Stoml2 (stomatin like 2) - Rat Genome Database

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Gene: Stoml2 (stomatin like 2) Heterocephalus glaber
Analyze
Symbol: Stoml2
Name: stomatin like 2
RGD ID: 18936327
Description: ENCODES a protein that exhibits cardiolipin binding (ortholog); GTPase binding (ortholog); T cell receptor binding (ortholog); INVOLVED IN CD4-positive, alpha-beta T cell activation (ortholog); intracellular calcium ion homeostasis (ortholog); lipid localization (ortholog); PARTICIPATES IN mitochondria fusion pathway; ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); autosomal recessive distal hereditary motor neuronopathy 2 (ortholog); FOUND IN actin cytoskeleton (ortholog); immunological synapse (ortholog); membrane raft (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Stomatin-like protein 2; stomatin-like protein 2, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624915294,777 - 298,278 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624915294,781 - 298,312 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Stoml2Naked Mole-Ratacromesomelic dysplasia, Maroteaux type  ISOSTOML2 (Homo sapiens)8554872ClinVar Annotator: match by term: Acromesomelic dysplasia 1 and Maroteaux typeClinVarPMID:28492532
Stoml2Naked Mole-Ratanauxetic dysplasia  ISOSTOML2 (Homo sapiens)8554872ClinVar Annotator: match by term: Anauxetic dysplasiaClinVarPMID:28492532
Stoml2Naked Mole-Ratautosomal recessive distal hereditary motor neuronopathy 2  ISOSTOML2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive distal spinal muscular atrophy 2ClinVarPMID:28492532
Stoml2Naked Mole-Ratdistal arthrogryposis type 1A  ISOSTOML2 (Homo sapiens)8554872ClinVar Annotator: match by term: Arthrogryposis more ...ClinVarPMID:28492532
Stoml2Naked Mole-Ratfrontotemporal dementia and/or amyotrophic lateral sclerosis 6  ISOSTOML2 (Homo sapiens)8554872ClinVar Annotator: match by term: Frontotemporal dementia and/or amyotrophic lateral sclerosis 6ClinVarPMID:28492532
Stoml2Naked Mole-Ratgalactosemia  ISOSTOML2 (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferaseClinVarPMID:28492532
Stoml2Naked Mole-Rathyperphosphatasia with impaired intellectual development syndrome 2  ISOSTOML2 (Homo sapiens)8554872ClinVar Annotator: match by term: GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 6ClinVarPMID:22683086 more ...
Stoml2Naked Mole-Ratparaplegia  ISOSTOML2 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:23332916 more ...
Stoml2Naked Mole-Ratprimary ciliary dyskinesia  ISOSTOML2 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesiaClinVarPMID:28492532
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Stoml2Naked Mole-Ratcontact dermatitis  ISOSTOML2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25724174


Biological Process
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Stoml2Naked Mole-RatCD4-positive, alpha-beta T cell activation involved_inISOStoml2 (Mus musculus)9068941 PMID:23028053UniProtPMID:23028053
Stoml2Naked Mole-Ratintracellular calcium ion homeostasis involved_inISOSTOML2 (Homo sapiens)9068941 PMID:19944461UniProtPMID:19944461
Stoml2Naked Mole-Ratlipid localization involved_inISOStoml2 (Mus musculus)9068941 PMID:23028053UniProtPMID:23028053
Stoml2Naked Mole-Ratmitochondrial protein processing involved_inISOStoml2 (Mus musculus)9068941 PMID:19360003UniProtPMID:19360003
Stoml2Naked Mole-Ratmitochondrion localization NOT|involved_inISOStoml2 (Mus musculus)9068941 PMID:22623988UniProtPMID:22623988
Stoml2Naked Mole-Ratmitochondrion organization involved_inIEAPANTHER:PTN000029985150520179 TreeGrafterGO_REF:0000118
Stoml2Naked Mole-Ratpositive regulation of interleukin-2 production involved_inISOStoml2 (Mus musculus)9068941 PMID:23028053UniProtPMID:23028053
Stoml2Naked Mole-Ratprotein complex oligomerization involved_inISOSTOML2 (Homo sapiens)9068941 PMID:17121834UniProtPMID:17121834
Stoml2Naked Mole-Ratproton motive force-driven mitochondrial ATP synthesis involved_inISOStoml2 (Mus musculus)9068941 PMID:23028053UniProtPMID:23028053
Stoml2Naked Mole-Ratstress-induced mitochondrial fusion involved_inISOStoml2 (Mus musculus)9068941 PMID:19360003UniProtPMID:19360003
Stoml2Naked Mole-RatT cell receptor signaling pathway acts_upstream_of_or_withinISOSTOML2 (Homo sapiens)9068941 PMID:18641330UniProtPMID:18641330
1 to 11 of 11 rows

Cellular Component
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Stoml2Naked Mole-Ratactin cytoskeleton located_inISOSTOML2 (Homo sapiens)9068941 PMID:18641330UniProtPMID:18641330
Stoml2Naked Mole-Ratimmunological synapse located_inISOSTOML2 (Homo sapiens)9068941 PMID:22623988UniProtPMID:22623988
Stoml2Naked Mole-Ratmembrane located_inIEAInterPro:IPR001972150520179 InterProGO_REF:0000002
Stoml2Naked Mole-Ratmembrane raft located_inISOSTOML2 (Homo sapiens)9068941 PMID:18641330UniProtPMID:18641330
Stoml2Naked Mole-Ratmitochondrial inner membrane located_inISOSTOML2 (Homo sapiens)9068941 PMID:17121834UniProtPMID:17121834
Stoml2Naked Mole-Ratmitochondrial intermembrane space located_inISOSTOML2 (Homo sapiens)9068941 PMID:17121834UniProtPMID:17121834
Stoml2Naked Mole-Ratmitochondrion located_inIEAPANTHER:PTN000029985150520179 TreeGrafterGO_REF:0000118
Stoml2Naked Mole-Ratmitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
Stoml2Naked Mole-Ratmitochondrion located_inIEAUniProtKB-SubCell:SL-0173150520179 UniProtGO_REF:0000044
Stoml2Naked Mole-Ratplasma membrane located_inISOStoml2 (Mus musculus)9068941 PMID:22623988UniProtPMID:22623988
Stoml2Naked Mole-Ratplasma membrane located_inISOSTOML2 (Homo sapiens)9068941 PMID:22623988UniProtPMID:22623988
1 to 11 of 11 rows

Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Stoml2Naked Mole-Ratmitochondria fusion pathway  ISOSTOML2 (Homo sapiens)9068941 RGDPMID:21683788 and REF_RGD_ID:10402101
PMID:21993625   PMID:22301074  



Stoml2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624915294,777 - 298,278 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624915294,781 - 298,312 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
STOML2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,099,776 - 35,103,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl935,099,776 - 35,103,195 (-)EnsemblGRCh38hg38GRCh38
GRCh37935,099,773 - 35,103,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,089,888 - 35,093,154 (-)NCBINCBI36Build 36hg18NCBI36
Build 34935,089,892 - 35,093,154NCBI
Celera935,031,870 - 35,035,129 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef935,055,364 - 35,058,623 (-)NCBIHuRef
CHM1_1935,099,754 - 35,103,015 (-)NCBICHM1_1
T2T-CHM13v2.0935,118,954 - 35,122,373 (-)NCBIT2T-CHM13v2.0
Stoml2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39443,027,690 - 43,031,402 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl443,027,690 - 43,031,710 (-)EnsemblGRCm39 Ensembl
GRCm38443,027,690 - 43,031,976 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl443,027,690 - 43,031,710 (-)EnsemblGRCm38mm10GRCm38
MGSCv37443,040,562 - 43,044,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36443,048,790 - 43,052,484 (-)NCBIMGSCv36mm8
Celera443,057,751 - 43,061,444 (-)NCBICelera
Cytogenetic Map4A5NCBI
cM Map422.99NCBI
Stoml2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8562,052,042 - 62,055,639 (-)NCBIGRCr8
mRatBN7.2557,256,227 - 57,259,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl557,256,220 - 57,259,920 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx559,229,312 - 59,232,909 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0561,048,128 - 61,051,725 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0561,033,300 - 61,036,897 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0558,472,561 - 58,476,158 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,472,550 - 58,476,251 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0562,998,097 - 63,001,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,518,467 - 59,522,064 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1559,518,582 - 59,522,264 (-)NCBI
Celera555,844,984 - 55,848,581 (-)NCBICelera
Cytogenetic Map5q22NCBI
Stoml2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554721,079,578 - 1,082,486 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554721,079,261 - 1,082,632 (+)NCBIChiLan1.0ChiLan1.0
STOML2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,486,677 - 89,489,997 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1989,492,617 - 89,495,937 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0934,950,387 - 34,953,707 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1935,755,790 - 35,759,091 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl935,755,790 - 35,759,091 (-)Ensemblpanpan1.1panPan2
STOML2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11151,675,963 - 51,679,313 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1151,675,963 - 51,679,199 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,244,774 - 50,248,124 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01152,741,661 - 52,745,011 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1152,741,665 - 52,744,982 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11151,285,489 - 51,288,839 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01151,270,641 - 51,273,991 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01151,972,516 - 51,975,866 (-)NCBIUU_Cfam_GSD_1.0
Stoml2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947166,581,569 - 166,584,841 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365243,129,148 - 3,133,056 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365243,129,149 - 3,132,405 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STOML2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1235,890,679 - 235,894,737 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11235,891,479 - 235,894,944 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21263,416,861 - 263,420,324 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STOML2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11245,513,578 - 45,516,876 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1245,513,307 - 45,517,110 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603842,628,934 - 42,632,249 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000002768   ⟹   ENSHGLP00000002714
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_004624915294,777 - 298,278 (-)Ensembl
RefSeq Acc Id: XM_004873931   ⟹   XP_004873988
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624915294,781 - 298,312 (-)NCBI
RefSeq Acc Id: XM_013068939   ⟹   XP_012924393
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624915294,781 - 298,280 (-)NCBI
RefSeq Acc Id: XM_013068941   ⟹   XP_012924395
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624915294,781 - 298,063 (-)NCBI
RefSeq Acc Id: XM_021251490   ⟹   XP_021107149
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624915294,781 - 298,283 (-)NCBI
Protein RefSeqs XP_004873988 (Get FASTA)   NCBI Sequence Viewer  
  XP_012924393 (Get FASTA)   NCBI Sequence Viewer  
  XP_012924395 (Get FASTA)   NCBI Sequence Viewer  
  XP_021107149 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB13933 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000002714
  ENSHGLP00000037052
GenBank Protein JAN97818 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004873988   ⟸   XM_004873931
- Peptide Label: isoform X3
- UniProtKB: G5BXC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021107149   ⟸   XM_021251490
- Peptide Label: isoform X1
- UniProtKB: A0AAX6SEC2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924393   ⟸   XM_013068939
- Peptide Label: isoform X2
- UniProtKB: A0AAX6QR57 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012924395   ⟸   XM_013068941
- Peptide Label: isoform X4
- UniProtKB: A0AAX6QNW3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000002714   ⟸   ENSHGLT00000002768



1 to 22 of 22 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000002045 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000002768 ENTREZGENE
  ENSHGLT00000059901 UniProtKB/TrEMBL
Gene3D-CATH 3.30.479.30 UniProtKB/TrEMBL
InterPro Band7/mec-2_domain UniProtKB/TrEMBL
  Band_7 UniProtKB/TrEMBL
  Band_7/SPFH_dom_sf UniProtKB/TrEMBL
  Band_7_C UniProtKB/TrEMBL
  Stomatin_HflK_HflKC_fam UniProtKB/TrEMBL
KEGG Report hgl:101715609 UniProtKB/TrEMBL
NCBI Gene Stoml2 ENTREZGENE
PANTHER STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL UniProtKB/TrEMBL
  STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Band_7 UniProtKB/TrEMBL
  Band_7_C UniProtKB/TrEMBL
PRINTS STOMATIN UniProtKB/TrEMBL
SMART PHB UniProtKB/TrEMBL
Superfamily-SCOP SSF117892 UniProtKB/TrEMBL
UniProt A0AAX6QNW3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QR57 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SEC2 ENTREZGENE, UniProtKB/TrEMBL
  G5BXC2 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows