RGD Reference Report - Developmental changes of eukaryotic initiation factor 2B subunits in rat hippocampus. - Rat Genome Database

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Developmental changes of eukaryotic initiation factor 2B subunits in rat hippocampus.

Authors: Inamura, N  Nawa, H  Takei, N 
Citation: Inamura N, etal., Neurosci Lett. 2003 Jul 31;346(1-2):117-9.
RGD ID: 11041879
Pubmed: PMID:12850562   (View Abstract at PubMed)

Regulated protein synthesis is critical for neural development, such as the formation of synapses and neural circuits and the modulation of synaptic plasticity. Protein synthesis is controlled by translation factors, including initiation, elongation and release factors. Here we investigated the developmental changes of eukaryotic initiation factor 2B (eIF2B) subunits in rat hippocampus. The eIF2B beta, gamma, delta and epsilon subunit protein levels were maximal at embryonic day 18 and then decreased during development. Aged hippocampus contained only trace amounts of these subunits. The finding that eIF2B subunit levels are high in developing hippocampus suggests that regulated protein synthesis is active in young, highly plastic brain.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hippocampus development  IEP 11041879; 11041879; 11041879; 11041879 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Eif2b2  (eukaryotic translation initiation factor 2B subunit beta)
Eif2b3  (eukaryotic translation initiation factor 2B subunit gamma)
Eif2b4  (eukaryotic translation initiation factor 2B subunit delta)
Eif2b5  (eukaryotic translation initiation factor 2B subunit epsilon)


Additional Information