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ONTOLOGY REPORT - ANNOTATIONS

Term:nucleotide-binding oligomerization domain containing 1 signaling pathway
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Accession:GO:0070427 term browser browse the term
Definition:The series of molecular signals initiated by the binding of a ligand (such as a bacterial peptidoglycan) to a cytoplasmic nucleotide-binding oligomerization domain containing 1 (NOD1) protein receptor, and ending with regulation of a downstream cellular process.
Synonyms:exact_synonym: NOD1 signaling pathway;   nucleotide-binding oligomerization domain containing 1 signalling pathway


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nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nfkbia NFKB inhibitor alpha acts_upstream_of_or_within ISO (PMID:18261938) RGD PMID:18261938 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 involved_in ISO (PMID:11058605), (PMID:12791997), (PMID:12796777)
(PMID:27007849)		 RGD PMID:11058605 PMID:12791997 PMID:12796777 PMID:27007849 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404 		JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 involved_in
acts_upstream_of_or_within		 ISO (PMID:29452636), (PMID:30279485)
MGI:2660793 (PMID:11894098)		 RGD PMID:11894098 PMID:29452636 PMID:30279485 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
(PMID:18261938)		 Ensembl
RGD		 PMID:18261938 GO_REF:0000107 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Xiap X-linked inhibitor of apoptosis involved_in ISO
IEA		 (PMID:29452636)
GO_REF:0000107		 RGD
Ensembl		 PMID:29452636 GO_REF:0000107 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfaip3 TNF alpha induced protein 3 involved_in ISO (PMID:18342009) RGD PMID:18342009 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282 		JBrowse link
positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc15a4 solute carrier family 15 member 4 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:19570976), (PMID:21277849)		 Ensembl
UniProt
RGD		 PMID:19570976 PMID:21277849 GO_REF:0000024 GO_REF:0000107 NCBI chr12:29,048,634...29,082,480
Ensembl chr12:29,063,015...29,082,480 		JBrowse link
G Slc46a2 solute carrier family 46, member 2 involved_in ISO (PMID:28539433) RGD PMID:28539433 NCBI chr 5:74,800,226...74,808,128
Ensembl chr 5:74,800,226...74,808,128 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:18261938)		 Ensembl
RGD		 PMID:18261938 GO_REF:0000107 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Peli3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO (PMID:23892723) RGD PMID:23892723 NCBI chr 1:202,230,034...202,242,900
Ensembl chr 1:202,232,228...202,242,857 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      signal transduction 7180
        intracellular signal transduction 3073
          intracellular receptor signaling pathway 392
            cytoplasmic pattern recognition receptor signaling pathway 181
              nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 24
                nucleotide-binding oligomerization domain containing 1 signaling pathway 9
                  negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway 1
                  positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway 3
                  regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 20069
    response to stimulus 10792
      response to biotic stimulus 1910
        response to external biotic stimulus 1863
          response to other organism 1859
            defense response to other organism 1311
              defense response to symbiont 1177
                innate immune response 1005
                  regulation of innate immune response 480
                    positive regulation of innate immune response 386
                      activation of innate immune response 314
                        innate immune response-activating signaling pathway 287
                          pattern recognition receptor signaling pathway 276
                            cytoplasmic pattern recognition receptor signaling pathway 181
                              nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway 24
                                nucleotide-binding oligomerization domain containing 1 signaling pathway 9
                                  negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway 1
                                  positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway 3
                                  regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway + 5
paths to the root