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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:Trail mediated signaling pathway
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Accession:PW:0000682 term browser browse the term
Definition:Trail-mediated signaling leads to apoptosis via assembly of the DISC complex (Death-Inducing Signaling Complex) downstream of its receptors.
Synonyms:related_synonym: TRAIL signaling;   TRAIL-activated apoptotic signaling pathway
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Trail mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BID BH3 interacting domain death agonist ISO RGD PMID:17403612 PMID:19961901 RGD:4143170 RGD:4143171 NCBI chr27:45,344,304...45,355,735
Ensembl chr27:45,337,145...45,384,059 		JBrowse link
G CASP10 caspase 10 ISO PID PID:200068 NCBI chr37:10,315,867...10,350,585 JBrowse link
G CASP3 caspase 3 ISO RGD PMID:17403612 PMID:19961901 RGD:4143170 RGD:4143171 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
G CASP7 caspase 7 ISO RGD PMID:19961901 RGD:4143171 NCBI chr28:24,599,866...24,630,018
Ensembl chr28:24,599,493...24,628,668 		JBrowse link
G CASP8 caspase 8 ISO PID
RGD		 PMID:17403612 PMID:19961901 PID:200068 RGD:4143170 RGD:4143171 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator ISO PID
RGD		 PMID:17403612 PMID:19961901 PID:200068 RGD:4143170 RGD:4143171 NCBI chr37:10,268,407...10,307,803
Ensembl chr37:10,268,582...10,345,095 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200068 NCBI chr28:12,964,670...13,001,557
Ensembl chr28:12,965,479...13,001,512 		JBrowse link
G DAP3 death associated protein 3 ISO PID PID:200068 NCBI chr 7:42,011,485...42,045,900
Ensembl chr 7:42,011,506...42,026,894 		JBrowse link
G FADD Fas associated via death domain ISO PID
RGD		 PMID:17403612 PMID:19961901 PID:200068 RGD:4143170 RGD:4143171 NCBI chr18:48,087,447...48,094,497 JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200068 NCBI chr16:23,359,551...23,419,114
Ensembl chr16:23,359,813...23,419,075 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID PID:200068 NCBI chr  X:122,232,052...122,253,499
Ensembl chr  X:122,235,878...122,250,562 		JBrowse link
G LOC100688321 tumor necrosis factor receptor superfamily member 26-like ISO PID PID:200068 NCBI chr18:47,008,850...47,029,029 JBrowse link
G LOC100856339 phosphatidylinositol 3-kinase regulatory subunit gamma ISO PID PID:200068 NCBI chr15:14,222,059...14,357,200
Ensembl chr15:14,235,824...14,353,832 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 ISO PID PID:200068 NCBI chr 5:36,142,610...36,243,673
Ensembl chr 5:36,118,388...36,241,296 		JBrowse link
G MAP3K1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200068 NCBI chr 2:43,918,210...43,996,817
Ensembl chr 2:43,917,604...43,995,209 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 ISO PID PID:200068 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 ISO PID PID:200068 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 ISO PID PID:200068 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO PID PID:200068 NCBI chr34:12,600,140...12,681,905
Ensembl chr34:12,600,233...12,675,910 		JBrowse link
G PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO PID PID:200068 NCBI chr23:34,832,661...34,955,410
Ensembl chr23:34,836,540...34,993,939 		JBrowse link
G PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta ISO PID PID:200068 NCBI chr 5:62,884,596...62,936,882
Ensembl chr 5:62,909,009...62,935,971 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200068 NCBI chr 2:53,447,802...53,527,563
Ensembl chr 2:53,448,286...53,524,970 		JBrowse link
G PIK3R2 phosphoinositide-3-kinase regulatory subunit 2 ISO PID PID:200068 NCBI chr20:44,826,037...44,838,449
Ensembl chr20:44,826,339...44,836,558 		JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 ISO PID PID:200068 NCBI chr35:3,367,796...3,407,631
Ensembl chr35:3,263,226...3,405,883 		JBrowse link
G SMPD1 sphingomyelin phosphodiesterase 1 ISO PID PID:200068 NCBI chr21:29,714,418...29,719,035
Ensembl chr21:29,714,557...29,719,033 		JBrowse link
G TNFSF10 TNF superfamily member 10 ISO RGD
PID		 PMID:17403612 PMID:19385008 PMID:19961901 PID:200068 RGD:2312745 RGD:4143170 RGD:4143171 NCBI chr34:36,719,249...36,734,989
Ensembl chr34:36,670,849...36,735,060 		JBrowse link
G TRADD TNFRSF1A associated via death domain ISO PID PID:200068 NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963 		JBrowse link
G TRAF2 TNF receptor associated factor 2 ISO PID PID:200068 NCBI chr 9:48,688,071...48,713,936
Ensembl chr 9:48,689,331...48,703,633 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4052
    signaling pathway 1939
      cytokine and chemokine mediated signaling pathway 335
        cytokine mediated signaling pathway 334
          tumor necrosis factor superfamily mediated signaling pathway 88
            Trail mediated signaling pathway 28
              altered Trail mediated signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 4052
    regulatory pathway 2511
      cell death pathway 185
        programmed cell death pathway 185
          apoptotic cell death pathway 114
            extrinsic apoptotic pathway 88
              Trail mediated signaling pathway 28
                altered Trail mediated signaling pathway 0
paths to the root