Mesp1 (mesoderm posterior bHLH transcription factor 1) - Rat Genome Database

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Gene: Mesp1 (mesoderm posterior bHLH transcription factor 1) Ictidomys tridecemlineatus
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Symbol: Mesp1
Name: mesoderm posterior bHLH transcription factor 1
RGD ID: 12529872
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN cardiac atrium formation (ortholog); cardiac cell fate determination (ortholog); cardiac muscle cell differentiation (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); colon cancer (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: mesoderm posterior 1 homolog; mesoderm posterior protein 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,799,944 - 130,801,262 (+)NCBI
SpeTri2.0NW_00493648315,533,264 - 15,534,576 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac atrium formation  (ISO)
cardiac cell fate determination  (ISO)
cardiac muscle cell differentiation  (ISO)
cardiac vascular smooth muscle cell differentiation  (ISO)
cardiac ventricle formation  (ISO)
cardioblast anterior-lateral migration  (ISO)
cardioblast migration  (ISO)
cardioblast migration to the midline involved in heart field formation  (ISO)
embryonic heart tube morphogenesis  (ISO)
endothelial cell differentiation  (ISO)
gastrulation  (ISO)
gene expression  (ISO)
growth involved in heart morphogenesis  (ISO)
heart looping  (ISO)
heart morphogenesis  (ISO)
lateral mesoderm development  (ISO)
mesodermal cell migration  (ISO)
negative regulation of endodermal cell fate specification  (ISO)
negative regulation of mesodermal cell fate specification  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
neurogenesis  (ISO)
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of hepatocyte differentiation  (ISO)
positive regulation of Notch signaling pathway  (ISO)
positive regulation of Notch signaling pathway involved in heart induction  (ISO)
positive regulation of striated muscle cell differentiation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
secondary heart field specification  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
sinoatrial node cell differentiation  (ISO)
sinus venosus morphogenesis  (ISO)

Cellular Component
nucleus  (ISO)

References

Genomics

Comparative Map Data
Mesp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,799,944 - 130,801,262 (+)NCBI
SpeTri2.0NW_00493648315,533,264 - 15,534,576 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MESP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1589,748,661 - 89,751,310 (-)EnsemblGRCh38hg38GRCh38
GRCh381589,734,772 - 89,751,309 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371590,293,098 - 90,294,540 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,094,110 - 88,095,552 (-)NCBINCBI36hg18NCBI36
Celera1566,695,858 - 66,697,300 (-)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1566,406,054 - 66,407,496 (-)NCBIHuRef
CHM1_11590,133,926 - 90,135,368 (-)NCBICHM1_1
Mesp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39779,441,989 - 79,443,338 (-)NCBIGRCm39mm39
GRCm39 Ensembl779,441,989 - 79,443,536 (-)Ensembl
GRCm38779,792,241 - 79,793,590 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,792,241 - 79,793,788 (-)EnsemblGRCm38mm10GRCm38
MGSCv37786,937,127 - 86,938,476 (-)NCBIGRCm37mm9NCBIm37
MGSCv36779,665,760 - 79,667,119 (-)NCBImm8
Celera777,191,445 - 77,192,794 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.16NCBI
Mesp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21133,738,357 - 133,739,875 (-)NCBI
Rnor_6.0 Ensembl1141,532,390 - 141,533,908 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01141,532,390 - 141,533,908 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01142,493,452 - 142,494,970 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41135,571,777 - 135,573,295 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11135,650,456 - 135,651,437 (-)NCBI
Celera1125,801,663 - 125,803,181 (-)NCBICelera
Cytogenetic Map1q31NCBI
MESP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11587,645,768 - 87,647,210 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1587,645,768 - 87,647,210 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01568,440,626 - 68,441,935 (-)NCBIMhudiblu_PPA_v0panPan3
MESP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1352,738,333 - 52,739,962 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl352,738,366 - 52,739,755 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,372,284 - 55,373,854 (-)NCBI
ROS_Cfam_1.0353,155,122 - 53,156,692 (-)NCBI
UMICH_Zoey_3.1352,676,925 - 52,678,493 (-)NCBI
UNSW_CanFamBas_1.0352,886,866 - 52,888,431 (-)NCBI
UU_Cfam_GSD_1.0353,227,220 - 53,228,790 (-)NCBI
MESP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl755,322,010 - 55,325,732 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1755,322,016 - 55,327,600 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2760,211,078 - 60,218,711 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MESP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,286,551 - 8,288,777 (-)NCBI
ChlSab1.1 Ensembl298,286,828 - 8,287,918 (-)Ensembl


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005320139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010003700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005320139   ⟹   XP_005320196
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024408640130,799,944 - 130,801,262 (+)NCBI
SpeTri2.0NW_00493648315,533,264 - 15,534,576 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005320196 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005320196   ⟸   XM_005320139
- Sequence:
Protein Domains
bHLH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000026434 UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000020441 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000019886 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Mesogenin/MesP UniProtKB/TrEMBL
NCBI Gene Mesp1 ENTREZGENE
PANTHER PTHR20937 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt I3N7U5_ICTTR UniProtKB/TrEMBL