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Gene: Brix1 (biogenesis of ribosomes BRX1) Rattus norvegicus

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Symbol:

Brix1

Name:

biogenesis of ribosomes BRX1

RGD ID:

1308508

Description:

Predicted to enable RNA binding activity. Predicted to be involved in ribosomal large subunit assembly. Predicted to be located in chromosome. Predicted to be active in nucleolus. Orthologous to human BRIX1 (biogenesis of ribosomes BRX1); INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

brix domain containing 2; brix domain-containing protein 2; BRX1, biogenesis of ribosomes; BRX1, biogenesis of ribosomes, homolog; BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Bxdc2; LOC294799; MGC116151; RGD1308508; ribosome biogenesis protein Brix; ribosome biogenesis protein BRX1 homolog; similar to BRIX

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BRIX1 (biogenesis of ribosomes BRX1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Brix1 (BRX1, biogenesis of ribosomes)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Brix1 (biogenesis of ribosomes BRX1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BRIX1 (biogenesis of ribosomes BRX1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BRIX1 (biogenesis of ribosomes BRX1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Brix1 (biogenesis of ribosomes BRX1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BRIX1 (biogenesis of ribosomes BRX1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BRIX1 (biogenesis of ribosomes BRX1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Brix1 (biogenesis of ribosomes BRX1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Brix1 (BRX1, biogenesis of ribosomes)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	BRIX1 (biogenesis of ribosomes BRX1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	bxdc2 (brix domain containing 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BRX1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG11583	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	K12H4.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	brix1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	61,177,769 - 61,188,647 (-)	NCBI		GRCr8
mRatBN7.2	2	59,450,608 - 59,461,486 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	59,450,614 - 59,461,495 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	66,558,326 - 66,569,203 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	64,679,856 - 64,690,733 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	59,681,217 - 59,692,094 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	60,450,547 - 60,461,425 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	60,450,374 - 60,461,458 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	84,212,803 - 84,223,681 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	59,826,894 - 59,837,772 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	59,755,126 - 59,766,005 (-)	NCBI
Celera	2	59,212,330 - 59,223,208 (+)	NCBI		Celera
Cytogenetic Map	2	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alpha-methylacyl-CoA racemase deficiency (ISO)

Neurodevelopmental Disorders (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

atrazine (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

calcitriol (ISO)

chromium(6+) (ISO)

coumarin (ISO)

cyclosporin A (ISO)

DDE (ISO)

dexamethasone (ISO)

dicrotophos (ISO)

dioxygen (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

glafenine (EXP)

indometacin (ISO)

ivermectin (ISO)

methidathion (ISO)

nefazodone (EXP)

nickel atom (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

propiconazole (EXP,ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sulfadimethoxine (EXP)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

trichostatin A (ISO)

triphenyl phosphate (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ribosomal large subunit assembly (IBA)

rRNA processing (IEA)

Cellular Component

chromosome (IEA,ISO)

membrane (IEA)

nucleolus (IBA,IEA,ISO)

Molecular Function

protein binding (ISO)

RNA binding (IBA)

rRNA binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:22658674	PMID:22681889

Genomics

Comparative Map Data

Brix1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	61,177,769 - 61,188,647 (-)	NCBI		GRCr8
mRatBN7.2	2	59,450,608 - 59,461,486 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	59,450,614 - 59,461,495 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	66,558,326 - 66,569,203 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	64,679,856 - 64,690,733 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	59,681,217 - 59,692,094 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	60,450,547 - 60,461,425 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	60,450,374 - 60,461,458 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	84,212,803 - 84,223,681 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	59,826,894 - 59,837,772 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	59,755,126 - 59,766,005 (-)	NCBI
Celera	2	59,212,330 - 59,223,208 (+)	NCBI		Celera
Cytogenetic Map	2	q16	NCBI

BRIX1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	34,915,711 - 34,925,996 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	34,915,677 - 34,925,996 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	34,915,816 - 34,926,101 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	34,951,577 - 34,961,544 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	5	34,798,052 - 34,808,019 (+)	NCBI		Celera
Cytogenetic Map	5	p13.2	NCBI
HuRef	5	34,864,475 - 34,874,444 (+)	NCBI		HuRef
CHM1_1	5	34,918,180 - 34,928,149 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	35,162,745 - 35,173,028 (+)	NCBI		T2T-CHM13v2.0

Brix1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	10,474,865 - 10,486,023 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	10,474,865 - 10,486,033 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	10,474,779 - 10,485,937 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	10,474,779 - 10,485,947 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	10,404,534 - 10,415,692 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	10,420,906 - 10,430,632 (-)	NCBI		MGSCv36	mm8
Celera	15	10,271,850 - 10,283,020 (-)	NCBI		Celera
Cytogenetic Map	15	A1	NCBI
cM Map	15	5.35	NCBI

Brix1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955426	20,042,274 - 20,051,606 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955426	20,042,274 - 20,051,606 (+)	NCBI	ChiLan1.0	ChiLan1.0

BRIX1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	75,410,743 - 75,420,843 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	73,564,375 - 73,574,589 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	75,444,136 - 75,454,911 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	80,723,896 - 80,734,348 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	80,723,896 - 80,734,348 (-)	Ensembl	panpan1.1		panPan2

BRIX1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	73,375,310 - 73,385,451 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	73,375,304 - 73,385,396 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	72,991,753 - 73,001,881 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	73,881,066 - 73,891,206 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	73,881,060 - 73,891,154 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	73,628,665 - 73,638,767 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	73,752,321 - 73,762,448 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	74,285,566 - 74,295,689 (-)	NCBI		UU_Cfam_GSD_1.0

Brix1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	224,751,432 - 224,760,886 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936518	6,610,623 - 6,620,383 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936518	6,610,623 - 6,620,369 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BRIX1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	20,512,280 - 20,522,181 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	20,512,281 - 20,520,579 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	21,414,147 - 21,422,488 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BRIX1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	33,807,951 - 33,818,546 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	4	33,808,309 - 33,820,658 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666071	24,110,260 - 24,121,180 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Brix1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624759	19,982,513 - 19,994,637 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624759	19,982,612 - 19,994,621 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	576
Count of miRNA genes:	256
Interacting mature miRNAs:	313
Transcripts:	ENSRNOT00000024285
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6480225	Gdil1	Gastrointestinal dilation QTL 1			enteric ganglion morphology trait (VT:0001045)	length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)	2	58388201	77302351	Rat
631500	Bp99	Blood pressure QTL 99	2.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	61051883	104684275	Rat
10755436	Coatc8	Coat color QTL 8		0.02431	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	2	36750344	81750344	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
5684996	Bmd85	Bone mineral density QTL 85	4.7	0.024	tibia mineral mass (VT:1000283)	bone mineral density (CMO:0001226)	2	61051541	105724065	Rat
731167	Glom4	Glomerulus QTL 4	2.4	0.0082	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	2	22038044	67038044	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1302794	Stl27	Serum triglyceride level QTL 27	4.4	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	2	27148328	145807373	Rat
9590095	Sffal3	Serum free fatty acids level QTL 3	6.78	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	2	28889991	73889991	Rat
70174	BpQTLCluster2	Blood pressure QTL cluster 2	4.24		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	41801363	104744824	Rat
1358901	Cm38	Cardiac mass QTL 38	2		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
631208	Bw1	Body weight QTL1	5.09		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	2	44904355	85286097	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
1358899	Kidm23	Kidney mass QTL 23	3.88		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
1358908	Bw49	Body weight QTL 49	3.36		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
1300155	Bp174	Blood pressure QTL 174	4.09		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	2	44537979	112567334	Rat
2293835	Kiddil5	Kidney dilation QTL 5	3.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	159440891	Rat
5684990	Bmd82	Bone mineral density QTL 82	2.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	2	61051541	105724065	Rat
1358910	Kidm27	Kidney mass QTL 27	5.77		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
61355	Bp36	Blood pressure QTL 36	2.9		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	2	7605533	104774005	Rat
1358911	Kidm28	Kidney mass QTL 28	5.42		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
1358904	Cm39	Cardiac mass QTL 39	2.26		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	159440891	Rat
1354617	Bp240	Blood pressure QTL 240	4		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	83465677	Rat
1359034	Bp274	Blood pressure QTL 274			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	51266859	96266859	Rat
1558648	Smcn1	Smooth muscle cell number QTL 1		0.039	blood vessel smooth muscle cell quantity (VT:0010525)	aorta smooth muscle cell count per unit vessel length (CMO:0001646)	2	60861391	105861391	Rat
2293843	Kiddil6	Kidney dilation QTL 6	3.1		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	44537979	184731399	Rat
1358887	Bw50	Body weight QTL 50	2.39		body mass (VT:0001259)	body weight (CMO:0000012)	2	27148557	159440760	Rat
2306903	Bp336	Blood pressure QTL 336		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	38426449	111295694	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
2290453	Scl55	Serum cholesterol level QTL 55	2.83		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	28652666	139067443	Rat
1358894	Kidm24	Kidney mass QTL 24	4.03		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	27148328	159440891	Rat
731184	Mamtr4	Mammary tumor resistance QTL 4		0.0003	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	2	18227137	63227137	Rat
61371	Edpm1	Estrogen-dependent pituitary mass QTL 1	4	0.05	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	36868643	81868643	Rat
1354601	Slep1	Serum leptin concentration QTL 1	5.39		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	2	44904355	89904355	Rat
1582246	Cm60	Cardiac mass QTL 60	5.8		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	33269996	78269996	Rat
61438	Cia7	Collagen induced arthritis QTL 7	4.6	0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	2	61051541	143746880	Rat
1354603	Bp243	Blood pressure QTL 243	3.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	28652666	73652666	Rat

Markers in Region

RH132206

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	61,177,828 - 61,178,036 (+)	Marker Load Pipeline
mRatBN7.2	2	59,450,667 - 59,450,875 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	60,450,607 - 60,450,814	NCBI	Rnor6.0
Rnor_5.0	2	84,223,414 - 84,223,621	UniSTS	Rnor5.0
RGSC_v3.4	2	59,826,954 - 59,827,161	UniSTS	RGSC3.4
Celera	2	59,222,941 - 59,223,148	UniSTS
Cytogenetic Map	2	q16	UniSTS

RH139712

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	59,451,878 - 59,452,059 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	60,451,818 - 60,451,998	NCBI	Rnor6.0
Rnor_5.0	2	84,222,230 - 84,222,410	UniSTS	Rnor5.0
RGSC_v3.4	2	59,828,165 - 59,828,345	UniSTS	RGSC3.4
Celera	2	59,221,757 - 59,221,937	UniSTS
Cytogenetic Map	2	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001029915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213839	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000024285 ⟹ ENSRNOP00000024285

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	59,451,810 - 59,461,489 (-)	Ensembl
Rnor_6.0 Ensembl	2	60,450,374 - 60,461,458 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118075 ⟹ ENSRNOP00000082868

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	59,450,614 - 59,461,495 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000119136 ⟹ ENSRNOP00000084824

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	59,450,614 - 59,461,495 (-)	Ensembl

RefSeq Acc Id:

NM_001029915 ⟹ NP_001025086

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	61,177,769 - 61,188,647 (-)	NCBI
mRatBN7.2	2	59,450,608 - 59,461,486 (-)	NCBI
Rnor_6.0	2	60,450,547 - 60,461,425 (-)	NCBI
Rnor_5.0	2	84,212,803 - 84,223,681 (+)	NCBI
RGSC_v3.4	2	59,826,894 - 59,837,772 (-)	RGD
Celera	2	59,212,330 - 59,223,208 (+)	RGD

Sequence:

show sequence

CAGGATGGCGGCGACTAAGAGAAAGCGGCGTGGGGACCTGGAGGTTCAAGCAAAGAAGCCAAAA
AAGAACCGGAAAGATGCCGGGCAGCCAGCTAAGCAGGCCGATGTGGCAAAAGAGGCGGAGGAAG
AAAAAGATCGTATTCCAGGTCCTGTTTGCAAGGGCAAATGGAAAAATAAAGAGCGGATCCTCAT
CTTTTCTTCCAGAGGAATAAATTTCAGAACAAGACACTTGATGCAAGACTTGAGAATGTTGATG
CCTCATTCTAAAGCAGATACTAAAATGGATCGTAAAGATAAGTTATTTGTGATAAATGAGGTCT
GTGAAATGAAAAATTGCAACAAATGCATCTACTTTGAAGCTAAGAAAAAGCAGGATCTCTATAT
GTGGCTTTCAAATTCACCTCATGGGCCATCTGCCAAATTCTTGGTTCAAAATATTCATACCCTG
GCTGAACTAAAGATGACTGGGAACTGTTTGAAAGGTTCTCGGCCCCTTTTATCTTTTGACCCTG
CTTTTGATGACTTGCCACATTATGCTTTGTTAAAAGAATTCTTAATTCAGATCTTTAGTACACC
ACGGTACCATCCCAAGAGTCAGCCGTTTGTGGACCACGTGTTTACGTTCACCATTCTGGATAAC
CGGATCTGGTTTCGGAACTTCCAGATTATAGAAGAAGACGCTGCTCTAGTGGAAATTGGACCTC
GTTTTGTCTTAAATCTCATAAAGATTTTTCAGGGAAGCTTTGGAGGACCAACCTTATATGAAAA
TCCTCATTACCAGTCTCCAAACATGCATCGGCGCGTCGTAAGGTCCATCACAGCTGCCAAGTAC
AGAGAGAAACAGCAAGTCAAAGATGTTCAGAAATCAAGGAAGAAAGAACCAAAGACTATTCTTC
CACACGATCCCACTGCAGATGTGTTTGTTACACCAGCAGAGGAGAAACCAATAGAAGTACAATG
GGTGAAACCAGAGCCAAAAGTGGATCTGAAAGCGAGAAAGAGAAGGATTTACAAAAGGCATCGG
AAACTGCAGCAGAAGATGAGCAGAGGGGGTGCCAAATGAATCCATGGATAACTATCTCTTTTAG
TTACTGTGTATTTATTTCGTATTCCATGTGTAAATACTTTTAGTATACAGAATTAGCTGTCTGA
TTAGGGCGCTATTTTAAAAAATTAAAAATCTTTAAGTCAGTATTGGTATTTTTCTAAATAAAGC
ATCTTCAGAACTCACCAGCTACTTTATTCTTTTCAGAGCCTCACTTAGTATTGAGTCTTTAGCA
CACTTAACAGTTATCTTGCCTTGTTTGCTTAGAATTATAGTTTGGTTAAGCTGAAATTCAAAAG
AACTAGTTGGGTCTGTAATTACTTACAAAGATGTTAGAGACTGGATGGGAGGGTGGAGGTCATT
TCACTGAGCTTTCTCTGCTGAGGTCACTAATTCACGAAGCCTTAGGAAGCAGACTTCTGATCGT
TATAGGATATTTGATTGCAGTGAATCCCAAAATTGTGGTGTTTACTGGAAAACCCTGTTTTTAG
TTGTGGCTCAGCCTTAGCACACACCTTTAATCCCCCTGACTGGAATACAGACCAGAGAACAAAG
AAAACAAAGAACAGAGAACAAAGTTCTGGGAGCAGCAGAGAAAAGGAAGTTGTACTGGGACAAT
TGTACGGAGACATGTTGAAAGAACAAGCCAGAAGATTAGAACAGATAGTCAGGGTTAATTTAAG
GCTAAGCACAGCAAAGAGGCCAAGAGAAAAGATTGATCAGCTTTGAGAAGAGTTTGAGGCAGAA
CACCTGAGTTGAATTGAGTCAGCTATCTGAGATCAGAAAGAACTAGAAGGGGTGACAGAACTAG
AAAGGGTGAGTTTATTCGGTGTCTTGAGGCTGAAAGCATTCTAGGCCTAGATTTGATTGTACAG
AGGCTAGAAGCTTCCAGGACTAGGCCTAGGCTAGTCTGAGGCAGTAAGCCTCGGAGACAACAAT
TACATCAGGAGAATAAGTTACTTTTACATTTTAGTACCTGTACCATTTAATTCTTAGGCTTTAA
AAAACAACTAATACCTGTTTGTAAGCAACTTTAATTTTAGACAACTTCAGATTCTAGATAGCAG
TAGCAATAGGGAAAGCAGCAACCTGATCCACCAGTGGTGATGGGGCTGGCTGGCTGGTGAGATG
CATGGACATAGATGTTTTTTATACATACATATATATGTTAAATTGTATCAGATGGTTTTGTCAC
ACCTTTTCACTTAACATGGTGTGTTTCCCCACACCTGCAGCATGTTTACTGACTAAACATGTAT
GCTTTCTCCATTCAAAGATTTCTAAATGTTTCTAGTGTTTCTAGTATGGTGCCTGTGGTAAACA
TTTCGGTACAGAAATCTCTTTGTACAACACTTGTTAAATAAAACTGGTCAAAGGTTTTTAGTAA
AAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001025086	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98005	(Get FASTA)	NCBI Sequence Viewer
	EDL82990	(Get FASTA)	NCBI Sequence Viewer
	EDL82991	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000024285.6
	ENSRNOP00000082868.1
	ENSRNOP00000084824.1
GenBank Protein	Q4QQT6	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001025086 ⟸ NM_001029915

- UniProtKB:

Q4QQT6 (UniProtKB/Swiss-Prot), A0A8I6G7Z4 (UniProtKB/TrEMBL), A6KJT1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAATKRKRRGDLEVQAKKPKKNRKDAGQPAKQADVAKEAEEEKDRIPGPVCKGKWKNKERILIF
SSRGINFRTRHLMQDLRMLMPHSKADTKMDRKDKLFVINEVCEMKNCNKCIYFEAKKKQDLYMW
LSNSPHGPSAKFLVQNIHTLAELKMTGNCLKGSRPLLSFDPAFDDLPHYALLKEFLIQIFSTPR
YHPKSQPFVDHVFTFTILDNRIWFRNFQIIEEDAALVEIGPRFVLNLIKIFQGSFGGPTLYENP
HYQSPNMHRRVVRSITAAKYREKQQVKDVQKSRKKEPKTILPHDPTADVFVTPAEEKPIEVQWV
KPEPKVDLKARKRRIYKRHRKLQQKMSRGGAK

hide sequence

Ensembl Acc Id:

ENSRNOP00000024285 ⟸ ENSRNOT00000024285

Ensembl Acc Id:

ENSRNOP00000082868 ⟸ ENSRNOT00000118075

Ensembl Acc Id:

ENSRNOP00000084824 ⟸ ENSRNOT00000119136

Protein Domains

Brix

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4QQT6-F1-model_v2	AlphaFold	Q4QQT6	1-352	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691183

Promoter ID:

EPDNEW_R1708

Type:

multiple initiation site

Name:

Brix1_1

Description:

BRX1, biogenesis of ribosomes

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	60,461,441 - 60,461,501	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308508	AgrOrtholog
BioCyc Gene	G2FUF-54083	BioCyc
Ensembl Genes	ENSRNOG00000018021	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000024285.7	UniProtKB/TrEMBL
	ENSRNOT00000118075.1	UniProtKB/TrEMBL
	ENSRNOT00000119136.1	UniProtKB/TrEMBL
Gene3D-CATH	Probable brix-domain ribosomal biogenesis protein	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7453609	IMAGE-MGC_LOAD
InterPro	Brix	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	BRX1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:294799	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:116151	IMAGE-MGC_LOAD
NCBI Gene	294799	ENTREZGENE
PANTHER	PTHR13634	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Brix	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Brix1	PhenoGen
PROSITE	BRIX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018021	RatGTEx
SMART	Brix	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Class II aaRS ABD-related	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZZZ9_RAT	UniProtKB/TrEMBL
	A0A8I6G7Z4	ENTREZGENE, UniProtKB/TrEMBL
	A6KJT1	ENTREZGENE, UniProtKB/TrEMBL
	BRX1_RAT	UniProtKB/Swiss-Prot
	G3V8B4_RAT	UniProtKB/TrEMBL
	Q4QQT6	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-05-06	Brix1	biogenesis of ribosomes BRX1	Brix1	biogenesis of ribosomes BRX1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2019-04-10	Brix1	biogenesis of ribosomes BRX1	Brix1	BRX1, biogenesis of ribosomes	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-02-19	Brix1	BRX1, biogenesis of ribosomes	Brix1	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-07-28	Brix1	BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)	Bxdc2	brix domain containing 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Bxdc2	brix domain containing 2	RGD1308508	similar to BRIX	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1308508	similar to BRIX	RGD1308508_predicted	similar to BRIX (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1308508_predicted	similar to BRIX (predicted)	LOC294799_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC294799_predicted	similar to BRIX (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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