Hnf1b (HNF1 homeobox B) - Rat Genome Database

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Gene: Hnf1b (HNF1 homeobox B) Ictidomys tridecemlineatus
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Symbol: Hnf1b
Name: HNF1 homeobox B
RGD ID: 12697983
Description: ENCODES a protein that exhibits cis-regulatory region sequence-specific DNA binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); branching morphogenesis of an epithelial tube (ortholog); circadian regulation of gene expression (ortholog); PARTICIPATES IN forkhead class A signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); CAKUT (ortholog); FOUND IN intracellular membrane-bounded organelle (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: hepatocyte nuclear factor 1-beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560236,371,915 - 36,425,499 (-)NCBI
SpeTri2.0NW_004936490649,551 - 702,448 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
circadian regulation of gene expression  (ISO)
embryonic digestive tract morphogenesis  (ISO)
embryonic morphogenesis  (ISO)
endocrine pancreas development  (ISO)
endoderm development  (ISO)
endodermal cell fate specification  (ISO)
epithelial cell proliferation  (ISO)
epithelium development  (ISO)
genitalia development  (ISO)
hepatoblast differentiation  (ISO)
hepatocyte differentiation  (ISO)
hindbrain development  (ISO)
inner cell mass cell differentiation  (ISO)
insulin secretion  (ISO)
kidney development  (ISO)
kidney morphogenesis  (ISO)
liver development  (ISO)
mesonephric duct development  (ISO)
mesonephric duct formation  (ISO)
mesonephric tubule development  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis  (ISO)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
nephric duct development  (ISO)
nephric duct formation  (ISO)
Notch signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription initiation from RNA polymerase II promoter  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
pronephric nephron tubule development  (ISO)
pronephros development  (ISO)
protein-DNA complex assembly  (ISO)
regulation of branch elongation involved in ureteric bud branching  (ISO)
regulation of pronephros size  (ISO)
regulation of Wnt signaling pathway  (ISO)
response to carbohydrate  (ISO)
response to drug  (ISO)
response to glucose  (ISO)
response to organic cyclic compound  (ISO)
ureteric bud elongation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Hnf1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560236,371,915 - 36,425,499 (-)NCBI
SpeTri2.0NW_004936490649,551 - 702,448 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HNF1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1737,686,431 - 37,745,105 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1737,686,431 - 37,745,059 (-)EnsemblGRCh38hg38GRCh38
GRCh381737,686,431 - 37,745,059 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371736,046,434 - 36,105,050 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361733,120,547 - 33,179,209 (-)NCBINCBI36hg18NCBI36
Build 341733,162,728 - 33,179,182NCBI
Celera1732,869,487 - 32,928,989 (-)NCBI
Cytogenetic Map17q12ENTREZGENE
HuRef1731,984,120 - 32,042,660 (-)NCBIHuRef
CHM1_11736,077,994 - 36,136,641 (-)NCBICHM1_1
Hnf1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,741,035 - 83,796,743 (+)NCBIGRCm39mm39
GRCm39 Ensembl1183,740,889 - 83,796,645 (+)Ensembl
GRCm381183,850,209 - 83,905,917 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,850,063 - 83,905,819 (+)EnsemblGRCm38mm10GRCm38
MGSCv371183,664,371 - 83,719,317 (+)NCBIGRCm37mm9NCBIm37
MGSCv361183,667,244 - 83,721,542 (+)NCBImm8
Celera1193,455,173 - 93,510,691 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.23NCBI
Hnf1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21068,735,894 - 68,789,888 (+)NCBI
Rnor_6.0 Ensembl1071,159,869 - 71,218,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01071,159,863 - 71,218,902 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01070,778,492 - 70,829,745 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41072,081,091 - 72,187,014 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11072,095,460 - 72,201,382 (+)NCBI
Celera1067,668,848 - 67,719,403 (+)NCBICelera
Cytogenetic Map10q26NCBI
Hnf1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955451320,283 - 371,420 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955451320,283 - 371,420 (+)NCBIChiLan1.0ChiLan1.0
HNF1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11719,633,424 - 19,691,863 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1719,633,424 - 19,691,863 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01719,333,485 - 19,392,147 (+)NCBIMhudiblu_PPA_v0panPan3
HNF1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1937,437,992 - 37,493,200 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,438,583 - 37,492,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha936,661,511 - 36,717,034 (-)NCBI
ROS_Cfam_1.0938,248,175 - 38,303,484 (-)NCBI
UMICH_Zoey_3.1937,029,129 - 37,084,643 (-)NCBI
UNSW_CanFamBas_1.0937,316,583 - 37,372,144 (-)NCBI
UU_Cfam_GSD_1.0937,403,808 - 37,459,176 (-)NCBI
HNF1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1239,143,121 - 39,313,511 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11239,143,119 - 39,201,631 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21240,788,316 - 40,846,557 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HNF1B
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11630,033,486 - 30,097,106 (+)NCBI
ChlSab1.1 Ensembl1630,036,766 - 30,097,088 (+)Ensembl
Vero_WHO_p1.0NW_023666077760,378 - 820,920 (+)NCBI
Hnf1b
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248714,662,104 - 4,713,125 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005321506   ⟹   XP_005321563
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560236,371,915 - 36,425,324 (-)NCBI
SpeTri2.0NW_004936490649,726 - 702,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005321507   ⟹   XP_005321564
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560236,372,721 - 36,425,499 (-)NCBI
SpeTri2.0NW_004936490649,551 - 702,329 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005321508   ⟹   XP_005321565
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560236,372,798 - 36,425,324 (-)NCBI
SpeTri2.0NW_004936490649,726 - 702,252 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005321509   ⟹   XP_005321566
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440560236,372,602 - 36,425,499 (-)NCBI
SpeTri2.0NW_004936490649,551 - 702,448 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013356985   ⟹   XP_013212439
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_004936490649,599 - 702,382 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005321563 (Get FASTA)   NCBI Sequence Viewer  
  XP_005321564 (Get FASTA)   NCBI Sequence Viewer  
  XP_005321565 (Get FASTA)   NCBI Sequence Viewer  
  XP_005321566 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005321563   ⟸   XM_005321506
- Peptide Label: isoform X1
- UniProtKB: I3MJ59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005321565   ⟸   XM_005321508
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005321564   ⟸   XM_005321507
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005321566   ⟸   XM_005321509
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013212439   ⟸   XM_013356985
- Peptide Label: isoform X5
- Sequence:
Protein Domains
Homeobox


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000012440 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000011150 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000012442 UniProtKB/TrEMBL
Gene3D-CATH 1.10.260.40 UniProtKB/TrEMBL
InterPro HNF-1 UniProtKB/TrEMBL
  HNF-1_N UniProtKB/TrEMBL
  HNF1_dimer_dom UniProtKB/TrEMBL
  HNF1b_C UniProtKB/TrEMBL
  Homeobox-like UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Lambda_DNA-bd_dom UniProtKB/TrEMBL
NCBI Gene Hnf1b ENTREZGENE
PANTHER PTHR11568 UniProtKB/TrEMBL
Pfam HNF-1_N UniProtKB/TrEMBL
  HNF-1B_C UniProtKB/TrEMBL
PROSITE HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF100957 UniProtKB/TrEMBL
  SSF46689 UniProtKB/TrEMBL
  SSF47413 UniProtKB/TrEMBL
UniProt I3MJ59 ENTREZGENE, UniProtKB/TrEMBL