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Gene: PPIB (peptidylprolyl isomerase B) Pan paniscus

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Symbol:

PPIB

Name:

peptidylprolyl isomerase B

RGD ID:

11755090

Description:

ENCODES a protein that exhibits cyclosporin A binding (inferred); peptidyl-prolyl cis-trans isomerase activity (inferred); RNA polymerase binding (inferred); INVOLVED IN chaperone-mediated protein folding (ortholog); regulation of post-translational protein modification (ortholog); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); genetic disease (ortholog); FOUND IN smooth endoplasmic reticulum (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

peptidyl-prolyl cis-trans isomerase B

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	53,411,365 - 53,418,816 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	57,585,689 - 57,592,998 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	43,108,139 - 43,115,470 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	61,400,275 - 61,406,758 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	61,400,272 - 61,406,758 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

genetic disease (ISO)

human immunodeficiency virus infectious disease (ISO)

nemaline myopathy 6 (ISO)

osteogenesis imperfecta (ISO)

osteogenesis imperfecta type 9 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

bone development (IEA)

chaperone-mediated protein folding (IEA,ISO)

neutrophil chemotaxis (IEA)

positive regulation by host of viral genome replication (IEA)

positive regulation by host of viral process (IEA)

positive regulation of multicellular organism growth (IEA)

protein folding (IEA)

protein stabilization (IEA)

regulation of post-translational protein modification (ISO)

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

cytoplasm (IEA)

endoplasmic reticulum (IEA)

endoplasmic reticulum chaperone complex (IEA)

endoplasmic reticulum lumen (IEA)

intracellular membrane-bounded organelle (IEA)

melanosome (IEA)

nucleoplasm (IEA)

perinuclear region of cytoplasm (IEA)

smooth endoplasmic reticulum (ISO)

Molecular Function

cyclosporin A binding (IEA)

peptidyl-prolyl cis-trans isomerase activity (IEA)

protein binding (ISO)

RNA polymerase binding (IEA)

RNA polymerase II CTD heptapeptide repeat P3 isomerase activity (IEA)

RNA polymerase II CTD heptapeptide repeat P6 isomerase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

codeine and morphine pharmacodynamics pathway (ISO)

codeine and morphine pharmacokinetics pathway (ISO)

etoposide pharmacodynamics pathway (ISO)

etoposide pharmacokinetics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacokinetics pathway (ISO)

irinotecan pharmacodynamics pathway (ISO)

irinotecan pharmacokinetics pathway (ISO)

paracetamol pharmacokinetics pathway (ISO)

phenytoin pharmacodynamics pathway (ISO)

retinol metabolic pathway (ISO)

sorafenib pharmacokinetics pathway (ISO)

syndecan signaling pathway (ISO)

vitamin A deficiency pathway (ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

PPIB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	53,411,365 - 53,418,816 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	57,585,689 - 57,592,998 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	43,108,139 - 43,115,470 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	61,400,275 - 61,406,758 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	61,400,272 - 61,406,758 (-)	Ensembl	panpan1.1		panPan2

PPIB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	64,155,817 - 64,163,022 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	64,155,740 - 64,163,134 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	64,448,016 - 64,455,221 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	62,235,067 - 62,242,407 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	62,235,067 - 62,242,407	NCBI
Celera	15	41,326,958 - 41,334,299 (-)	NCBI		Celera
Cytogenetic Map	15	q22.31	NCBI
HuRef	15	41,272,716 - 41,280,027 (-)	NCBI		HuRef
CHM1_1	15	64,567,543 - 64,574,883 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	61,962,993 - 61,970,198 (-)	NCBI		T2T-CHM13v2.0

Ppib
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	65,967,451 - 65,973,911 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	65,967,504 - 65,973,905 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	66,060,169 - 66,066,629 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	66,060,222 - 66,066,623 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	65,907,976 - 65,914,436 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	65,858,175 - 65,864,635 (+)	NCBI		MGSCv36	mm8
Celera	9	63,295,684 - 63,302,172 (+)	NCBI		Celera
Cytogenetic Map	9	C	NCBI
cM Map	9	35.69	NCBI

Ppib
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	75,498,966 - 75,504,823 (+)	NCBI		GRCr8
mRatBN7.2	8	66,603,877 - 66,609,734 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	66,603,861 - 66,630,428 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	72,116,410 - 72,122,281 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	70,389,471 - 70,395,342 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	68,259,312 - 68,265,165 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	71,719,681 - 71,725,538 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	71,719,563 - 71,725,562 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	71,388,620 - 71,394,477 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	70,343,463 - 70,349,320 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	70,362,516 - 70,368,374 (+)	NCBI
Celera	8	65,993,837 - 65,999,694 (+)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Ppib
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	11,241,279 - 11,249,056 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	11,241,279 - 11,246,628 (+)	NCBI	ChiLan1.0	ChiLan1.0

PPIB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	28,654,193 - 28,660,129 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	28,654,200 - 28,788,801 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	28,573,442 - 28,579,364 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	28,830,352 - 28,836,280 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	28,830,352 - 28,836,229 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	28,764,458 - 28,770,385 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	28,826,745 - 28,832,670 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	29,065,950 - 29,071,877 (-)	NCBI		UU_Cfam_GSD_1.0

Ppib
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	106,785,707 - 106,792,093 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	24,632,311 - 24,640,316 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	24,633,769 - 24,640,246 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPIB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	107,886,658 - 107,893,253 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	107,886,663 - 107,893,155 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	118,800,893 - 118,806,498 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPIB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	19,380,496 - 19,399,596 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666048	122,005,937 - 122,012,943 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppib
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	8,402,430 - 8,411,003 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	8,402,518 - 8,407,950 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003827949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000043271 ⟹ ENSPPAP00000020477

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	15	61,400,272 - 61,406,758 (-)	Ensembl

RefSeq Acc Id:

XM_003827949 ⟹ XP_003827997

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	53,411,365 - 53,418,816 (-)	NCBI
NHGRI_mPanPan1	15	57,585,689 - 57,592,998 (-)	NCBI
Mhudiblu_PPA_v0	15	43,108,139 - 43,115,470 (-)	NCBI
PanPan1.1	15	61,400,275 - 61,406,758 (-)	NCBI

Sequence:

show sequence

CCTGTGGATGCTGCGCCTCTCCGAACGCAACATGAAGGTGCTCCTTGCCGCCGCCCTCATCGCG
GGGTCCGTCTTCTTCCTGCTGCTGCCGGAACCTTCTGTGGCCGATGAGAAGAAGAAGGGGCCCA
AAGTCACCGTCAAGGTGTATTTTGACCTACGAATTGGAGATGAAGATGTAGGCCGGGTGATCTT
TGGTCTCTTCGGAAAGACTGTTCCAAAAACAGTGGATAATTTTGTGGCCTTAGCTACAGGAGAG
AAAGGATTTGGCTACAAAAACAGCAAATTCCATCGTGTAATCAAGGACTTCATGATCCAGGGCG
GAGACTTCACCAGGGGAGATGGCACAGGAGGAAAGAGCATCTACGGTGAGCGCTTCCCCGATGA
GAACTTCAAACTGAAGCACTACGGGCCTGGCTGGGTGAGCATGGCCAACGCAGGCAAAGACACC
AACGGCTCCCAGTTCTTCATCACGACAGTCAAGACAGCCTGGCTAGATGGCAAGCATGTGGTGT
TTGGCAAAGTTCTAGAGGGCATGGAGGTGGTGCGGAAGGTGGAGAGCACCAAGACAGACAGCCG
GGATAAACCCCTGAAGGATGTGATCATCGCAGACTGCGGCAAGATCGAGGTGGAGAAGCCCTTT
GCCATCGCCAAGGAGTAGGGCACAGGGACGTCTTTCTTTGAGTGACCGTCTGTGCAGGCCCTGT
AGTCCGCCACAGGGCTCTGAGCTGCACTGGCCCCGGTGCTGGCATCTGGTGGAGCGGACCCACT
CCCCTCACATTCCACAGGCCCATGGACTCAGTTTTGTAACAAACTCCTACCAACACTGACCAAT
AAAAAAAAAGTGGGTTTTTTTTTTAAATATA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003827997	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000020477.1

RefSeq Acc Id:

XP_003827997 ⟸ XM_003827949

- UniProtKB:

A0A2R9AT23 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLRLSERNMKVLLAAALIAGSVFFLLLPEPSVADEKKKGPKVTVKVYFDLRIGDEDVGRVIFGL
FGKTVPKTVDNFVALATGEKGFGYKNSKFHRVIKDFMIQGGDFTRGDGTGGKSIYGERFPDENF
KLKHYGPGWVSMANAGKDTNGSQFFITTVKTAWLDGKHVVFGKVLEGMEVVRKVESTKTDSRDK
PLKDVIIADCGKIEVEKPFAIAKE

hide sequence

Ensembl Acc Id:

ENSPPAP00000020477 ⟸ ENSPPAT00000043271

Protein Domains

PPIase cyclophilin-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000033464	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000043271.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.100.10	UniProtKB/TrEMBL
InterPro	Cyclophilin-like_dom_sf	UniProtKB/TrEMBL
	Cyclophilin-type_PPIase_CS	UniProtKB/TrEMBL
	Cyclophilin-type_PPIase_dom	UniProtKB/TrEMBL
KEGG Report	pps:100974285	UniProtKB/TrEMBL
NCBI Gene	PPIB	ENTREZGENE
PANTHER	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE	UniProtKB/TrEMBL
	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B	UniProtKB/TrEMBL
Pfam	Pro_isomerase	UniProtKB/TrEMBL
PRINTS	CSAPPISMRASE	UniProtKB/TrEMBL
PROSITE	CSA_PPIASE_1	UniProtKB/TrEMBL
	CSA_PPIASE_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50891	UniProtKB/TrEMBL
UniProt	A0A2R9AT23	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - PID (archival)