ALOX12 (arachidonate 12-lipoxygenase, 12S type)

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Gene: ALOX12 (arachidonate 12-lipoxygenase, 12S type) Pan paniscus

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Symbol:

ALOX12

Name:

arachidonate 12-lipoxygenase, 12S type

RGD ID:

11680877

Description:

ENCODES a protein that exhibits arachidonate 12(S)-lipoxygenase activity (inferred); arachidonate 15-lipoxygenase activity (inferred); dioxygenase activity (inferred); INVOLVED IN cellular response to lipid (ortholog); hepoxilin biosynthetic process (ortholog); leukotriene A4 metabolic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Albuminuria (ortholog); autism spectrum disorder (ortholog); Bone Metastasis (ortholog); FOUND IN sarcolemma (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

arachidonate 12-lipoxygenase, 12S-type; polyunsaturated fatty acid lipoxygenase ALOX12

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	14,589,497 - 14,604,366 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	16,555,472 - 16,571,790 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	7,026,839 - 7,041,598 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	7,014,038 - 7,029,602 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	7,014,591 - 7,029,602 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Albuminuria (ISO)

autism spectrum disorder (ISO)

Bone Metastasis (ISO)

breast cancer (ISO)

Carotid Artery Injuries (ISO)

Chemical Burns (ISO)

common variable immunodeficiency (ISO)

congenital myasthenic syndrome 2A (ISO)

congestive heart failure (ISO)

Crohn's disease (ISO)

developmental and epileptic encephalopathy 25 (ISO)

dyskeratosis congenita (ISO)

Hyperalgesia (ISO)

hypertension (ISO)

juvenile rheumatoid arthritis (ISO)

Lung Neoplasms (ISO)

Nasal Polyps (ISO)

obesity (ISO)

peripheral nervous system disease (ISO)

prostate cancer (ISO)

psoriasis (ISO)

renal cell carcinoma (ISO)

Reperfusion Injury (ISO)

skin disease (ISO)

Testicular Neoplasms (ISO)

type 2 diabetes mellitus (ISO)

ulcerative colitis (ISO)

urinary bladder cancer (ISO)

very long chain acyl-CoA dehydrogenase deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

arachidonate metabolic process (IEA)

cellular response to lipid (ISO)

establishment of skin barrier (IEA)

fatty acid oxidation (IEA)

hepoxilin biosynthetic process (ISO)

icosanoid metabolic process (IEA)

leukotriene A4 metabolic process (IEA,ISO)

linoleic acid metabolic process (IEA,ISO)

lipid metabolic process (IEA)

lipid oxidation (IEA)

lipoxin A4 biosynthetic process (IEA)

lipoxin B4 biosynthetic process (IEA)

lipoxygenase pathway (IEA)

long-chain fatty acid metabolic process (IEA)

negative regulation of apoptotic process (ISO)

negative regulation of muscle cell apoptotic process (IEA)

negative regulation of platelet aggregation (IEA)

positive regulation of apoptotic signaling pathway (ISO)

positive regulation of blood vessel endothelial cell migration (ISO)

positive regulation of endothelial tube morphogenesis (ISO)

positive regulation of mitochondrial depolarization (ISO)

positive regulation of reactive oxygen species biosynthetic process (ISO)

positive regulation of smooth muscle cell proliferation (ISO)

unsaturated fatty acid metabolic process (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

membrane (IEA)

sarcolemma (IEA,ISO)

Molecular Function

arachidonate 12(S)-lipoxygenase activity (IEA)

arachidonate 15-lipoxygenase activity (IEA)

dioxygenase activity (IEA)

iron ion binding (IEA)

linoleate 13S-lipoxygenase activity (IEA)

metal ion binding (IEA)

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylsalicylic acid pharmacodynamics pathway (ISO)

antipyrine drug pathway (ISO)

arachidonic acid metabolic pathway (ISO)

celecoxib pharmacodynamics pathway (ISO)

diclofenac pharmacodynamics pathway (ISO)

diflunisal pharmacodynamics pathway (ISO)

etodolac pharmacodynamics pathway (ISO)

fenoprofen pharmacodynamics pathway (ISO)

flurbiprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

indometacin pharmacodynamics pathway (ISO)

ketoprofen pharmacodynamics pathway (ISO)

ketorolac pharmacodynamics pathway (ISO)

leukotriene C4 synthase deficiency pathway (ISO)

lipoxygenase mediated pathway of arachidonic acid metabolism (ISO)

lornoxicam pharmacodynamics pathway (ISO)

magnesium salicylate pharmacodynamics pathway (ISO)

mefenamic acid pharmacodynamics pathway (ISO)

meloxicam pharmacodynamics pathway (ISO)

nabumetone pharmacodynamics pathway (ISO)

naproxen pharmacodynamics pathway (ISO)

paracetamol drug pathway (ISO)

piroxicam pharmacodynamics pathway (ISO)

salicylic acid pharmacodynamics pathway (ISO)

sodium salicylate pharmacodynamics pathway (ISO)

sulindac pharmacodynamics pathway (ISO)

tenoxicam pharmacodynamics pathway (ISO)

tiaprofenic acid pharmacodynamics pathway (ISO)

tolmetin pharmacodynamics pathway (ISO)

valdecoxib pharmacodynamics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ALOX12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	14,589,497 - 14,604,366 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	16,555,472 - 16,571,790 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	7,026,839 - 7,041,598 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	7,014,038 - 7,029,602 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	7,014,591 - 7,029,602 (+)	Ensembl	panpan1.1		panPan2

ALOX12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	6,996,049 - 7,010,754 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	6,996,049 - 7,010,754 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	6,899,368 - 6,914,073 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	6,840,108 - 6,854,779 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	6,840,127 - 6,854,776	NCBI
Celera	17	6,924,952 - 6,939,560 (+)	NCBI		Celera
Cytogenetic Map	17	p13.1	NCBI
HuRef	17	6,793,203 - 6,807,748 (+)	NCBI		HuRef
CHM1_1	17	6,908,840 - 6,923,485 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	6,896,743 - 6,911,368 (+)	NCBI		T2T-CHM13v2.0

Alox12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	70,132,283 - 70,146,206 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	70,132,283 - 70,146,179 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	70,241,457 - 70,255,380 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	70,241,457 - 70,255,353 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	70,054,957 - 70,068,843 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	70,057,650 - 70,071,536 (-)	NCBI		MGSCv36	mm8
Celera	11	77,785,930 - 77,799,829 (-)	NCBI		Celera
Cytogenetic Map	11	B3	NCBI
cM Map	11	42.99	NCBI

Alox12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	55,456,923 - 55,469,239 (-)	NCBI		GRCr8
mRatBN7.2	10	54,958,263 - 54,970,542 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	54,958,271 - 54,970,542 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	59,637,904 - 59,650,163 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	59,126,503 - 59,138,762 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	54,625,627 - 54,637,884 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	56,851,734 - 56,864,049 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	56,851,734 - 56,864,005 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	56,595,898 - 56,608,192 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	57,080,603 - 57,092,874 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	57,095,024 - 57,106,540 (-)	NCBI
Celera	10	54,109,834 - 54,122,106 (-)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

ALOX12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	32,026,193 - 32,038,698 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	31,882,501 - 32,038,119 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	32,164,885 - 32,176,845 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	32,131,142 - 32,143,103 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	32,131,150 - 32,143,103 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	32,097,211 - 32,109,170 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	32,056,686 - 32,068,416 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	32,232,935 - 32,244,895 (+)	NCBI		UU_Cfam_GSD_1.0

ALOX12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	52,401,810 - 52,414,903 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	52,401,861 - 52,414,913 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	54,724,529 - 54,738,428 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ALOX12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	6,355,795 - 6,370,051 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	6,356,058 - 6,369,738 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	15,044,892 - 15,059,177 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Alox12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624786	9,542,970 - 9,555,214 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624786	9,542,966 - 9,555,235 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003810126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008962484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000034295 ⟹ ENSPPAP00000011635

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	17	7,014,591 - 7,029,602 (+)	Ensembl

RefSeq Acc Id:

XM_003810126 ⟹ XP_003810174

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	14,589,497 - 14,604,366 (+)	NCBI
NHGRI_mPanPan1	17	16,555,472 - 16,571,790 (+)	NCBI
Mhudiblu_PPA_v0	17	7,026,839 - 7,041,598 (+)	NCBI
PanPan1.1	17	7,014,591 - 7,029,602 (+)	NCBI

Sequence:

show sequence

TCTAGCCGCGGGACATCCCCAGACCCCAGCACGGCCTCCCAGGCCGACCTTCCAGAAGCCGGCC
CACTGCCTTCCCCGGGTCCCAGCCCAGAAAAGCGGAGACCTTCCCCTCCGTTTGGAAGATGGAC
TCATCCCCTACTTCCTCCTGGCTCCCCAGAAGACCTGGAGACCTCGGGAAGTGTTCTCATCTAT
GTTCGCTCCAACCCGGGGGCTCAGGCCCACCTCGATCCCGCCTTCCCGGGAGGTCCAGGAAGGT
CCCGCCGCACCCACCCCGTTGGCCTCACCCTGGCTCGGGCCCCTTTATCATCCTGCAGCTACGC
TCCGACCAGGAGGCACAGCCAGTCCCCGCAGCCGGCTCTACCGCTCTGCTCGCAGGTTTGGGCT
AGTCTGGGGCGGGGACTTGGGAGCGCCTAAAACTTGCGAGGAGGGCGGGGCCGCAGACCGGTCC
TTTAAAGGTTGGAAGTGGCCCCGAGGCGCCGGCAGCCCTGGGCGGTCCCGGGAATCGCACAGGA
CCCGGCTCCCCTCGCCTAAGCTGCTGGGGGGCGCCATGGGCCGCTACCGCATCCGCGTGGCCAC
CGGGGCCTGGCTCTTCTCCGGGTCGTACAACCGCGTGCAGCTTTGGCTGGTCGGGGCGCGCGGG
GAGGCGGAGCTGGAGCTGCAGCTGCGGCCGGCGCGGGGCGAGGAGGAGGAGTTTGATCATGACG
TTGCAGAGGACTTGGGGCTCCTGCAGTTCGTGAGGCTGCGCAAGCACCACTGGCTGGTGGACGA
CGCGTGGTTCTGCGACCGCATCACGGTGCAGGGCCCTGGAGCCTGCGCGGAGGTGGCCTTCCCG
TGCTACCGCTGGGTGCAGGGCGAGGACATCCTGAGCCTGCCCGAGGGCACCGCCCGCCTGCCAG
GAGACAATGCTTTGGACGTGTTCCAGAAGCATCGAGAGAAGGAACTGAAAGACAGACAGCAGAT
CTACTGCTGGGCCACCTGGAAGGAAGGGTTACCCCTGACCATCGCTGCAGACCGTAAGGATGAT
CTACCTCCAAATATGAGATTCCATGAGGAGAAGAGGCTGGACTTTGAATGGACACTGAAGGCAG
GGGCTCTGGAGATGGCCCTCAAACGTGTTTACACCCTCCTGAGCTCCTGGAACTGCCTAGAAGA
CTTTGATCAGATCTTCTGGGGCCAGAAGAGTGCCCTGGCTGAGAAGGTTCGCCAGTGCTGGCAG
GATGATGAGTTGTTCGGCTACCAGTTCCTCAATGGTGCCAACCCCATGCTGTTGAGACGCTCGA
CCTCTCTGCCCTGCAGGCTAGTGCTGCCCTCGGGGATGGAAGAGCTTCGTGCTCAACTGGAGAA
AGAACTTCAGAATGGTTCCCTGTTTGAAGCTGACTTCATCCTTCTGGATGGAATTCCAGCCAAC
GTGATCCGAGGAGAGAAGCAATACCTGGCTGCCCCCCTCATTATGCTGAAGATGGAGCCCAATG
GGAAGCTGCAGCCCATGGTCATCCAGATTCAGCCTCCCAACCCCAGCTCTCCAACCCCAACACT
GTTCCTGCCCTCAGACCCCCCACTTGCCTGGCTCCTGGCAAAGTCCTGGGTCCGAAATTCAGAT
TTCCAACTGCACGAGATCCAGTATCACTTACTGAACACTCATCTGGTGGCTGAGGTCATCGCTG
TCGCCACCATGCGGTGCCTCCCAGGACTGCACCCCATCTTCAAGTTCCTGATCCCCCATATCCG
CTACACCATGGAAATCAACACCCGGGCCCGGACCCAACTCATCTCAGATGGAGGAATTTTTGAT
AAGGCAGTGAGCACAGGTGGAGGGGGCCATGTACAGTTGCTCCGTCGGGCGGCAGCTCAGCTGA
CCTACTGCTCCCTCTGTCCTCCTGACGACCTGGCTGACCGGGGCCTGCTGGGACTCCCAGGTGC
TCTCTATGCCCGTGATGCTTTACGGCTCTGGGAGATCATTGCCAGGTATGTGGAGGGGATCGTC
CACCTCTTCTACCAAAGGGATGACGTAGTGAAGGGGGACCCTGAGCTGCAGGCCTGGTGTCGGG
AGATCACGGAGGTGGGGCTGTGCCAGGCCCAGGACCGAGGTTTCCCTGTCTCCTTTCAGTCCCA
GAGTCAACTCTGCCATTTCCTCACCATGTGCGTCTTCACGTGCACTGCCCAGCATGCCGCCATC
AACCAGGGCCAGCTGGACTGGTATGCCTGGGTCCCTAATGCTCCATGCACAATGCGGATGCCCC
CACCCACCACCAAGGAAGATGTAACGATGGCCACAGTGATGGGGTCACTACCTGATGTCCGGCA
GGCCTGTCTTCAAATGGCCATCTCATGGCATCTGAGTCGCCGCCAGCCAGACATGGTGCCTCTG
GGGCATCACAAAGAAAAATATTTCTCAGGCCCCAAGCCCAAAGCTGTGCTAAACCAATTCCGAA
CAGATTTGGAAAAGCTGGAAAAGGAGATTACAGCCCGGAATGAGCAACTTGACTGGCCCTATGA
ATATCTGAAGCCCAGCTGCATAGAGAACAGTGTCACCATCTGAGCCCTAGAGTGACTCTACCTG
CAAGATTTCACATCAGCTTTAGGACTGACATTTCTATCTTGAATTTCATGCTTTCCTAAAGTCT
CTGCTGCTAAGGCTCTATTTCCTCCCCCAGTTAAACCCCCTACATTAGTATCCCACTAGCCCAG
GGGAGCAGTAAACTTTCTCTGCAAAGACTAGATCCTTTTTTACGCTTTGCAGACCGCATAGTCA
CTGTCTCAACTACTCAGCTCTCCTGCTGCAGCATGAAGGCAGCCACAGACAACATAGAAATGAG
TGTGACTATGTTCCAATAAAACTTTATGGACACTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003810174	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000011635.1

RefSeq Acc Id:

XP_003810174 ⟸ XM_003810126

- UniProtKB:

A0A2R9A7K3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MFAPTRGLRPTSIPPSREVQEGPAAPTPLASPWLGPLYHPAATLRPGGTASPRSRLYRSARRFG
LVWGGDLGAPKTCEEGGAADRSFKGWKWPRGAGSPGRSRESHRTRLPSPKLLGGAMGRYRIRVA
TGAWLFSGSYNRVQLWLVGARGEAELELQLRPARGEEEEFDHDVAEDLGLLQFVRLRKHHWLVD
DAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNALDVFQKHREKELKDRQQ
IYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLE
DFDQIFWGQKSALAEKVRQCWQDDELFGYQFLNGANPMLLRRSTSLPCRLVLPSGMEELRAQLE
KELQNGSLFEADFILLDGIPANVIRGEKQYLAAPLIMLKMEPNGKLQPMVIQIQPPNPSSPTPT
LFLPSDPPLAWLLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHI
RYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPG
ALYARDALRLWEIIARYVEGIVHLFYQRDDVVKGDPELQAWCREITEVGLCQAQDRGFPVSFQS
QSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVR
QACLQMAISWHLSRRQPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPY
EYLKPSCIENSVTI

hide sequence

Ensembl Acc Id:

ENSPPAP00000011635 ⟸ ENSPPAT00000034295

Protein Domains

Lipoxygenase PLAT

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000029029	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000034295.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.450.60	UniProtKB/TrEMBL
	PLAT/LH2 domain	UniProtKB/TrEMBL
InterPro	LipOase	UniProtKB/TrEMBL
	LipOase_C	UniProtKB/TrEMBL
	LipOase_C_sf	UniProtKB/TrEMBL
	LipOase_CS	UniProtKB/TrEMBL
	LipOase_Fe_BS	UniProtKB/TrEMBL
	LipOase_mml	UniProtKB/TrEMBL
	PLAT/LH2_dom	UniProtKB/TrEMBL
	PLAT/LH2_dom_sf	UniProtKB/TrEMBL
NCBI Gene	ALOX12	ENTREZGENE
PANTHER	POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX12	UniProtKB/TrEMBL
	PTHR11771	UniProtKB/TrEMBL
Pfam	Lipoxygenase	UniProtKB/TrEMBL
	PLAT	UniProtKB/TrEMBL
PRINTS	LIPOXYGENASE	UniProtKB/TrEMBL
	MAMLPOXGNASE	UniProtKB/TrEMBL
PROSITE	LIPOXYGENASE_1	UniProtKB/TrEMBL
	LIPOXYGENASE_2	UniProtKB/TrEMBL
	LIPOXYGENASE_3	UniProtKB/TrEMBL
	PLAT	UniProtKB/TrEMBL
SMART	LH2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48484	UniProtKB/TrEMBL
	SSF49723	UniProtKB/TrEMBL
UniProt	A0A2R9A7K3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB