Hhex (hematopoietically expressed homeobox) - Rat Genome Database

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Gene: Hhex (hematopoietically expressed homeobox) Ictidomys tridecemlineatus
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Symbol: Hhex
Name: hematopoietically expressed homeobox
RGD ID: 12576728
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding, bending (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); B cell differentiation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); fatty liver disease (ortholog); type 2 diabetes mellitus (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); protein-DNA complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: hematopoietically-expressed homeobox protein HHEX
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721340,504,266 - 40,511,263 (-)NCBI
SpeTri2.0NW_0049366012,137,490 - 2,143,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
anterior/posterior pattern specification  (ISO)
B cell differentiation  (ISO)
cell differentiation  (ISO)
common bile duct development  (ISO)
DNA conformation change  (ISO)
embryonic heart tube development  (ISO)
embryonic organ development  (ISO)
endoderm development  (ISO)
forebrain development  (ISO)
forebrain morphogenesis  (ISO)
gall bladder development  (ISO)
hemopoiesis  (ISO)
hepatic duct development  (ISO)
hepatoblast differentiation  (ISO)
hepatocyte differentiation  (ISO)
in utero embryonic development  (ISO)
interkinetic nuclear migration  (ISO)
liver development  (ISO)
morphogenesis of an epithelium  (ISO)
mRNA export from nucleus  (ISO)
multicellular organism growth  (ISO)
myeloid leukocyte differentiation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cyclin-dependent protein serine/threonine kinase activity  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
negative regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
Notch signaling pathway  (ISO)
pancreas development  (ISO)
poly(A)+ mRNA export from nucleus  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of Wnt signaling pathway  (ISO)
primary lung bud formation  (ISO)
primitive streak formation  (ISO)
protein localization to nucleus  (ISO)
regulation of cell population proliferation  (ISO)
regulation of leukocyte proliferation  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to peptide hormone  (ISO)
response to wounding  (ISO)
signal transduction  (ISO)
thyroid gland development  (ISO)
tissue morphogenesis  (ISO)
vasculogenesis  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
Hhex
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721340,504,266 - 40,511,263 (-)NCBI
SpeTri2.0NW_0049366012,137,490 - 2,143,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HHEX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1092,689,955 - 92,695,647 (+)EnsemblGRCh38hg38GRCh38
GRCh381092,689,955 - 92,695,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371094,449,712 - 94,455,404 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,439,661 - 94,445,388 (+)NCBINCBI36hg18NCBI36
Build 341094,439,691 - 94,445,383NCBI
Celera1088,191,085 - 88,196,812 (+)NCBI
Cytogenetic Map10q23.33NCBI
HuRef1088,076,253 - 88,081,980 (+)NCBIHuRef
CHM1_11094,732,137 - 94,737,863 (+)NCBICHM1_1
Hhex
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,423,289 - 37,429,179 (+)NCBIGRCm39mm39
GRCm39 Ensembl1937,423,258 - 37,429,179 (+)Ensembl
GRCm381937,434,841 - 37,440,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,434,810 - 37,440,731 (+)EnsemblGRCm38mm10GRCm38
MGSCv371937,509,331 - 37,515,221 (+)NCBIGRCm37mm9NCBIm37
MGSCv361937,499,985 - 37,505,875 (+)NCBImm8
Celera1938,221,629 - 38,227,525 (+)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.28NCBI
Hhex
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21235,190,455 - 235,196,042 (+)NCBI
Rnor_6.0 Ensembl1256,101,903 - 256,107,649 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01256,101,994 - 256,107,581 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01263,583,988 - 263,589,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,736,542 - 241,742,129 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11241,926,133 - 241,931,721 (+)NCBI
Celera1232,281,249 - 232,286,836 (+)NCBICelera
Cytogenetic Map1q53NCBI
Hhex
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955425735,378 - 742,775 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955425737,506 - 742,775 (-)NCBIChiLan1.0ChiLan1.0
HHEX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11092,947,373 - 92,952,992 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1092,947,373 - 92,952,992 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01089,433,402 - 89,439,137 (+)NCBIMhudiblu_PPA_v0panPan3
HHEX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,057,379 - 7,063,326 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,057,283 - 7,063,330 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,233,996 - 7,239,896 (+)NCBI
ROS_Cfam_1.0287,317,251 - 7,323,151 (+)NCBI
UMICH_Zoey_3.1287,037,744 - 7,043,641 (+)NCBI
UNSW_CanFamBas_1.0287,072,416 - 7,078,310 (+)NCBI
UU_Cfam_GSD_1.0287,236,847 - 7,242,744 (+)NCBI
HHEX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14104,194,343 - 104,200,221 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114104,194,424 - 104,199,684 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214113,794,343 - 113,799,603 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HHEX
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1985,957,684 - 85,963,414 (+)NCBI
ChlSab1.1 Ensembl985,957,779 - 85,963,404 (+)Ensembl
Hhex
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247373,897,907 - 3,903,828 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005333728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010002273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005333728   ⟹   XP_005333785
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440721340,504,266 - 40,511,263 (-)NCBI
SpeTri2.0NW_0049366012,137,490 - 2,143,797 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005333785 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005333785   ⟸   XM_005333728
- UniProtKB: I3M7I6 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000006255 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000005583 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000006245 UniProtKB/TrEMBL
InterPro Homeobox-like UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
NCBI Gene Hhex ENTREZGENE
Pfam Homeobox UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt I3M7I6 ENTREZGENE, UniProtKB/TrEMBL