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Gene: AGO2 (argonaute RISC catalytic component 2) Homo sapiens
Symbol: AGO2
Name: argonaute RISC catalytic component 2
Description: Exhibits several functions, including endoribonuclease activity, producing 5'-phosphomonoesters; nucleic acid binding activity; and protein C-terminus binding activity. Involved in several processes, including RNA secondary structure unwinding; positive regulation of trophoblast cell migration; and posttranscriptional regulation of gene expression. Localizes to several cellular components, including the P-body; RISC complex; and RISC-loading complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: argonaute 2; argonaute 2, RISC catalytic component; argonaute2; cancer susceptibility candidate 7; cancer susceptibility candidate 7 (non-protein coding); CASC7; CTA-204B4.6; eIF-2C 2; eIF2C 2; EIF2C2; eukaryotic translation initiation factor 2C, 2; hAgo2; LINC00980; long intergenic non-protein coding RNA 980; MGC3183; PAZ Piwi domain protein; PPD; protein argonaute-2; protein slicer; Q10
Mus musculus (house mouse) : Ago2 (argonaute RISC catalytic subunit 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ago2 (argonaute RISC catalytic component 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ago2 (argonaute RISC catalytic component 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AGO2 (argonaute RISC catalytic component 2)
Canis lupus familiaris (dog) : AGO2 (argonaute RISC catalytic component 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ago2 (argonaute RISC catalytic component 2)
Sus scrofa (pig) : AGO2 (argonaute RISC catalytic component 2)
Chlorocebus sabaeus (green monkey) : AGO2 (argonaute RISC catalytic component 2)
Heterocephalus glaber (naked mole-rat) : Ago2 (argonaute RISC catalytic component 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl8140,520,156 - 140,635,633 (-)Ensembl
GRCh388140,520,156 - 140,642,406 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378141,541,264 - 141,645,646 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368141,610,446 - 141,714,827 (-)NCBINCBI36hg18NCBI36
Build 348141,610,446 - 141,714,827NCBI
Celera8137,710,380 - 137,814,765 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8136,853,198 - 136,907,219 (-)NCBIHuRef
CHM1_18141,581,910 - 141,685,882 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AGO2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732767
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.