBL
  ArgoL2 UniProtKB/TrEMBL
  Argonaute_Mid_dom UniProtKB/TrEMBL
  Argonaute_N UniProtKB/TrEMBL
  PAZ_dom UniProtKB/TrEMBL
  PAZ_dom_sf UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
  Piwi_ago-like UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
KEGG Report pps:100968333 UniProtKB/TrEMBL
NCBI Gene AGO1 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2C UniProtKB/TrEMBL
  PROTEIN ARGONAUTE-1 UniProtKB/TrEMBL
Pfam ArgoL1 UniProtKB/TrEMBL
  ArgoL2 UniProtKB/TrEMBL
  ArgoMid UniProtKB/TrEMBL
  ArgoN UniProtKB/TrEMBL
  PAZ UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
PROSITE PAZ UniProtKB/TrEMBL
  PIWI UniProtKB/TrEMBL
SMART DUF1785 UniProtKB/TrEMBL
  PAZ UniProtKB/TrEMBL
  Piwi UniProtKB/TrEMBL
Superfamily-SCOP SSF101690 UniProtKB/TrEMBL
  SSF53098 UniProtKB/TrEMBL
UniProt A0A2R9B1M6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B1P1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-11 AGO1  argonaute RISC component 1  AGO1  argonaute RISC catalytic component 1  Symbol and/or name change 5135510 APPROVED
2018-11-29 AGO1  argonaute RISC catalytic component 1    argonaute 1, RISC catalytic component  Symbol and/or name change 5135510 APPROVED