ALOX12 (arachidonate 12-lipoxygenase, 12S type) - Rat Genome Database

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Gene: ALOX12 (arachidonate 12-lipoxygenase, 12S type) Sus scrofa
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Symbol: ALOX12
Name: arachidonate 12-lipoxygenase, 12S type
RGD ID: 14142812
Description: ENCODES a protein that exhibits arachidonate 12(S)-lipoxygenase activity (inferred); arachidonate 15-lipoxygenase activity (inferred); dioxygenase activity (inferred); INVOLVED IN cellular response to lipid (ortholog); leukotriene A4 metabolic process (ortholog); linoleic acid metabolic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Albuminuria (ortholog); autism spectrum disorder (ortholog); Bone Metastasis (ortholog); FOUND IN sarcolemma (ortholog); INTERACTS WITH dichlorine
Type: protein-coding
RefSeq Status: MODEL
Previously known as: arachidonate 12-lipoxygenase, 12S-type
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,401,810 - 52,414,903 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,401,861 - 52,414,913 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,724,529 - 54,738,428 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
dichlorine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic cell clearance  (IEA)
arachidonic acid metabolic process  (IEA)
bone mineralization  (IEA)
cellular response to calcium ion  (IEA)
cellular response to interleukin-13  (IEA)
cellular response to lipid  (ISO)
establishment of skin barrier  (IEA)
fatty acid oxidation  (IEA)
hepoxilin biosynthetic process  (IEA)
leukotriene A4 metabolic process  (IEA,ISO)
linoleic acid metabolic process  (IEA,ISO)
lipid metabolic process  (IEA)
lipid oxidation  (IEA)
lipoxin A4 biosynthetic process  (IEA)
lipoxin B4 biosynthetic process  (IEA)
lipoxygenase pathway  (IEA)
negative regulation of adaptive immune response  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of muscle cell apoptotic process  (IEA)
negative regulation of platelet aggregation  (IEA)
ossification  (IEA)
phosphatidylethanolamine biosynthetic process  (IEA)
positive regulation of actin filament polymerization  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell-substrate adhesion  (IEA)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of endothelial tube morphogenesis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
regulation of engulfment of apoptotic cell  (IEA)
regulation of inflammatory response  (IEA)
regulation of peroxisome proliferator activated receptor signaling pathway  (IEA)
response to endoplasmic reticulum stress  (IEA)
unsaturated fatty acid metabolic process  (IEA)
wound healing  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ALOX12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,401,810 - 52,414,903 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,401,861 - 52,414,913 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,724,529 - 54,738,428 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALOX12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38176,996,049 - 7,010,754 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl176,996,049 - 7,010,754 (+)EnsemblGRCh38hg38GRCh38
GRCh37176,899,368 - 6,914,073 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36176,840,108 - 6,854,779 (+)NCBINCBI36Build 36hg18NCBI36
Build 34176,840,127 - 6,854,776NCBI
Celera176,924,952 - 6,939,560 (+)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef176,793,203 - 6,807,748 (+)NCBIHuRef
CHM1_1176,908,840 - 6,923,485 (+)NCBICHM1_1
T2T-CHM13v2.0176,896,743 - 6,911,368 (+)NCBIT2T-CHM13v2.0
Alox12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,132,283 - 70,146,206 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,132,283 - 70,146,179 (-)EnsemblGRCm39 Ensembl
GRCm381170,241,457 - 70,255,380 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,241,457 - 70,255,353 (-)EnsemblGRCm38mm10GRCm38
MGSCv371170,054,957 - 70,068,843 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361170,057,650 - 70,071,536 (-)NCBIMGSCv36mm8
Celera1177,785,930 - 77,799,829 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
Alox12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81055,456,923 - 55,469,239 (-)NCBIGRCr8
mRatBN7.21054,958,263 - 54,970,542 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,958,271 - 54,970,542 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1059,637,904 - 59,650,163 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01059,126,503 - 59,138,762 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01054,625,627 - 54,637,884 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,851,734 - 56,864,049 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,851,734 - 56,864,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01056,595,898 - 56,608,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,080,603 - 57,092,874 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11057,095,024 - 57,106,540 (-)NCBI
Celera1054,109,834 - 54,122,106 (-)NCBICelera
Cytogenetic Map10q24NCBI
ALOX12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21914,589,497 - 14,604,366 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11716,555,472 - 16,571,790 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,026,839 - 7,041,598 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,014,038 - 7,029,602 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,014,591 - 7,029,602 (+)Ensemblpanpan1.1panPan2
ALOX12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,026,193 - 32,038,698 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,882,501 - 32,038,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,164,885 - 32,176,845 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,131,142 - 32,143,103 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,131,150 - 32,143,103 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,097,211 - 32,109,170 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,056,686 - 32,068,416 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,232,935 - 32,244,895 (+)NCBIUU_Cfam_GSD_1.0
ALOX12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,355,795 - 6,370,051 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,356,058 - 6,369,738 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605915,044,892 - 15,059,177 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Alox12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247869,542,970 - 9,555,214 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247869,542,966 - 9,555,235 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ALOX12
402 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 22 2 3 1
Below cutoff 1 2

Sequence


RefSeq Acc Id: ENSSSCT00000019506   ⟹   ENSSSCP00000018988
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,287,160 - 52,295,871 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000019513   ⟹   ENSSSCP00000018995
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,401,810 - 52,414,903 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000035060   ⟹   ENSSSCP00000030128
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,286,019 - 52,295,830 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000040620   ⟹   ENSSSCP00000034426
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,287,160 - 52,414,907 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000047524   ⟹   ENSSSCP00000032499
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,286,019 - 52,295,830 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000068037   ⟹   ENSSSCP00000066871
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,401,810 - 52,405,806 (+)Ensembl
RefSeq Acc Id: XM_003483092   ⟹   XP_003483140
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,401,861 - 52,414,913 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021067800   ⟹   XP_020923459
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,402,213 - 52,414,913 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021067801   ⟹   XP_020923460
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,402,213 - 52,411,480 (+)NCBI
Sequence:
RefSeq Acc Id: XP_003483140   ⟸   XM_003483092
- Peptide Label: isoform X2
- UniProtKB: F1RF49 (UniProtKB/TrEMBL),   A0A8D0Y413 (UniProtKB/TrEMBL),   A0A8D1JI81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923459   ⟸   XM_021067800
- Peptide Label: isoform X1
- UniProtKB: A0A8D0JS53 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020923460   ⟸   XM_021067801
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSSSCP00000034426   ⟸   ENSSSCT00000040620
RefSeq Acc Id: ENSSSCP00000030128   ⟸   ENSSSCT00000035060
RefSeq Acc Id: ENSSSCP00000066871   ⟸   ENSSSCT00000068037
RefSeq Acc Id: ENSSSCP00000018988   ⟸   ENSSSCT00000019506
RefSeq Acc Id: ENSSSCP00000018995   ⟸   ENSSSCT00000019513
RefSeq Acc Id: ENSSSCP00000032499   ⟸   ENSSSCT00000047524
Protein Domains
Lipoxygenase   PLAT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000017923 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00000060177 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005030323 UniProtKB/TrEMBL
  ENSSSCG00025049493 UniProtKB/TrEMBL
  ENSSSCG00030068889 UniProtKB/TrEMBL
  ENSSSCG00035018522 UniProtKB/TrEMBL
  ENSSSCG00040039743 UniProtKB/TrEMBL
  ENSSSCG00045021886 UniProtKB/TrEMBL
  ENSSSCG00050003263 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000019506.6 UniProtKB/TrEMBL
  ENSSSCT00000019513 ENTREZGENE
  ENSSSCT00000019513.6 UniProtKB/TrEMBL
  ENSSSCT00005048294.1 UniProtKB/TrEMBL
  ENSSSCT00025067887.1 UniProtKB/TrEMBL
  ENSSSCT00025068091.1 UniProtKB/TrEMBL
  ENSSSCT00030096372.1 UniProtKB/TrEMBL
  ENSSSCT00030096448.1 UniProtKB/TrEMBL
  ENSSSCT00035023912.1 UniProtKB/TrEMBL
  ENSSSCT00035023915.1 UniProtKB/TrEMBL
  ENSSSCT00040055813.1 UniProtKB/TrEMBL
  ENSSSCT00040055979.1 UniProtKB/TrEMBL
  ENSSSCT00045037991.1 UniProtKB/TrEMBL
  ENSSSCT00045038083.1 UniProtKB/TrEMBL
  ENSSSCT00050004455.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.60 UniProtKB/TrEMBL
  PLAT/LH2 domain UniProtKB/TrEMBL
InterPro LipOase UniProtKB/TrEMBL
  LipOase_C UniProtKB/TrEMBL
  LipOase_C_sf UniProtKB/TrEMBL
  LipOase_CS UniProtKB/TrEMBL
  LipOase_Fe_BS UniProtKB/TrEMBL
  LipOase_mml UniProtKB/TrEMBL
  PLAT/LH2_dom UniProtKB/TrEMBL
  PLAT/LH2_dom_sf UniProtKB/TrEMBL
  PLAT_LOX_verte UniProtKB/TrEMBL
KEGG Report ssc:100620614 UniProtKB/TrEMBL
NCBI Gene ALOX12 ENTREZGENE
PANTHER POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX12 UniProtKB/TrEMBL
  POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX15 UniProtKB/TrEMBL
  PTHR11771 UniProtKB/TrEMBL
Pfam Lipoxygenase UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
PRINTS LIPOXYGENASE UniProtKB/TrEMBL
  MAMLPOXGNASE UniProtKB/TrEMBL
PROSITE LIPOXYGENASE_1 UniProtKB/TrEMBL
  LIPOXYGENASE_2 UniProtKB/TrEMBL
  LIPOXYGENASE_3 UniProtKB/TrEMBL
  PLAT UniProtKB/TrEMBL
SMART LH2 UniProtKB/TrEMBL
Superfamily-SCOP SSF48484 UniProtKB/TrEMBL
  SSF49723 UniProtKB/TrEMBL
UniProt A0A2C9F3G7_PIG UniProtKB/TrEMBL
  A0A8D0JS53 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Y413 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Y4S0_PIG UniProtKB/TrEMBL
  A0A8D0YYV3_PIG UniProtKB/TrEMBL
  A0A8D1CNF7_PIG UniProtKB/TrEMBL
  A0A8D1JI81 ENTREZGENE, UniProtKB/TrEMBL
  F1RF49 ENTREZGENE, UniProtKB/TrEMBL