Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
activating signal cointegrator 1 complex  
activin responsive factor complex  
ATF1-ATF4 transcription factor complex  
ATF4-CREB1 transcription factor complex  
beta-catenin-TCF complex +   
C/EBP complex  
CCAAT-binding factor complex  
CHOP-ATF4 complex  
CHOP-C/EBP complex  
CLOCK-BMAL transcription complex  
core mediator complex  
A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
core-binding factor complex  
CSL-Notch-Mastermind transcription factor complex 
ecdysone receptor holocomplex +  
heteromeric SMAD protein complex  
insulin control element activator complex 
ISGF3 complex  
M/G1 phase-specific MADS box-forkhead transcription factor complex 
MBF transcription complex 
Myc-Max complex  
Nkx-2.5 complex  
Pi Mi complex 
Pip2-Oaf1 complex 
Rb-E2F complex  
SBF transcription complex 
SMN-Gemin2 complex  
SRF-myogenin-E12 complex  
TEAD-YAP complex  
transcription factor AP-1 complex +   
transcription factor TFIIA complex  
transcription factor TFIID complex +   
transcription factor TFIIE complex  
transcription factor TFIIF complex  
transcription factor TFIIH core complex +   
transcription factor TFIIH holo complex +   
transcription factor TFIIK complex  
transcription factor TFTC complex  
upstream stimulatory factor complex 

Synonyms
Exact Synonyms: C mediator complex ;   S mediator complex
Definition Sources: PMID:11454195, PMID:16168358, PMID:17870225

paths to the root