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Gene: Wfdc2 (WAP four-disulfide core domain 2) Mus musculus
Symbol: Wfdc2
Name: WAP four-disulfide core domain 2
Description: Predicted to have aspartic-type endopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to localize to the extracellular region. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; liver; and retina. Orthologous to human WFDC2 (WAP four-disulfide core domain 2); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1600023A02Rik; HE4; WAP domain-containing protein HE4; WAP four-disulfide core domain protein 2; WAP5
Homo sapiens (human) : WFDC2 (WAP four-disulfide core domain 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Wfdc2 (WAP four-disulfide core domain 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wfdc2 (WAP four-disulfide core domain 2)
Pan paniscus (bonobo/pygmy chimpanzee) : WFDC2 (WAP four-disulfide core domain 2)
Canis lupus familiaris (dog) : WFDC2 (WAP four-disulfide core domain 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wfdc2 (WAP four-disulfide core domain 2)
Sus scrofa (pig) : WFDC2 (WAP four-disulfide core domain 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm382164,562,562 - 164,568,510 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372164,388,216 - 164,394,006 (+)NCBIGRCm37mm9NCBIm37
MGSCv362165,511,843 - 165,517,633 (+)NCBImm8
MGSCv362164,253,921 - 164,259,711 (+)NCBImm8
Celera2170,502,300 - 170,504,943 (+)NCBICelera
Cytogenetic Map2 H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Wfdc2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1551892
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.