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ONTOLOGY REPORT - ANNOTATIONS


Term:core mediator complex
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Accession:GO:0070847 term browser browse the term
Definition:A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
Synonyms:exact_synonym: C mediator complex;   S mediator complex


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core mediator complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Med14 mediator complex subunit 14 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:10,964,035...11,082,403
Ensembl chr  X:10,963,809...11,082,565
JBrowse link
G Med17 mediator complex subunit 17 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:13,522,257...13,835,302
Ensembl chr 8:13,819,563...13,835,168
JBrowse link
G Med18 mediator complex subunit 18 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:150,649,136...150,654,123
Ensembl chr 5:150,649,829...150,653,172
JBrowse link
G Med26 mediator complex subunit 26 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:19,001,061...19,050,874
Ensembl chr16:19,001,061...19,050,874
JBrowse link
G Med31 mediator complex subunit 31 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:58,780,987...58,784,369
Ensembl chr10:58,780,597...58,784,374
JBrowse link
G Med4 mediator complex subunit 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:55,406,543...55,416,816
Ensembl chr15:55,406,543...55,416,815
JBrowse link
G Med6 mediator complex subunit 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:105,302,558...105,316,024
Ensembl chr 6:105,302,558...105,316,024
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6092
      transcription regulator complex 434
        RNA polymerase II transcription regulator complex 162
          core mediator complex 7
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      organelle 13258
        membrane-bounded organelle 11449
          intracellular membrane-bounded organelle 10704
            nucleus 7183
              core mediator complex 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.