Ago1 (argonaute RISC catalytic subunit 1) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Ago1 (argonaute RISC catalytic subunit 1) Mus musculus
Analyze
Symbol: Ago1
Name: argonaute RISC catalytic subunit 1
RGD ID: 1312164
MGI Page MGI
Description: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and miRNA binding activity. Involved in positive regulation of gene expression and positive regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within miRNA metabolic process and positive regulation of transcription by RNA polymerase II. Located in P-body; cytosol; and nucleus. Part of RISC complex. Is expressed in several structures, including 2-cell stage embryo; central nervous system; lung epithelium; sensory organ; and tooth. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human AGO1 (argonaute RISC component 1).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: argonaute 1; argonaute RISC catalytic component 1; argonaute1; eIF-2C 1; Eif2c; eIF2C 1; Eif2c1; eukaryotic translation initiation factor 2C, 1; mAgo1; Piwi/Argonaute family protein meIF2C1; protein argonaute-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394126,328,805 - 126,362,500 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4126,328,805 - 126,362,376 (-)EnsemblGRCm39 Ensembl
GRCm384126,435,012 - 126,468,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4126,435,012 - 126,468,583 (-)EnsemblGRCm38mm10GRCm38
MGSCv374126,112,256 - 126,145,665 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364125,941,807 - 125,970,725 (-)NCBIMGSCv36mm8
Celera4124,771,815 - 124,805,219 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map460.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytoplasmic ribonucleoprotein granule  (IBA,ISO)
cytosol  (IDA,ISO)
nucleus  (IBA,IDA)
P-body  (IDA)
RISC complex  (IBA,IDA,ISO,ISS)
RISC-loading complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Argonaute proteins at a glance. Ender C and Meister G, J Cell Sci. 2010 Jun 1;123(Pt 11):1819-23.
2. Association of microRNA biogenesis pathway gene variants and alcohol dependence risk. Gedik H, etal., DNA Cell Biol. 2015 Mar;34(3):220-6. doi: 10.1089/dna.2014.2549. Epub 2014 Dec 11.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10512203   PMID:10512872   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11726686   PMID:12414724   PMID:12466851   PMID:12477932   PMID:12520002  
PMID:12526743   PMID:12904583   PMID:14610273   PMID:15284456   PMID:15840001   PMID:16036130   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17626790   PMID:17967808   PMID:18799693  
PMID:19269368   PMID:19345100   PMID:19536157   PMID:19898466   PMID:20014101   PMID:20102707   PMID:20424607   PMID:21267068   PMID:21677750   PMID:21731673   PMID:21873635   PMID:22053081  
PMID:22318144   PMID:22474261   PMID:22508726   PMID:23185045   PMID:24949972   PMID:24992693   PMID:26764146   PMID:26850657   PMID:26995025   PMID:28378742   PMID:28671696   PMID:29021386  
PMID:30201950   PMID:30973865   PMID:31040226   PMID:31138677   PMID:32049003   PMID:32325033   PMID:32393053   PMID:32560809   PMID:34321999   PMID:34907157   PMID:35236760   PMID:37142655  
PMID:38355793   PMID:38458189  


Genomics

Comparative Map Data
Ago1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394126,328,805 - 126,362,500 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4126,328,805 - 126,362,376 (-)EnsemblGRCm39 Ensembl
GRCm384126,435,012 - 126,468,707 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4126,435,012 - 126,468,583 (-)EnsemblGRCm38mm10GRCm38
MGSCv374126,112,256 - 126,145,665 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364125,941,807 - 125,970,725 (-)NCBIMGSCv36mm8
Celera4124,771,815 - 124,805,219 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map460.76NCBI
AGO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38135,869,761 - 35,930,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl135,869,808 - 35,930,532 (+)EnsemblGRCh38hg38GRCh38
GRCh37136,335,362 - 36,396,133 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,121,397 - 36,162,486 (+)NCBINCBI36Build 36hg18NCBI36
Build 34136,017,902 - 36,058,992NCBI
Celera134,623,239 - 34,664,327 (+)NCBICelera
Cytogenetic Map1p34.3NCBI
HuRef134,466,263 - 34,506,900 (+)NCBIHuRef
CHM1_1136,465,187 - 36,506,280 (+)NCBICHM1_1
T2T-CHM13v2.0135,732,654 - 35,793,426 (+)NCBIT2T-CHM13v2.0
Ago1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85144,006,618 - 144,064,740 (-)NCBIGRCr8
mRatBN7.25138,722,111 - 138,757,118 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5138,722,111 - 138,773,546 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5141,419,895 - 141,454,732 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05143,189,892 - 143,224,724 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05143,190,669 - 143,225,508 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05144,444,390 - 144,479,430 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5144,448,792 - 144,479,306 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05148,214,328 - 148,246,407 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45145,797,436 - 145,829,516 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15145,806,727 - 145,840,972 (-)NCBI
Celera5137,218,551 - 137,248,255 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ago1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545213,934,346 - 13,968,624 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545213,935,028 - 13,967,281 (+)NCBIChiLan1.0ChiLan1.0
AGO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21190,922,849 - 190,963,905 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11190,038,742 - 190,085,087 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0135,148,984 - 35,196,252 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1136,324,733 - 36,370,798 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl136,324,733 - 36,360,832 (+)Ensemblpanpan1.1panPan2
AGO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1156,258,359 - 6,294,911 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl156,263,882 - 6,295,338 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha156,501,590 - 6,538,192 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0156,394,522 - 6,431,156 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl156,395,742 - 6,431,512 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1156,247,517 - 6,284,126 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0156,321,049 - 6,352,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0156,330,625 - 6,367,229 (-)NCBIUU_Cfam_GSD_1.0
AGO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12096,929,985 - 96,971,074 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2096,934,659 - 96,971,014 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603319,754,613 - 19,801,453 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ago1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476418,904,639 - 18,940,594 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476418,904,607 - 18,940,594 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4227
Count of miRNA genes:919
Interacting mature miRNAs:1340
Transcripts:ENSMUST00000097888, ENSMUST00000127800, ENSMUST00000149425, ENSMUST00000156533, ENSMUST00000176315
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142139Adip12_madiposity 12 (mouse)Not determined4124621281156860686Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112824389146824389Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124264957150676858Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
14746982Manh56_mmandible shape 56 (mouse)4117815917151815917Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105835310141433838Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105835310141433838Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111009051145009280Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107791564141791756Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124264957142230960Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105835310141433838Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4123993793144326570Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105835310141433838Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125230872156860686Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116154678150154782Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107264957141265153Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124055093142438020Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120617848154617995Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117401141151401275Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125230872156860686Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124055093141572792Mouse
10412072Ssen1_msuseptibility to Sendai virus 1 (mouse)Not determined4109658132133154782Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120617848154617995Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
1300655Nidds_mnon-insulin-dependent diabetes mellitus in SJL (mouse)Not determined4115030777129465915Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107264957141265153Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120674005154674151Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4119864433153864536Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121342649155342753Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124621281156860686Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120674005154674151Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121342649155342753Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125230872156860686Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107264957141265153Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121342649155342753Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4119864433153864536Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined494957579128009280Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108477692142477692Mouse
10755521Hct1_mhematocrit 1 (mouse)4108477692142477692Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108477692142477692Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124621281156860686Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124553483156860686Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494732255128732454Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105705794139705794Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125289325156860686Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111009051145009280Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105705794139705794Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112523489146523489Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498545539128009280Mouse
15039378Adip30_madiposity 30 (mouse)4105705794139705794Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107055093141055180Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112182386146182386Mouse

Markers in Region
Eif2c1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map4D2.2UniSTS
cM Map4 UniSTS
cM Map460.76UniSTS
A006G35  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384126,435,028 - 126,435,258UniSTSGRCm38
MGSCv374126,112,272 - 126,112,502UniSTSGRCm37
Celera4124,771,831 - 124,772,061UniSTS
Cytogenetic Map4D2.2UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001317173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001317174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001378879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_153403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011240521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB081471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI451331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK080954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL606976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY135687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC129915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ130124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV559803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000097888   ⟹   ENSMUSP00000095498
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,328,805 - 126,362,376 (-)Ensembl
GRCm38.p6 Ensembl4126,435,012 - 126,468,583 (-)Ensembl
Ensembl Acc Id: ENSMUST00000127800   ⟹   ENSMUSP00000135662
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,332,114 - 126,355,575 (-)Ensembl
GRCm38.p6 Ensembl4126,438,321 - 126,461,782 (-)Ensembl
Ensembl Acc Id: ENSMUST00000149425
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,353,108 - 126,353,918 (-)Ensembl
GRCm38.p6 Ensembl4126,459,315 - 126,460,125 (-)Ensembl
Ensembl Acc Id: ENSMUST00000156533
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,336,393 - 126,337,154 (-)Ensembl
GRCm38.p6 Ensembl4126,442,600 - 126,443,361 (-)Ensembl
Ensembl Acc Id: ENSMUST00000176315   ⟹   ENSMUSP00000134871
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,333,296 - 126,353,000 (-)Ensembl
GRCm38.p6 Ensembl4126,439,503 - 126,459,207 (-)Ensembl
Ensembl Acc Id: ENSMUST00000239399   ⟹   ENSMUSP00000159364
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,328,805 - 126,362,376 (-)Ensembl
GRCm38.p6 Ensembl4126,435,012 - 126,468,583 (-)Ensembl
Ensembl Acc Id: ENSMUST00000239428   ⟹   ENSMUSP00000159361
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4126,328,805 - 126,362,214 (-)Ensembl
GRCm38.p6 Ensembl4126,435,012 - 126,468,421 (-)Ensembl
RefSeq Acc Id: NM_001317173   ⟹   NP_001304102
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394126,328,805 - 126,362,376 (-)NCBI
GRCm384126,435,012 - 126,468,583 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001317174   ⟹   NP_001304103
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394126,328,805 - 126,362,376 (-)NCBI
GRCm384126,435,012 - 126,468,583 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001378879   ⟹   NP_001365808
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394126,328,805 - 126,362,424 (-)NCBI
GRCm384126,435,012 - 126,468,631 (-)NCBI
Sequence:
RefSeq Acc Id: NM_153403   ⟹   NP_700452
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394126,328,805 - 126,362,376 (-)NCBI
GRCm384126,435,012 - 126,468,583 (-)NCBI
MGSCv374126,112,256 - 126,145,665 (-)RGD
Celera4124,771,815 - 124,805,219 (-)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011240521   ⟹   XP_011238823
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394126,328,805 - 126,362,500 (-)NCBI
GRCm384126,435,012 - 126,468,707 (-)NCBI
Sequence:
RefSeq Acc Id: NP_700452   ⟸   NM_153403
- Peptide Label: isoform 1
- UniProtKB: Q8CJG1 (UniProtKB/Swiss-Prot),   A1L365 (UniProtKB/Swiss-Prot),   A2VDG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011238823   ⟸   XM_011240521
- Peptide Label: isoform X1
- UniProtKB: A2VDG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304102   ⟸   NM_001317173
- Peptide Label: isoform 1x
- UniProtKB: A0A6I8MX18 (UniProtKB/TrEMBL),   A2VDG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304103   ⟸   NM_001317174
- Peptide Label: isoform 2
- UniProtKB: A2VDG1 (UniProtKB/TrEMBL),   Q8BJP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001365808   ⟸   NM_001378879
- Peptide Label: isoform 3
- UniProtKB: A2VDG1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000135662   ⟸   ENSMUST00000127800
Ensembl Acc Id: ENSMUSP00000159361   ⟸   ENSMUST00000239428
Ensembl Acc Id: ENSMUSP00000159364   ⟸   ENSMUST00000239399
Ensembl Acc Id: ENSMUSP00000095498   ⟸   ENSMUST00000097888
Ensembl Acc Id: ENSMUSP00000134871   ⟸   ENSMUST00000176315
Protein Domains
PAZ   Piwi   Protein argonaute N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CJG1-F1-model_v2 AlphaFold Q8CJG1 1-857 view protein structure

Promoters
RGD ID:6835186
Promoter ID:MM_KWN:39655
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   Spleen
Transcripts:ENSMUST00000097888
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364126,145,481 - 126,146,032 (-)MPROMDB
RGD ID:6884652
Promoter ID:EPDNEW_M5777
Type:initiation region
Name:Ago1_1
Description:Mus musculus argonaute RISC catalytic subunit 1 , transcriptvariant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384126,468,624 - 126,468,684EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2446630 AgrOrtholog
Ensembl Genes ENSMUSG00000041530 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000097888 ENTREZGENE
  ENSMUST00000097888.10 UniProtKB/Swiss-Prot
  ENSMUST00000127800.2 UniProtKB/TrEMBL
  ENSMUST00000176315.2 UniProtKB/TrEMBL
  ENSMUST00000239399 ENTREZGENE
  ENSMUST00000239399.2 UniProtKB/TrEMBL
  ENSMUST00000239428.2 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.420.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  paz domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ArgoL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArgoL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Argonaute_Mid_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Argonaute_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi_ago-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:236511 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2446630 ENTREZGENE
NCBI Gene Ago1 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN ARGONAUTE-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ArgoL1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArgoL2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArgoMid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ArgoN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ago1 PhenoGen
PROSITE PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIWI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DUF1785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6I8MX18 ENTREZGENE, UniProtKB/TrEMBL
  A1L365 ENTREZGENE
  A2VDG1 ENTREZGENE, UniProtKB/TrEMBL
  AGO1_MOUSE UniProtKB/Swiss-Prot
  H3BJ70_MOUSE UniProtKB/TrEMBL
  H3BL59_MOUSE UniProtKB/TrEMBL
  Q8BJP2 ENTREZGENE, UniProtKB/TrEMBL
  Q8CGU0_MOUSE UniProtKB/TrEMBL
  Q8CJG1 ENTREZGENE
UniProt Secondary A1L365 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-08-26 Ago1  argonaute RISC catalytic subunit 1  Eif2c1  eukaryotic translation initiation factor 2C, 1  Symbol and/or name updated 27372883 PROVISIONAL
2024-08-21 Eif2c1  eukaryotic translation initiation factor 2C, 1  Ago1  argonaute RISC catalytic subunit 1  Symbol and/or name change 5135510 APPROVED
2013-02-27 Ago1  argonaute RISC catalytic subunit 1  Eif2c1  eukaryotic translation initiation factor 2C, 1  Symbol and/or name change 5135510 APPROVED