ABCC1 (ATP binding cassette subfamily C member 1)

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Gene: ABCC1 (ATP binding cassette subfamily C member 1) Pan paniscus

Analyze

Symbol:

ABCC1

Name:

ATP binding cassette subfamily C member 1

RGD ID:

11773617

Description:

ENCODES a protein that exhibits ABC-type glutathione S-conjugate transporter activity (ortholog); ABC-type transporter activity (ortholog); ABC-type xenobiotic transporter activity (ortholog); INVOLVED IN carboxylic acid transmembrane transport (ortholog); cell chemotaxis (ortholog); cellular response to amyloid-beta (ortholog); PARTICIPATES IN docetaxel pharmacodynamics pathway; doxorubicin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); asthma (ortholog); autistic disorder (ortholog); FOUND IN apical plasma membrane (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

LOC100969990; multidrug resistance-associated protein 1

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

No map positions available.

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

asthma (ISO)

autistic disorder (ISO)

autosomal dominant nonsyndromic deafness 77 (ISO)

bacterial pneumonia (ISO)

Breast Cancer, Familial (ISO)

Breast Neoplasms (ISO)

Chemical and Drug Induced Liver Injury (ISO)

chronic obstructive pulmonary disease (ISO)

Colorectal Neoplasms (ISO)

Disease Progression (ISO)

Familial Thoracic Aortic Aneurysm 4 (ISO)

head and neck squamous cell carcinoma (ISO)

heart disease (ISO)

hypertension (ISO)

intestinal volvulus (ISO)

peripheral nervous system disease (ISO)

pseudoxanthoma elasticum (ISO)

schizophrenia (ISO)

Volvulus Of Midgut (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carboxylic acid transmembrane transport (ISO)

cell chemotaxis (ISO)

cellular response to amyloid-beta (ISO)

export across plasma membrane (ISO)

glutathione transmembrane transport (ISO)

leukotriene transport (ISO)

long-chain fatty acid import across plasma membrane (ISO)

negative regulation of cell death (ISO)

negative regulation of neuron death (ISO)

phospholipid efflux (ISO)

phospholipid translocation (ISO)

positive regulation of cell migration (ISO)

positive regulation of inflammatory response (ISO)

response to drug (ISO)

response to oxidative stress (ISO)

sphingolipid translocation (ISO)

transepithelial transport (ISO)

transmembrane transport (ISO)

xenobiotic detoxification by transmembrane export across the plasma membrane (ISO)

xenobiotic transport (ISO)

xenobiotic transport across blood-brain barrier (ISO)

Cellular Component

apical plasma membrane (ISO)

basal plasma membrane (ISO)

basolateral plasma membrane (ISO)

cytoplasm (ISO)

integral component of plasma membrane (ISO)

lateral plasma membrane (ISO)

membrane (ISO)

plasma membrane (ISO)

Molecular Function

ABC-type glutathione S-conjugate transporter activity (ISO)

ABC-type transporter activity (ISO)

ABC-type xenobiotic transporter activity (ISO)

amide transmembrane transporter activity (ISO)

ATPase-coupled lipid transmembrane transporter activity (ISO)

carboxylic acid transmembrane transporter activity (ISO)

efflux transmembrane transporter activity (ISO)

glutathione transmembrane transporter activity (ISO)

long-chain fatty acid transporter activity (ISO)

xenobiotic transmembrane transporter activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

docetaxel pharmacodynamics pathway (ISO)

doxorubicin pharmacokinetics pathway (ISO)

irinotecan pharmacodynamics pathway (ISO)

irinotecan pharmacokinetics pathway (ISO)

lamivudine pharmacokinetics pathway (ISO)

paracetamol pharmacokinetics pathway (ISO)

sphingosine 1-phosphate signaling pathway (ISO)

tyrosinemia type III pathway (ISO)

vinblastine pharmacodynamics pathway (ISO)

vincristine pharmacodynamics pathway (ISO)

vindesine pharmacodynamics pathway (ISO)

vinorelbine pharmacodynamics pathway (ISO)

References

Genomics

Comparative Map Data

ABCC1
(Pan paniscus - bonobo/pygmy chimpanzee)

No map positions available.

ABCC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	16	15,949,138 - 16,143,257 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	16	15,949,577 - 16,143,074 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	16	15,949,616 - 16,143,062 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	16	16,043,473 - 16,236,910 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	15,950,935 - 16,144,432 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	16	15,950,934 - 16,143,774	NCBI
Celera	16	15,781,784 - 15,917,085 (+)	NCBI
Cytogenetic Map	16	p13.11	NCBI
HuRef	16	15,436,705 - 15,630,893 (+)	NCBI		HuRef
CHM1_1	16	16,185,916 - 16,321,192 (+)	NCBI		CHM1_1

Abcc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	14,179,317 - 14,292,743 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	16	14,179,422 - 14,293,601 (+)	Ensembl
GRCm38	16	14,361,453 - 14,474,878 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	14,361,558 - 14,475,737 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	14,361,653 - 14,474,968 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	16	14,275,138 - 14,388,453 (+)	NCBI			mm8
Celera	16	14,966,079 - 15,077,783 (+)	NCBI		Celera
Cytogenetic Map	16	A1	NCBI

Abcc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	528,961 - 655,179 (-)	NCBI
Rnor_6.0 Ensembl	10	549,883 - 672,196 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	10	549,537 - 672,235 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	10	11,232,233 - 11,354,931 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	452,239 - 575,705 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	10	452,238 - 575,705 (-)	NCBI
Celera	10	11,130,945 - 11,246,232 (-)	NCBI		Celera
Cytogenetic Map	10	q11	NCBI

Abcc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	729,316 - 860,290 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	729,322 - 858,826 (+)	NCBI	ChiLan1.0	ChiLan1.0

ABCC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	6	27,855,702 - 27,989,331 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	6	27,855,702 - 27,950,140 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Abcc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936501	3,400,971 - 3,467,061 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ABCC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	28,360,868 - 28,485,477 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	28,360,868 - 28,472,940 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	29,082,788 - 29,172,693 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ABCC1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	14,972,589 - 15,164,594 (+)	NCBI
ChlSab1.1 Ensembl	5	14,972,646 - 15,164,567 (+)	Ensembl

Abcc1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624782	449,217 - 590,306 (+)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_034950820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034950821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034950822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034950823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034950824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034950825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000585	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Protein Sequences


Protein RefSeqs	XP_034806711	(Get FASTA)	NCBI Sequence Viewer
	XP_034806712	(Get FASTA)	NCBI Sequence Viewer
	XP_034806713	(Get FASTA)	NCBI Sequence Viewer
	XP_034806714	(Get FASTA)	NCBI Sequence Viewer
	XP_034806715	(Get FASTA)	NCBI Sequence Viewer
	XP_034806716	(Get FASTA)	NCBI Sequence Viewer

Protein Domains

ABC transmembrane type-1 ABC transporter

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000027658	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000008824	UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000031463	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1560.10	UniProtKB/TrEMBL
InterPro	AAA+_ATPase	UniProtKB/TrEMBL
	ABC1_TM_dom	UniProtKB/TrEMBL
	ABC1_TM_sf	UniProtKB/TrEMBL
	ABC_transporter-like	UniProtKB/TrEMBL
	ABC_transporter_CS	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
KEGG Report	pps:100969990	UniProtKB/TrEMBL
NCBI Gene	LOC100969990	ENTREZGENE
Pfam	ABC_membrane	UniProtKB/TrEMBL
	ABC_tran	UniProtKB/TrEMBL
PROSITE	ABC_TM1F	UniProtKB/TrEMBL
	ABC_TRANSPORTER_1	UniProtKB/TrEMBL
	ABC_TRANSPORTER_2	UniProtKB/TrEMBL
SMART	AAA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
	SSF90123	UniProtKB/TrEMBL
UniProt	A0A2R8ZV32_PANPA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-07-01	ABCC1	ATP binding cassette subfamily C member 1	LOC100969990	multidrug resistance-associated protein 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - PID (archival)