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ONTOLOGY REPORT - ANNOTATIONS


Term:heteromeric SMAD protein complex
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Accession:GO:0071144 term browser browse the term
Definition:A protein complex composed of SMAD family proteins, a transcription factor complex which binds to the promoters of target genes and recruits co-activators and histone acetyltransferases, facilitating transcription. Phosphorylation of the non-SMAD4 subunit(s) enables binding of SMAD4 to form heteromeric complexes that enter the nucleus to initiate gene transcription. DNA-binding specificity is conferred by other transcription factors binding to SMAD complexes. Interactions with coactivators or corepressors modulate their transcriptional activity. Can be heterotrimeric or heterodimeric.
Synonyms:narrow_synonym: SMAD1-SMAD4 protein complex;   SMAD2-SMAD3-SMAD4 protein complex;   SMAD2-SMAD4 protein complex;   SMAD3-SMAD4 protein complex
 alt_id: GO:0071145;   GO:0071146
 xref: IntAct:EBI-10021614;   IntAct:EBI-10043452;   IntAct:EBI-10127301;   IntAct:EBI-10828741;   IntAct:EBI-9692430;   IntAct:EBI-9826270;   IntAct:EBI-9826300;   IntAct:EBI-9990274


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heteromeric SMAD protein complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad1 SMAD family member 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
JBrowse link
G Smad2 SMAD family member 2 ISO
IBA
(PMID:21828274)
PMID:21873635
RGD PMID:21828274, PMID:21873635 RGD:13792537 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 ISO
IBA
(PMID:21828274)
PMID:21873635
RGD PMID:21828274, PMID:21873635 RGD:13792537 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad4 SMAD family member 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Smad5 SMAD family member 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:8,307,448...8,336,996
Ensembl chr17:8,311,796...8,331,032
JBrowse link
G Smad6 SMAD family member 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:68,897,746...68,967,221
Ensembl chr 8:68,898,296...68,966,108
JBrowse link
G Smad7 SMAD family member 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Smad9 SMAD family member 9 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:143,951,725...144,002,025
Ensembl chr 2:144,191,846...144,212,138
Ensembl chr 2:144,191,846...144,212,138
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6092
      SMAD protein complex 10
        heteromeric SMAD protein complex 8
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      organelle 13258
        membrane-bounded organelle 11449
          intracellular membrane-bounded organelle 10704
            nucleus 7183
              heteromeric SMAD protein complex 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.