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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:paracetamol drug pathway
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Accession:PW:0001524 term browser browse the term
Definition:The pharmacokinetics/pharmacodynamics of paracetamol, a widely used analgesic, known as acetaminophen (APAP). The analgesic effect is believed to be due to the inhibition of prostaglandins biosynthesis. Paracetamol overdose is associated with hepatic toxicity and a leading cause of liver failure. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.
Synonyms:exact_synonym: acetaminophen drug pathway
 related_synonym: SMP:00710
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paracetamol drug pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C3 aldo-keto reductase family 1 member C3 ISO SMPDB SMP:00710 NCBI chr10:5,079,580...5,157,572
Ensembl chr10:5,081,214...5,139,812 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO SMPDB SMP:00710 NCBI chr17:7,026,839...7,041,598
Ensembl chr17:7,014,591...7,029,602 		JBrowse link
G ALOX12B arachidonate 12-lipoxygenase, 12R type ISO SMPDB SMP:00710 NCBI chr17:43,569,858...43,588,039
Ensembl chr17:48,302,450...48,317,029 		JBrowse link
G ALOX15 arachidonate 15-lipoxygenase ISO SMPDB SMP:00710 NCBI chr17:4,686,339...4,696,877
Ensembl chr17:4,677,125...4,687,669 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase ISO SMPDB SMP:00710 NCBI chr10:42,461,398...42,531,576
Ensembl chr10:45,639,946...45,710,016 		JBrowse link
G CBR1 carbonyl reductase 1 ISO SMPDB SMP:00710 NCBI chr21:22,440,726...22,443,950
Ensembl chr21:35,800,177...35,803,458 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 ISO SMPDB SMP:00710 NCBI chr19:38,003,083...38,028,980
Ensembl chr19:46,509,370...46,534,672 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 ISO SMPDB SMP:00710 NCBI chr10:91,646,387...91,679,998
Ensembl chr10:95,157,661...95,186,620 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO SMPDB SMP:00710 Ensembl chr10:134,839,025...134,852,719 JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 ISO SMPDB SMP:00710 NCBI chr 1:59,151,079...59,184,625
Ensembl chr 1:60,856,269...60,889,810 		JBrowse link
G CYP2U1 cytochrome P450 family 2 subfamily U member 1 ISO SMPDB SMP:00710 NCBI chr 4:100,436,365...100,458,845
Ensembl chr 4:111,009,198...111,031,269 		JBrowse link
G CYP4A11 cytochrome P450 family 4 subfamily A member 11 ISO SMPDB SMP:00710 NCBI chr 1:46,228,434...46,240,736
Ensembl chr 1:47,583,564...47,594,870 		JBrowse link
G CYP4F3 cytochrome P450 family 4 subfamily F member 3 ISO SMPDB SMP:00710 NCBI chr19:15,162,886...15,182,334
Ensembl chr19:16,146,664...16,165,869 		JBrowse link
G CYP4F8 cytochrome P450 family 4 subfamily F member 8 ISO SMPDB SMP:00710 NCBI chr19:15,134,029...15,150,378
Ensembl chr19:16,118,830...16,133,182 		JBrowse link
G EPHX2 epoxide hydrolase 2 ISO SMPDB SMP:00710 NCBI chr 8:26,761,090...26,818,436
Ensembl chr 8:23,964,094...24,017,749 		JBrowse link
G GGT1 gamma-glutamyltransferase 1 ISO SMPDB SMP:00710 NCBI chr22:5,424,334...5,469,705 JBrowse link
G GPX1 glutathione peroxidase 1 ISO SMPDB SMP:00710 NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826 		JBrowse link
G LOC100971127 arachidonate 15-lipoxygenase type B ISO SMPDB SMP:00710 NCBI chr17:43,609,146...43,619,713
Ensembl chr17:48,340,777...48,350,808 		JBrowse link
G LTA4H leukotriene A4 hydrolase ISO SMPDB SMP:00710 NCBI chr12:93,589,758...93,624,529
Ensembl chr12:96,978,203...97,012,427 		JBrowse link
G LTC4S leukotriene C4 synthase ISO SMPDB SMP:00710 NCBI chr 5:174,946,346...174,950,805 JBrowse link
G PRXL2B peroxiredoxin like 2B ISO SMPDB SMP:00710 NCBI chr 1:1,319,718...1,324,409 JBrowse link
G PTGDS prostaglandin D2 synthase ISO SMPDB SMP:00710 NCBI chr 9:108,037,994...108,042,136
Ensembl chr 9:137,006,601...137,009,680 		JBrowse link
G PTGES prostaglandin E synthase ISO SMPDB SMP:00710 NCBI chr 9:100,865,702...100,880,408
Ensembl chr 9:129,522,547...129,537,020 		JBrowse link
G PTGIS prostaglandin I2 synthase ISO SMPDB SMP:00710 NCBI chr20:45,841,238...45,905,641
Ensembl chr20:46,905,665...46,971,612 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 ISO SMPDB
RGD		 PMID:23719833 RGD:8552695 SMP:00710 NCBI chr 9:93,495,365...93,517,557
Ensembl chr 9:121,837,095...121,859,283 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 ISO SMPDB
RGD		 PMID:23719833 RGD:8552695 SMP:00710 NCBI chr 1:162,205,534...162,214,130
Ensembl chr 1:166,355,845...166,364,519 		JBrowse link
G TBXAS1 thromboxane A synthase 1 ISO SMPDB SMP:00710 NCBI chr 7:131,772,947...131,958,647
Ensembl chr 7:144,255,211...144,439,523 		JBrowse link
paracetamol pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00640 NCBI chr 7:79,497,536...79,706,277
Ensembl chr 7:93,147,950...93,243,238 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00640
G ABCC2 ATP binding cassette subfamily C member 2 ISO RGD PMID:23462933 RGD:8552693 NCBI chr10:96,385,534...96,458,571
Ensembl chr10:99,889,160...99,947,270 		JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 ISO RGD PMID:23462933 RGD:8552693 Ensembl chr17:49,603,268...49,659,318 JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 (PEL blood group) ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 NCBI chr13:76,193,929...76,476,119
Ensembl chr13:95,349,915...95,582,058 		JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 ISO SMPDB SMP:00640 NCBI chr 3:180,956,139...181,054,112
Ensembl chr 3:189,122,590...189,219,492 		JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 NCBI chr 4:80,379,108...80,446,641
Ensembl chr 4:91,101,321...91,170,157 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 ISO SMPDB SMP:00640 NCBI chr15:53,692,877...53,699,279
Ensembl chr15:73,311,720...73,319,447 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 Ensembl chr10:134,839,025...134,852,719 JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 ISO SMPDB SMP:00640 NCBI chr 7:91,797,037...91,824,696
Ensembl chr 7:105,230,666...105,258,401 		JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00640 NCBI chr 3:183,601,386...183,617,013
Ensembl chr 3:192,069,326...192,084,943 		JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00640 NCBI chr12:109,610,692...109,620,390
Ensembl chr12:113,004,125...113,013,674 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO SMPDB SMP:00640 NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00640 NCBI chr12:101,506,845...101,524,407
Ensembl chr12:104,901,997...104,919,329 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00640 NCBI chr 9:96,351,645...96,356,761
Ensembl chr 9:124,865,211...124,870,458 		JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00640 NCBI chr11:113,882,418...113,895,438
Ensembl chr11:117,812,975...117,824,005 		JBrowse link
G LOC100969764 sulfotransferase 1A1 ISO RGD
SMPDB		 PMID:23462933 RGD:8552693 SMP:00640
G LOC100988273 cytochrome P450 2D6-like ISO SMPDB SMP:00640 NCBI chr22:23,022,449...23,031,627 JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00640 Ensembl chr16:273,764...277,914 JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00640 NCBI chr 7:140,731,333...140,757,599
Ensembl chr 7:153,210,553...153,236,721 		JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00640 NCBI chr2A:10,781,671...10,809,235
Ensembl chr2A:10,934,756...10,986,200 		JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00640 NCBI chr15:43,108,139...43,115,470
Ensembl chr15:61,400,272...61,406,758 		JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00640 NCBI chr22:3,764,899...3,766,932
Ensembl chr22:20,248,566...20,250,607 		JBrowse link
G SULT1A3 sulfotransferase family 1A member 3 ISO RGD
SMPDB		 PMID:23462933 RGD:8552693 SMP:00640
G SULT1E1 sulfotransferase family 1E member 1 ISO SMPDB
RGD		 PMID:23462933 RGD:8552693 SMP:00640 NCBI chr 4:54,377,681...54,396,619
Ensembl chr 4:60,713,392...60,733,229 		JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 ISO SMPDB SMP:00640 NCBI chr19:44,864,747...44,880,688
Ensembl chr19:53,517,248...53,532,573 		JBrowse link
G UGT2B15 UDP glucuronosyltransferase family 2 member B15 ISO SMPDB SMP:00640 NCBI chr 4:55,421,974...55,446,352 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    drug pathway 395
      nervous system drug pathway 181
        analgesic and/or antipyretic drug pathway 93
          paracetamol drug pathway 53
            paracetamol pharmacokinetics pathway 27
paths to the root