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Term:ATF4-CREB1 transcription factor complex
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Accession:GO:1990589 term browser browse the term
Definition:Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway.
Synonyms:xref: IntAct:EBI-10043081;   IntAct:EBI-10043332

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ATF4-CREB1 transcription factor complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 ISO (PMID:12871976)
RGD PMID:12871976 MGI:MGI:5613480 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
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G Creb1 cAMP responsive element binding protein 1 ISO (PMID:12871976)
RGD PMID:12871976 MGI:MGI:5613480 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
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Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6093
      transcription regulator complex 434
        RNA polymerase II transcription regulator complex 162
          ATF4-CREB1 transcription factor complex 2
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      organelle 13258
        membrane-bounded organelle 11449
          intracellular membrane-bounded organelle 10704
            nucleus 7183
              ATF4-CREB1 transcription factor complex 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.