LTC4S (leukotriene C4 synthase) - Rat Genome Database

Name: LTC4S
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: LTC4S (leukotriene C4 synthase) Pan paniscus

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Symbol:

LTC4S

Name:

leukotriene C4 synthase

RGD ID:

11873802

Description:

ENCODES a protein that exhibits glutathione binding (ortholog); identical protein binding (ortholog); leukotriene-C4 synthase activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); cellular response to vitamin A (ortholog); leukotriene biosynthetic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Acute Liver Failure (ortholog); acute promyelocytic leukemia (ortholog); aspirin-induced respiratory disease (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); nuclear envelope (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LTC4S (leukotriene C4 synthase)	NCBI	Ortholog
Mus musculus (house mouse):	Ltc4s (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ltc4s (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ltc4s (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LTC4S (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ltc4s (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LTC4S (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LTC4S (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ltc4s (leukotriene C4 synthase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	174,735,060 - 174,739,519 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	172,874,599 - 172,879,058 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	174,946,346 - 174,950,805 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	182,256,113 - 182,261,003 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Liver Failure (ISO)

acute promyelocytic leukemia (ISO)

aspirin-induced respiratory disease (ISO)

asthma, nasal polyps, and aspirin intolerance (ISO)

drug allergy (ISO)

Ehlers-Danlos syndrome dermatosparaxis type (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 1 (ISO)

glomerulonephritis (ISO)

Leukotriene C4 Synthase Deficiency (ISO)

otitis media (ISO)

peripheral nervous system disease (ISO)

Sotos syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to lipopolysaccharide (ISO)

cellular response to vitamin A (ISO)

leukotriene biosynthetic process (ISO)

leukotriene metabolic process (ISO)

long-chain fatty acid biosynthetic process (ISO)

response to axon injury (ISO)

response to lipopolysaccharide (ISO)

response to xenobiotic stimulus (ISO)

Cellular Component

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (ISO)

nuclear envelope (ISO)

nuclear membrane (ISO)

nuclear outer membrane (ISO)

Molecular Function

glutathione binding (ISO)

identical protein binding (ISO)

leukotriene-C4 synthase activity (ISO)

lipid binding (ISO)

protein binding (ISO)

protein-containing complex binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylsalicylic acid pharmacodynamics pathway (ISO)

antipyrine drug pathway (ISO)

arachidonic acid metabolic pathway (ISO)

celecoxib pharmacodynamics pathway (ISO)

diclofenac pharmacodynamics pathway (ISO)

diflunisal pharmacodynamics pathway (ISO)

etodolac pharmacodynamics pathway (ISO)

fenoprofen pharmacodynamics pathway (ISO)

flurbiprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

indometacin pharmacodynamics pathway (ISO)

ketoprofen pharmacodynamics pathway (ISO)

ketorolac pharmacodynamics pathway (ISO)

leukotriene C4 synthase deficiency pathway (ISO)

leukotriene metabolic pathway (ISO)

lipoxygenase mediated pathway of arachidonic acid metabolism (ISO)

lornoxicam pharmacodynamics pathway (ISO)

magnesium salicylate pharmacodynamics pathway (ISO)

mefenamic acid pharmacodynamics pathway (ISO)

meloxicam pharmacodynamics pathway (ISO)

nabumetone pharmacodynamics pathway (ISO)

naproxen pharmacodynamics pathway (ISO)

paracetamol drug pathway (ISO)

piroxicam pharmacodynamics pathway (ISO)

salicylic acid pharmacodynamics pathway (ISO)

sodium salicylate pharmacodynamics pathway (ISO)

sulindac pharmacodynamics pathway (ISO)

tenoxicam pharmacodynamics pathway (ISO)

tiaprofenic acid pharmacodynamics pathway (ISO)

tolmetin pharmacodynamics pathway (ISO)

valdecoxib pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LTC4S
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	174,735,060 - 174,739,519 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	172,874,599 - 172,879,058 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	174,946,346 - 174,950,805 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	182,256,113 - 182,261,003 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

LTC4S
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	179,793,986 - 179,796,647 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	179,793,980 - 179,796,647 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	179,220,987 - 179,223,648 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	179,153,592 - 179,156,119 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	179,153,591 - 179,156,119	NCBI
Celera	5	174,846,142 - 174,848,669 (+)	NCBI		Celera
Cytogenetic Map	5	q35.3	NCBI
HuRef	5	173,947,161 - 173,949,688 (+)	NCBI		HuRef
CHM1_1	5	178,653,394 - 178,655,921 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	180,349,182 - 180,351,843 (+)	NCBI		T2T-CHM13v2.0

Ltc4s
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	50,127,288 - 50,129,378 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	50,127,288 - 50,129,443 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	50,236,461 - 50,238,532 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	50,236,461 - 50,238,616 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	50,049,974 - 50,051,973 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	50,079,895 - 50,081,894 (-)	NCBI		MGSCv36	mm8
Celera	11	54,797,050 - 54,799,049 (-)	NCBI		Celera
Cytogenetic Map	11	B1.3	NCBI
cM Map	11	30.4	NCBI

Ltc4s
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	35,060,002 - 35,066,466 (-)	NCBI		GRCr8
mRatBN7.2	10	34,560,476 - 34,562,790 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	34,560,360 - 34,562,651 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	39,235,902 - 39,237,857 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	7,775,154 - 7,777,109 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	34,229,574 - 34,231,529 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	35,736,486 - 35,743,088 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	35,737,664 - 35,739,625 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	35,498,195 - 35,506,088 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	35,786,877 - 35,788,838 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	35,787,925 - 35,789,881 (-)	NCBI
Celera	10	33,909,805 - 33,911,766 (-)	NCBI		Celera
Cytogenetic Map	10	q22	NCBI

Ltc4s
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955408	788,856 - 791,505 (-)	NCBI	ChiLan1.0	ChiLan1.0

LTC4S
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	1,893,927 - 1,897,028 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	1,894,380 - 1,897,752 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	2,012,534 - 2,020,224 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	1,863,608 - 1,871,298 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	1,867,307 - 1,871,411 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	1,835,205 - 1,842,895 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	1,914,372 - 1,922,062 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	2,154,596 - 2,162,286 (-)	NCBI		UU_Cfam_GSD_1.0

Ltc4s
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	119,765,712 - 119,768,688 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936739	975,493 - 978,482 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936739	975,494 - 978,426 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LTC4S
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	78,799,449 - 78,802,285 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	78,799,446 - 78,802,281 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	80,365,497 - 80,368,339 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LTC4S
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	81,523,784 - 81,526,297 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	81,523,775 - 81,526,179 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666075	12,900,551 - 12,903,368 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ltc4s
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	42,670,632 - 42,672,846 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	42,668,963 - 42,673,385 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_034961211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_034961211 ⟹ XP_034817102

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	4	174,735,060 - 174,739,519 (+)	NCBI
NHGRI_mPanPan1	5	172,874,599 - 172,879,058 (+)	NCBI
Mhudiblu_PPA_v0	5	174,946,346 - 174,950,805 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_034817102	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_034817102 ⟸ XM_034961211

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	LTC4S	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB