RGD Reference Report - Association of microRNA biogenesis pathway gene variants and alcohol dependence risk. - Rat Genome Database

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Association of microRNA biogenesis pathway gene variants and alcohol dependence risk.

Authors: Gedik, Huseyin  Erdal, Mehmet Emin  Yilmaz, Senay Gorucu  Sengul, Cem  Sengul, Ceyhan Balci  Herken, Hasan 
Citation: Gedik H, etal., DNA Cell Biol. 2015 Mar;34(3):220-6. doi: 10.1089/dna.2014.2549. Epub 2014 Dec 11.
RGD ID: 401900681
Pubmed: PMID:25495208   (View Abstract at PubMed)
DOI: DOI:10.1089/dna.2014.2549   (Journal Full-text)

Alcohol dependence (AD) is a neuropsychiatric disorder to which both genetic and environmental factors contribute. Especially, multiple genetic factors are promising to explain the etiology of AD. microRNAs (miRNAs) are members of a family of noncoding small RNAs, which are thought to be responsible for the altered gene expression in neuropsychiatric disorders. We hypothesized that single nucleotide polymorphisms (SNPs) in the miRNA biogenesis pathway may result in dysregulation of miRNA levels inside the cell. The aim of this study was to test an association between miRNA biogenesis gene variants and AD risk. Real-time polymerase chain reaction genotyping experiment was conducted on DNA samples from 123 alcohol-dependent patients and 135 healthy controls. We found that AGO1 rs595961 (χ(2) = 9.066, p = 0.003; odds ratio [OR] = 0.459, 95% confidence interval [CI]: 0.275-0.768) and AGO2 rs4961280 (χ(2) = 4.111, p = 0.043; OR = 0.590, 95% CI: 0.353-0.986) G alleles have significantly altered the risk for AD, and also there is a significant association of GEMIN4 rs910924 (χ(2) = 5.291, p = 0.021; OR = 1.913, 95% CI: 1.094-3.344) T allele with the risk for AD. We also found statistically significant difference in AGO1 rs595961 (χ(2) = 11.139, p = 0.001) and DGCR8 rs1640299 (χ(2) = 13.001, p = 0.002) genotype frequencies between case-control groups. This is the first study to investigate the effects of SNPs in the miRNA biogenesis pathway on AD risk. In conclusion, we identified a significant association of miRNA biogenesis genes with altered AD risk, and these results could be a guide to research on the role of miRNAs in AD in the future.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AGO1Humanalcohol dependence susceptibilityIAGP DNA:SNP:intron:A>G(rs595961)(human)RGD 
AGO2Humanalcohol dependence susceptibilityIAGP DNA:SNP:promoter:A>C(rs4961280)(human)RGD 
Ago1Ratalcohol dependence susceptibilityISOAGO1 (Homo sapiens)DNA:SNP:intron:A>G(rs595961)(human)RGD 
Ago1Mousealcohol dependence susceptibilityISOAGO1 (Homo sapiens)DNA:SNP:intron:A>G(rs595961)(human)RGD 
Ago2Ratalcohol dependence susceptibilityISOAGO2 (Homo sapiens)DNA:SNP:promoter:A>C(rs4961280)(human)RGD 
Ago2Mousealcohol dependence susceptibilityISOAGO2 (Homo sapiens)DNA:SNP:promoter:A>C(rs4961280)(human)RGD 
DGCR8Humanalcohol dependence susceptibilityIAGP DNA:SNP:3���-UTR:G>T(rs1640299)(human)RGD 
Dgcr8Ratalcohol dependence susceptibilityISODGCR8 (Homo sapiens)DNA:SNP:3���-UTR:G>T(rs1640299)(human)RGD 
Dgcr8Mousealcohol dependence susceptibilityISODGCR8 (Homo sapiens)DNA:SNP:3���-UTR:G>T(rs1640299)(human)RGD 
GEMIN4Humanalcohol dependence susceptibilityIAGP DNA:SNP:Promoter:C>T(rs910924)(human)RGD 
Gemin4Ratalcohol dependence susceptibilityISOGEMIN4 (Homo sapiens)DNA:SNP:Promoter:C>T(rs910924)(human)RGD 
Gemin4Mousealcohol dependence susceptibilityISOGEMIN4 (Homo sapiens)DNA:SNP:Promoter:C>T(rs910924)(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ago1  (argonaute RISC component 1)
Ago2  (argonaute RISC catalytic component 2)
Dgcr8  (DGCR8 microprocessor complex subunit)
Gemin4  (gem (nuclear organelle) associated protein 4)

Genes (Mus musculus)
Ago1  (argonaute RISC catalytic subunit 1)
Ago2  (argonaute RISC catalytic subunit 2)
Dgcr8  (DGCR8, microprocessor complex subunit)
Gemin4  (gem nuclear organelle associated protein 4)

Genes (Homo sapiens)
AGO1  (argonaute RISC component 1)
AGO2  (argonaute RISC catalytic component 2)
DGCR8  (DGCR8 microprocessor complex subunit)
GEMIN4  (gem nuclear organelle associated protein 4)


Additional Information