Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:central nervous system myelination
go back to main search page
Accession:GO:0022010 term browser browse the term
Definition:The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
Synonyms:exact_synonym: myelination in central nervous system
 only_in_taxon: NCBITaxon:33213 ! Bilateria


show annotations for term's descendants           Sort by:
central nervous system myelination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASPA aspartoacylase ISO RGD PMID:12524181 RGD:632029 NCBI chr12:49,612,845...49,630,303
Ensembl chr12:49,610,519...49,641,864 		JBrowse link
G B4GALT5 beta-1,4-galactosyltransferase 5 involved_in ISS UniProt GO_REF:0000024 NCBI chr17:51,257,273...51,334,566
Ensembl chr17:51,259,813...51,334,020 		JBrowse link
G B4GALT6 beta-1,4-galactosyltransferase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:115,525,515...115,593,265
Ensembl chr 6:115,524,636...115,593,270 		JBrowse link
G CNTN2 contactin 2 acts_upstream_of_or_within ISO (PMID:18650339) MGI PMID:18650339 NCBI chr 9:65,737,488...65,776,412
Ensembl chr 9:65,736,740...65,776,396 		JBrowse link
G CNTNAP1 contactin associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:20,141,222...20,157,341
Ensembl chr12:20,141,641...20,157,044 		JBrowse link
G CNTNAP2 contactin associated protein 2 involved_in ISO (PMID:29300891) MGI PMID:29300891 NCBI chr 9:109,740,510...111,781,144 JBrowse link
G ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO (PMID:21935678) MGI PMID:21935678 NCBI chr 1:31,724,290...31,796,594
Ensembl chr 1:31,722,721...31,796,595 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 acts_upstream_of_or_within ISO (PMID:12574417) MGI PMID:12574417 NCBI chr 8:879,151...894,968
Ensembl chr 8:879,159...894,964 		JBrowse link
G GPM6B glycoprotein M6B involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:10,429,496...10,582,768
Ensembl chr  X:10,430,301...10,582,354 		JBrowse link
G HES5 hes family bHLH transcription factor 5 acts_upstream_of_or_within ISO (PMID:17006542) MGI PMID:17006542 NCBI chr 6:64,409,110...64,410,541
Ensembl chr 6:64,408,956...64,410,881 		JBrowse link
G ID4 inhibitor of DNA binding 4 acts_upstream_of_or_within ISO (PMID:16862533) MGI PMID:16862533 NCBI chr 7:15,281,535...15,284,895
Ensembl chr 7:15,281,757...15,282,839 		JBrowse link
G KCNJ10 potassium inwardly rectifying channel subfamily J member 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17942730) Ensembl
MGI		 PMID:17942730 GO_REF:0000107 NCBI chr 4:90,421,956...90,457,406
Ensembl chr 4:90,422,025...90,457,406 		JBrowse link
G MAG myelin associated glycoprotein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:44,794,197...44,809,933
Ensembl chr 6:44,794,204...44,809,926 		JBrowse link
G MAL mal, T cell differentiation protein acts_upstream_of ISO (PMID:15337780) MGI PMID:15337780 NCBI chr 3:46,223,610...46,242,306
Ensembl chr 3:46,181,555...46,242,047 		JBrowse link
G MYRF myelin regulatory factor involved_in ISO (MGI:3850982|PMID:19596243), (MGI:5544144|PMID:24204311), (MGI:5805298|PMID:27532821) UniProt PMID:19596243 PMID:24204311 PMID:27532821 MGI:3850982 MGI:5544144 MGI:5805298 NCBI chr 2:9,761,230...9,795,873 JBrowse link
G NCSTN nicastrin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:27008863) Ensembl
MGI		 PMID:27008863 GO_REF:0000107 NCBI chr 4:90,121,209...90,142,934
Ensembl chr 4:90,119,002...90,142,890 		JBrowse link
G NKX6-2 NK6 homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15601927) Ensembl
MGI		 PMID:15601927 GO_REF:0000107 NCBI chr14:140,895,622...140,899,114
Ensembl chr14:140,897,874...140,899,155 		JBrowse link
G PLP1 proteolipid protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:1694232) Ensembl
MGI
TreeGrafter
GO_Central		 PMID:1694232 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr  X:84,676,627...84,683,517
Ensembl chr  X:84,666,733...84,685,058 		JBrowse link
G SOX10 SRY-box transcription factor 10 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:9,890,439...9,901,746
Ensembl chr 5:9,891,525...9,901,743 		JBrowse link
G ULK4 unc-51 like kinase 4 acts_upstream_of_or_within ISO (PMID:29034508) MGI PMID:29034508 NCBI chr13:25,207,890...25,751,465
Ensembl chr13:25,209,368...25,751,500 		JBrowse link
central nervous system myelin formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 involved_in
acts_upstream_of_or_within		 ISO PMID:12210128
(MGI:3697245|PMID:17060448)		 UniProt
ARUK-UCL		 PMID:12210128 PMID:17060448 MGI:3697245 RGD:631995
G CKAP5 cytoskeleton associated protein 5 acts_upstream_of_or_within ISO (PMID:28063167) MGI PMID:28063167 NCBI chr 2:15,680,723...15,790,580
Ensembl chr 2:15,680,787...15,790,569 		JBrowse link
G CNTN1 contactin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:72,168,496...72,495,454
Ensembl chr 5:72,168,511...72,495,633 		JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17952069) Ensembl
MGI		 PMID:17952069 GO_REF:0000107 NCBI chr 6:51,734,318...51,757,508
Ensembl chr 6:51,734,320...51,757,553 		JBrowse link
G MAG myelin associated glycoprotein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:44,794,197...44,809,933
Ensembl chr 6:44,794,204...44,809,926 		JBrowse link
G MIOS meiosis regulator for oocyte development involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:77,851,764...77,892,417
Ensembl chr 9:77,851,765...77,893,216 		JBrowse link
G MOBP myelin associated oligodendrocyte basic protein ISO RGD PMID:9306245 RGD:27226697 NCBI chr13:24,138,078...24,186,838 JBrowse link
G TENM4 teneurin transmembrane protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:13,040,615...13,826,957
Ensembl chr 9:13,045,196...13,820,420 		JBrowse link
G TLR2 toll like receptor 2 ISO RGD PMID:21971760 RGD:7241097 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
central nervous system myelin maintenance term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLU clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:11,336,585...11,352,569
Ensembl chr14:11,336,595...11,349,764 		JBrowse link
G FA2H fatty acid 2-hydroxylase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21491498)
(PMID:18815260)		 Ensembl
MGI		 PMID:18815260 PMID:21491498 GO_REF:0000107 NCBI chr 6:12,855,330...12,910,821
Ensembl chr 6:12,855,421...12,910,818 		JBrowse link
G MYRF myelin regulatory factor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 2:9,761,230...9,795,873 JBrowse link
G PTEN phosphatase and tensin homolog involved_in ISO (MGI:3772418|PMID:18082964) CACAO PMID:18082964 MGI:3772418 NCBI chr14:99,929,590...100,021,619 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17806
    cellular process 16838
      ensheathment of neurons 195
        axon ensheathment 195
          myelination 192
            central nervous system myelination 31
              central nervous system myelin formation 9
              central nervous system myelin maintenance 4
Path 2
Term Annotations click to browse term
  biological_process 17806
    developmental process 6728
      anatomical structure development 6324
        multicellular organism development 5115
          system development 4465
            nervous system development 2777
              neurogenesis 2067
                gliogenesis 440
                  glial cell differentiation 325
                    oligodendrocyte differentiation 147
                      oligodendrocyte development 63
                        central nervous system myelination 31
                          central nervous system myelin formation 9
                          central nervous system myelin maintenance 4
paths to the root