Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: AGO3 (argonaute RISC catalytic component 3) Homo sapiens
Symbol: AGO3
Name: argonaute RISC catalytic component 3
RGD ID: 1319350
Description: Exhibits RNA binding activity and endoribonuclease activity, cleaving miRNA-paired mRNA. Involved in RNA metabolic process; gene silencing by miRNA; and regulation of stem cell proliferation. Localizes to several cellular components, including RISC complex; RISC-loading complex; and cytoplasmic ribonucleoprotein granule.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: argonaute 3; argonaute 3, RISC catalytic component; argonaute3; eIF-2C 3; eIF2C 3; EIF2C3; eukaryotic translation initiation factor 2C, 3; FLJ12765; hAgo3; MGC86946; protein argonaute-3
Mus musculus (house mouse) : Ago3 (argonaute RISC catalytic subunit 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ago3 (argonaute RISC catalytic component 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ago3 (argonaute RISC catalytic component 3)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100968913 (argonaute RISC catalytic component 3)
Canis lupus familiaris (dog) : AGO3 (argonaute RISC catalytic component 3)
Sus scrofa (pig) : AGO3 (argonaute RISC catalytic component 3)
Chlorocebus sabaeus (African green monkey) : AGO3 (argonaute RISC catalytic component 3)
Heterocephalus glaber (naked mole-rat) : Ago3 (argonaute RISC catalytic component 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl135,930,718 - 36,072,500 (+)EnsemblGRCh38hg38GRCh38
GRCh38135,925,683 - 36,072,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37136,396,364 - 36,522,360 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36136,169,359 - 36,294,650 (+)NCBINCBI36hg18NCBI36
Celera134,671,200 - 34,796,478 (+)NCBI
Cytogenetic Map1p34.3NCBI
HuRef134,513,684 - 34,638,740 (+)NCBIHuRef
CHM1_1136,513,064 - 36,638,399 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AGO3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319350
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.