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ONTOLOGY REPORT - ANNOTATIONS

Term:hepatocyte differentiation
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Accession:GO:0070365 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver.
Synonyms:exact_synonym: liver cell differentiation

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hepatocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:11668598 GO_REF:0000118 RGD:2306909 NCBI chrNW_004936503:9,124,314...9,142,372
Ensembl chrNW_004936503:9,124,264...9,142,413 		JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 ISO RGD PMID:12939595 RGD:4144098 NCBI chrNW_004936586:5,739,038...5,850,317
Ensembl chrNW_004936586:5,739,337...5,850,312 		JBrowse link
G E2f7 E2F transcription factor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936568:5,206,135...5,245,324
Ensembl chrNW_004936568:5,206,135...5,244,450 		JBrowse link
G E2f8 E2F transcription factor 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936654:322,863...339,365
Ensembl chrNW_004936654:322,863...338,699 		JBrowse link
G Foxh1 forkhead box H1 ISO RGD PMID:22715131 RGD:155791677 NCBI chrNW_004936470:7,789,486...7,791,067
Ensembl chrNW_004936470:7,789,541...7,791,039 		JBrowse link
G Frzb frizzled related protein involved_in
acts_upstream_of		 IEA
ISO		 (PMID:19562671) Ensembl
MGI		 PMID:19562671 GO_REF:0000107 NCBI chrNW_004936509:11,440,414...11,471,042
Ensembl chrNW_004936509:11,440,148...11,470,967 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO RGD PMID:10934156 RGD:14701049 NCBI chrNW_004936619:762,278...791,610 JBrowse link
G Hhex hematopoietically expressed homeobox acts_upstream_of_or_within ISO (PMID:11027604) MGI PMID:11027604 NCBI chrNW_004936601:2,137,490...2,143,797
Ensembl chrNW_004936601:2,136,873...2,143,857 		JBrowse link
G Hnf1b HNF1 homeobox B ISO RGD PMID:18286537 RGD:2312718 NCBI chrNW_004936490:649,551...702,448
Ensembl chrNW_004936490:649,546...702,672 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4 alpha ISO RGD PMID:19621519 RGD:12904750 NCBI chrNW_004936530:2,401,053...2,425,989
Ensembl chrNW_004936530:2,401,043...2,454,466 		JBrowse link
G Itga2 integrin subunit alpha 2 ISO RGD PMID:16458388 RGD:2307397 NCBI chrNW_004936480:14,320,292...14,417,828
Ensembl chrNW_004936480:14,320,692...14,417,786 		JBrowse link
G Krt18 keratin 18 ISO RGD PMID:24340101 PMID:28941653 RGD:27226712 RGD:27226713 NCBI chrNW_004936512:10,290,706...10,294,647
Ensembl chrNW_004936512:10,290,690...10,294,651 		JBrowse link
G LOC101969148 cytochrome P450 1A1 ISO RGD PMID:17574236 RGD:2306655 NCBI chrNW_004936471:33,682,730...33,688,332
Ensembl chrNW_004936471:33,682,730...33,688,332 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936530:361,872...367,005
Ensembl chrNW_004936530:361,872...367,005 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2, mitochondrial involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936722:428,473...450,452
Ensembl chrNW_004936722:428,307...437,328 		JBrowse link
G Prox1 prospero homeobox 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936628:4,185,712...4,240,680
Ensembl chrNW_004936628:4,185,706...4,238,451 		JBrowse link
G Smarcb1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16138077) Ensembl
MGI		 PMID:16138077 GO_REF:0000107 NCBI chrNW_004936619:1,276,239...1,308,945
Ensembl chrNW_004936619:1,275,362...1,308,913 		JBrowse link
G Taf10 TATA-box binding protein associated factor 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18722179) Ensembl
MGI		 PMID:18722179 GO_REF:0000107 NCBI chrNW_004936842:667,960...669,367
Ensembl chrNW_004936842:667,936...669,441 		JBrowse link
G Wnt1 Wnt family member 1 ISO RGD PMID:20413689 RGD:2326223 NCBI chrNW_004936512:6,781,001...6,785,358
Ensembl chrNW_004936512:6,780,882...6,785,358 		JBrowse link
negative regulation of hepatocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Frzb frizzled related protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19562671) Ensembl
MGI		 PMID:19562671 GO_REF:0000107 NCBI chrNW_004936509:11,440,414...11,471,042
Ensembl chrNW_004936509:11,440,148...11,470,967 		JBrowse link
positive regulation of hepatocyte differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 ISO RGD PMID:19229878 RGD:8885195 NCBI chrNW_004936697:1,054,237...1,061,468
Ensembl chrNW_004936697:1,056,636...1,061,468 		JBrowse link
G Foxa3 forkhead box A3 ISO RGD PMID:9878541 RGD:2315086 NCBI chrNW_004936706:2,196,530...2,202,924
Ensembl chrNW_004936706:2,196,468...2,203,113 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:15,533,264...15,534,576
Ensembl chrNW_004936483:15,533,522...15,534,576 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15975
    cellular process 15076
      cellular developmental process 4259
        cell differentiation 4258
          epithelial cell differentiation 762
            hepatocyte differentiation 22
              negative regulation of hepatocyte differentiation 1
              positive regulation of hepatocyte differentiation 3
              regulation of hepatocyte differentiation + 4
Path 2
Term Annotations click to browse term
  biological_process 15975
    developmental process 6338
      anatomical structure development 5971
        multicellular organism development 4846
          system development 4223
            hepaticobiliary system development 265
              liver development 262
                hepatocyte differentiation 22
                  negative regulation of hepatocyte differentiation 1
                  positive regulation of hepatocyte differentiation 3
                  regulation of hepatocyte differentiation + 4
paths to the root