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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:T cell receptor signaling pathway
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Accession:GO:0050852 term browser browse the term
Definition:The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.
Synonyms:exact_synonym: T lymphocyte receptor signaling pathway;   T lymphocyte receptor signalling pathway;   T-cell receptor signalling pathway;   TCR signaling pathway

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T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:18305217) MGI PMID:18305217 NCBI chrNW_004624760:4,878,811...5,032,719
Ensembl chrNW_004624760:4,878,556...5,031,491 		JBrowse link
G Ada adenosine deaminase acts_upstream_of ISO (PMID:11435465) MGI PMID:11435465 NCBI chrNW_004624790:9,809,550...9,829,199
Ensembl chrNW_004624790:9,809,492...9,829,883 		JBrowse link
G Bcl10 BCL10 immune signaling adaptor involved_in ISO (PMID:15125833) UniProt PMID:15125833 NCBI chrNW_004624742:12,210,333...12,222,533
Ensembl chrNW_004624742:12,210,360...12,221,759 		JBrowse link
G Bmx BMX non-receptor tyrosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624829:297,187...344,555
Ensembl chrNW_004624829:297,351...344,164 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase acts_upstream_of_or_within ISO (PMID:18228248) MGI PMID:18228248 NCBI chrNW_004624765:20,766,368...20,951,560
Ensembl chrNW_004624765:20,773,885...20,951,736 		JBrowse link
G Btk Bruton tyrosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624902:1,173,101...1,216,662
Ensembl chrNW_004624902:1,182,682...1,216,171 		JBrowse link
G Btn1a1 butyrophilin subfamily 1 member A1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624756:356,124...362,425
Ensembl chrNW_004624756:357,047...362,415 		JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 acts_upstream_of_or_within ISO (PMID:17028169) MGI PMID:17028169 NCBI chrNW_004624816:3,334,934...3,348,355
Ensembl chrNW_004624816:3,334,684...3,347,842 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 acts_upstream_of_or_within ISO (PMID:15637280), (PMID:17028169) MGI PMID:15637280 PMID:17028169 NCBI chrNW_004624866:4,973,087...5,287,477
Ensembl chrNW_004624866:4,973,207...5,281,746 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 acts_upstream_of_or_within ISO (PMID:23793062) MGI PMID:23793062 NCBI chrNW_004624746:18,692,179...18,704,952
Ensembl chrNW_004624746:18,692,225...18,704,476 		JBrowse link
G Cblb Cbl proto-oncogene B acts_upstream_of_or_within ISO (PMID:12697763) MGI PMID:12697763 NCBI chrNW_004624731:43,803,743...44,018,682
Ensembl chrNW_004624731:43,803,768...44,015,870 		JBrowse link
G Cd247 CD247 molecule acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11435465) MGI
TreeGrafter		 PMID:11435465 GO_REF:0000118 NCBI chrNW_004624826:5,504,676...5,574,037
Ensembl chrNW_004624826:5,505,569...5,573,783 		JBrowse link
G Cd276 CD276 molecule involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624781:691,348...703,202 JBrowse link
G Cd28 CD28 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23793062) TreeGrafter
MGI		 PMID:23793062 GO_REF:0000118 NCBI chrNW_004624765:12,650,092...12,667,168 JBrowse link
G Cd2ap CD2 associated protein acts_upstream_of_or_within ISO (PMID:14512504) MGI PMID:14512504 NCBI chrNW_004624754:13,420,594...13,511,672
Ensembl chrNW_004624754:13,420,603...13,511,523 		JBrowse link
G Cd3e CD3e molecule acts_upstream_of_or_within ISO (PMID:10485657) MGI PMID:10485657 NCBI chrNW_004624784:13,714,667...13,726,881
Ensembl chrNW_004624784:13,712,920...13,726,950 		JBrowse link
G Cd8a CD8 subunit alpha involved_in ISO (PMID:17145893) ComplexPortal PMID:17145893 NCBI chrNW_004624749:16,564,944...16,569,890 JBrowse link
G Cd8b CD8 subunit beta involved_in ISO (PMID:17145893) ComplexPortal PMID:17145893 NCBI chrNW_004624749:16,513,360...16,525,494 JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein acts_upstream_of_or_within ISO (PMID:18305217) MGI PMID:18305217 NCBI chrNW_004624945:734,532...767,184
Ensembl chrNW_004624945:734,532...767,168 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte associated protein 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624765:12,449,205...12,454,324
Ensembl chrNW_004624765:12,449,205...12,454,324 		JBrowse link
G Dennd1b DENN domain containing 1B involved_in ISO (PMID:26774822)
(MGI:5751612|PMID:26774822)		 UniProt PMID:26774822 MGI:5751612 NCBI chrNW_004624798:2,621,604...2,844,370
Ensembl chrNW_004624798:2,622,379...2,838,775 		JBrowse link
G Eif2b1 eukaryotic translation initiation factor 2B subunit alpha involved_in ISO (PMID:8626696) UniProt PMID:8626696 NCBI chrNW_004624747:23,413,045...23,422,227
Ensembl chrNW_004624747:23,414,077...23,421,074 		JBrowse link
G Eif2b2 eukaryotic translation initiation factor 2B subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624734:26,682,521...26,688,490
Ensembl chrNW_004624734:26,682,521...26,688,559 		JBrowse link
G Eif2b3 eukaryotic translation initiation factor 2B subunit gamma involved_in ISO (PMID:8626696) UniProt PMID:8626696 NCBI chrNW_004624906:733,148...882,690
Ensembl chrNW_004624906:733,146...892,362 		JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta involved_in ISO (PMID:8626696) UniProt PMID:8626696 NCBI chrNW_004624738:9,438,484...9,443,931
Ensembl chrNW_004624738:9,437,554...9,443,747 		JBrowse link
G Eif2b5 eukaryotic translation initiation factor 2B subunit epsilon involved_in ISO (PMID:8626696) UniProt PMID:8626696 NCBI chrNW_004624730:72,417,069...72,428,194
Ensembl chrNW_004624730:72,417,856...72,428,093 		JBrowse link
G Fcho1 FCH and mu domain containing endocytic adaptor 1 involved_in ISO (PMID:32098969) UniProt PMID:32098969 NCBI chrNW_004624908:1,327,569...1,340,741
Ensembl chrNW_004624908:1,327,602...1,340,240 		JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit acts_upstream_of_or_within ISO (PMID:32610127) MGI PMID:32610127 NCBI chrNW_004624738:10,370,479...10,391,623
Ensembl chrNW_004624738:10,370,103...10,391,623 		JBrowse link
G Foxp3 forkhead box P3 acts_upstream_of_or_within ISO (PMID:10072494), (PMID:11265635) MGI PMID:10072494 PMID:11265635 NCBI chrNW_004624893:995,145...1,008,492
Ensembl chrNW_004624893:995,182...1,008,679 		JBrowse link
G Fyb1 FYN binding protein 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624759:15,683,741...15,794,628
Ensembl chrNW_004624759:15,683,779...15,793,908 		JBrowse link
G Fyb2 FYN binding protein 2 involved_in ISO (PMID:27335501) UniProt PMID:27335501 NCBI chrNW_004624862:3,323,643...3,463,825 JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624933:248,298...456,933
Ensembl chrNW_004624933:389,627...456,520 		JBrowse link
G Gata3 GATA binding protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624775:2,985,077...3,014,567
Ensembl chrNW_004624775:2,994,164...3,015,392 		JBrowse link
G Hras HRas proto-oncogene, GTPase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:21444916) MGI
Ensembl		 PMID:21444916 GO_REF:0000107 NCBI chrNW_004624766:21,907,423...21,913,414
Ensembl chrNW_004624766:21,911,241...21,913,653 		JBrowse link
G Icoslg inducible T cell costimulator ligand involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624745:29,880,943...29,888,635
Ensembl chrNW_004624745:29,880,992...29,888,717 		JBrowse link
G Ifng interferon gamma acts_upstream_of_or_within ISO (PMID:21444916) MGI PMID:21444916 NCBI chrNW_004624802:163,261...166,534
Ensembl chrNW_004624802:163,261...166,534 		JBrowse link
G Itk IL2 inducible T cell kinase involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624733:32,125,005...32,198,901
Ensembl chrNW_004624733:32,127,388...32,198,869 		JBrowse link
G Khdrbs1 KH RNA binding domain containing, signal transduction associated 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624764:15,244,521...15,292,901
Ensembl chrNW_004624764:15,244,390...15,275,379 		JBrowse link
G Lat linker for activation of T cells involved_in ISO (PMID:25907557) UniProt PMID:25907557 NCBI chrNW_004624782:12,795,104...12,799,496
Ensembl chrNW_004624782:12,795,104...12,799,410 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:8943371) UniProt PMID:8943371 NCBI chrNW_004624764:15,469,582...15,495,351
Ensembl chrNW_004624764:15,472,685...15,495,351 		JBrowse link
G Lcp2 lymphocyte cytosolic protein 2 involved_in ISO (PMID:20551903) UniProt PMID:20551903 NCBI chrNW_004624733:19,625,276...19,720,125
Ensembl chrNW_004624733:19,672,868...19,719,584 		JBrowse link
G LOC101697345 HLA class II histocompatibility antigen, DP beta 1 chain involved_in ISO (PMID:32341563) UniProt PMID:32341563 NCBI chrNW_004624754:23,661,031...23,672,549
Ensembl chrNW_004624754:23,658,339...23,672,663 		JBrowse link
G LOC101698274 V-set domain-containing T-cell activation inhibitor 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624731:27,867,562...27,900,768 JBrowse link
G LOC101703821 HLA class II histocompatibility antigen, DQ beta 1 chain involved_in ISO (PMID:32341563) UniProt PMID:32341563 NCBI chrNW_004624754:23,895,509...23,902,487
Ensembl chrNW_004624754:23,895,607...23,906,713 		JBrowse link
G LOC101716577 tyrosine-protein kinase ZAP-70 involved_in
acts_upstream_of_or_within		 ISO (PMID:9489702)
(PMID:9208839)		 UniProt
MGI		 PMID:9208839 PMID:9489702 NCBI chrNW_004624749:2,893,601...2,901,256
Ensembl chrNW_004624749:2,893,601...2,901,035 		JBrowse link
G LOC106008672 butyrophilin-like protein 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624958:519,966...591,348 JBrowse link
G Malt1 MALT1 paracaspase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624792:4,148,258...4,223,431
Ensembl chrNW_004624792:4,148,453...4,217,548 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 acts_upstream_of_or_within ISO (PMID:9064344) MGI PMID:9064344 NCBI chrNW_004624747:1,296,062...1,389,674
Ensembl chrNW_004624747:1,296,221...1,389,757 		JBrowse link
G Mog myelin oligodendrocyte glycoprotein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624754:25,397,191...25,412,123
Ensembl chrNW_004624754:25,397,144...25,411,319 		JBrowse link
G Nfkbid NFKB inhibitor delta involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624794:10,172,789...10,180,693
Ensembl chrNW_004624794:10,168,792...10,179,510 		JBrowse link
G Nfkbiz NFKB inhibitor zeta involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624789:15,612,311...15,623,878
Ensembl chrNW_004624789:15,612,335...15,624,152 		JBrowse link
G Nras NRAS proto-oncogene, GTPase acts_upstream_of_or_within ISO (PMID:21444916) MGI PMID:21444916 NCBI chrNW_004624772:10,358,554...10,369,371 JBrowse link
G Pde4b phosphodiesterase 4B involved_in ISO (PMID:17404263) BHF-UCL PMID:17404263 NCBI chrNW_004624742:28,557,159...29,113,269
Ensembl chrNW_004624742:28,557,283...29,016,844 		JBrowse link
G Plcg1 phospholipase C gamma 1 acts_upstream_of_or_within ISO (PMID:15728238) MGI PMID:15728238 NCBI chrNW_004624919:1,766,533...1,800,130
Ensembl chrNW_004624919:1,766,149...1,803,097 		JBrowse link
G Plcg2 phospholipase C gamma 2 acts_upstream_of_or_within ISO (PMID:15728238) MGI PMID:15728238 NCBI chrNW_004624746:5,678,057...5,824,663
Ensembl chrNW_004624746:5,682,666...5,821,855 		JBrowse link
G Pram1 PML-RARA regulated adaptor molecule 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624828:1,251,566...1,259,032
Ensembl chrNW_004624828:1,251,815...1,256,314 		JBrowse link
G Prkd2 protein kinase D2 involved_in ISO (PMID:17077180) BHF-UCL PMID:17077180 NCBI chrNW_004624832:6,885,627...6,915,316
Ensembl chrNW_004624832:6,886,327...6,915,179 		JBrowse link
G Psen1 presenilin 1 acts_upstream_of_or_within ISO (PMID:17698590) MGI PMID:17698590 NCBI chrNW_004624734:28,200,358...28,272,684
Ensembl chrNW_004624734:28,200,140...28,272,743 		JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO (PMID:17698590) MGI PMID:17698590 NCBI chrNW_004624771:17,183,538...17,205,460
Ensembl chrNW_004624771:17,183,447...17,224,188 		JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14752163) MGI
Ensembl
TreeGrafter		 PMID:14752163 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624772:9,472,869...9,552,751
Ensembl chrNW_004624772:9,472,913...9,550,990 		JBrowse link
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:9064344) Ensembl
MGI		 PMID:9064344 GO_REF:0000107 NCBI chrNW_004624860:3,580,225...3,595,403
Ensembl chrNW_004624860:3,580,560...3,595,090 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004624798:1,700,732...1,814,603
Ensembl chrNW_004624798:1,699,541...1,814,656 		JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 involved_in ISO (PMID:20005846) UniProt PMID:20005846 NCBI chrNW_004624741:1,503,017...1,523,542
Ensembl chrNW_004624741:1,502,942...1,523,675 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (MGI:6142401|PMID:25282160) UniProt PMID:25282160 MGI:6142401 NCBI chrNW_004624771:7,837,547...7,948,217 JBrowse link
G Rc3h2 ring finger and CCCH-type domains 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624760:12,025,206...12,074,548 JBrowse link
G Rftn1 raftlin, lipid raft linker 1 involved_in ISO (MGI:3850290|PMID:19414744) UniProt PMID:19414744 MGI:3850290 NCBI chrNW_004624821:1,561,845...1,763,654
Ensembl chrNW_004624821:1,562,778...1,751,345 		JBrowse link
G Ripk2 receptor interacting serine/threonine kinase 2 involved_in
acts_upstream_of_or_within		 ISO (MGI:5285496|PMID:21469090)
(PMID:11894098)		 UniProt
MGI		 PMID:11894098 PMID:21469090 MGI:5285496 NCBI chrNW_004624744:2,194,339...2,227,498
Ensembl chrNW_004624744:2,201,319...2,226,890 		JBrowse link
G Rnf31 ring finger protein 31 involved_in ISO (PMID:20005846) UniProt PMID:20005846 NCBI chrNW_004624820:8,376,530...8,388,596
Ensembl chrNW_004624820:8,375,871...8,388,569 		JBrowse link
G Shb SH2 domain containing adaptor protein B acts_upstream_of_or_within ISO (PMID:24645804) MGI PMID:24645804 NCBI chrNW_004624825:3,846,604...3,972,780
Ensembl chrNW_004624825:3,845,092...3,973,636 		JBrowse link
G Skap1 src kinase associated phosphoprotein 1 involved_in ISO (PMID:11909961) UniProt PMID:11909961 NCBI chrNW_004624795:4,726,715...4,960,167
Ensembl chrNW_004624795:4,727,149...4,960,082 		JBrowse link
G Slc39a6 solute carrier family 39 member 6 involved_in ISO (PMID:34394081) UniProt PMID:34394081 NCBI chrNW_004624779:10,400,581...10,433,405
Ensembl chrNW_004624779:10,399,198...10,432,869 		JBrowse link
G Spn sialophorin involved_in ISO PMID:12496963 ARUK-UCL PMID:12496963 RGD:1358565 NCBI chrNW_004624782:13,471,083...13,483,712 JBrowse link
G Sppl3 signal peptide peptidase like 3 involved_in ISO (PMID:25384971)
(MGI:5640905|PMID:25384971)		 UniProt PMID:25384971 MGI:5640905 NCBI chrNW_004624747:12,795,803...12,925,319
Ensembl chrNW_004624747:12,795,563...12,928,649 		JBrowse link
G Stk11 serine/threonine kinase 11 acts_upstream_of_or_within ISO (PMID:21487392) MGI PMID:21487392 NCBI chrNW_004624828:7,444,339...7,466,926
Ensembl chrNW_004624828:7,445,069...7,467,298 		JBrowse link
G Stoml2 stomatin like 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:18641330) UniProt
Ensembl		 PMID:18641330 GO_REF:0000107 NCBI chrNW_004624915:294,781...298,312
Ensembl chrNW_004624915:294,777...298,278 		JBrowse link
G Tec tec protein tyrosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624761:18,695,168...18,824,045
Ensembl chrNW_004624761:18,695,177...18,822,078 		JBrowse link
G Themis thymocyte selection associated involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624753:2,214,779...2,292,936 JBrowse link
G Themis2 thymocyte selection associated family member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22732588) TreeGrafter
MGI		 PMID:22732588 GO_REF:0000118 NCBI chrNW_004624764:11,717,083...11,732,791
Ensembl chrNW_004624764:11,717,950...11,732,799 		JBrowse link
G Thy1 Thy-1 cell surface antigen involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624784:14,779,533...14,784,315
Ensembl chrNW_004624784:14,780,698...14,784,897 		JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 involved_in ISO (MGI:2137821|PMID:11485735) UniProt PMID:11485735 MGI:2137821 NCBI chrNW_004624754:13,567,898...13,633,368
Ensembl chrNW_004624754:13,567,734...13,634,009 		JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in ISO (PMID:23514740)
(PMID:15125833)		 UniProt PMID:15125833 PMID:23514740 NCBI chrNW_004624767:10,729,766...10,803,253
Ensembl chrNW_004624767:10,729,413...10,748,455 		JBrowse link
G Txk TXK tyrosine kinase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624761:18,841,795...18,897,564
Ensembl chrNW_004624761:18,841,795...18,897,458 		JBrowse link
G Ube2n ubiquitin conjugating enzyme E2 N involved_in ISO (PMID:15125833) UniProt PMID:15125833 NCBI chrNW_004624750:13,432,657...13,468,797
Ensembl chrNW_004624750:13,432,661...13,457,776 		JBrowse link
G Vtcn1 V-set domain containing T cell activation inhibitor 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624772:12,837,940...12,911,263
Ensembl chrNW_004624772:12,837,668...12,911,802 		JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 involved_in ISO (MGI:6141968|PMID:27400149) BHF-UCL PMID:27400149 MGI:6141968 NCBI chrNW_004624735:8,987,390...9,122,277
Ensembl chrNW_004624735:8,987,469...9,124,516 		JBrowse link
G Zc3h12a zinc finger CCCH-type containing 12A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624764:20,224,919...20,234,108
Ensembl chrNW_004624764:20,224,906...20,234,629 		JBrowse link
G Znf683 zinc finger protein 683 involved_in ISO (PMID:26179882) UniProt PMID:26179882 NCBI chrNW_004624764:10,382,733...10,388,608 JBrowse link
negative regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase involved_in ISO (PMID:38225265) UniProt PMID:38225265 NCBI chrNW_004624831:868,417...1,065,591
Ensembl chrNW_004624831:868,563...1,060,248 		JBrowse link
G Cblb Cbl proto-oncogene B acts_upstream_of_or_within ISO (PMID:14738763) MGI PMID:14738763 NCBI chrNW_004624731:43,803,743...44,018,682
Ensembl chrNW_004624731:43,803,768...44,015,870 		JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in ISO (MGI:2672999|PMID:12883552) UniProt PMID:12883552 MGI:2672999 NCBI chrNW_004624767:2,173,774...2,210,304
Ensembl chrNW_004624767:2,173,272...2,210,279 		JBrowse link
G Dusp22 dual specificity phosphatase 22 involved_in
acts_upstream_of_or_within		 ISO (PMID:38225265)
(PMID:24714587)		 UniProt
MGI		 PMID:24714587 PMID:38225265 NCBI chrNW_004624756:23,968,148...24,017,340
Ensembl chrNW_004624756:23,968,017...24,017,332 		JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624795:994,103...1,001,697 JBrowse link
G Elf1 E74 like ETS transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14738763) Ensembl
MGI		 PMID:14738763 GO_REF:0000107 NCBI chrNW_004624748:13,987,001...14,090,451
Ensembl chrNW_004624748:14,017,621...14,091,619 		JBrowse link
G Ezr ezrin involved_in ISO (PMID:20551903) UniProt PMID:20551903 NCBI chrNW_004624929:827,275...873,743
Ensembl chrNW_004624929:826,531...873,572 		JBrowse link
G Laptm5 lysosomal protein transmembrane 5 involved_in ISO (MGI:3803048|PMID:18619870) ARUK-UCL PMID:18619870 MGI:3803048 NCBI chrNW_004624764:14,208,144...14,277,208
Ensembl chrNW_004624764:14,207,094...14,228,135 		JBrowse link
G Lgals3 galectin 3 involved_in ISO (MGI:4355752|PMID:19706535) BHF-UCL PMID:19706535 MGI:4355752 NCBI chrNW_004624731:14,300,138...14,307,843
Ensembl chrNW_004624731:14,298,201...14,304,637 		JBrowse link
G Pawr pro-apoptotic WT1 regulator acts_upstream_of_or_within ISO (PMID:12970181) MGI PMID:12970181 NCBI chrNW_004624750:18,562,270...18,710,397
Ensembl chrNW_004624750:18,562,221...18,705,540 		JBrowse link
G Prnp prion protein (Kanno blood group) involved_in ISO (MGI:4943618|PMID:20145049) BHF-UCL PMID:20145049 MGI:4943618 NCBI chrNW_004624741:5,785,139...5,802,162
Ensembl chrNW_004624741:5,785,158...5,802,162 		JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (MGI:5320871|PMID:22080863) UniProt PMID:22080863 MGI:5320871 NCBI chrNW_004624770:19,808,400...19,877,494
Ensembl chrNW_004624770:19,808,400...19,876,503 		JBrowse link
G Ptpn22 protein tyrosine phosphatase non-receptor type 22 involved_in ISO (PMID:18056643) UniProt PMID:18056643 NCBI chrNW_004624772:9,472,869...9,552,751
Ensembl chrNW_004624772:9,472,913...9,550,990 		JBrowse link
G Ptpn6 protein tyrosine phosphatase non-receptor type 6 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:9064344) MGI
Ensembl		 PMID:9064344 GO_REF:0000107 NCBI chrNW_004624860:3,580,225...3,595,403
Ensembl chrNW_004624860:3,580,560...3,595,090 		JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J involved_in ISO (PMID:11259588), (PMID:9780142)
(MGI:4942249|PMID:12913111)
(PMID:12913111)		 UniProt PMID:9780142 PMID:11259588 PMID:12913111 MGI:4942249 NCBI chrNW_004624767:942,786...1,051,112
Ensembl chrNW_004624767:945,553...1,051,138 		JBrowse link
G Sh2d1a SH2 domain containing 1A involved_in ISO (PMID:9774102) UniProt PMID:9774102 NCBI chrNW_004624797:3,120,123...3,142,564
Ensembl chrNW_004624797:3,120,123...3,142,564 		JBrowse link
G Sla2 Src like adaptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624842:2,853,183...2,882,269
Ensembl chrNW_004624842:2,853,144...2,881,116 		JBrowse link
G Thy1 Thy-1 cell surface antigen involved_in ISO (MGI:1096761|PMID:9285719) UniProt PMID:9285719 MGI:1096761 NCBI chrNW_004624784:14,779,533...14,784,315
Ensembl chrNW_004624784:14,780,698...14,784,897 		JBrowse link
G Ubash3a ubiquitin associated and SH3 domain containing A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14738763) TreeGrafter
MGI		 PMID:14738763 GO_REF:0000118 NCBI chrNW_004624745:28,026,274...28,057,922 JBrowse link
positive regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase acts_upstream_of_or_within ISO (PMID:11435465) MGI PMID:11435465 NCBI chrNW_004624790:9,809,550...9,829,199
Ensembl chrNW_004624790:9,809,492...9,829,883 		JBrowse link
G Bcl10 BCL10 immune signaling adaptor involved_in ISO (PMID:18287044), (PMID:27777308) UniProt PMID:18287044 PMID:27777308 NCBI chrNW_004624742:12,210,333...12,222,533
Ensembl chrNW_004624742:12,210,360...12,221,759 		JBrowse link
G Card11 caspase recruitment domain family member 11 involved_in ISO (MGI:6695669|PMID:12154356)
(PMID:12154360)		 UniProt PMID:12154356 PMID:12154360 MGI:6695669 NCBI chrNW_004624740:29,974,707...30,085,498
Ensembl chrNW_004624740:29,974,689...30,085,981 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624795:2,777,766...2,787,664
Ensembl chrNW_004624795:2,779,627...2,788,897 		JBrowse link
G Cd226 CD226 molecule involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624806:11,324,239...11,390,487
Ensembl chrNW_004624806:11,324,344...11,388,206 		JBrowse link
G Cd81 CD81 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624767:15,192,446...15,210,923
Ensembl chrNW_004624767:15,192,452...15,210,922 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase acts_upstream_of_or_within ISO (PMID:16501569) MGI PMID:16501569 NCBI chrNW_004624757:5,895,912...5,953,485 JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma involved_in ISO (PMID:18287044), (PMID:27777308) UniProt PMID:18287044 PMID:27777308 NCBI chrNW_004624946:997,571...1,015,748
Ensembl chrNW_004624946:996,814...1,013,379 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 involved_in ISO (PMID:18796614) BHF-UCL PMID:18796614 NCBI chrNW_004624907:1,266,348...1,279,258
Ensembl chrNW_004624907:1,266,348...1,278,699 		JBrowse link
G Lipa lipase A, lysosomal acid type acts_upstream_of_or_within ISO (PMID:19179613) MGI PMID:19179613 NCBI chrNW_004624737:49,471...82,981
Ensembl chrNW_004624737:49,371...83,514 		JBrowse link
G LOC101706523 T-cell receptor-associated transmembrane adapter 1 acts_upstream_of_or_within ISO (PMID:11390434) MGI PMID:11390434 NCBI chrNW_004624731:40,281,086...40,319,254
Ensembl chrNW_004624731:40,280,884...40,306,653 		JBrowse link
G LOC101712173 poliovirus receptor homolog involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624907:1,582,636...1,596,528 JBrowse link
G Nectin2 nectin cell adhesion molecule 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624907:1,713,786...1,739,158
Ensembl chrNW_004624907:1,713,443...1,740,627 		JBrowse link
G Prkd2 protein kinase D2 involved_in ISO (MGI:4849903|PMID:20819079) UniProt PMID:20819079 MGI:4849903 NCBI chrNW_004624832:6,885,627...6,915,316
Ensembl chrNW_004624832:6,886,327...6,915,179 		JBrowse link
G Rab29 RAB29, member RAS oncogene family involved_in ISO (PMID:26021297) ParkinsonsUK-UCL PMID:26021297 NCBI chrNW_004624807:5,478,570...5,483,473
Ensembl chrNW_004624807:5,478,707...5,483,475 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624767:20,732,813...20,742,016
Ensembl chrNW_004624767:20,732,938...20,741,272 		JBrowse link
G Rps3 ribosomal protein S3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624817:1,710,768...1,715,923
Ensembl chrNW_004624817:1,710,768...1,716,224 		JBrowse link
G Tespa1 thymocyte expressed, positive selection associated 1 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624983:31,552...47,575
Ensembl chrNW_004624983:31,766...45,077 		JBrowse link
G Ubr2 ubiquitin protein ligase E3 component n-recognin 2 involved_in ISO (PMID:38225265) UniProt PMID:38225265 NCBI chrNW_004624754:16,701,950...16,798,293
Ensembl chrNW_004624754:16,701,331...16,798,897 		JBrowse link
regulation of T cell receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl10 BCL10 immune signaling adaptor acts_upstream_of_or_within ISO (PMID:14614861) MGI PMID:14614861 NCBI chrNW_004624742:12,210,333...12,222,533
Ensembl chrNW_004624742:12,210,360...12,221,759 		JBrowse link
G Cd300a CD300a molecule involved_in ISO (PMID:22046970) UniProt PMID:22046970 NCBI chrNW_004624801:4,404,376...4,420,836
Ensembl chrNW_004624801:4,404,262...4,421,097 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase acts_upstream_of_or_within ISO (PMID:14752163) MGI PMID:14752163 NCBI chrNW_004624764:15,469,582...15,495,351
Ensembl chrNW_004624764:15,472,685...15,495,351 		JBrowse link
G Malt1 MALT1 paracaspase acts_upstream_of_or_within ISO (PMID:14614861) MGI PMID:14614861 NCBI chrNW_004624792:4,148,258...4,223,431
Ensembl chrNW_004624792:4,148,453...4,217,548 		JBrowse link
G Rc3h1 ring finger and CCCH-type domains 1 involved_in ISO (MGI:3580753|PMID:15917799) BHF-UCL PMID:15917799 MGI:3580753 NCBI chrNW_004624771:7,837,547...7,948,217 JBrowse link
G Tespa1 thymocyte expressed, positive selection associated 1 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:28598420) MGI
Ensembl		 PMID:28598420 GO_REF:0000107 NCBI chrNW_004624983:31,552...47,575
Ensembl chrNW_004624983:31,766...45,077 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15093
    immune system process 2103
      activation of immune response 460
        immune response-activating signaling pathway 405
          immune response-activating cell surface receptor signaling pathway 247
            antigen receptor-mediated signaling pathway 159
              T cell receptor signaling pathway 119
                negative regulation of T cell receptor signaling pathway + 19
                positive regulation of T cell receptor signaling pathway 19
                regulation of T cell receptor signaling pathway + 42
                termination of T cell signal transduction 0
Path 2
Term Annotations click to browse term
  biological_process 15093
    biological regulation 10618
      regulation of biological process 10301
        regulation of immune system process 1351
          positive regulation of immune system process 948
            positive regulation of immune response 617
              activation of immune response 460
                immune response-activating signaling pathway 405
                  immune response-activating cell surface receptor signaling pathway 247
                    antigen receptor-mediated signaling pathway 159
                      T cell receptor signaling pathway 119
                        negative regulation of T cell receptor signaling pathway + 19
                        positive regulation of T cell receptor signaling pathway 19
                        regulation of T cell receptor signaling pathway + 42
                        termination of T cell signal transduction 0
paths to the root