Eif2b2 (eukaryotic translation initiation factor 2B subunit beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Eif2b2 (eukaryotic translation initiation factor 2B subunit beta) Heterocephalus glaber
Analyze
Symbol: Eif2b2
Name: eukaryotic translation initiation factor 2B subunit beta
RGD ID: 18912396
Description: ENCODES a protein that exhibits ATP binding (ortholog); GTP binding (ortholog); guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN central nervous system development (ortholog); cytoplasmic translational initiation (ortholog); hippocampus development (ortholog); PARTICIPATES IN translation initiation pathway; ASSOCIATED WITH genetic disease (ortholog); hereditary nonpolyposis colorectal cancer type 7 (ortholog); intellectual disability (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Translation initiation factor eIF-2B subunit beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,682,521 - 26,688,559 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,682,521 - 26,688,490 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Eif2b2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,682,521 - 26,688,559 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,682,521 - 26,688,490 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
EIF2B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,002,921 - 75,012,366 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,002,921 - 75,012,366 (+)EnsemblGRCh38hg38GRCh38
GRCh371475,469,624 - 75,479,069 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,539,365 - 74,546,045 (+)NCBINCBI36Build 36hg18NCBI36
Build 341474,539,400 - 74,546,045NCBI
Celera1455,507,321 - 55,513,985 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,637,467 - 55,644,134 (+)NCBIHuRef
CHM1_11475,408,166 - 75,414,844 (+)NCBICHM1_1
T2T-CHM13v2.01469,212,006 - 69,221,436 (+)NCBIT2T-CHM13v2.0
Eif2b2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,266,255 - 85,273,402 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,266,255 - 85,273,402 (+)EnsemblGRCm39 Ensembl
GRCm381285,219,481 - 85,226,628 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,219,481 - 85,226,628 (+)EnsemblGRCm38mm10GRCm38
MGSCv371286,560,463 - 86,567,578 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,108,616 - 86,115,731 (+)NCBIMGSCv36mm8
Celera1286,677,163 - 86,684,278 (+)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.6NCBI
Eif2b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,597,979 - 110,604,403 (+)NCBIGRCr8
mRatBN7.26104,866,926 - 104,873,351 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6104,866,753 - 104,873,353 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,036,549 - 105,042,974 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,335,420 - 105,341,845 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,705,081 - 104,711,507 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,044,830 - 109,051,254 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,043,880 - 109,051,253 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,505,786 - 116,512,210 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,266,354 - 109,272,778 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,269,805 - 109,276,234 (+)NCBI
Celera6102,689,874 - 102,696,298 (+)NCBICelera
Cytogenetic Map6q31NCBI
Eif2b2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523553,356 - 559,376 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955523553,356 - 559,376 (-)NCBIChiLan1.0ChiLan1.0
EIF2B2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,083,418 - 76,091,858 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,299,983 - 75,308,362 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,554,516 - 55,561,201 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,399,056 - 74,405,770 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,399,056 - 74,405,770 (+)Ensemblpanpan1.1panPan2
EIF2B2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,110,521 - 48,117,175 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,110,050 - 48,116,686 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,794,633 - 47,801,288 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,338,118 - 48,344,788 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,338,090 - 48,346,938 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1848,008,933 - 48,015,589 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0848,030,425 - 48,037,077 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,428,882 - 48,435,552 (+)NCBIUU_Cfam_GSD_1.0
Eif2b2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,907,242 - 27,918,497 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,150,460 - 4,156,480 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,150,504 - 4,156,483 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2B2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,203,815 - 98,224,462 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,203,820 - 98,246,199 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27104,047,924 - 104,054,506 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2B2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,217,390 - 52,224,045 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,217,365 - 52,227,930 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605340,447,520 - 40,454,221 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000023386   ⟹   ENSHGLP00000023171
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462473426,682,521 - 26,688,559 (-)Ensembl
RefSeq Acc Id: XM_004837184   ⟹   XP_004837241
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473426,682,521 - 26,688,490 (-)NCBI
RefSeq Acc Id: XM_004837185   ⟹   XP_004837242
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462473426,682,521 - 26,688,488 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004837241 (Get FASTA)   NCBI Sequence Viewer  
  XP_004837242 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB15424 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000023171
GenBank Protein JAO03202 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004837241   ⟸   XM_004837184
- Peptide Label: isoform X1
- UniProtKB: A0AAX6NUJ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004837242   ⟸   XM_004837185
- Peptide Label: isoform X2
- UniProtKB: G5C1L3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000023171   ⟸   ENSHGLT00000023386


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000016520 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000023386 ENTREZGENE
InterPro eIF2B_beta_subunit UniProtKB/TrEMBL
  IF-2B-related UniProtKB/TrEMBL
  IF_2B-like_C UniProtKB/TrEMBL
  NagB/RpiA_transferase-like UniProtKB/TrEMBL
NCBI Gene Eif2b2 ENTREZGENE
PANTHER TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA UniProtKB/TrEMBL
  TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA UniProtKB/TrEMBL
Pfam IF-2B UniProtKB/TrEMBL
Superfamily-SCOP SSF100950 UniProtKB/TrEMBL
UniProt A0AAX6NUJ5 ENTREZGENE, UniProtKB/TrEMBL
  G5C1L3 ENTREZGENE, UniProtKB/TrEMBL