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ONTOLOGY REPORT - ANNOTATIONS


Term:transcription factor TFIIH holo complex
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Accession:GO:0005675 term browser browse the term
Definition:A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex.
Synonyms:exact_synonym: holo TFIIH complex


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transcription factor TFIIH holo complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07063323.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 6:28,557,633...28,557,848 JBrowse link
G Ccnh cyclin H ISO
IBA
ISS
(PMID:9852112)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:9852112, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:13,593,100...13,613,910
Ensembl chr 2:13,593,100...13,613,910
JBrowse link
G Cdk7 cyclin-dependent kinase 7 IDA
ISS
ISO
GO_REF:0000024
(PMID:9852112)
UniProt
RGD
PMID:9852112, PMID:7553866 GO_REF:0000024, RGD:9590319 NCBI chr 2:30,710,642...30,735,522
Ensembl chr 2:30,710,643...30,735,514
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit ISO (PMID:9852112) RGD PMID:9852112 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344
JBrowse link
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit ISS
ISO
IBA
GO_REF:0000024
(PMID:9852112)
PMID:21873635
UniProt
RGD
PMID:9852112, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr18:25,037,668...25,068,380
Ensembl chr18:25,037,625...25,068,389
JBrowse link
G Gtf2f2 general transcription factor IIF subunit 2 IDA RGD PMID:7553866 RGD:9590319 NCBI chr15:57,942,057...58,068,892
Ensembl chr15:57,942,059...58,068,892
JBrowse link
G Gtf2h1 general transcription factor IIH subunit 1 IDA
IBA
ISO
PMID:21873635
(PMID:9852112)
RGD PMID:9852112, PMID:7553866, PMID:21873635 RGD:9590319, RGD:13792537 NCBI chr 1:102,849,618...102,877,939
Ensembl chr 1:102,849,889...102,877,944
JBrowse link
G Gtf2h2 general transcription factor IIH subunit 2 ISS
IBA
GO_REF:0000024
PMID:21873635
UniProt PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:30,494,718...30,522,716
Ensembl chr 2:30,494,825...30,522,727
JBrowse link
G Gtf2h3 general transcription factor IIH subunit 3 ISO
IBA
ISS
(PMID:9852112)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:9852112, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr12:37,427,556...37,444,027
Ensembl chr12:37,427,546...37,444,282
JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 ISO
IBA
(PMID:9852112)
PMID:21873635
RGD PMID:9852112, PMID:21873635 RGD:13792537 NCBI chr20:3,582,688...3,588,373
Ensembl chr20:3,582,742...3,588,375
JBrowse link
G Gtf2h5 general transcription factor IIH subunit 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:46,978,345...46,985,032
Ensembl chr 1:46,978,458...46,985,032
JBrowse link
G Mnat1 MNAT1 component of CDK activating kinase ISO
IBA
(PMID:9852112)
PMID:21873635
RGD PMID:9852112, PMID:21873635 RGD:13792537 NCBI chr 6:95,995,341...96,153,331
Ensembl chr 6:96,007,805...96,153,330
JBrowse link
core TFIIH complex portion of holo TFIIH complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gtf2h2 general transcription factor IIH subunit 2 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 2:30,494,718...30,522,716
Ensembl chr 2:30,494,825...30,522,727
JBrowse link
G Gtf2h3 general transcription factor IIH subunit 3 ISO
ISS
(PMID:27193682)
GO_REF:0000024
RGD
UniProt
PMID:27193682 GO_REF:0000024 NCBI chr12:37,427,556...37,444,027
Ensembl chr12:37,427,546...37,444,282
JBrowse link
G Gtf2h4 general transcription factor 2H subunit 4 ISO (PMID:27193682) RGD PMID:27193682 NCBI chr20:3,582,688...3,588,373
Ensembl chr20:3,582,742...3,588,375
JBrowse link
transcription factor TFIIK complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnh cyclin H IBA
ISO
PMID:21873635
(PMID:8692841)
RGD PMID:8692841, PMID:21873635 RGD:13792537 NCBI chr 2:13,593,100...13,613,910
Ensembl chr 2:13,593,100...13,613,910
JBrowse link
G Cdk7 cyclin-dependent kinase 7 IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(PMID:8692841)
Ensembl
RGD
PMID:8692841, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 2:30,710,642...30,735,522
Ensembl chr 2:30,710,643...30,735,514
JBrowse link
G Mnat1 MNAT1 component of CDK activating kinase ISO
IEA
(PMID:8692841)
GO_REF:0000107
RGD
Ensembl
PMID:8692841 GO_REF:0000107 NCBI chr 6:95,995,341...96,153,331
Ensembl chr 6:96,007,805...96,153,330
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6093
      transcription regulator complex 434
        RNA polymerase II transcription regulator complex 162
          transcription factor TFIIH holo complex 12
            core TFIIH complex portion of holo TFIIH complex 3
            transcription factor TFIIK complex 3
Path 2
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6093
      catalytic complex 1487
        transferase complex 818
          transferase complex, transferring phosphorus-containing groups 266
            RNA polymerase complex 110
              DNA-directed RNA polymerase complex 108
                nuclear DNA-directed RNA polymerase complex 107
                  RNA polymerase II, holoenzyme 84
                    transcription factor TFIIH holo complex 12
                      core TFIIH complex portion of holo TFIIH complex 3
                      transcription factor TFIIK complex 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.