Ago1 (argonaute RISC catalytic subunit 1) - Rat Genome Database

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Gene: Ago1 (argonaute RISC catalytic subunit 1) Mus musculus
Analyze
Symbol: Ago1
Name: argonaute RISC catalytic subunit 1
RGD ID: 1312164
MGI Page MGI
Description: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and miRNA binding activity. Involved in positive regulation of gene expression and positive regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within miRNA metabolic process and positive regulation of transcription by RNA polymerase II. Located in P-body; cytosol; and nucleus. Part of RISC complex. Is expressed in several structures, including 2-cell stage embryo; central nervous system; lung epithelium; sensory organ; and tooth. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human AGO1 (argonaute RISC component 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: argonaute 1; argonaute RISC catalytic component 1; argonaute1; eIF-2C 1; Eif2c; eIF2C 1; Eif2c1; eukaryotic translation initiation factor 2C, 1; mAgo1; Piwi/Argonaute family protein meIF2C1; protein argonaute-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394126,328,805 - 126,362,500 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4126,328,805 - 126,362,376 (-)EnsemblGRCm39 Ensembl
GRCm384126,435,012 - 126,468,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4126,435,012 - 126,468,583 (-)EnsemblGRCm38mm10GRCm38
MGSCv374126,112,256 - 126,145,665 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364125,941,807 - 125,970,725 (-)NCBIMGSCv36mm8
Celera4124,771,815 - 124,805,219 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map460.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Source
Original Reference(s)
Ago1Mousealcohol dependence susceptibilityISOAGO1 (Homo sapiens)401900681DNA:SNP:intron:A>G(rs595961)(human)RGD 
Object Symbol
Species
Term
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Evidence
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Reference
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Original Reference(s)
Ago1MouseCharcot-Marie-Tooth disease dominant intermediate C  ISOAGO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate CClinVarPMID:28492532
Ago1Mousegenetic disease  ISOAGO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:23809764 more ...
Ago1Mouseintellectual disability  ISOAGO1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25356899 more ...
Ago1MouseNEURODEVELOPMENTAL DISORDER WITH LANGUAGE DELAY AND BEHAVIORAL ABNORMALITIES, WITH OR WITHOUT SEIZURES  ISOAGO1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23020937 more ...
Ago1MouseNeurodevelopmental Disorders  ISOAGO1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23020937 more ...
Object Symbol
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Original Reference(s)
Ago1Mousemalignant mesothelioma  ISOAGO1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25756049
Object Symbol
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Original Reference(s)
Ago1MouseNEURODEVELOPMENTAL DISORDER WITH LANGUAGE DELAY AND BEHAVIORAL ABNORMALITIES, WITH OR WITHOUT SEIZURES  ISOAGO1 (Homo sapiens)7240710 OMIM 

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Object Symbol
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Reference
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Original Reference(s)
Ago1Mouse(+)-catechin multiple interactionsISOAGO1 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of AGO1 mRNACTDPMID:24763279
Ago1Mouse(1->4)-beta-D-glucan multiple interactionsEXP 6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of AGO1 mRNACTDPMID:36331819
Ago1Mouse1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of AGO1 mRNACTDPMID:22206623
Ago1Mouse1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine decreases expressionISOAgo1 (Rattus norvegicus)6480464chlorcyclizine results in decreased expression of AGO1 mRNACTDPMID:21058326
Ago1Mouse17alpha-ethynylestradiol increases expressionISOAgo1 (Rattus norvegicus)6480464Ethinyl Estradiol results in increased expression of AGO1 mRNACTDPMID:29097150
Ago1Mouse17beta-estradiol affects expressionISOAGO1 (Homo sapiens)6480464Estradiol affects the expression of AGO1 mRNACTDPMID:22574217
Ago1Mouse17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of AGO1 mRNACTDPMID:39298647
Ago1Mouse17beta-estradiol multiple interactionsISOAgo1 (Rattus norvegicus)6480464[bisphenol A co-treated with Estradiol] results in decreased expression of AGO1 mRNACTDPMID:26496021
Ago1Mouse4,4'-diaminodiphenylmethane increases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in increased expression of AGO1 mRNACTDPMID:18648102
Ago1Mouse4,4'-sulfonyldiphenol decreases expressionEXP 6480464bisphenol S results in decreased expression of AGO1 mRNACTDPMID:39298647
Ago1Mouse4,4'-sulfonyldiphenol multiple interactionsISOAgo1 (Rattus norvegicus)6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of AGO1 mRNACTDPMID:36041667
Ago1Mouseaconitine increases expressionISOAgo1 (Rattus norvegicus)6480464Aconitine results in increased expression of AGO1 proteinCTDPMID:33236894
Ago1Mouseacrylamide decreases expressionISOAGO1 (Homo sapiens)6480464Acrylamide results in decreased expression of AGO1 mRNACTDPMID:32763439
Ago1Mouseaflatoxin B1 decreases methylationISOAGO1 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of AGO1 geneCTDPMID:27153756
Ago1Mouseaflatoxin B1 increases methylationISOAGO1 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of AGO1 exonCTDPMID:30157460
Ago1Mouseall-trans-retinoic acid increases expressionISOAGO1 (Homo sapiens)6480464Tretinoin results in increased expression of AGO1 mRNACTDPMID:16140955 and PMID:33167477
Ago1Mouseamitrole decreases expressionISOAgo1 (Rattus norvegicus)6480464Amitrole results in decreased expression of AGO1 mRNACTDPMID:38685447
Ago1Mouseamphetamine decreases expressionISOAgo1 (Rattus norvegicus)6480464Amphetamine results in decreased expression of AGO1 mRNACTDPMID:30779732
Ago1Mousearsenite(3-) increases expressionEXP 6480464arsenite results in increased expression of AGO1 proteinCTDPMID:37955338
Ago1Mousebenzene increases expressionISOAGO1 (Homo sapiens)6480464Benzene results in increased expression of AGO1 mRNACTDPMID:19162166

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Biological Process
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Object Symbol
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Original Reference(s)
Ago1MousemiRNA metabolic process acts_upstream_of_or_withinIDA 2290270 PMID:22053081MGIPMID:22053081
Ago1MousemiRNA processing involved_inISOUniProtKB:Q9UL182290270 GO_CentralGO_REF:0000119
Ago1MousemiRNA-mediated gene silencing by inhibition of translation involved_inISSUniProtKB:Q9UL182290270 UniProtGO_REF:0000024
Ago1MousemiRNA-mediated gene silencing by inhibition of translation involved_inISOUniProtKB:Q9UL182290270 GO_CentralGO_REF:0000119
Ago1MousemiRNA-mediated gene silencing by mRNA destabilization NOT|involved_inISOAGO1 (Homo sapiens)9068941 PMID:15260970BHF-UCLPMID:15260970
Ago1Mousenegative regulation of angiogenesis involved_inISOUniProtKB:Q9UL182290270 GO_CentralGO_REF:0000119
Ago1Mousenuclear-transcribed mRNA catabolic process involved_inISOUniProtKB:Q9UL182290270 GO_CentralGO_REF:0000119
Ago1Mousenuclear-transcribed mRNA catabolic process involved_inISSUniProtKB:Q9UL182290270 UniProtGO_REF:0000024
Ago1Mousepositive regulation of gene expression involved_inIMP 2290270 PMID:26764146BHF-UCLPMID:26764146
Ago1Mousepositive regulation of gene expression acts_upstream_of_or_withinIMP 2290270 PMID:22053081MGIPMID:22053081
Ago1Mousepositive regulation of non-canonical NF-kappaB signal transduction involved_inIMP 2290270 PMID:26764146BHF-UCLPMID:26764146
Ago1Mousepositive regulation of transcription by RNA polymerase II involved_inISOUniProtKB:Q9UL182290270 GO_CentralGO_REF:0000119
Ago1Mousepositive regulation of transcription by RNA polymerase II acts_upstream_of_or_withinIDA 2290270 PMID:22053081MGIPMID:22053081
Ago1Mousepositive regulation of transcription by RNA polymerase II involved_inIMP 2290270 PMID:22053081BHF-UCLPMID:22053081
Ago1Mousepre-miRNA processing involved_inISOUniProtKB:Q9UL182290270 GO_CentralGO_REF:0000119
Ago1Mousepre-miRNA processing involved_inIBAPANTHER:PTN000527278 more ...2290270 GO_CentralGO_REF:0000033
Ago1Mouseregulation of mRNA stability  ISOAgo1 (Rattus norvegicus)9068941 RGDPMID:26846850 and REF_RGD_ID:11526737
Ago1Mouseregulation of mRNA stability involved_inISOAgo1 (Rattus norvegicus)2290270 GO_CentralGO_REF:0000096
Ago1Mouseregulatory ncRNA-mediated post-transcriptional gene silencing involved_inIBAPANTHER:PTN001113179 more ...2290270 GO_CentralGO_REF:0000033
Ago1MouseRISC complex assembly involved_inISOUniProtKB:Q9UL182290270 GO_CentralGO_REF:0000119
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Cellular Component
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Original Reference(s)
Ago1Mousecytoplasm is_active_inIBAPANTHER:PTN000527275 more ...2290270 GO_CentralGO_REF:0000033
Ago1Mousecytoplasm located_inISOUniProtKB:Q9UL182290270 PMID:20014101MGIGO_REF:0000119 and PMID:20014101
Ago1Mousecytoplasm located_inISSUniProtKB:Q9UL182290270 UniProtGO_REF:0000024
Ago1Mousecytoplasmic ribonucleoprotein granule located_inISOUniProtKB:Q9UL182290270 GO_CentralGO_REF:0000119
Ago1Mousecytoplasmic ribonucleoprotein granule is_active_inIBAPANTHER:PTN001113179 more ...2290270 GO_CentralGO_REF:0000033
Ago1Mousecytosol located_inISOUniProtKB:Q9UL182290270 GO_CentralGO_REF:0000119
Ago1Mousecytosol located_inIDA 2290270 PMID:22053081MGIPMID:22053081
Ago1Mousenucleus is_active_inIBAPANTHER:PTN001875625 more ...2290270 GO_CentralGO_REF:0000033
Ago1Mousenucleus located_inIDA 2290270 PMID:22053081MGIPMID:22053081
Ago1MouseP-body located_inIDA 2290270 PMID:19898466MGIPMID:19898466
Ago1MouseRISC complex part_ofISOUniProtKB:Q9UL182290270 GO_CentralGO_REF:0000119
Ago1MouseRISC complex part_ofIDA 2290270 PMID:19536157MGIPMID:19536157
Ago1MouseRISC complex part_ofISSUniProtKB:Q9UL182290270 UniProtGO_REF:0000024
Ago1MouseRISC complex part_ofIBAPANTHER:PTN001113179 more ...2290270 GO_CentralGO_REF:0000033
Ago1MouseRISC-loading complex part_ofISOUniProtKB:Q9UL182290270 GO_CentralGO_REF:0000119
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Molecular Function
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RGD Manual Annotations


  
Object Symbol
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Evidence
With
Reference
Notes
Source
Original Reference(s)
Ago1MousemicroRNA pathway   ISOAGO1 (Homo sapiens)4144862 RGD 

#
Reference Title
Reference Citation
1. Argonaute proteins at a glance. Ender C and Meister G, J Cell Sci. 2010 Jun 1;123(Pt 11):1819-23.
2. Association of microRNA biogenesis pathway gene variants and alcohol dependence risk. Gedik H, etal., DNA Cell Biol. 2015 Mar;34(3):220-6. doi: 10.1089/dna.2014.2549. Epub 2014 Dec 11.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:10349636   PMID:10512203   PMID:10512872   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11726686   PMID:12414724   PMID:12466851   PMID:12477932   PMID:12520002  
PMID:12526743   PMID:12904583   PMID:14610273   PMID:15284456   PMID:15840001   PMID:16036130   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17626790   PMID:17967808   PMID:18799693  
PMID:19269368   PMID:19345100   PMID:19536157   PMID:19898466   PMID:20014101   PMID:20102707   PMID:20424607   PMID:21267068   PMID:21677750   PMID:21731673   PMID:21873635   PMID:22053081  
PMID:22318144   PMID:22474261   PMID:22508726   PMID:23185045   PMID:24949972   PMID:24992693   PMID:26764146   PMID:26850657   PMID:26995025   PMID:28378742   PMID:28671696   PMID:29021386  
PMID:30201950   PMID:30973865   PMID:31040226   PMID:31138677   PMID:32049003   PMID:32325033   PMID:32393053   PMID:32560809   PMID:34321999   PMID:34907157   PMID:35236760   PMID:37142655  
PMID:38355793   PMID:38458189  



Ago1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394126,328,805 - 126,362,500 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4126,328,805 - 126,362,376 (-)EnsemblGRCm39 Ensembl
GRCm384126,435,012 - 126,468,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4126,435,012 - 126,468,583 (-)EnsemblGRCm38mm10GRCm38
MGSCv374126,112,256 - 126,145,665 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364125,941,807 - 125,970,725 (-)NCBIMGSCv36mm8
Celera4124,771,815 - 124,805,219 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map460.76NCBI
AGO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38135,869,761 - 35,930,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl135,869,808 - 35,930,532 (+)EnsemblGRCh38hg38GRCh38
GRCh37136,335,362 - 36,396,133 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,121,397 - 36,162,486 (+)NCBINCBI36Build 36hg18NCBI36
Build 34136,017,902 - 36,058,992NCBI
Celera134,623,239 - 34,664,327 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef134,466,263 - 34,506,900 (+)NCBIHuRef
CHM1_1136,465,187 - 36,506,280 (+)NCBICHM1_1
T2T-CHM13v2.0135,732,654 - 35,793,426 (+)NCBIT2T-CHM13v2.0
Ago1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,006,618 - 144,064,740 (-)NCBIGRCr8
mRatBN7.25138,722,111 - 138,757,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5138,722,111 - 138,773,546 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5141,419,895 - 141,454,732 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,189,892 - 143,224,724 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,190,669 - 143,225,508 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05144,444,390 - 144,479,430 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5144,448,792 - 144,479,306 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05148,214,328 - 148,246,407 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45145,797,436 - 145,829,516 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15145,806,727 - 145,840,972 (-)NCBI
Celera5137,218,551 - 137,248,255 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ago1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545213,934,346 - 13,968,624 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545213,935,028 - 13,967,281 (+)NCBIChiLan1.0ChiLan1.0
AGO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21190,922,849 - 190,963,905 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,038,742 - 190,085,087 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0135,148,984 - 35,196,252 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1136,324,733 - 36,370,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl136,324,733 - 36,360,832 (+)Ensemblpanpan1.1panPan2
AGO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,258,359 - 6,294,911 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,263,882 - 6,295,338 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha156,501,590 - 6,538,192 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0156,394,522 - 6,431,156 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl156,395,742 - 6,431,512 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1156,247,517 - 6,284,126 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,321,049 - 6,352,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0156,330,625 - 6,367,229 (-)NCBIUU_Cfam_GSD_1.0
AGO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12096,929,985 - 96,971,074 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2096,934,659 - 96,971,014 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603319,754,613 - 19,801,453 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ago1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476418,904,639 - 18,940,594 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476418,904,607 - 18,940,594 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ago1
1896 total Variants

Predicted Target Of
Summary Value
Count of predictions:4227
Count of miRNA genes:919
Interacting mature miRNAs:1340
Transcripts:ENSMUST00000097888, ENSMUST00000127800, ENSMUST00000149425, ENSMUST00000156533, ENSMUST00000176315
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse

1 to 10 of 71 rows
Eif2c1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D2.2UniSTS
cM Map4 UniSTS
cM Map460.76UniSTS
A006G35  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384126,435,028 - 126,435,258UniSTSGRCm38
MGSCv374126,112,272 - 126,112,502UniSTSGRCm37
Celera4124,771,831 - 124,772,061UniSTS
Cytogenetic Map4D2.2UniSTS






1 to 17 of 17 rows
RefSeq Transcripts NM_001317173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001317174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_153403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011240521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB081471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI451331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY135687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ130124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV559803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSMUST00000097888   ⟹   ENSMUSP00000095498
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,328,805 - 126,362,376 (-)Ensembl
GRCm38.p6 Ensembl4126,435,012 - 126,468,583 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127800   ⟹   ENSMUSP00000135662
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,332,114 - 126,355,575 (-)Ensembl
GRCm38.p6 Ensembl4126,438,321 - 126,461,782 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149425
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,353,108 - 126,353,918 (-)Ensembl
GRCm38.p6 Ensembl4126,459,315 - 126,460,125 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156533
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,336,393 - 126,337,154 (-)Ensembl
GRCm38.p6 Ensembl4126,442,600 - 126,443,361 (-)Ensembl
Ensembl Acc Id: ENSMUST00000176315   ⟹   ENSMUSP00000134871
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,333,296 - 126,353,000 (-)Ensembl
GRCm38.p6 Ensembl4126,439,503 - 126,459,207 (-)Ensembl
Ensembl Acc Id: ENSMUST00000239399   ⟹   ENSMUSP00000159364
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,328,805 - 126,362,376 (-)Ensembl
GRCm38.p6 Ensembl4126,435,012 - 126,468,583 (-)Ensembl
Ensembl Acc Id: ENSMUST00000239428   ⟹   ENSMUSP00000159361
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,328,805 - 126,362,214 (-)Ensembl
GRCm38.p6 Ensembl4126,435,012 - 126,468,421 (-)Ensembl
RefSeq Acc Id: NM_001317173   ⟹   NP_001304102
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394126,328,805 - 126,362,376 (-)NCBI
GRCm384126,435,012 - 126,468,583 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001317174   ⟹   NP_001304103
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394126,328,805 - 126,362,376 (-)NCBI
GRCm384126,435,012 - 126,468,583 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001378879   ⟹   NP_001365808
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394126,328,805 - 126,362,424 (-)NCBI
GRCm384126,435,012 - 126,468,631 (-)NCBI
Sequence:
RefSeq Acc Id: NM_153403   ⟹   NP_700452
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394126,328,805 - 126,362,376 (-)NCBI
GRCm384126,435,012 - 126,468,583 (-)NCBI
MGSCv374126,112,256 - 126,145,665 (-)RGD
Celera4124,771,815 - 124,805,219 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011240521   ⟹   XP_011238823
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394126,328,805 - 126,362,500 (-)NCBI
GRCm384126,435,012 - 126,468,707 (-)NCBI
Sequence:
1 to 5 of 10 rows
1 to 5 of 10 rows
RefSeq Acc Id: NP_700452   ⟸   NM_153403
- Peptide Label: isoform 1
- UniProtKB: Q8CJG1 (UniProtKB/Swiss-Prot),   A1L365 (UniProtKB/Swiss-Prot),   A2VDG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011238823   ⟸   XM_011240521
- Peptide Label: isoform X1
- UniProtKB: A2VDG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304102   ⟸   NM_001317173
- Peptide Label: isoform 1x
- UniProtKB: A0A6I8MX18 (UniProtKB/TrEMBL),   A2VDG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304103   ⟸   NM_001317174
- Peptide Label: isoform 2
- UniProtKB: A2VDG1 (UniProtKB/TrEMBL),   Q8BJP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001365808   ⟸   NM_001378879
- Peptide Label: isoform 3
- UniProtKB: A2VDG1 (UniProtKB/TrEMBL)
PAZ   Piwi   Protein argonaute N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-Q8CJG1-F1-model_v2 AlphaFold Q8CJG1 1-857 view protein structure

RGD ID:6835186
Promoter ID:MM_KWN:39655
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000097888
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364126,145,481 - 126,146,032 (-)MPROMDB
RGD ID:6884652
Promoter ID:EPDNEW_M5777
Type:initiation region
Name:Ago1_1
Description:Mus musculus argonaute RISC catalytic subunit 1 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384126,468,624 - 126,468,684EPDNEW


1 to 40 of 46 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSMUSG00000041530 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000097888 ENTREZGENE
  ENSMUST00000097888.10 UniProtKB/Swiss-Prot
  ENSMUST00000239399 ENTREZGENE
  ENSMUST00000239428.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.10 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  paz domain UniProtKB/Swiss-Prot
InterPro ArgoL1 UniProtKB/Swiss-Prot
  ArgoL2 UniProtKB/Swiss-Prot
  Argonaute_Mid_dom UniProtKB/Swiss-Prot
  Argonaute_N UniProtKB/Swiss-Prot
  PAZ_dom UniProtKB/Swiss-Prot
  PAZ_dom_sf UniProtKB/Swiss-Prot
  Piwi UniProtKB/Swiss-Prot
  Piwi_ago-like UniProtKB/Swiss-Prot
  RNaseH-like_sf UniProtKB/Swiss-Prot
  RNaseH_sf UniProtKB/Swiss-Prot
KEGG Report mmu:236511 UniProtKB/Swiss-Prot
MGD MGI:2446630 ENTREZGENE
NCBI Gene Ago1 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2C UniProtKB/Swiss-Prot
Pfam ArgoL1 UniProtKB/Swiss-Prot
  ArgoL2 UniProtKB/Swiss-Prot
  ArgoMid UniProtKB/Swiss-Prot
  ArgoN UniProtKB/Swiss-Prot
  PAZ UniProtKB/Swiss-Prot
  Piwi UniProtKB/Swiss-Prot
PhenoGen Ago1 PhenoGen
PROSITE PAZ UniProtKB/Swiss-Prot
  PIWI UniProtKB/Swiss-Prot
SMART DUF1785 UniProtKB/Swiss-Prot
  PAZ UniProtKB/Swiss-Prot
  Piwi UniProtKB/Swiss-Prot
Superfamily-SCOP SSF101690 UniProtKB/Swiss-Prot
  SSF53098 UniProtKB/Swiss-Prot
UniProt A0A6I8MX18 ENTREZGENE, UniProtKB/TrEMBL
  A1L365 ENTREZGENE
  A2VDG1 ENTREZGENE, UniProtKB/TrEMBL
  AGO1_MOUSE UniProtKB/Swiss-Prot
1 to 40 of 46 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Ago1  argonaute RISC catalytic subunit 1  Eif2c1  eukaryotic translation initiation factor 2C, 1  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Eif2c1  eukaryotic translation initiation factor 2C, 1  Ago1  argonaute RISC catalytic subunit 1  Symbol and/or name change 5135510 APPROVED
2013-02-27 Ago1  argonaute RISC catalytic subunit 1  Eif2c1  eukaryotic translation initiation factor 2C, 1  Symbol and/or name change 5135510 APPROVED