Abca2 (ATP binding cassette subfamily A member 2) - Rat Genome Database
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Gene: Abca2 (ATP binding cassette subfamily A member 2) Chinchilla lanigera
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Symbol: Abca2
Name: ATP binding cassette subfamily A member 2
RGD ID: 8931344
Description: ENCODES a protein that exhibits ATP binding (ortholog); ATPase activity (ortholog); ceramide floppase activity (ortholog); INVOLVED IN cellular sphingolipid homeostasis (ortholog); central nervous system myelin formation (ortholog); ceramide translocation (ortholog); ASSOCIATED WITH autosomal dominant non-syndromic intellectual disability 8 (ortholog); INTELLECTUAL DEVELOPMENTAL DISORDER WITH POOR GROWTH AND WITH OR WITHOUT SEIZURES OR ATAXIA (ortholog); Kleefstra syndrome 1 (ortholog); FOUND IN cytoplasmic vesicle (ortholog); endosome (ortholog); endosome membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: ATP-binding cassette sub-family A member 2; ATP-binding cassette, sub-family A (ABC1), member 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,033,771 - 5,051,200 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,035,879 - 5,051,140 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular sphingolipid homeostasis  (ISO)
central nervous system myelin formation  (ISO)
ceramide translocation  (ISO)
cholesterol homeostasis  (ISO)
ganglioside metabolic process  (ISO)
glycosphingolipid metabolic process  (ISO)
locomotory behavior  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of cholesterol esterification  (ISO)
negative regulation of intracellular cholesterol transport  (ISO)
negative regulation of low-density lipoprotein receptor activity  (ISO)
negative regulation of phospholipid biosynthetic process  (ISO)
negative regulation of receptor-mediated endocytosis involved in cholesterol transport  (ISO)
negative regulation of sphingolipid biosynthetic process  (ISO)
positive regulation of amyloid precursor protein biosynthetic process  (ISO)
positive regulation of amyloid precursor protein catabolic process  (ISO)
positive regulation of amyloid-beta formation  (ISO)
positive regulation of low-density lipoprotein particle receptor catabolic process  (ISO)
regulation of cholesterol biosynthetic process  (ISO)
regulation of cholesterol esterification  (ISO)
regulation of intracellular cholesterol transport  (ISO)
regulation of post-translational protein modification  (ISO)
regulation of protein glycosylation  (ISO)
regulation of protein localization to cell periphery  (ISO)
regulation of protein localization to cell surface  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to cholesterol  (ISO)
response to steroid hormone  (ISO)
sphingomyelin metabolic process  (ISO)
sphingosine biosynthetic process  (ISO)

Cellular Component

Molecular Function

References


Genomics

Comparative Map Data
Abca2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,033,771 - 5,051,200 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,035,879 - 5,051,140 (-)NCBIChiLan1.0ChiLan1.0
ABCA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9137,007,234 - 137,028,922 (-)EnsemblGRCh38hg38GRCh38
GRCh389137,007,234 - 137,028,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379139,901,686 - 139,923,374 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,021,507 - 139,043,195 (-)NCBINCBI36hg18NCBI36
Build 349137,177,522 - 137,199,211NCBI
Celera9110,414,121 - 110,431,191 (-)NCBI
Cytogenetic Map9q34.3NCBI
HuRef9109,360,841 - 109,382,226 (-)NCBIHuRef
CHM1_19140,050,436 - 140,072,137 (-)NCBICHM1_1
Abca2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,318,611 - 25,338,556 (+)NCBIGRCm39mm39
GRCm38225,428,599 - 25,448,544 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,428,703 - 25,448,540 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,284,194 - 25,304,059 (+)NCBIGRCm37mm9NCBIm37
MGSCv36225,250,779 - 25,270,208 (+)NCBImm8
Celera225,156,185 - 25,176,102 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.25NCBI
Abca2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.032,648,787 - 2,668,770 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,648,885 - 2,668,809 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,630,237 - 2,650,183 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,595,423 - 3,615,328 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.133,595,422 - 3,615,327 (+)NCBI
Celera33,069,743 - 3,089,646 (+)NCBICelera
Cytogenetic Map3p13NCBI
ABCA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19137,039,264 - 137,057,527 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,036,696 - 137,057,776 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09108,067,633 - 108,089,742 (-)NCBIMhudiblu_PPA_v0panPan3
ABCA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl948,613,996 - 48,629,857 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1948,610,906 - 48,630,932 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Abca2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936669922,978 - 941,996 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCA2
(Sus scrofa - pig)
No map positions available.
ABCA2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl121,162,865 - 1,183,113 (+)Ensembl
ChlSab1.1121,161,340 - 1,183,807 (+)NCBI
Abca2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624760880,216 - 898,753 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000011983   ⟹   ENSCLAP00000011844
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555135,033,771 - 5,051,200 (-)Ensembl
RefSeq Acc Id: XM_013506707   ⟹   XP_013362161
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555135,035,879 - 5,051,140 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013362161 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013362161   ⟸   XM_013506707
- Sequence:
RefSeq Acc Id: ENSCLAP00000011844   ⟸   ENSCLAT00000011983


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000008162 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000011844 ENTREZGENE
Ensembl Transcript ENSCLAT00000011983 ENTREZGENE
NCBI Gene Abca2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Abca2  ATP binding cassette subfamily A member 2    ATP-binding cassette, sub-family A (ABC1), member 2  Symbol and/or name change 5135510 APPROVED