Alox12 (arachidonate 12-lipoxygenase) - Rat Genome Database

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Gene: Alox12 (arachidonate 12-lipoxygenase) Mus musculus
Analyze
Symbol: Alox12
Name: arachidonate 12-lipoxygenase
RGD ID: 1322470
MGI Page MGI
Description: Enables arachidonate 12(S)-lipoxygenase activity and linoleate 13S-lipoxygenase activity. Involved in establishment of skin barrier; fatty acid metabolic process; and negative regulation of platelet aggregation. Located in cytoplasm. Is expressed in alimentary system; liver; liver left lobe; liver right lobe; and lung vascular element. Orthologous to human ALOX12 (arachidonate 12-lipoxygenase, 12S type).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 12S-lipoxygenase; 12S-LOX; 9930022G08Rik; Alo; Alox12p; arachidonate (12S)-lipoxygenase; arachidonate (15S)-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; arachidonate 15-lipoxygenase,15S-type; linoleate 13S-lipoxygenase; lipoxin synthase 12-LO; P-1; P-12LO; platelet-type lipoxygenase 12; polyunsaturated fatty acid lipoxygenase ALOX12
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,132,283 - 70,146,206 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,132,283 - 70,146,179 (-)EnsemblGRCm39 Ensembl
GRCm381170,241,457 - 70,255,380 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,241,457 - 70,255,353 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,054,957 - 70,068,843 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,057,650 - 70,071,536 (-)NCBIMGSCv36mm8
Celera1177,785,930 - 77,799,829 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4-hydroxyphenyl retinamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
arachidonic acid  (EXP,ISO)
aristolochic acid A  (ISO)
baicalein  (ISO)
benoxaprofen  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bifenthrin  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
carmustine  (EXP,ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
cisplatin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
dextran sulfate  (EXP)
Dibutyl phosphate  (ISO)
dioxygen  (ISO)
dithiol  (ISO)
diuron  (ISO)
docebenone  (EXP)
fenofibrate  (ISO)
flavonoids  (ISO)
genistein  (EXP)
glucose  (ISO)
glutathione disulfide  (EXP)
hydroquinone  (ISO)
indometacin  (ISO)
kaempferol  (ISO)
lanthanum trichloride  (ISO)
Licochalcone B  (ISO)
lidocaine  (ISO)
masoprocol  (ISO)
methotrexate  (ISO)
nickel atom  (ISO)
nicotine  (EXP)
oxaliplatin  (ISO)
ozone  (EXP)
perfluorohexanesulfonic acid  (EXP)
picrotoxin  (ISO)
pirinixic acid  (EXP)
polymyxin B2  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
tamoxifen  (EXP)
tetraphene  (EXP)
tioguanine  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
trimellitic anhydride  (EXP)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,ISO)
cytosol  (IBA,IEA,ISO)
membrane  (ISO,ISS)
sarcolemma  (IBA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Arachidonic acid cascade in endothelial pathobiology. Bogatcheva NV, etal., Microvasc Res. 2005 May;69(3):107-27.
2. Evidence for activation of inflammatory lipoxygenase pathways in visceral adipose tissue of obese Zucker rats. Chakrabarti SK, etal., Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E175-87. Epub 2010 Oct 26.
3. Endogenous 12(S)-HETE production by tumor cells and its role in metastasis. Chen YQ, etal., Cancer Res. 1994 Mar 15;54(6):1574-9.
4. Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer. Gao X, etal., Urology. 1995 Aug;46(2):227-37.
5. 12/15-Lipoxygenase deficiency protects mice from allergic airways inflammation and increases secretory IgA levels. Hajek AR, etal., J Allergy Clin Immunol. 2008 Sep;122(3):633-9.e3. Epub 2008 Aug 9.
6. Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis. Hussain H, etal., Am J Physiol. 1994 Jan;266(1 Pt 1):C243-53.
7. Basal transepidermal water loss is increased in platelet-type 12-lipoxygenase deficient mice. Johnson EN, etal., J Invest Dermatol. 1999 Jun;112(6):861-5.
8. Increased platelet sensitivity to ADP in mice lacking platelet-type 12-lipoxygenase. Johnson EN, etal., Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3100-5.
9. Genetic expression profiles during physiological and pathological cardiac hypertrophy and heart failure in rats. Kong SW, etal., Physiol Genomics. 2005 Mar 21;21(1):34-42. Epub 2004 Dec 28.
10. An aldosterone-related system in the ventrolateral medulla oblongata of spontaneously hypertensive and Wistar-Kyoto rats. Kumar NN, etal., Clin Exp Pharmacol Physiol. 2006 Jan-Feb;33(1-2):71-5.
11. Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays. Lemon WJ, etal., J Med Genet 2002 Sep;39(9):644-55.
12. Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. Liu Y, etal., Am J Kidney Dis. 2008 Aug;52(2):242-50. Epub 2008 Mar 25.
13. The expression of cyclooxygenases and lipoxygenases in renal ischemia-reperfusion injury. Matsuyama M, etal., Transplant Proc. 2004 Sep;36(7):1939-42.
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. MGD IEA MGD IEA
16. Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase. Nie D, etal., Clin Exp Metastasis. 2003;20(7):657-63.
17. 12-Lipoxygenase-knockout mice are resistant to inflammatory effects of obesity induced by Western diet. Nunemaker CS, etal., Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1065-75. Epub 2008 Sep 9.
18. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
19. Activation of the 12-lipoxygenase and signal transducer and activator of transcription pathway during neointima formation in a model of the metabolic syndrome. Pei H, etal., Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E92-E102. Epub 2005 Aug 23.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
22. Mouse MP Annotation Import Pipeline RGD automated import pipeline
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. A microarray study of gene expression profiles in nasal polyps. Rostkowska-Nadolska B, etal., Auris Nasus Larynx. 2011 Feb;38(1):58-64. Epub 2010 Jun 15.
25. Induction of epithelial arachidonate 12-lipoxygenase at active sites of inflammatory bowel disease. Shannon VR, etal., Am J Physiol. 1993 Jan;264(1 Pt 1):G104-11.
26. Decreased activity of arachidonate 12-lipoxygenase in platelets of Japanese patients with non-insulin-dependent diabetes mellitus. Tohjima T, etal., Metabolism. 1998 Mar;47(3):257-63.
27. Angiotensin II type 1 receptor expression is increased via 12-lipoxygenase in high glucose-stimulated glomerular cells and type 2 diabetic glomeruli. Xu ZG, etal., Nephrol Dial Transplant. 2009 Jun;24(6):1744-52. Epub 2008 Dec 22.
28. Arachidonate 12-lipoxygenases. Yoshimoto T and Takahashi Y, Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:245-62.
29. Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor. Yoshimura R, etal., Int J Mol Med. 2004 Jan;13(1):41-6.
30. Relationship between lipoxygenase and human testicular cancer. Yoshimura R, etal., Int J Mol Med. 2004 Mar;13(3):389-93.
31. Expression of lipoxygenase in human bladder carcinoma and growth inhibition by its inhibitors. Yoshimura R, etal., J Urol. 2003 Nov;170(5):1994-9.
32. Survival effects of cyclooxygenase-2 and 12-lipooxygenase in Egyptian women with operable breast cancer. Zeeneldin AA, etal., Indian J Cancer. 2009 Jan-Mar;46(1):54-60.
Additional References at PubMed
PMID:7576099   PMID:7792391   PMID:7868854   PMID:8188678   PMID:8944751   PMID:9518531   PMID:10330425   PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861  
PMID:11130978   PMID:11217851   PMID:11256953   PMID:11299195   PMID:12122008   PMID:12198250   PMID:12477932   PMID:12664580   PMID:14676201   PMID:14681479   PMID:15161019   PMID:15328042  
PMID:15576842   PMID:15610241   PMID:15681297   PMID:15708862   PMID:15781699   PMID:15879104   PMID:16141072   PMID:16141073   PMID:16254318   PMID:16514433   PMID:17045234   PMID:17873277  
PMID:18296557   PMID:18311922   PMID:18346986   PMID:19095999   PMID:19373248   PMID:19509298   PMID:19555433   PMID:19633199   PMID:19675173   PMID:19713213   PMID:19752233   PMID:19787041  
PMID:19819949   PMID:19822654   PMID:20068575   PMID:20599608   PMID:20724598   PMID:20947825   PMID:21220563   PMID:21267068   PMID:21307302   PMID:21619415   PMID:21677750   PMID:21873635  
PMID:22215650   PMID:22267335   PMID:22279185   PMID:22384268   PMID:22493235   PMID:22637477   PMID:23070608   PMID:23079635   PMID:23528921   PMID:23664097   PMID:23784669   PMID:24300237  
PMID:25100742   PMID:25187369   PMID:25245389   PMID:25251155   PMID:25293588   PMID:25313597   PMID:25549319   PMID:25598081   PMID:25698732   PMID:26106157   PMID:26438362   PMID:27470510  
PMID:27689697   PMID:28775075   PMID:29184033   PMID:29227475   PMID:30792307   PMID:30855276   PMID:30944221   PMID:30962574   PMID:31277941   PMID:31353262   PMID:32492133   PMID:32760397  
PMID:33290842   PMID:34536344   PMID:34910546   PMID:34910548   PMID:35129022   PMID:36239312   PMID:36599368  


Genomics

Comparative Map Data
Alox12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,132,283 - 70,146,206 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,132,283 - 70,146,179 (-)EnsemblGRCm39 Ensembl
GRCm381170,241,457 - 70,255,380 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,241,457 - 70,255,353 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,054,957 - 70,068,843 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,057,650 - 70,071,536 (-)NCBIMGSCv36mm8
Celera1177,785,930 - 77,799,829 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
ALOX12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38176,996,049 - 7,010,754 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl176,996,049 - 7,010,754 (+)EnsemblGRCh38hg38GRCh38
GRCh37176,899,368 - 6,914,073 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36176,840,108 - 6,854,779 (+)NCBINCBI36Build 36hg18NCBI36
Build 34176,840,127 - 6,854,776NCBI
Celera176,924,952 - 6,939,560 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef176,793,203 - 6,807,748 (+)NCBIHuRef
CHM1_1176,908,840 - 6,923,485 (+)NCBICHM1_1
T2T-CHM13v2.0176,896,743 - 6,911,368 (+)NCBIT2T-CHM13v2.0
Alox12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,456,923 - 55,469,239 (-)NCBIGRCr8
mRatBN7.21054,958,263 - 54,970,542 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,958,271 - 54,970,542 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,637,904 - 59,650,163 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,126,503 - 59,138,762 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,625,627 - 54,637,884 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,851,734 - 56,864,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,851,734 - 56,864,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,595,898 - 56,608,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,080,603 - 57,092,874 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,095,024 - 57,106,540 (-)NCBI
Celera1054,109,834 - 54,122,106 (-)NCBICelera
Cytogenetic Map10q24NCBI
ALOX12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,589,497 - 14,604,366 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,555,472 - 16,571,790 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,026,839 - 7,041,598 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,014,038 - 7,029,602 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,014,591 - 7,029,602 (+)Ensemblpanpan1.1panPan2
ALOX12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,026,193 - 32,038,698 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,882,501 - 32,038,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,164,885 - 32,176,845 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,131,142 - 32,143,103 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,131,150 - 32,143,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,097,211 - 32,109,170 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,056,686 - 32,068,416 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,232,935 - 32,244,895 (+)NCBIUU_Cfam_GSD_1.0
ALOX12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,401,810 - 52,414,903 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,401,861 - 52,414,913 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,724,529 - 54,738,428 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,355,795 - 6,370,051 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,356,058 - 6,369,738 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605915,044,892 - 15,059,177 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alox12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,542,970 - 9,555,214 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,542,966 - 9,555,235 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Alox12
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:585
Count of miRNA genes:428
Interacting mature miRNAs:476
Transcripts:ENSMUST00000000329, ENSMUST00000108574
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116899082672490826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116899082672490826Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116707819179813912Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116899082672490826Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116899082672490826Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116899082672490826Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116899082672490826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116899082672490826Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116899082672490826Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116899082672490826Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116899082672490826Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116899082672490826Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116331940781830473Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
AU014726  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381170,242,046 - 70,242,272UniSTSGRCm38
MGSCv371170,055,548 - 70,055,774UniSTSGRCm37
Celera1177,786,521 - 77,786,747UniSTS
Cytogenetic Map11B3UniSTS
cM Map1140.0UniSTS
Whitehead/MRC_RH11911.04UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001331118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001779865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK036898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK087724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK172488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL669869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC152329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC152403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR933731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S80446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000000329   ⟹   ENSMUSP00000000329
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,132,283 - 70,146,179 (-)Ensembl
GRCm38.p6 Ensembl1170,241,457 - 70,255,353 (-)Ensembl
Ensembl Acc Id: ENSMUST00000108574   ⟹   ENSMUSP00000104214
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,139,789 - 70,146,167 (-)Ensembl
GRCm38.p6 Ensembl1170,248,963 - 70,255,341 (-)Ensembl
RefSeq Acc Id: NM_001331118   ⟹   NP_001318047
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,132,283 - 70,146,196 (-)NCBI
GRCm381170,241,457 - 70,255,370 (-)NCBI
Sequence:
RefSeq Acc Id: NM_007440   ⟹   NP_031466
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,132,283 - 70,146,196 (-)NCBI
GRCm381170,241,457 - 70,255,370 (-)NCBI
MGSCv371170,054,957 - 70,068,843 (-)RGD
Celera1177,785,930 - 77,799,829 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_001779865
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,133,813 - 70,146,206 (-)NCBI
GRCm381170,242,987 - 70,255,380 (-)NCBI
Sequence:
RefSeq Acc Id: NP_031466   ⟸   NM_007440
- Peptide Label: isoform 1
- UniProtKB: Q8BHG4 (UniProtKB/Swiss-Prot),   P39655 (UniProtKB/Swiss-Prot),   A2CF85 (UniProtKB/TrEMBL),   Q3T9I9 (UniProtKB/TrEMBL),   Q3T9Y3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001318047   ⟸   NM_001331118
- Peptide Label: isoform 2
- UniProtKB: P39655 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000104214   ⟸   ENSMUST00000108574
Ensembl Acc Id: ENSMUSP00000000329   ⟸   ENSMUST00000000329
Protein Domains
Lipoxygenase   PLAT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P39655-F1-model_v2 AlphaFold P39655 1-663 view protein structure

Promoters
RGD ID:8675306
Promoter ID:EPDNEW_M15684
Type:single initiation site
Name:Alox12_1
Description:Mus musculus arachidonate 12-lipoxygenase , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381170,255,338 - 70,255,398EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87998 AgrOrtholog
Ensembl Genes ENSMUSG00000000320 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000000329 ENTREZGENE
  ENSMUST00000000329.9 UniProtKB/Swiss-Prot
  ENSMUST00000108574.3 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro LipOase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LipOase_mml UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT_LOX_verte UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11684 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:87998 ENTREZGENE
NCBI Gene 11684 ENTREZGENE
PANTHER POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11771 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Alox12 PhenoGen
PRINTS LIPOXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2CF85 ENTREZGENE, UniProtKB/TrEMBL
  LOX12_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3T9I9 ENTREZGENE, UniProtKB/TrEMBL
  Q3T9Y3 ENTREZGENE, UniProtKB/TrEMBL
  Q8BHG4 ENTREZGENE
  Q8C587_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q8BHG4 UniProtKB/Swiss-Prot