ABCA2 (ATP binding cassette subfamily A member 2) - Rat Genome Database

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Gene: ABCA2 (ATP binding cassette subfamily A member 2) Sus scrofa
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Symbol: ABCA2
Name: ATP binding cassette subfamily A member 2
RGD ID: 14216518
Description: ENCODES a protein that exhibits ABC-type transporter activity (inferred); ATP binding (inferred); ATP hydrolysis activity (inferred); INVOLVED IN central nervous system myelin formation (ortholog); ganglioside metabolic process (ortholog); glycosphingolipid metabolic process (ortholog); ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); autism spectrum disorder (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); FOUND IN cytoplasmic vesicle (ortholog); endosome membrane (ortholog); lysosomal membrane (ortholog); INTERACTS WITH deoxynivalenol
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-binding cassette sub-family A member 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position: No map positions available.


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
central nervous system myelin formation  (ISO)
ceramide translocation  (IEA)
cholesterol homeostasis  (IEA)
ganglioside metabolic process  (ISO)
glycosphingolipid metabolic process  (ISO)
intracellular sphingolipid homeostasis  (IEA)
locomotory behavior  (ISO)
negative regulation of cholesterol efflux  (IEA,ISO)
negative regulation of intracellular cholesterol transport  (IEA,ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of phospholipid biosynthetic process  (IEA)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (IEA,ISO)
negative regulation of sphingolipid biosynthetic process  (IEA)
negative regulation of steroid metabolic process  (ISO)
positive regulation of amyloid precursor protein biosynthetic process  (IEA)
positive regulation of amyloid precursor protein catabolic process  (IEA,ISO)
positive regulation of amyloid-beta formation  (IEA,ISO)
positive regulation of low-density lipoprotein particle receptor catabolic process  (IEA,ISO)
regulation of cholesterol biosynthetic process  (ISO)
regulation of intracellular cholesterol transport  (IEA)
regulation of post-translational protein modification  (IEA,ISO)
regulation of protein glycosylation  (ISO)
regulation of protein localization to cell periphery  (ISO)
regulation of protein localization to cell surface  (ISO)
regulation of steroid metabolic process  (IEA,ISO)
response to cholesterol  (IEA)
response to steroid hormone  (IEA)
sphingomyelin metabolic process  (ISO)
sphingosine biosynthetic process  (IEA,ISO)
transmembrane transport  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ABCA2
(Sus scrofa - pig)		 No map positions available.
ABCA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,007,234 - 137,028,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,007,234 - 137,028,915 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,901,686 - 139,923,374 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,021,507 - 139,043,195 (-)NCBINCBI36Build 36hg18NCBI36
Build 349137,177,522 - 137,199,211NCBI
Celera9110,414,121 - 110,431,191 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,360,841 - 109,382,226 (-)NCBIHuRef
CHM1_19140,050,436 - 140,072,137 (-)NCBICHM1_1
T2T-CHM13v2.09149,241,651 - 149,263,357 (-)NCBIT2T-CHM13v2.0
Abca2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,318,611 - 25,338,556 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,318,715 - 25,338,552 (+)EnsemblGRCm39 Ensembl
GRCm38225,428,599 - 25,448,544 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,428,703 - 25,448,540 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,284,194 - 25,304,059 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,250,779 - 25,270,208 (+)NCBIMGSCv36mm8
Celera225,156,185 - 25,176,102 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.25NCBI
Abca2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,642,660 - 28,662,689 (+)NCBIGRCr8
mRatBN7.238,244,515 - 8,264,545 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,244,639 - 8,264,537 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,349,736 - 11,369,666 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,935,958 - 19,955,888 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,125,806 - 18,145,736 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,648,787 - 2,668,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,648,885 - 2,668,809 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,630,237 - 2,650,183 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,595,423 - 3,615,328 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,595,422 - 3,615,327 (+)NCBI
Celera33,069,743 - 3,089,646 (+)NCBICelera
Cytogenetic Map3p13NCBI
Abca2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,033,771 - 5,051,200 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,035,879 - 5,051,140 (-)NCBIChiLan1.0ChiLan1.0
ABCA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,369,797 - 2,391,636 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,372,769 - 2,393,970 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,067,633 - 108,089,742 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,039,264 - 137,057,527 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,036,696 - 137,057,776 (-)Ensemblpanpan1.1panPan2
ABCA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,610,906 - 48,630,932 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,613,996 - 48,629,857 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,824,500 - 47,844,585 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,488,905 - 49,509,018 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1948,265,133 - 48,285,232 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,563,850 - 48,583,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,611,199 - 48,631,304 (+)NCBIUU_Cfam_GSD_1.0
Abca2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,433,062 - 202,454,661 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669926,622 - 942,167 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936669922,978 - 941,996 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,161,340 - 1,183,807 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,162,865 - 1,183,113 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,118,329 - 4,134,713 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abca2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760880,148 - 898,751 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760880,216 - 898,753 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Protein Domains
ABC transporter


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000039264 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00030016841 UniProtKB/TrEMBL
  ENSSSCG00035041528 UniProtKB/TrEMBL
  ENSSSCG00040041759 UniProtKB/TrEMBL
  ENSSSCG00045012856 UniProtKB/TrEMBL
  ENSSSCG00055017252 UniProtKB/TrEMBL
  ENSSSCG00060035905 UniProtKB/TrEMBL
  ENSSSCG00065009350 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000058993.3 UniProtKB/TrEMBL
  ENSSSCT00000092858 ENTREZGENE
  ENSSSCT00000092858.1 UniProtKB/TrEMBL
  ENSSSCT00000094336.1 UniProtKB/TrEMBL
  ENSSSCT00000096193.1 UniProtKB/TrEMBL
  ENSSSCT00000097843.1 UniProtKB/TrEMBL
  ENSSSCT00000100238.1 UniProtKB/TrEMBL
  ENSSSCT00000100962.1 UniProtKB/TrEMBL
  ENSSSCT00000104903.1 UniProtKB/TrEMBL
  ENSSSCT00030023307.1 UniProtKB/TrEMBL
  ENSSSCT00030023378.1 UniProtKB/TrEMBL
  ENSSSCT00035055179.1 UniProtKB/TrEMBL
  ENSSSCT00035055202.1 UniProtKB/TrEMBL
  ENSSSCT00035055232.1 UniProtKB/TrEMBL
  ENSSSCT00040055859.1 UniProtKB/TrEMBL
  ENSSSCT00045021911.1 UniProtKB/TrEMBL
  ENSSSCT00045022044.1 UniProtKB/TrEMBL
  ENSSSCT00045022163.1 UniProtKB/TrEMBL
  ENSSSCT00055033950.1 UniProtKB/TrEMBL
  ENSSSCT00055034492.1 UniProtKB/TrEMBL
  ENSSSCT00055034900.1 UniProtKB/TrEMBL
  ENSSSCT00060048656.1 UniProtKB/TrEMBL
  ENSSSCT00060048689.1 UniProtKB/TrEMBL
  ENSSSCT00065012511.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  ABC2_TM UniProtKB/TrEMBL
  ABC_transporter-like_ATP-bd UniProtKB/TrEMBL
  ABC_transporter-like_CS UniProtKB/TrEMBL
  ABCA UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene ABCA2 ENTREZGENE
PANTHER PTHR19229 UniProtKB/TrEMBL
  PTHR19229:SF225 UniProtKB/TrEMBL
Pfam ABC2_membrane_3 UniProtKB/TrEMBL
  ABC_tran UniProtKB/TrEMBL
PROSITE ABC_TRANSPORTER_1 UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8D0ZXZ6_PIG UniProtKB/TrEMBL
  A0A8D0ZZ64_PIG UniProtKB/TrEMBL
  A0A8D1CUL2_PIG UniProtKB/TrEMBL
  A0A8D1ENH4_PIG UniProtKB/TrEMBL
  A0A8D1H8S7_PIG UniProtKB/TrEMBL
  A0A8D1HC59_PIG UniProtKB/TrEMBL
  A0A8D1HEG2_PIG UniProtKB/TrEMBL
  A0A8D1V9E7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1XHK7_PIG UniProtKB/TrEMBL
  A0A8W4F7M9_PIG UniProtKB/TrEMBL
  A0A8W4F8D9_PIG UniProtKB/TrEMBL
  A0A8W4F9B5_PIG UniProtKB/TrEMBL
  A0A8W4FFW8_PIG UniProtKB/TrEMBL
  A0A8W4FHG4_PIG UniProtKB/TrEMBL
  A0A8W4FLY6_PIG UniProtKB/TrEMBL
  A0A8W4FMJ6_PIG UniProtKB/TrEMBL
  A0A8W4FR26_PIG UniProtKB/TrEMBL