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Gene: Ago2 (argonaute RISC catalytic subunit 2) Mus musculus
Symbol: Ago2
Name: argonaute RISC catalytic subunit 2
Description: Exhibits endoribonuclease activity; mRNA binding activity; and miRNA binding activity. Involved in miRNA metabolic process; post-embryonic development; and regulation of gene expression. Localizes to several cellular components, including P-body; RISC complex; and RISC-loading complex. Is expressed in several structures, including central nervous system; early embryo; lung; sensory organ; and vibrissa. Orthologous to human AGO2 (argonaute RISC catalytic component 2); PARTICIPATES IN microRNA pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110029L17Rik; 2310051F07Rik; AI225898; AL022874; argonaute 2; argonaute RISC catalytic component 2; argonaute2; AW546247; eIF-2C 2; eIF2C 2; Eif2c2; ENSMUSG00000072493; eukaryotic translation initiation factor 2C, 2; Gerp95; Gm10365; KIAA4215; mAgo2; mKIAA4215; Piwi/Argonaute family protein meIF2C2; predicted gene 10365; protein argonaute-2; protein slicer; RIKEN cDNA 1110029L17 gene; RIKEN cDNA 2310051F07 gene
Homo sapiens (human) : AGO2 (argonaute RISC catalytic component 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ago2 (argonaute RISC catalytic component 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ago2 (argonaute RISC catalytic component 2)
Pan paniscus (bonobo/pygmy chimpanzee) : AGO2 (argonaute RISC catalytic component 2)
Canis lupus familiaris (dog) : AGO2 (argonaute RISC catalytic component 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ago2 (argonaute RISC catalytic component 2)
Sus scrofa (pig) : AGO2 (argonaute RISC catalytic component 2)
Chlorocebus sabaeus (African green monkey) : AGO2 (argonaute RISC catalytic component 2)
Heterocephalus glaber (naked mole-rat) : Ago2 (argonaute RISC catalytic component 2)
more info ...
Related Pseudogenes: Gm11511   Gm12904   Gm5281   Gm6088  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1573,095,844 - 73,184,935 (-)EnsemblGRCm38mm10GRCm38
GRCm381573,101,625 - 73,184,947 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371572,932,055 - 73,015,377 (-)NCBIGRCm37mm9NCBIm37
MGSCv361572,934,117 - 73,012,065 (-)NCBImm8
Celera1574,601,857 - 74,646,651 (-)NCBICelera
Cytogenetic Map15D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Ago2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732768
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-07-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.