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Term:transcription factor AP-1 complex
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Accession:GO:0035976 term browser browse the term
Definition:A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes.
Synonyms:exact_synonym: AP-1 complex;   AP1 complex;   Activating protein 1 complex;   transcription factor AP1 complex

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transcription factor AP-1 complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO (PMID:10508860), (PMID:26514923) RGD PMID:10508860, PMID:26514923 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO (PMID:10508860), (PMID:26514923) RGD PMID:10508860, PMID:26514923 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit IEA
PMID:10508860 GO_REF:0000107 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit ISO (PMID:10508860) RGD PMID:10508860 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link

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  cellular_component 20609
    protein-containing complex 6093
      transcription regulator complex 434
        RNA polymerase II transcription regulator complex 162
          transcription factor AP-1 complex 4
            atf1-pcr1 complex 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.