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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal type I pneumocyte morphology
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Accession:MP:0002274 term browser browse the term
Definition:any structural anomaly of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange
Synonyms:exact_synonym: abnormal AT1 morphology;   abnormal ATI morphology;   abnormal Pulmonary alveolar type I cell morphology;   abnormal Type 1 pneumocyte morphology;   abnormal lung type 1 cells morphology;   abnormal membranous pneumocytes morphology;   abnormal small alveolar cells morphology;   abnormal squamous alveolar cell morphology;   abnormal squamous alveolar lining cell morphology;   abnormal type 1 alveolar epithelial cells morphology;   abnormal type I alveolar epithelial cells morphology;   abnormal type I cells morphology;   abnormal type I pneumocytes morphology;   abnormal type I pneumonocytes morphology
 xref: CL:0002062;   FMA:62500


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abnormal type I pneumocyte morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb1 arrestin, beta 1 IAGP MGI PMID:20060823 NCBI chr 7:99,184,356...99,255,979
Ensembl chr 7:99,184,673...99,255,978 		JBrowse link
G Arrb2 arrestin, beta 2 IAGP MGI PMID:20060823 NCBI chr11:70,323,051...70,331,654
Ensembl chr11:70,323,461...70,331,654 		JBrowse link
G Cby1 chibby family member 1, beta catenin antagonist IAGP MGI PMID:21049041 NCBI chr15:79,543,437...79,551,861
Ensembl chr15:79,543,400...79,551,861 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha IAGP MGI PMID:16467360 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 IAGP MGI PMID:18358466 NCBI chr10:17,598,452...17,601,422
Ensembl chr10:17,598,966...17,601,422 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase IAGP MGI PMID:15005800 NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147 		JBrowse link
G Klf5 Kruppel-like transcription factor 5 IAGP MGI PMID:18599506 NCBI chr14:99,536,127...99,550,848
Ensembl chr14:99,536,127...99,552,472 		JBrowse link
G Pdpn podoplanin IAGP MGI PMID:12654292 NCBI chr 4:142,993,979...143,026,134
Ensembl chr 4:142,994,001...143,026,134 		JBrowse link
G Pten phosphatase and tensin homolog IAGP MGI PMID:17909629 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Trip11 thyroid hormone receptor interactor 11 IAGP MGI PMID:19112494 NCBI chr12:101,800,304...101,879,463
Ensembl chr12:101,800,302...101,879,526 		JBrowse link
absent type I pneumocytes term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca3 ATP-binding cassette, sub-family A member 3 IAGP MGI PMID:17267394 NCBI chr17:24,570,997...24,629,178
Ensembl chr17:24,570,924...24,629,175 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha IAGP MGI PMID:16428462 PMID:16467360 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Foxa2 forkhead box A2 IAGP MGI PMID:15452354 NCBI chr 2:147,884,797...147,888,889
Ensembl chr 2:147,884,797...147,888,889 		JBrowse link
G Igf1 insulin-like growth factor 1 IAGP MGI PMID:12591604 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Lama5 laminin, alpha 5 IAGP MGI PMID:15936333 NCBI chr 2:179,818,166...179,867,652
Ensembl chr 2:179,818,166...179,867,652 		JBrowse link
G Lif leukemia inhibitory factor IAGP MGI PMID:12591604 NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514 		JBrowse link
G Pthlh parathyroid hormone-like peptide IAGP MGI PMID:15162506 NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681 		JBrowse link
decreased type I pneumocyte number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Emb embigin IAGP MGI PMID:38318368 NCBI chr13:117,357,109...117,410,951
Ensembl chr13:117,345,072...117,410,951 		JBrowse link
G Foxm1 forkhead box M1 IAGP MGI PMID:19033457 NCBI chr 6:128,339,957...128,352,849
Ensembl chr 6:128,339,930...128,353,109 		JBrowse link
G Fstl1 follistatin-like 1 IAGP MGI PMID:21482757 NCBI chr16:37,597,417...37,656,878
Ensembl chr16:37,597,235...37,656,876 		JBrowse link
G Klf5 Kruppel-like transcription factor 5 IAGP MGI PMID:18599506 NCBI chr14:99,536,127...99,550,848
Ensembl chr14:99,536,127...99,552,472 		JBrowse link
G Mycn v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived IAGP MGI PMID:15716345 NCBI chr12:12,986,094...12,991,837
Ensembl chr12:12,986,094...12,991,915 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 IAGP MGI PMID:14578211 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Snx5 sorting nexin 5 IAGP MGI PMID:23526992 NCBI chr 2:144,092,043...144,112,713
Ensembl chr 2:144,092,043...144,112,826 		JBrowse link
G Wfdc2 WAP four-disulfide core domain 2 IAGP MGI PMID:31780266 NCBI chr 2:164,404,635...164,410,430
Ensembl chr 2:164,404,333...164,410,430 		JBrowse link
G Wnt7b wingless-type MMTV integration site family, member 7B IAGP MGI PMID:12361974 NCBI chr15:85,419,638...85,466,022
Ensembl chr15:85,419,638...85,466,674 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16883
    respiratory system phenotype 1853
      abnormal respiratory system morphology 1274
        abnormal lung morphology 830
          abnormal lung epithelium morphology 161
            abnormal pulmonary alveolus epithelium morphology 100
              abnormal pulmonary alveolus epithelial cell morphology 96
                abnormal type I pneumocyte morphology 24
                  decreased type I pneumocyte number + 16
Path 2
Term Annotations click to browse term
  mammalian phenotype 16883
    respiratory system phenotype 1853
      abnormal respiratory system morphology 1274
        abnormal lung morphology 830
          abnormal pulmonary alveolar system morphology 376
            abnormal pulmonary acinus morphology 362
              abnormal pulmonary alveolus morphology 324
                abnormal pulmonary alveolus epithelium morphology 100
                  abnormal pulmonary alveolus epithelial cell morphology 96
                    abnormal type I pneumocyte morphology 24
                      decreased type I pneumocyte number + 16
paths to the root