RGD Reference Report - Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer. - Rat Genome Database

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Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer.

Authors: Gao, X  Grignon, DJ  Chbihi, T  Zacharek, A  Chen, YQ  Sakr, W  Porter, AT  Crissman, JD  Pontes, JE  Powell, IJ 
Citation: Gao X, etal., Urology. 1995 Aug;46(2):227-37.
RGD ID: 2315611
Pubmed: PMID:7624992   (View Abstract at PubMed)

OBJECTIVES. Prostate cancer is the most frequently diagnosed cancer and the second leading cause of cancer death in males in the United States. The mortality is due mainly to distant metastasis. Therefore, predicting the prognosis of prostate cancer patients is an important clinical problem. Previously, we demonstrated that a 12-lipoxygenase (12-LOX) metabolite of arachidonic acid, 12(S)-hydroxyeicosatetraenoic acid, enhances the invasiveness of prostate cancer cells and that a 12-LOX-selective inhibitor [N-benzyl-N-hydroxy-5-phenylpentanamide] reduces experimental metastasis in animal model systems. In this study, we investigated the potential of 12-LOX as a predictor for the aggressiveness of prostate cancer. METHODS. The mRNA expression level of 12-LOX in 122 matching prostate normal and cancerous tissues were measured by quantitative reverse transcription- polymerase chain reaction. Possible association between 12-LOX expression and histologic grade, pathologic and clinical stage, margin positivity, age, and race was analyzed. RESULTS. 12-LOX mRNA levels were elevated in cancer cells and the expression associated with poor differentiation and invasiveness of prostate cancer. Overall, 46 (38%) of 122 evaluable patients showed elevated levels of 12-LOX mRNA in prostate cancer tissues compared with the matching normal tissues. A statistically significantly greater number of cases were found to have an elevated level of 12-LOX among T3, high grade, and surgical margin-positive than T2, intermediate, and low grade, and surgical margin-negative prostatic adenocarcinomas. CONCLUSIONS. Our data suggest that elevation of 12-LOX mRNA expression occurs more frequently in advanced stage, high-grade prostate cancer and that 12-LOX may serve as an indicator for progression and prognosis of prostate cancer. This enzyme also may be a novel target for the development of anti-invasive and antimetastatic agents.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ALOX12Humanprostate cancer disease_progressionIEP mRNA:increased expression:prostate glandRGD 
Alox12Ratprostate cancer disease_progressionISOALOX12 (Homo sapiens)mRNA:increased expression:prostate glandRGD 
Alox12Mouseprostate cancer disease_progressionISOALOX12 (Homo sapiens)mRNA:increased expression:prostate glandRGD 

Objects Annotated

Genes (Rattus norvegicus)
Alox12  (arachidonate 12-lipoxygenase, 12S type)

Genes (Mus musculus)
Alox12  (arachidonate 12-lipoxygenase)

Genes (Homo sapiens)
ALOX12  (arachidonate 12-lipoxygenase, 12S type)


Additional Information