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Term: core mediator complex
Accession: GO:0070847
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Definition: A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
Synonyms: exact_synonym: C mediator complex; S mediator complex
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LOC103694537
mediator of RNA polymerase II transcription subunit 14-like
part_of
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
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Med1
mediator complex subunit 1
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr10:83,641,851...83,685,560
Ensembl chr10:83,145,568...83,189,299
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Med10
mediator complex subunit 10
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr 1:35,298,494...35,310,163
Ensembl chr 1:33,470,066...33,475,767
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Med11
mediator complex subunit 11
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr10:55,662,956...55,664,574
Ensembl chr10:55,164,326...55,166,533
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Med14
mediator complex subunit 14
part_of
IBA ISO
GO_REF:0000033 (PMID:24882805)
GO_Central RGD
PMID:24882805
GO_REF:0000033
NCBI chr X:10,036,749...10,127,910
Ensembl chr X:10,036,805...10,126,240
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Med15
mediator complex subunit 15
part_of
ISO IBA
(PMID:24882805) GO_REF:0000033
RGD GO_Central
PMID:24882805
GO_REF:0000033
NCBI chr11:83,280,722...83,356,006
Ensembl chr11:83,280,762...83,355,362
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Med16
mediator complex subunit 16
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr 7:9,798,641...9,811,172
Ensembl chr 7:9,798,668...9,811,172
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Med17
mediator complex subunit 17
part_of
IBA ISO
GO_REF:0000033 (PMID:24882805)
GO_Central RGD
PMID:24882805
GO_REF:0000033
NCBI chr 8:12,101,594...12,120,592
Ensembl chr 8:12,101,594...12,120,592
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Med18
mediator complex subunit 18
part_of
ISO IBA
(PMID:24882805) GO_REF:0000033
RGD GO_Central
PMID:24882805
GO_REF:0000033
NCBI chr 5:144,663,316...144,668,652
Ensembl chr 5:144,663,252...144,668,635
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Med19
mediator complex subunit 19
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr 3:69,762,138...69,772,661
Ensembl chr 3:69,762,166...69,772,036
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Med20
mediator complex subunit 20
part_of
IEA ISO
GO_REF:0000107 (PMID:24882805)
Ensembl RGD
PMID:24882805
GO_REF:0000107
NCBI chr 9:13,370,146...13,382,756
Ensembl chr 9:13,370,146...13,382,476
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Med21
mediator complex subunit 21
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr 4:179,560,509...179,583,811
Ensembl chr 4:179,560,579...179,567,548
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Med22
mediator complex subunit 22
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr 3:30,631,829...30,636,911
Ensembl chr 3:10,233,754...10,238,836
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Med23
mediator complex subunit 23
part_of
IEA ISO
GO_REF:0000107 (PMID:24882805)
Ensembl RGD
PMID:24882805
GO_REF:0000107
NCBI chr 1:22,309,613...22,377,745
Ensembl chr 1:20,490,315...20,537,463
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Med24
mediator complex subunit 24
part_of
IEA ISO
GO_REF:0000107 (PMID:24882805)
Ensembl RGD
PMID:24882805
GO_REF:0000107
NCBI chr10:84,160,866...84,198,607
Ensembl chr10:83,664,609...83,690,123
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Med25
mediator complex subunit 25
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr 1:95,359,961...95,375,827
Ensembl chr 1:95,360,284...95,375,877
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Med26
mediator complex subunit 26
part_of
IBA ISO
GO_REF:0000033 (PMID:24882805)
GO_Central RGD
PMID:24882805
GO_REF:0000033
NCBI chr16:17,299,722...17,350,168
Ensembl chr16:17,299,722...17,349,543
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Med27
mediator complex subunit 27
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr 3:12,629,593...12,803,340
Ensembl chr 3:12,629,603...12,803,339
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Med28
mediator complex subunit 28
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr14:69,807,319...69,816,115
Ensembl chr14:65,594,647...65,603,583
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Med29
mediator complex subunit 29
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr 1:92,805,505...92,810,908
Ensembl chr 1:83,677,961...83,683,365
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Med30
mediator complex subunit 30
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr 7:85,894,638...85,916,373
Ensembl chr 7:84,004,722...84,026,595
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Med31
mediator complex subunit 31
part_of
IBA ISO
GO_REF:0000033 (PMID:24882805)
GO_Central RGD
PMID:24882805
GO_REF:0000033
NCBI chr10:56,836,944...56,840,326
Ensembl chr10:56,836,944...56,840,326
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Med4
mediator complex subunit 4
part_of
IEA IBA ISO
GO_REF:0000107 GO_REF:0000033 (PMID:24882805)
Ensembl GO_Central RGD
PMID:24882805
GO_REF:0000033 GO_REF:0000107
NCBI chr15:48,696,542...48,706,818
Ensembl chr15:48,696,511...48,706,820
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Med6
mediator complex subunit 6
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr 6:101,270,410...101,283,929
Ensembl chr 6:101,270,410...101,283,876
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Med7
mediator complex subunit 7
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr10:30,842,330...30,857,873
Ensembl chr10:30,842,292...30,859,220
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Med8
mediator complex subunit 8
part_of
ISO IBA
(PMID:24882805) GO_REF:0000033
RGD GO_Central
PMID:24882805
GO_REF:0000033
NCBI chr 5:131,948,632...131,949,516
Ensembl chr 5:131,943,982...131,950,305
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Med9
mediator complex subunit 9
part_of
ISO
(PMID:24882805)
RGD
PMID:24882805
NCBI chr10:45,250,229...45,264,988
Ensembl chr10:44,750,698...44,765,464
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